LOCUS       NP_001158151            1060 aa            linear   ROD 30-APR-2024
DEFINITION  anoctamin-8 [Mus musculus].
ACCESSION   NP_001158151 XP_894573
VERSION     NP_001158151.1
DBSOURCE    REFSEQ: accession NM_001164679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1060)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1060)
  AUTHORS   Suzuki,J., Fujii,T., Imao,T., Ishihara,K., Kuba,H. and Nagata,S.
  TITLE     Calcium-dependent phospholipid scramblase activity of TMEM16
            protein family members
  JOURNAL   J Biol Chem 288 (19), 13305-13316 (2013)
   PUBMED   23532839
REFERENCE   3  (residues 1 to 1060)
  AUTHORS   Schreiber,R., Uliyakina,I., Kongsuphol,P., Warth,R., Mirza,M.,
            Martins,J.R. and Kunzelmann,K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   4  (residues 1 to 1060)
  AUTHORS   Gritli-Linde,A., Vaziri Sani,F., Rock,J.R., Hallberg,K.,
            Iribarne,D., Harfe,B.D. and Linde,A.
  TITLE     Expression patterns of the Tmem16 gene family during cephalic
            development in the mouse
  JOURNAL   Gene Expr Patterns 9 (3), 178-191 (2009)
   PUBMED   19059364
  REMARK    GeneRIF: during mouse cephalic development: detected in
            subventricular zone and differentiating fields, In organs
            developing through epithelial-mesenchymal interactions, such as the
            palate, tooth and tongue
REFERENCE   5  (residues 1 to 1060)
  AUTHORS   Rock,J.R. and Harfe,B.D.
  TITLE     Expression of TMEM16 paralogs during murine embryogenesis
  JOURNAL   Dev Dyn 237 (9), 2566-2574 (2008)
   PUBMED   18729231
  REMARK    GeneRIF: Data show the expression of Tmem16h during murine
            embryogenesis with an emphasis on the respiratory, digestive,
            skeletal, and integumentary systems.
REFERENCE   6  (residues 1 to 1060)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of TMEM16H gene in silico
  JOURNAL   Int J Mol Med 15 (2), 353-358 (2005)
   PUBMED   15647853
REFERENCE   7  (residues 1 to 1060)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX201380.1, CD355145.1, BU708306.1, CK624319.1 and BC059855.1.
            
            On Sep 11, 2009 this sequence version replaced XP_894573.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027735.1, SRR13948564.2300172.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     Protein         1..1060
                     /product="anoctamin-8"
                     /note="transmembrane protein 16H"
                     /calculated_mol_wt=118970
     Region          1..32
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCE9; propagated from
                     UniProtKB/Swiss-Prot (Q6PB70.3)"
     Region          237..>495
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     Site            245..265
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            282..302
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            318
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            357..377
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            401..421
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            438..458
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Region          529..605
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Region          619..640
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Region          653..672
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            665
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6PB70.3)"
     Region          680..723
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Region          <703..872
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     Site            708
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            746..766
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            796
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCE9; propagated from
                     UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            803..823
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            837..857
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Region          884..1060
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PB70.3)"
     Region          <917..1057
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau; cl46901"
                     /db_xref="CDD:481241"
     Site            991
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0007744|PubMed:24129315;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q6PB70.3)"
     Site            999
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q6PB70.3)"
     CDS             1..1060
                     /gene="Ano8"
                     /gene_synonym="Tmem16h"
                     /coded_by="NM_001164679.1:209..3391"
                     /db_xref="CCDS:CCDS52585.1"
                     /db_xref="GeneID:382014"
                     /db_xref="MGI:MGI:2687327"
ORIGIN      
        1 maeaasgagd vtlegergkr pppegepaap asgvldklfg krllqagryl vshkawmktv
       61 ptedcdvlmt fpdttddhtl lwllnhirvg ipelivqvrh hrhtrayaff vtatyesllr
      121 gadelglrka vkaefgggtr sfsceedfiy enveselrff tsqerqsiir fwlqnlrakq
      181 gealhnvrfl edqpiipela argiiqqvfp vheqrilnrl mkswvqavce nqplddicdy
      241 fgvkiamyfa wlgfytsamv ypavfgsvly tfteadqtsr dvscvvfalf nviwstlfle
      301 ewkrrgaela ykwgtldspg eaveeprpqf rgirrispit raeefyyppw krllfqllvs
      361 lplclaclic vfilmlgcfq lqelvlsvkg lprlvrflpk vmlallvsvs aegykklavw
      421 lndmenyrle styerhliik vvlfqfvnsy lslfyigfyl kdmdrlkeml atllitrqll
      481 qnvrevlqph lyrrlgsgel glrtilelar allgllnplr pdprrhleaq adeggagsrr
      541 clgggcgape eeneeeeeaa verrpagegg evpegprggk eedeeeddde dedeeyegee
      601 gslldcglrl kkvsfaerga grrrpgpspd glleegsptm vekglepgvf tlaeeddepe
      661 gppgspgpep qtvllrrarg egrdqgpdgd rdtetgsgda agrqkrhnrs swidppeeeh
      721 spqltqaele scmkkyedtf qdyqemfvqf gyvvlfssaf plaalcalvn nlieirsdaf
      781 klctglqrpf grrvesigqw qkvmeamgvl aivvncylig qcgqlqrlfp wlspeaaivs
      841 vvvlehlall vkylihvaip dipgwvaeem akleyqrrea fkrherqaqq rfqqqqrrrr
      901 eeeerqrhae qqarrerdtg greearaeap gpdpvaerga akakgserpr rpgallppgp
      961 vlrlkqiipl qtrppaptgc appprspadt rlpaflslrf lkapergpsp prpgklfafs
     1021 arepsangap gggarahrsa gdepaaaepe prpedaghrp
//
