LOCUS       NM_175344               5662 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus anoctamin 6 (Ano6), transcript variant 2, mRNA.
ACCESSION   NM_175344
VERSION     NM_175344.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5662)
  AUTHORS   Tang,J., Song,H., Li,S., Lam,S.M., Ping,J., Yang,M., Li,N.,
            Chang,T., Yu,Z., Liu,W., Lu,Y., Zhu,M., Tang,Z., Liu,Z., Guo,Y.R.,
            Shui,G., Veillette,A., Zeng,Z. and Wu,N.
  TITLE     TMEM16F Expressed in Kupffer Cells Regulates Liver Inflammation and
            Metabolism to Protect Against Listeria Monocytogenes
  JOURNAL   Adv Sci (Weinh) 11 (39), e2402693 (2024)
   PUBMED   39136057
  REMARK    GeneRIF: TMEM16F Expressed in Kupffer Cells Regulates Liver
            Inflammation and Metabolism to Protect Against Listeria
            Monocytogenes.
REFERENCE   2  (bases 1 to 5662)
  AUTHORS   Zubia,M.V., Yong,A.J.H., Holtz,K.M., Huang,E.J., Jan,Y.N. and
            Jan,L.Y.
  TITLE     TMEM16F exacerbates tau pathology and mediates phosphatidylserine
            exposure in phospho-tau-burdened neurons
  JOURNAL   Proc Natl Acad Sci U S A 121 (27), e2311831121 (2024)
   PUBMED   38941274
REFERENCE   3  (bases 1 to 5662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5662)
  AUTHORS   Xu,Y., Koch,S.C., Chamessian,A., He,Q., Sundukova,M.,
            Heppenstall,P., Ji,R., Fitzgerald,M. and Beggs,S.
  TITLE     Microglial Refinement of A-Fiber Projections in the Postnatal
            Spinal Cord Dorsal Horn Is Required for Normal Maturation of
            Dynamic Touch
  JOURNAL   J Neurosci 44 (2), e1354232023 (2024)
   PUBMED   37989592
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5662)
  AUTHORS   Zhang,Y., Liang,P., Yang,L., Shan,K.Z., Feng,L., Chen,Y.,
            Liedtke,W., Coyne,C.B. and Yang,H.
  TITLE     Functional coupling between TRPV4 channel and TMEM16F modulates
            human trophoblast fusion
  JOURNAL   Elife 11, e78840 (2022)
   PUBMED   35670667
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5662)
  AUTHORS   Schreiber,R., Uliyakina,I., Kongsuphol,P., Warth,R., Mirza,M.,
            Martins,J.R. and Kunzelmann,K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   7  (bases 1 to 5662)
  AUTHORS   Gritli-Linde,A., Vaziri Sani,F., Rock,J.R., Hallberg,K.,
            Iribarne,D., Harfe,B.D. and Linde,A.
  TITLE     Expression patterns of the Tmem16 gene family during cephalic
            development in the mouse
  JOURNAL   Gene Expr Patterns 9 (3), 178-191 (2009)
   PUBMED   19059364
  REMARK    GeneRIF: during mouse cephalic development: detected in
            subventricular zone and differentiating fields, in rostral spinal
            cord motor neuron area, stria vascularis,in submandibular autonomic
            ganglia, in palate, tooth and tongue, and in osteoblasts and
            chondrocytes
REFERENCE   8  (bases 1 to 5662)
  AUTHORS   Rock,J.R. and Harfe,B.D.
  TITLE     Expression of TMEM16 paralogs during murine embryogenesis
  JOURNAL   Dev Dyn 237 (9), 2566-2574 (2008)
   PUBMED   18729231
  REMARK    GeneRIF: Data show the expression of Tmem16f during murine
            embryogenesis with an emphasis on the respiratory, digestive,
            skeletal, and integumentary systems.
REFERENCE   9  (bases 1 to 5662)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of TMEM16E and TMEM16F genes in
            silico
  JOURNAL   Int J Oncol 24 (5), 1345-1349 (2004)
   PUBMED   15067359
REFERENCE   10 (bases 1 to 5662)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060732.1, BY717873.1 and BE853067.1.
            
            On Dec 7, 2011 this sequence version replaced NM_175344.3.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            5' coding region, compared to variant 1. The resulting isoform (2)
            is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060732.1, SRR9219380.8079.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4950              BC060732.1         1-4950
            4951-5176           BY717873.1         415-640
            5177-5662           BE853067.1         1-486               c
FEATURES             Location/Qualifiers
     source          1..5662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 50.66 cM"
     gene            1..5662
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /note="anoctamin 6"
                     /db_xref="GeneID:105722"
                     /db_xref="MGI:MGI:2145890"
     exon            1..214
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2877
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transmembrane protein 16F; SCAN channel; small-conductance
                     calcium-activated nonselective cation channel"
                     /codon_start=1
                     /product="anoctamin-6 isoform 2"
                     /protein_id="NP_780553.2"
                     /db_xref="CCDS:CCDS37184.1"
                     /db_xref="GeneID:105722"
                     /db_xref="MGI:MGI:2145890"
                     /translation="MQMMTRKVLLNMELEEDDDEDGDIVLENFDQTIVCPTFGSLENQ
                     QDFRTPEFEEFNGKPDSLFFTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYE
                     SNLICHGLQLEATRSVSDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRSPFG
                     NLNWFTKVLRVNESVIKPEQEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILS
                     RVKYQVMNNVNKFGINRLVSSGIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHP
                     RSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWS
                     KEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTL
                     FLEFWKRRQAELEYEWDTVELQQEEQARPEYEAQCNHVVINEITQEEERIPFTTCGKC
                     IRVTLCASAVFFWILLIIASVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMA
                     TSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSS
                     CFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPGGCLLELTTQLTIIMGGKAIWNNIQE
                     VLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFV
                     ASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVVTN
                     AMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFKNTDKENPY
                     IGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHIIYSVKFFISYA
                     IPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGIIAERIGGTVDNSVRPKLE"
     exon            215..297
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            298..426
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            427..492
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            493..777
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            778..891
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1007
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1142
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1248
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1309
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1452
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1530
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1756
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1926
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2024
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2155
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2361
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2564
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2670
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..5648
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5626..5631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /note="hexamer: AATAAA"
     polyA_site      5648
                     /gene="Ano6"
                     /gene_synonym="2900059G15Rik; F730003B03Rik; Tmem16f"
                     /note="major polyA site"
ORIGIN      
        1 gcaggctgag cagcgcctgc tgaagcagag cgcgggcgga gcgcagcggg gcagtgccga
       61 gagggcagag cggagcttgc ggcccgagcc gagcggagcc gagcggagcc gagagcagcc
      121 gagtgacggt ctccgggaga catgcagatg atgactagga aggtcctgct gaacatggag
      181 ctggaggagg acgacgatga ggatggagac attgtgctgg aaaactttga ccagacaatt
      241 gtctgcccca cctttggatc actggagaat cagcaggact tcaggactcc agagtttgaa
      301 gaatttaacg ggaagcccga ctccctcttt ttcaccgatg gccagaggcg aatcgacttc
      361 atcctcgtgt atgaagatga gagcaaaaag gagaacaata agaaagggac aaatgagaaa
      421 cagaagagga aaagacaagc atacgaatct aaccttatct gccatgggct gcagctggaa
      481 gcaacaagat ctgtttctga tgacaagctt gtgttcgtaa aagtgcacgc gccctgggaa
      541 gtgctgtgca cctatgctga gatcatgcac atcaaactcc cgctaaagcc aaacgacctg
      601 aaaacgcgct cgccctttgg caacctcaac tggttcacca aggtcctccg ggtgaacgag
      661 agtgtcatca agccagagca ggagttcttc actgcccctt ttgagaagag ccggatgaat
      721 gatttctaca tcctcgatag agattccttc ttcaaccctg ccaccagaag ccgcattgtt
      781 tatttcatcc tctctcgggt caaataccaa gtgatgaaca acgttaacaa atttgggatt
      841 aatagactgg tcagctctgg aatctacaaa gcagcgtttc ctctgcacga ctgcagattc
      901 aactatgagt cggaggacat cagttgtcct agcgagcgtt acctcctgta cagagaatgg
      961 gctcaccctc ggagtatata caagaagcag cccttggatc ttatcaggaa gtattacggc
     1021 gagaagattg gaatctactt tgcttggctg ggctattaca cgcagatgct ccttctcgca
     1081 gctgtggtgg gcgtggcctg cttcctctat ggatatcttg atcaggataa ctgcacttgg
     1141 agcaaagagg tctgtgatcc tgacatcggt ggccagatcc tgatgtgccc ccagtgtgac
     1201 aggctgtgtc cgttctggag gctgaatatc acctgtgaat cttctaagaa attgtgcatc
     1261 tttgacagtt ttggaaccct gatcttcgct gtatttatgg gagtgtgggt tacattgttt
     1321 ttggagtttt ggaagcggcg ccaggcagag ctcgaatatg aatgggacac cgttgagcta
     1381 cagcaagagg aacaggcccg gccagagtat gaggcccagt gcaatcacgt ggtgataaac
     1441 gagatcactc aggaggagga gcgcatccca tttaccacct gtgggaagtg catccgggtc
     1501 acgctgtgtg cgagcgccgt cttcttctgg atcctgctca tcatcgcctc tgtgatcggg
     1561 atcattgtct acaggctgtc cgtgttcatc gtattttcca caacgctccc caagaacccc
     1621 aacgggacag acccgatcca gaagtacctg accccacaga tggccacatc catcacagcc
     1681 tccatcatca gcttcatcat catcatgatc ctcaacacga tctacgagaa ggtggccatc
     1741 atgatcacca acttcgagct cccaaggacc cagacggatt atgagaacag cctgaccatg
     1801 aagatgttct tgttccagtt tgtcaactat tactcctcat gcttctacat cgcattcttc
     1861 aagggcaaat tcgtgggcta tcccggggac ccagtgtact tgctgggcaa atacagaagc
     1921 gaagagtgtg acccgggggg ctgcctcctt gaactgacca cacagctgac gatcatcatg
     1981 gggggaaagg caatctggaa caacatacaa gaagtcttgc tcccatgggt tatgaatcta
     2041 attggacgat ataaaagagt ctcgggatca gaaaagataa ccccacgatg ggaacaggat
     2101 taccatctgc agcccatggg caagctggga ttgttctatg agtatcttga aatgattatt
     2161 cagtttgggt tcgtcacttt atttgtggcc tctttcccac tggctcccct gctggctctg
     2221 gtgaacaata ttttggaaat aagagtggac gcgtggaagc tcacaaccca gtttaggcgc
     2281 atggtgcccg aaaaagccca ggatatcggc gcgtggcagc ccatcatgca aggaatagcc
     2341 atcctggccg tggtgaccaa cgccatgatc attgctttca catcagacat gatcccccgc
     2401 ctggtgtatt attggtcttt ctctatccct ccctacgggg accacactta ttacaccatg
     2461 gacggctaca tcaacaacac tctctctgtc ttcaacatca cggacttcaa gaacacagac
     2521 aaagaaaacc catacattgg gcttggtaac tataccttgt gcaggtaccg tgacttccga
     2581 aacccacctg ggcacccaca agagtataaa cacaacatct actattggca cgtgattgcc
     2641 gccaagctgg ccttcatcat tgtcatggag cacatcatct actctgtgaa gttcttcatt
     2701 tcctacgcaa ttccagatgt gtccaaaatc acgaaaagca agatcaagag ggagaaatac
     2761 ctcacgcaga agttgcttca cgagagtcac ctcaaagacc tgaccaaaaa catggggatc
     2821 atcgccgaga ggataggagg aacggttgac aacagcgtgc ggccaaaact cgaatgagcg
     2881 ggagctttag gcctggagaa gcactttaaa gagaattagc tgtcagacgt gtgtgaagca
     2941 ctagagagga tggcattgga actcctaggc aggcggagtc ttgcccatgc ccatttctgc
     3001 ctgtgtcatc ttccagtttc agcaagcagt gtggaaactg gagaacagaa aactgatcag
     3061 gcagagccta aaaccaccta cctggaggtc ctgaacatgc tccctctttt gataaattgg
     3121 aattttagta acaggaaaaa aagccctgag gtgtgcccaa gttctccccg ggacttcgct
     3181 tttctgacct cacgtgtgca gagctccttt tctgtgctta attttgcatt ttgccaaatc
     3241 tatcccagac ctattttgtc cggacagcac catcaccaaa gaccaggcag acctcagcct
     3301 taatcgcctc tgtgttatca acaatagcca gctcaggatt gagtttggat gctgtgttag
     3361 gtcccaggta ggctcaagag ttcacagtat ttcagtgtct tactgtacac tccaaggaag
     3421 gagactccgc tgcgtatgaa acagcttctg tatcatttca gcctgtattt ccacctccaa
     3481 gaaatactcg tcttagattg gcatgaagat ggagggtatt gaatgaagaa gcctgtccct
     3541 gttactccac ggtgacattt gctctctagc aatactccca gcatgctctg ggtctgacca
     3601 atgttgactg gctttcagat cttaagggta tataagatga aaaggtagca gcccttgttg
     3661 atctgaacgg ttaatttatc tcttcttggt agatgataat caaatgattg taactgtctc
     3721 gtcctcagca tcatgggccg ggaagcccat ccacttcatg agaacggact tagcagatgc
     3781 agaagggtgg cactaccaat caccaagcgc cttctgcctt gctcgctgaa aaaggctggt
     3841 ggcctgacga cactgggcgt agtcagagca acagccagct acccaatcac tagccatatc
     3901 ctgtgatccc tctgtggcag atgtcactca ctgggaaccc tactgacttc tctgcttgcc
     3961 acggtgacca gcttccttgc ccagctccat tcgttgcctg ctaactcgtt tgtaatcaca
     4021 gctgggctgg agacaagtct accaagattg ttgccctttg aggaaggaaa ccctgggttg
     4081 aatttgagcc ccaagcctcc tctcaagcca tcagggggtt atgggaaagg ctggtttatc
     4141 tgctggtggc ttgctgcgaa gcctcagctt cctagtgcct tgccctccct gttgcttggc
     4201 tgagcagtct ctctgcagcc tgtgctccgc ttctcctcca gtccatctgg aggagacatg
     4261 gcgatacctc gcacccttga ctgatcacag aggtcagtgc tgggtgaaga agggaggacc
     4321 tgcctcacac tgtttgggga tcgggccgct gctgactgga tgggtgtgga atgcctcggt
     4381 gcctaggaac caagccaagg aaagtgagcg gttttagaga ctgccttctc aacacccgtg
     4441 gtattaaatg cccaccacga atgatttact agagaattga gaatcaacat gattaatcaa
     4501 agcagtgttc tgggcttttg agtagcccag ggggtcagtg tgggagtatt tcccctcctc
     4561 ccttgtcctg ggagtccaga gcccgccata cagtgtctat ctgtgctgag ataaaaatga
     4621 ctaccttcct ccctgaggga tgctctcatt gcacagctga aaccaagtgc cactccttgc
     4681 ccctaccccc agattgccct ggagtgccct gctccctctg ttacctcttt tccagagcct
     4741 gtgctcactt cctaaggaca ggaaagtact cccactccat accatagaaa gaggaaattt
     4801 tcccttcctt tctttgtaga cacaaagaaa aatgtcaaat aaaaagtgca tttcttcatc
     4861 tatattcccc agccaagaac tcccttcaca aagtagaaag taccactatg gacagaagaa
     4921 ggaggaaaaa aaaaaaaaaa aaaaaaaaaa aaacttcctt ttctgaaagg agcactcatg
     4981 gcatctgatg ctaccagaat gctgaatgac agcaaggttg ctgtgagctg taggttccca
     5041 atggcgtcag tgtcattcct atgaggcctg tgccaagttg gtgatggata ggaacagggg
     5101 acaccttcgg tggcagtgag gtagacccca ggcccaggaa aaccaagggc atgactgtgg
     5161 ccacccacct gtctagcatg agccactaga gaagttccat ccttttgtaa tgcctttgca
     5221 ttttaatgga ttaatgtggt agacccagta ctcaggggat ttttccttaa atgctcctcg
     5281 gatgttttag gtattccgtt agaagtagaa gaccacaatt tttcttgaaa ttgaaagagg
     5341 ccgtctggta atgagtttgt caaggtttcc cctttgcagg gcacgtgggt cttgagtttc
     5401 ataggacatc cgtttgtgat ggggcagagc ggggtgagtt ggtctcacag gtcttgtgtg
     5461 ctccttgtgt tcgttcctac aatggttgag aagtggagac agtgcagagc tcagctgaaa
     5521 agggactcgt gatgcttccc atacactgtg tccccggtgt aatgtttgta actgatgtct
     5581 gttaatttct atgcatttta atatttttta attaatgagc attttaataa aatcagtttt
     5641 acaaacaaaa aaaaaaaaaa aa
//
