LOCUS       NM_177694               7783 bp    mRNA    linear   ROD 25-APR-2023
DEFINITION  Mus musculus anoctamin 5 (Ano5), transcript variant 1, mRNA.
ACCESSION   NM_177694
VERSION     NM_177694.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7783)
  AUTHORS   Li X, Wang L, Wang H, Qin A and Qin X.
  TITLE     Ano5 modulates calcium signaling during bone homeostasis in
            gnathodiaphyseal dysplasia
  JOURNAL   NPJ Genom Med 7 (1), 48 (2022)
   PUBMED   35982081
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7783)
  AUTHORS   Li H, Wang X, Chen E, Liu X, Ma X, Miao C, Tian Z, Dong R and Hu Y.
  TITLE     Introduction of a Cys360Tyr Mutation in ANO5 Creates a Mouse Model
            for Gnathodiaphyseal Dysplasia
  JOURNAL   J Bone Miner Res 37 (3), 515-530 (2022)
   PUBMED   34841576
  REMARK    GeneRIF: Introduction of a Cys360Tyr Mutation in ANO5 Creates a
            Mouse Model for Gnathodiaphyseal Dysplasia.
REFERENCE   3  (bases 1 to 7783)
  AUTHORS   Foltz S, Wu F, Ghazal N, Kwong JQ, Hartzell HC and Choo HJ.
  TITLE     Sex differences in the involvement of skeletal and cardiac muscles
            in myopathic Ano5-/- mice
  JOURNAL   Am J Physiol Cell Physiol 322 (2), C283-C295 (2022)
   PUBMED   35020501
  REMARK    GeneRIF: Sex differences in the involvement of skeletal and cardiac
            muscles in myopathic Ano5(-/-) mice.
REFERENCE   4  (bases 1 to 7783)
  AUTHORS   Yang Y, Paivinen P, Xie C, Krup AL, Makela TP, Mostov KE and Reiter
            JF.
  TITLE     Ciliary Hedgehog signaling patterns the digestive system to
            generate mechanical forces driving elongation
  JOURNAL   Nat Commun 12 (1), 7186 (2021)
   PUBMED   34893605
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7783)
  AUTHORS   Milenkovic VM, Brockmann M, Stohr H, Weber BH and Strauss O.
  TITLE     Evolution and functional divergence of the anoctamin family of
            membrane proteins
  JOURNAL   BMC Evol Biol 10, 319 (2010)
   PUBMED   20964844
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7783)
  AUTHORS   Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins
            JR and Kunzelmann K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   7  (bases 1 to 7783)
  AUTHORS   Mizuta K, Tsutsumi S, Inoue H, Sakamoto Y, Miyatake K, Miyawaki K,
            Noji S, Kamata N and Itakura M.
  TITLE     Molecular characterization of GDD1/TMEM16E, the gene product
            responsible for autosomal dominant gnathodiaphyseal dysplasia
  JOURNAL   Biochem Biophys Res Commun 357 (1), 126-132 (2007)
   PUBMED   17418107
  REMARK    GeneRIF: These observations suggest diverse cellular role(s) of
            GDD1 in the development of musculoskeletal system.
REFERENCE   8  (bases 1 to 7783)
  AUTHORS   Tsutsumi S, Inoue H, Sakamoto Y, Mizuta K, Kamata N and Itakura M.
  TITLE     Molecular cloning and characterization of the murine
            gnathodiaphyseal dysplasia gene GDD1
  JOURNAL   Biochem Biophys Res Commun 331 (4), 1099-1106 (2005)
   PUBMED   15882990
  REMARK    GeneRIF: characterized the complete cDNA sequence and genomic
            organization of the mouse GDD1 gene
REFERENCE   9  (bases 1 to 7783)
  AUTHORS   Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S,
            Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani
            M, Yamaoka T, Inoue H and Itakura M.
  TITLE     The novel gene encoding a putative transmembrane protein is mutated
            in gnathodiaphyseal dysplasia (GDD)
  JOURNAL   Am J Hum Genet 74 (6), 1255-1261 (2004)
   PUBMED   15124103
REFERENCE   10 (bases 1 to 7783)
  AUTHORS   Katoh M and Katoh M.
  TITLE     Identification and characterization of TMEM16E and TMEM16F genes in
            silico
  JOURNAL   Int J Oncol 24 (5), 1345-1349 (2004)
   PUBMED   15067359
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113306.6.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_177694.7.
            
            On Dec 7, 2012 this sequence version replaced NM_177694.5.
            
            Summary: This gene encodes a member of the anoctamin family, which
            in mammals is comprised of 10 members. Anoctamin proteins are
            proposed to have eight transmembrane domains with both termini
            facing the cytoplasm and a C-terminal domain of unknown function.
            While some members have been characterized as calcium-activated
            chloride channels, this protein is reported to have little anion
            conductance activity. Elevated levels of this protein were found in
            dystrophic mice. In humans, mutations of this gene are associated
            with with musculoskeletal disorders such as myopathies, muscular
            dystrophy and gnathodiaphyseal dysplasia. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Dec
            2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB206762.1, AB125740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01766820
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC113306.6         52867-53088
            223-266             AC113306.6         60655-60698
            267-320             AC113306.6         68036-68089
            321-362             AC113306.6         77286-77327
            363-476             AC113306.6         79560-79673
            477-545             AC113306.6         86629-86697
            546-830             AC113306.6         88500-88784
            831-944             AC113306.6         95668-95781
            945-1057            AC113306.6         97996-98108
            1058-1192           AC113306.6         107319-107453
            1193-1298           AC113306.6         108101-108206
            1299-1359           AC113306.6         108327-108387
            1360-1511           AC113306.6         112105-112256
            1512-1586           AC113306.6         114838-114912
            1587-1809           AC113306.6         116516-116738
            1810-1979           AC113306.6         118342-118511
            1980-2077           AC113306.6         121323-121420
            2078-2208           AC113306.6         125551-125681
            2209-2414           AC113306.6         127161-127366
            2415-2593           AC113306.6         129476-129654
            2594-2699           AC113306.6         132401-132506
            2700-7783           AC113306.6         135462-140545
FEATURES             Location/Qualifiers
     source          1..7783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..7783
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /note="anoctamin 5"
                     /db_xref="GeneID:233246"
                     /db_xref="MGI:MGI:3576659"
     exon            1..222
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2921
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     integral membrane protein GDD1; transmembrane protein 16E;
                     gnathodiaphyseal dysplasia 1 protein homolog"
                     /codon_start=1
                     /product="anoctamin-5 isoform 1"
                     /protein_id="NP_808362.2"
                     /db_xref="CCDS:CCDS39968.1"
                     /db_xref="GeneID:233246"
                     /db_xref="MGI:MGI:3576659"
                     /translation="MVEQEGLTAKEIDYAFQQNENLGSKETSFLIPEDLQSPPEKRFN
                     LFLRRRLMFQRSEHSKDSVFFRDGIRQIDFVLSYVEDLKKDGELKAERRREFEQNLRK
                     TGLDLETEDKLNSEDGKTYFVKIHAPWEVLVTYAEVLGIKMPIKLSDIPRPKYPPLSY
                     MLGAVKLPSSVKYPTPEYFTAQFSRHRQELFLIEDEATFFPSSTRNRIVYYILSRCPF
                     GVEEGKKKIGIERLLNSNTYLSAYPLHDGQYWKPSKTTRPNERYNLCKNWARFSYFYK
                     EQPFHLIRNYFGEKIGIYFVFLGYYTEMLLFAALVGLACFIYGLLSMENNRTSTEICD
                     PDIGGQMIMCPLCDEVCDYWRLNTTCLHSKFSHLFDNESTVFFALFMGIWVTLFLEFW
                     KQRQARLEYEWDLVDFEEEQQQLQLRPEFEAMCKHKKMNPVTKEMEPHMPLCHRIPWY
                     FVSGTTVTFGMALLLSSMVSILIYRLSVFATFASFMESEATLQSVKSFFTPQLATALS
                     GSCLNCIVILILNFFYEKISAWITKMEIPRTHQEYESSLTLKMFLFQFVNYYSSCFYV
                     AFFKGKFVGYPGSYTYMFNIWRSEECGPAGCLIELTTQLTIIMIGKQIFGNIHEAFQP
                     LIFNWWRRRRARTHSEKLYSRWEQDHDLQVYGHRGLFYEYLETVIQFGFATLFVASFP
                     LAPLFALMNNIMGIRVDAWKLTTQYRRPVAAKAHSIGVWQDILFGMAIVSVATNAFIV
                     SFTSDIIPRLVYFYAYSTNSTEPLSGYVNNSLSVFLIADFPNHTVPMEKKDFVTCRYR
                     DYRYPPDHEDKYSHNMQFWHVLAAKMTFIIVMEHVVFLFKFLLAWLIPDVPKDVVEKI
                     KREKLMTIKIIHDFELNKLKENLDVEYGNIMKNVLVDEDNSLKAKTTV"
     exon            223..266
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            267..320
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            321..362
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            363..476
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            477..545
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            546..830
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            831..944
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1057
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1192
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1298
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1359
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1511
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1586
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1809
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1979
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2077
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2208
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2414
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2593
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2699
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..7783
                     /gene="Ano5"
                     /gene_synonym="9330162L24; Gdd1; Tmem16e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctggtgct ccagatgcct ctggagtcgc agcaatcgga cagcttaaag aatgagagct
       61 ccagctggat tgcggaggcg gagctgaaaa ccaggaggca gacgatccgc ttcagcctcc
      121 gccccaagtc atcccgccgc ctgtcacaga ggtccttcaa tgccttcaac gagctggcaa
      181 agctaggtga ccccgacctg ctggagatgg tggagcagga aggcttaaca gccaaagaaa
      241 tagactatgc tttccaacag aatgagaacc tgggctccaa agagaccagc tttctcatcc
      301 ctgaagactt acagtcaccg cctgagaagc gattcaattt gttcctgagg aggcgtctta
      361 tgttccagag aagtgagcac agcaaagact cggtcttctt cagagatgga atccggcaga
      421 tcgactttgt cctgtcctac gtggaggatt tgaagaaaga tggagagctg aaggcagaaa
      481 gaagacgaga gtttgaacaa aatctcagaa aaacaggtct tgacttggaa acagaagaca
      541 aattgaactc tgaagatggg aaaacctatt ttgtgaagat tcacgcccca tgggaagtcc
      601 tggtcactta cgctgaagtg ctgggaatca agatgcctat taagttgagt gacatcccac
      661 ggccaaagta cccacccctg tcttacatgc ttggggcggt gaagcttcca tcctctgtga
      721 agtatcctac tcctgagtat ttcactgccc agttcagcag acaccgtcaa gaactcttcc
      781 tcattgaaga tgaggccact ttctttccat cctcaacaag gaacagaatt gtttactata
      841 ttctgtcacg atgccctttt ggagtggaag aggggaagaa aaagattggg atcgagagac
      901 tgctgaactc gaacacttat ttatctgcct acccgctcca tgatggccag tattggaaac
      961 catcaaaaac tactcgcccc aatgaaaggt acaacctttg caagaactgg gctcgatttt
     1021 cctactttta caaggagcaa ccttttcatt tgattcggaa ttattttgga gaaaaaatcg
     1081 gtatctattt tgtatttctc gggtattaca cagaaatgct gttgtttgcg gctctggtcg
     1141 gcttagcctg cttcatctat ggcttgttat caatggaaaa taaccgaact agcactgaaa
     1201 tctgtgaccc tgacatcgga ggtcagatga tcatgtgccc actttgcgat gaagtgtgtg
     1261 attactggag actgaacacc acgtgtttgc attcaaagtt ctcccatctg tttgataacg
     1321 agtcgactgt gttctttgcg ctcttcatgg ggatctgggt cacattgttt ctggagtttt
     1381 ggaagcagcg acaagccagg cttgagtacg aatgggatct ggtggacttt gaagaagaac
     1441 agcagcagct ccagcttcgg cctgaatttg aagctatgtg taaacacaag aagatgaatc
     1501 ctgtgacaaa ggaaatggag ccacacatgc ctctatgcca tcgcatccca tggtactttg
     1561 tgtcagggac cacagtgacc tttgggatgg ctctcctcct cagcagcatg gtgtccatcc
     1621 tcatataccg cctgtcagtc tttgccactt ttgccagctt catggaaagc gaagccaccc
     1681 tgcagagcgt gaagagcttc tttactccac agctggctac ggctctctct ggatcatgcc
     1741 tgaactgcat tgtcattttg atactgaatt ttttttatga gaagatatct gcctggatta
     1801 cgaaaatgga aataccacga actcaccagg agtatgagag cagcctcact ctgaagatgt
     1861 ttctcttcca atttgtgaac tattactcat cttgcttcta tgtggccttc tttaaaggga
     1921 agttcgtggg atatcctggg agttacacat atatgttcaa catatggaga agcgaagagt
     1981 gtggtcctgc aggctgtctg atagagctga ccacccagct aaccatcatt atgattggaa
     2041 aacagatttt tggaaacatc catgaagcct ttcaaccctt gatttttaat tggtggagac
     2101 gccgaagagc ccgaacccac tctgagaaac tgtacagtcg ttgggagcaa gatcatgacc
     2161 ttcaggttta tggacatcgt gggctgtttt atgagtactt ggaaacagtt atccagtttg
     2221 ggtttgccac gctgtttgtg gcctcttttc ctctggcacc cctgtttgct ctcatgaaca
     2281 acatcatggg aatccgagtg gatgcctgga agctgacaac tcagtacagg agacctgtcg
     2341 cagcgaaagc ccactccata ggtgtctggc aagacattct ttttggaatg gccatcgttt
     2401 ctgttgcaac taatgccttc attgtctcat ttacatctga catcatcccc cggttagttt
     2461 acttctatgc ctactcaacg aattccacag agcccttgag tggatacgtc aataacagcc
     2521 tgtcagtgtt cctgatagct gactttccca accacacagt gcccatggag aaaaaagact
     2581 tcgtcacctg caggtacaga gattataggt accctcctga tcatgaggat aagtatagcc
     2641 ataacatgca gttctggcat gttcttgctg ccaagatgac cttcatcata gtgatggaac
     2701 acgtcgtgtt tctgtttaaa tttttattag cctggctgat accagatgtt cctaaagatg
     2761 ttgtggagaa aatcaaacga gaaaagttaa tgactatcaa aattattcat gactttgagc
     2821 tcaacaagtt gaaagaaaac ttggatgttg aatatggtaa catcatgaag aatgttttag
     2881 tagatgaaga caattccctg aaggctaaaa ctacagtcta atccacatac aagtggagaa
     2941 gtttttagcc ccttctctat ccactgttgc ctctgggttt caggctggat gctagaagac
     3001 atgtagccat ttgtttttct ttccttcttt tatttttaac tcagagtgtt tatgcacttt
     3061 aatagaggtt ggcagtgtgc tatcagaaga gaatataggc agggtgatcc caggattctc
     3121 tggggtcctg taaagagtta caggtggagc ctgtgaactc agaaatctag gaaatcatgg
     3181 attgttgctt cttaaagtga aaccatggcc ttggggggag gaggtactct gctactaccc
     3241 agggcaattg tacatctcta ctgtctcctg ctgagtgttt tctgtctccc tcccaacaag
     3301 aaaaaggttg tttcaaagat aaatatagaa aagagaccta ccatgtccta aaacatccgc
     3361 tgttgtaaaa cgcacaaatg aaagccaaaa tcagaattct tgagaaatct catctactaa
     3421 caaacactgg ataaaaatca tagcagcagt gcatctttaa cagtgtcagg tgaaagttag
     3481 cttcagttag aatcccagat agcccttcct gggaaatgta gaattctttt tccatgagac
     3541 taagtgaatt tttgtaaacg atagtcagac ggcttttaaa ggtagtgtct ctgctctgtt
     3601 gactgttttc aacaccatgg tggctgcagg tctctaagtg caggtattat atgaagccag
     3661 cgtgttttct taagagttaa agaatgcaag acaacacata gagattaatt catttgatta
     3721 taaagtgaaa cttacaattt ctctaaatgc tgatttttgc atcatgaagc ctttttgagc
     3781 tctatccatt tgtataagtt gggcacaaac tgtttacaaa atgtgactct ttttgctata
     3841 aggaaactcc aaacttgtat gtttacagta ttttcaaggg ctacatcgcc cttcaatgtc
     3901 cagtgccttc tttctgtgcc cttgacacat gagcaattgt ctagatggca ttgatttgac
     3961 atgatacaac atttcagatc tcaacttgtc acctctgtca gtattgtgag cacagagttt
     4021 atcaccaaaa cataatcaac aaagtgagaa agtgatcgtg aggtgtcaaa atgactgttt
     4081 gttaaatgat cccatccaca ctcagggctt tgtggatacc tcaattcttg tcattggttc
     4141 agttaatacg atatcacata tgtgtcttta tgtaacttac tgccagagtg ggagacatac
     4201 tccaactata gtgtactcta atctttagac ttaaattaga attcagctat aaagaagtat
     4261 ttcttttaat cacatacata caaaaagctt ggtcacaaga tttttaaaag aagtgttcac
     4321 ttaccaataa cagtatttta cagcatagct gatatcacag tattaactaa ctactgatag
     4381 acattacgta tctaaaactg gggattatgg attttataaa aatgataaaa gagttagcac
     4441 atcacattat tgacaatatt gatttgtcat atactaggta gattttgtga gcatgtttgg
     4501 gtcacttgaa atgatttcat aattgaaaga taattttgtt ctatggagat ggtcaactta
     4561 agacaaccat ttgtcttgag gatgattcaa gccacaggta tggctcttac agcctgtcaa
     4621 atcacactgt caccaccatg cctgtcacac agtatgcatt accttcttca tggtgctaat
     4681 tttttaaaag gaagattata gggtttgttt tttgtttttt tgttttttag aaatatgctt
     4741 taattttgtg gcttgaaaat attatgaggc tagactgcaa gataaggaca aagctgactt
     4801 gcaaagctgc ccacacacag caggttcaaa accaagacaa gcactgtata tccaaagtaa
     4861 tcgtagaaat taacaaagct ggagtttatt ctacagcaag cacatcttaa gcttaatctg
     4921 tgacttcact atcaaatgca ttggtagatg catcacattt gctctgtact cttcccactg
     4981 agcactttct tctggtttca tgactctgag atactagagt cactttctgg aaagtctgtt
     5041 agccaaaatc gggtgtagtt tgtcccagca gatttgcttc gtttcaccca cggcattggt
     5101 tggtgtagga atgctcagct agatgctcct gactccagat gagttctagg ctgggatcct
     5161 ttaatccttc aaagaagcag ttagtcttca agtgctgaag ccccaagcca cacaactctt
     5221 ttcaaagtca tcatcatctt cattgtttct tttcacacaa aacccaaaat ccttcacatc
     5281 acttacttca ggcgtcaaga ggaggggact atcattaaat gaaatgatct gaatttggca
     5341 gtgtttctgg actcctggat ttcaatccct cctttttttt tttttttttt caagaggaaa
     5401 gagagttgtt gcctctgaat ctcatgtgga attctttggg atacagctgt gggtaggaat
     5461 agacaaatct cgtctcactg atatgccagt tagtaagagg gagagaacat ctggagaaat
     5521 tccaggtgga caattactgt gtgtcaaaag aaagcttttc cttgcaaagt gtgtttgtag
     5581 ggtcaggtac tgcgaacagc cattgactct gctctccaga aacaacagta ttggtcattc
     5641 aaaaaaagac aatccattgc tttggacgaa cctctcattg ttattatgta attgaatgat
     5701 gccatgaagg gaggcattgc actgccagac tttgaactct gccacaagga atcaatagaa
     5761 ctatcgtgtt actgtttttg caatttgaat gtactttttt gtgtagtaat taaagtatgt
     5821 cagttatttt agcattatgt gaaaattaat gacaatgttt aaaacacaat gtatagtatg
     5881 gcctaaactg tgtgagatac aagtgcccat tcctctaaat atgtcattgg atgcaggctg
     5941 cagctctcct gatatgagat gctgtgtcct gaggttaact cagggtatac aagcttggtc
     6001 tttcctcctg cccccccccc catccatccc attctccctc ctcctcctgt gcttcccttc
     6061 ctctctttct ctttccttcc ttcccttttc cttcatatat ttctgttctc tgctaaaggg
     6121 aggatgtggg tattcagaaa aaggtgtctt cagttattga cctcaatagc caaaccactc
     6181 agtaattaaa gtaacaaatt acttcaaata tgttgacaca aatatccttt tcatttctct
     6241 ccatttcatt atctgttaac tctatttatt ccctatgcta cagcttcttt tctttctctc
     6301 ccatctactt ttccttctca acttgggggg cgttgttttt taaaccatct aagttcattt
     6361 agcgctatct gaatcagctt ggatttagag ctgatttctt aaatgaagaa ctttaaagaa
     6421 ggcttgtcat gaaatatgat gttttgcaga gacttctaaa cacacccacc tacagggtta
     6481 gctcagaatg tcactgtatc atcatcaaag tgcagagcca atcaggagta gctgctgggt
     6541 ctagagaaat tgctgaaagc actttgacag agactcccaa acagccagcc tggcctacca
     6601 ccagttgcaa agttacttag gatcagggca gccaaacctc tttagctgct ctagtcctgt
     6661 cctttctgat cacatctgaa gactgtcagt tgagtagttt tacaccttta gttcccactt
     6721 cttaacgata ttatattcac tacatgcaac caatatatat tgaaggccag aatgctcaga
     6781 agccaaatga gcgtatcaca ttctaagtac tttatagatt gatcagagga tcatacagga
     6841 tgtaaataat gaagcaaaat tataaatatt atgggggaag gcatttcttt tgatcctgaa
     6901 acctggttgt ggacaaacag gagtctgcag ggccatcagg catgggcagg aactcccatg
     6961 aacttctgca caggggcctt gggtcttcta ttgcttatgt caatctgcag ccaagttcca
     7021 ctcatgggag cccagggctc atctggagta gacatatagg agaaaagaaa gcaaactggc
     7081 taggtggatt gtatgttcat catgccatgc tgatcttcaa gaagagtcac ataaagaaac
     7141 cttagctgct ttactgctgt ctgtcatttt ggcatgtaaa atctggttac atttttcatc
     7201 tctgtgacaa aatacccaac caatacatat taatgaaggt gggatttatt tgggctcact
     7261 gcctcctgag gacttggctt ctcatcctgg ggaaatcatg agagcagagc atgaggcagc
     7321 tggtttcatt gcatcggtaa tcaggaggca tgaatattgg ttatcagccc actacctttc
     7381 attaagttgg ggaccccagt ctatataatg atgccaacca tatccgagga aggtgtctta
     7441 cctccaatgt aaacttatct agaaacaccc agatgtgtgt ttctagtagt gatcctaaga
     7501 ccagtcaaat tgacaggatt agccatctca gaccttatag gaaaagattt cttggacaaa
     7561 caggtacaga ccactataca gaccaaagat atccctaagc ttaagcttgg taaggctata
     7621 aaccactcaa aaagcatgtt caacaaatag acgaagttta ttcccataaa atgttctcag
     7681 taaatgaaaa acaacaagtt cttataactc acattctaaa cattttaaat gtcagatcat
     7741 gtacaatctc aaaaccaaac acaactaata aacttcatag aac
//
