LOCUS       NM_001164679            3773 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus anoctamin 8 (Ano8), mRNA.
ACCESSION   NM_001164679 XM_889480
VERSION     NM_001164679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3773)
  AUTHORS   Suzuki,J., Fujii,T., Imao,T., Ishihara,K., Kuba,H. and Nagata,S.
  TITLE     Calcium-dependent phospholipid scramblase activity of TMEM16
            protein family members
  JOURNAL   J Biol Chem 288 (19), 13305-13316 (2013)
   PUBMED   23532839
REFERENCE   3  (bases 1 to 3773)
  AUTHORS   Schreiber,R., Uliyakina,I., Kongsuphol,P., Warth,R., Mirza,M.,
            Martins,J.R. and Kunzelmann,K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   4  (bases 1 to 3773)
  AUTHORS   Gritli-Linde,A., Vaziri Sani,F., Rock,J.R., Hallberg,K.,
            Iribarne,D., Harfe,B.D. and Linde,A.
  TITLE     Expression patterns of the Tmem16 gene family during cephalic
            development in the mouse
  JOURNAL   Gene Expr Patterns 9 (3), 178-191 (2009)
   PUBMED   19059364
  REMARK    GeneRIF: during mouse cephalic development: detected in
            subventricular zone and differentiating fields, In organs
            developing through epithelial-mesenchymal interactions, such as the
            palate, tooth and tongue
REFERENCE   5  (bases 1 to 3773)
  AUTHORS   Rock,J.R. and Harfe,B.D.
  TITLE     Expression of TMEM16 paralogs during murine embryogenesis
  JOURNAL   Dev Dyn 237 (9), 2566-2574 (2008)
   PUBMED   18729231
  REMARK    GeneRIF: Data show the expression of Tmem16h during murine
            embryogenesis with an emphasis on the respiratory, digestive,
            skeletal, and integumentary systems.
REFERENCE   6  (bases 1 to 3773)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of TMEM16H gene in silico
  JOURNAL   Int J Mol Med 15 (2), 353-358 (2005)
   PUBMED   15647853
REFERENCE   7  (bases 1 to 3773)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX201380.1, CD355145.1, BU708306.1, CK624319.1 and BC059855.1.
            
            On Sep 11, 2009 this sequence version replaced XM_889480.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027735.1, SRR13948564.2300172.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               CX201380.1         1-109
            110-597             CD355145.1         1-488
            598-972             BU708306.1         90-464
            973-1467            CK624319.1         1-495
            1468-3773           BC059855.1         1-2306
FEATURES             Location/Qualifiers
     source          1..3773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..3773
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /note="anoctamin 8"
                     /db_xref="GeneID:382014"
                     /db_xref="MGI:MGI:2687327"
     exon            1..314
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..3391
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /note="transmembrane protein 16H"
                     /codon_start=1
                     /product="anoctamin-8"
                     /protein_id="NP_001158151.1"
                     /db_xref="CCDS:CCDS52585.1"
                     /db_xref="GeneID:382014"
                     /db_xref="MGI:MGI:2687327"
                     /translation="MAEAASGAGDVTLEGERGKRPPPEGEPAAPASGVLDKLFGKRLL
                     QAGRYLVSHKAWMKTVPTEDCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHR
                     HTRAYAFFVTATYESLLRGADELGLRKAVKAEFGGGTRSFSCEEDFIYENVESELRFF
                     TSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILN
                     RLMKSWVQAVCENQPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAD
                     QTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGIR
                     RISPITRAEEFYYPPWKRLLFQLLVSLPLCLACLICVFILMLGCFQLQELVLSVKGLP
                     RLVRFLPKVMLALLVSVSAEGYKKLAVWLNDMENYRLESTYERHLIIKVVLFQFVNSY
                     LSLFYIGFYLKDMDRLKEMLATLLITRQLLQNVREVLQPHLYRRLGSGELGLRTILEL
                     ARALLGLLNPLRPDPRRHLEAQADEGGAGSRRCLGGGCGAPEEENEEEEEAAVERRPA
                     GEGGEVPEGPRGGKEEDEEEDDDEDEDEEYEGEEGSLLDCGLRLKKVSFAERGAGRRR
                     PGPSPDGLLEEGSPTMVEKGLEPGVFTLAEEDDEPEGPPGSPGPEPQTVLLRRARGEG
                     RDQGPDGDRDTETGSGDAAGRQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDTF
                     QDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQRPFGRRVESIG
                     QWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPEAAIVSVVVLEHLALLVKYLIH
                     VAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQQRFQQQQRRRREEEERQRHAEQQAR
                     RERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQT
                     RPPAPTGCAPPPRSPADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAP
                     GGGARAHRSAGDEPAAAEPEPRPEDAGHRP"
     exon            315..425
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            426..558
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            559..697
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            698..794
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            795..911
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1039
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1201
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1354
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1481
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1537
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1612
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..2419
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2611
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2743
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2854
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3757
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgctgaga ctaggaagaa gaattgaggt ttggcttggg cggggacgac aagcaagtgg
       61 agcgcaggga cggcgggctg cgcgggcggg cgagagaggc ctttgtctcc tcctccggcg
      121 cgctcggtgg tgccactccg gtcctcatga gcccgtggcc ccccagcgcc cgggcgtccc
      181 gcggccccta acctgccctg tcctcgccat ggccgaggcg gcttcgggcg ccggggacgt
      241 gaccctggag ggggagcggg gcaagaggcc ccctcccgag ggcgagcctg cggcgcctgc
      301 gtctggagta ctggataaac tatttgggaa gaggctcctg caggctggcc gctacctggt
      361 gtcccacaag gcatggatga agacagtgcc cactgaggac tgcgacgtgc tcatgacctt
      421 cccagacacc actgatgacc acacgctgct gtggctgctg aatcacatcc gggtgggcat
      481 tcccgagctg atcgtgcaag ttcgccacca ccgccacacg cgtgcctatg ccttctttgt
      541 caccgccaca tacgagagcc tgctccgtgg ggccgatgag ctgggtctgc gcaaggccgt
      601 gaaggccgaa tttggagggg gcacccgcag cttctcctgc gaagaggact tcatctacga
      661 gaatgtggag agcgagctac gcttcttcac atcgcaggag cggcagagca tcattcgctt
      721 ctggttgcag aaccttcgag ccaagcaggg ggaggctctg cacaacgtgc gcttcttgga
      781 ggaccagcca atcattccgg agctggctgc acgaggcatc atacagcagg tgtttccagt
      841 tcacgagcag cgtattctga atcgtctcat gaagtcctgg gtgcaggccg tgtgtgaaaa
      901 ccagccttta gatgatatct gtgactattt tggggtgaag attgccatgt attttgcctg
      961 gctgggcttc tacacatcgg caatggttta tcctgcagtt tttggctctg ttctgtatac
     1021 attcactgag gctgatcaga caagccggga tgtttcctgt gtggtcttcg ctctcttcaa
     1081 tgtgatctgg tcaacactgt tcttggagga gtggaaacgg aggggggcag agctagccta
     1141 caagtggggt acactagact cacctgggga ggctgtggag gagccacgtc cccagttcag
     1201 gggcatccgg cgcatcagcc ccatcacccg ggctgaggag ttctactacc caccctggaa
     1261 gcgattgctt ttccaactac ttgtcagcct gcctctgtgc ctggcctgtc ttatctgtgt
     1321 ctttatactg atgcttggct gcttccagct gcaggagcta gtcttgagtg tgaagggtct
     1381 gccccgcctg gttcgcttct tgcccaaggt tatgctagcc ctgctggtca gcgtgagtgc
     1441 tgagggctac aagaagttag ctgtgtggct aaatgacatg gagaattacc ggctagagag
     1501 cacctacgag aggcacctta tcatcaaagt cgtcttgttc cagtttgtca actcgtactt
     1561 gagtctgttc tacatcggct tctacctcaa agacatggac cgcctaaaag agatgctggc
     1621 caccctactc atcacccggc agctgctgca gaacgtgcgc gaggtgctgc agccgcacct
     1681 gtaccgcagg ctgggcagcg gggagctggg cttgcgaacc atcctggagc tggcccgggc
     1741 cctgctaggc ctgctgaacc ccttgcgccc ggatccccga cggcacttgg aggcccaggc
     1801 tgatgagggc ggagctggga gccgcaggtg cctgggcggt ggctgcgggg cgccagagga
     1861 ggagaatgag gaggaggagg aggcagctgt ggagcggagg ccagcagggg aaggagggga
     1921 ggttccagaa gggcctcggg gtggcaagga ggaggacgag gaggaggacg acgacgaaga
     1981 cgaggacgag gaatacgagg gcgaggaagg aagcctccta gactgcgggc tgcgcctcaa
     2041 gaaggtcagc tttgctgagc ggggcgcagg gcggcgcagg ccaggcccca gcccagacgg
     2101 cctcttggag gaggggagcc ctaccatggt ggagaagggg ctggagcctg gtgtgtttac
     2161 tctggccgaa gaagacgatg agcctgaggg gcctccaggc agtcccgggc cagagcccca
     2221 gactgtcttg cttcgtcggg cgaggggcga gggccgtgac caaggtcctg atggagaccg
     2281 agatacggag actggctctg gcgacgcggc tggaagacag aaaagacata acaggtcctc
     2341 gtggatcgac ccgccagagg aggagcattc accgcagctc acgcaggcag agctagagag
     2401 ctgcatgaag aagtatgagg acaccttcca ggactaccag gagatgttcg tgcagtttgg
     2461 ctatgtagtg ctcttctcct ctgccttccc actggccgcc ctgtgcgccc tcgtcaacaa
     2521 cctgattgag atccgaagtg atgccttcaa gctctgcact ggcctgcaga ggccctttgg
     2581 ccggcgtgtg gagagcattg gccagtggca gaaggtcatg gaggcgatgg gtgtgctggc
     2641 catcgtggta aactgctacc tcattggcca gtgtggccag ctgcagcgcc tgttcccctg
     2701 gctgagccca gaggcggcca ttgtatctgt ggtggtgcta gagcacttgg ctcttctagt
     2761 caagtacctc atccatgtag ccatccctga catccccggc tgggtagctg aggagatggc
     2821 caaactggag taccagcgac gggaagcttt caagcggcac gagcggcagg cgcagcagcg
     2881 ctttcagcag cagcagcggc ggcggcgcga ggaggaggag cggcagcggc acgcggagca
     2941 gcaggcgcgg cgggagcgcg acacgggagg ccgcgaggag gcgcgcgcgg aggcgccggg
     3001 tcctgacccc gtggcggagc ggggcgctgc caaggccaag ggcagcgagc ggccccgacg
     3061 gcccggagcg ctgctgccac ccggacctgt gctgcggctg aagcagatca tcccgttgca
     3121 gactcggccg cccgcgccca ccgggtgcgc gcccccgccg cgctcgcccg cggacacgcg
     3181 cctgcccgcc ttcctcagcc tgcgcttcct caaggctccg gagcgaggcc cgtccccgcc
     3241 gcggcccggg aagctgttcg cattctcggc gcgcgagccc tcagccaacg gggcccccgg
     3301 gggcggcgcg cgcgctcaca ggagcgccgg ggacgagccc gcggccgccg agcccgaacc
     3361 gcggccggag gacgcaggtc acaggcctta accggggcgc gcgtcgcgag ggcagtgggc
     3421 gccgtggggc cctgcgaacc gcgctctccc tccgcagggt ccgcctcgcc tcctgctggc
     3481 tgttggcgct gggacgcgcc ctggggctgc ggcgacaacc cgccccgtgt ccccgcggat
     3541 gtcccagcgg atgcccctgc acagcctgcc tgctggccca cagcccgcca ctagccccgc
     3601 cgcgcccctg ccgttctccc gaccaggatg ggggcctcga gcagaccccc cacaatacag
     3661 aaaaatacac aggatgggcg gttatttatt tgtttttaat ttattttgtc atatttttgt
     3721 aaaacggcag aaatgcaata aaatgtctat ttcaacaaaa aaaaaaaaaa aaa
//
