LOCUS       NM_207031               4019 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus anoctamin 7 (Ano7), transcript variant 1, mRNA.
ACCESSION   NM_207031
VERSION     NM_207031.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4019)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4019)
  AUTHORS   Suzuki,J., Fujii,T., Imao,T., Ishihara,K., Kuba,H. and Nagata,S.
  TITLE     Calcium-dependent phospholipid scramblase activity of TMEM16
            protein family members
  JOURNAL   J Biol Chem 288 (19), 13305-13316 (2013)
   PUBMED   23532839
REFERENCE   3  (bases 1 to 4019)
  AUTHORS   Milenkovic,V.M., Brockmann,M., Stohr,H., Weber,B.H. and Strauss,O.
  TITLE     Evolution and functional divergence of the anoctamin family of
            membrane proteins
  JOURNAL   BMC Evol Biol 10, 319 (2010)
   PUBMED   20964844
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4019)
  AUTHORS   Schreiber,R., Uliyakina,I., Kongsuphol,P., Warth,R., Mirza,M.,
            Martins,J.R. and Kunzelmann,K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   5  (bases 1 to 4019)
  AUTHORS   Bera,T.K., Das,S., Maeda,H., Beers,R., Wolfgang,C.D., Kumar,V.,
            Hahn,Y., Lee,B. and Pastan,I.
  TITLE     NGEP, a gene encoding a membrane protein detected only in prostate
            cancer and normal prostate
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 3059-3064 (2004)
   PUBMED   14981236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BK004075.1 and AC108412.8.
            
            On Dec 8, 2012 this sequence version replaced NM_207031.1.
            
            Summary: This gene encodes a member of the anoctamin family, which
            in mammals is comprised of 10 members. Anoctamin proteins are
            proposed to have eight transmembrane domains with both termini
            facing the cytoplasm and a C-terminal domain of unknown function.
            While some members have been characterized as calcium-activated
            chloride channels, this protein is reported to have little anion
            conductance activity. In humans, this protein is primarily found in
            prostate tissues and may serve as a target for prostate cancer
            immunotherapy. Alternative splicing results in multiple transcript
            variants that encode different isoforms. [provided by RefSeq, Dec
            2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3217              BK004075.1         1-3217
            3218-4019           AC108412.8         47761-48562
FEATURES             Location/Qualifiers
     source          1..4019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.24 cM"
     gene            1..4019
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /note="anoctamin 7"
                     /db_xref="GeneID:404545"
                     /db_xref="MGI:MGI:3052714"
     exon            1..152
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            153..267
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            268..325
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            326..456
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            457..564
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            565..701
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            702..759
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            760..870
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1036
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1127
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1224
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1368
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1506
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1605
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1708
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1820
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1875
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1973
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2104
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2310
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2453
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2544
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2664
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..4019
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4001..4006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /note="hexamer: AATAAA"
     polyA_site      4019
                     /gene="Ano7"
                     /gene_synonym="Ngep; Ngep-L; Pcanap5; Tmem16g"
                     /note="major polyA site"
ORIGIN      
        1 agtgaggcaa gggcaggtga gcggctgcca cagctcaggc agagcccagg agactggggt
       61 ggctggccct gattttgctc ctgctggaac caggcttgtg ttgatgggct ggctgtgaac
      121 tctgaggtct cctctggaag ccactgtgcc aggagtgaca tgctgcgggg gcaagcgcga
      181 gaagaagaca gcgtggtgct gatcgacatg gcctcccctg aagcagggaa tggatgctcc
      241 tatgggagca cagcccaagc ctcagaggca ggtaaacagc aggtggcccc cagcagagtt
      301 gggagctctg ccaaaccccc aattgatttt gttcttgttt gggaagaaga cctgaggaac
      361 caagagaacc ccacgaagga caagacagac acacacgagg tctggcggga gacttttctg
      421 gagaatcttt gcttggctgg cctgaaaata gatcagcatg atgtccagga tgaggccgct
      481 gcagttcatt acatcctcct ccgcgcaccc tgggctgtgc tttgctacta tgcagaagac
      541 ctgcgcctga agctgcctct acaggagtta cccaaccagg cctccaactg gtcagccacc
      601 cttctggagt ggctgggcat ccccaatatc ctgctggagc acgtgcctga cacgcccccc
      661 gagtattact cctgccagtt caaagcaagc aagctgcaat ggtttcttgg gagtgacaac
      721 caagacacct tcttcaccag caccaagagg catcagattc tatttgagat cctggccaag
      781 actccatatg ggcacgagaa gaaaggcctg tttgggattg accagctgct ggcagaaggt
      841 gtattcagtg cagccttccc tctgcatgac ggcccattct ctgcagtccc agagagctca
      901 caggtcctgg gtctcatcca acgccaagtc ttattccagc actgggctcg ctggggcaag
      961 tggaacaagt accagccatt ggaccatgtg cgaaggtact tcggggagaa ggtggctctc
     1021 tacttcgcct ggcttgggtt ttacactggt tggctcctgc ctgcggcagt agtgggcaca
     1081 gtggtcttcc tggtgggatg tttcctggtg ttctcagaca taccaacgca ggagctgtgt
     1141 cacagctcag acagcttcga catgtgcccg ctgtgctccg actgttcttt ttggctgctc
     1201 tccagtgcct gcaccctggc ccaggctggg cggctcttcg accatggcgg caccgtcttc
     1261 ttcagtttgt tcatggcact gtgggcggtg ctgcttctgg agtactggaa gcggaaaaac
     1321 gccacattgg cctaccgctg ggactgttct gactatgaag acattgagga gaggcctcgg
     1381 ccccagttcg ctgcaacggc ccccatgaca gccctgaacc ccatcacggg ggaagatgag
     1441 ccctactttc ctgagaagaa tcgtgtacgc cgcatgctgg ctggttctgt ggtgctcttg
     1501 atgatggtgg ctgtggtgat tatgtgcctt gtatctgtca tcctgtaccg ggccgtcatg
     1561 gctatcattg tgtccaggtc agacaacgcc ttcctctctg cctgggcttc acggattgcc
     1621 agcctcacag ggtcagtggt gaaccttgtc ttcatcctca tcctctccaa ggtctatgtg
     1681 ctcctggccc aggtcctaac aagatgggag atgcaccgga cacagaccga gtttgaggat
     1741 gccttcaccc tcaaggtgtt catcttccag tttgtgaatt tctacgcctc gcccgtgtat
     1801 atcgccttct tcaagggcag gtttgtggga tacccgggca actaccacac cttgtttgga
     1861 atccgaaatg aggagtgtcc agctggaggc tgcctcagtg agctggcaca ggagctcctg
     1921 gtcatcatgg tgggcaagca gatcatcaat aacgtgcagg aggttcttgt cccaaagctg
     1981 aaaggctgct ggcagaagtt ctccaggggc aagaaggctg gcacggggac ccacccagca
     2041 ccttgggagg ccgactatga gttgctgcct tgtgaggggc tgtttcacga ataccttgaa
     2101 atggtgctgc agtttggatt cgtcaccatc ttcgtagctg cctgcccgct ggcgccgctt
     2161 tttgccctac tcaacaactg ggtggagatc cgcctagatg cgcgcaagtt cgtgtgcgag
     2221 tatcggcgcc cagtggcgga gcgcgcccag gacatcggca tctggttcca catcctaacg
     2281 ggcctcacac acctcgcggt catcagcaat gccttcctgc tggccttctc ctccgacttc
     2341 ctgccacgtg tctactacag ctggacgcac gcccctgacc tgcatggctt cctcaatttc
     2401 acgctggcac gagcaccgcc cactttcacc tccgcacaca accgcacttg caggtaccgg
     2461 gctttccggg atgatgatgg acactattct ccgacttact ggactctcct ggccatccgc
     2521 ctggcctttg tcatcgtatt tgagcatgtg gtgttctcca ttggccgtgt tctggatctc
     2581 ttggttcctg acatcccaga atccgtggag atcaaggtga agcgggaata ctatttagct
     2641 aaacaagcac tggctgagaa cgaggctctc cttggagcaa caggagtgaa ggatgaccaa
     2701 cctccaagtt cagagcccag cctgggtctt ccagcctaag ggagactctt tggaatggtg
     2761 accacctccc tttccttctc tgaggtcaca gtaggggtta ccggaggctg acacacttgc
     2821 ctggaagact gttgaagatg tgtcaggaga cagttcacta ttgtgtgtct tttggagacc
     2881 atgatcctgg ccccagctca accatctcca cccttggttt agaataacca tgacccttgg
     2941 ctgccacagt cctgtgctca gtcactaccc ctgctacatg ttccttagga ctacccattt
     3001 ggagcagtgt ttagagagtt atctgctggc cttaggggct atcccctact gccattccta
     3061 agtcccatga gccaataact tgtgtctcat tcccctcccg atgtccacac ccctctcaag
     3121 gcaaaaggtc tgtctgaaat ccctgcttct gtggctgttt tgctgaccat tgtactcaaa
     3181 gtattttgtt cttcctttgc ttcacctatt ctgtccctaa tatcactagc gatgttccta
     3241 tccctaaacc aaaggctgag ggtcctctgt atacgatgcc ttcctgaatc ttaagatatg
     3301 aggaagtggc ttcacagttg acatatggtc cccatccccc atcccctacc atggcataac
     3361 tcttctgcca attgaaaggt taaacgctgg ggtccctgcc ttcccagggc tttgctcggt
     3421 cctcttgcag cattcctgtg gtattatagg gtcagatcac ccctccagat ccactacctt
     3481 acctcacatg gtcattatca ggcacacctg gctcttagac atgataccat ggcccaggcc
     3541 acagccctgg gaagtttgct taccccttgt accccttact ttcataccta actacccaag
     3601 gcctatctat gaattctttc ctatcatggc ctctttatcc tgacagatca aaggcctctg
     3661 cagtatcccc tttgcctcct gtgtaccttc cagtaccggg ccagaaactc agcacacagg
     3721 aagctctgaa gggggaaggc tgtggaacga agttttaccc ctaatagtgc aaacagaaaa
     3781 aagattcctg taatacctag taggtctatc cccccacccc cgcctccccg gtgtttagat
     3841 acaattgctt ctcaaactgg gtacaacgtg ggcctttcct gttgcctgcc ttctgttagc
     3901 tgggctaact gatggttagt tgctagttat tccctaactt agccactcac tcatgatggg
     3961 atatgtatgg gcctttcctc ctgccattca accatgctgg aataaaggtc tgaaagtca
//
