LOCUS       NM_001128103            6026 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus anoctamin 3 (Ano3), transcript variant 1, mRNA.
ACCESSION   NM_001128103
VERSION     NM_001128103.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6026)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6026)
  AUTHORS   Wang,T.A., Chen,C., Huang,F., Feng,S., Tien,J., Braz,J.M.,
            Basbaum,A.I., Jan,Y.N. and Jan,L.Y.
  TITLE     TMEM16C is involved in thermoregulation and protects rodent pups
            from febrile seizures
  JOURNAL   Proc Natl Acad Sci U S A 118 (20) (2021)
   PUBMED   33972431
  REMARK    GeneRIF: TMEM16C is involved in thermoregulation and protects
            rodent pups from febrile seizures.
REFERENCE   3  (bases 1 to 6026)
  AUTHORS   Keil,J.M., Doyle,D.Z., Qalieh,A., Lam,M.M., Funk,O.H., Qalieh,Y.,
            Shi,L., Mohan,N., Sorel,A. and Kwan,K.Y.
  TITLE     Symmetric neural progenitor divisions require chromatin-mediated
            homologous recombination DNA repair by Ino80
  JOURNAL   Nat Commun 11 (1), 3839 (2020)
   PUBMED   32737294
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6026)
  AUTHORS   Shi,L., Qalieh,A., Lam,M.M., Keil,J.M. and Kwan,K.Y.
  TITLE     Robust elimination of genome-damaged cells safeguards against brain
            somatic aneuploidy following Knl1 deletion
  JOURNAL   Nat Commun 10 (1), 2588 (2019)
   PUBMED   31197172
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6026)
  AUTHORS   Quintens,R., Verreet,T., Janssen,A., Neefs,M., Leysen,L.,
            Michaux,A., Verslegers,M., Samari,N., Pani,G., Verheyde,J.,
            Baatout,S. and Benotmane,M.A.
  TITLE     Identification of novel radiation-induced p53-dependent transcripts
            extensively regulated during mouse brain development
  JOURNAL   Biol Open 4 (3), 331-344 (2015)
   PUBMED   25681390
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6026)
  AUTHORS   Suzuki,J., Fujii,T., Imao,T., Ishihara,K., Kuba,H. and Nagata,S.
  TITLE     Calcium-dependent phospholipid scramblase activity of TMEM16
            protein family members
  JOURNAL   J Biol Chem 288 (19), 13305-13316 (2013)
   PUBMED   23532839
REFERENCE   7  (bases 1 to 6026)
  AUTHORS   Gritli-Linde,A., Vaziri Sani,F., Rock,J.R., Hallberg,K.,
            Iribarne,D., Harfe,B.D. and Linde,A.
  TITLE     Expression patterns of the Tmem16 gene family during cephalic
            development in the mouse
  JOURNAL   Gene Expr Patterns 9 (3), 178-191 (2009)
   PUBMED   19059364
  REMARK    GeneRIF: during mouse cephalic development: detectable in the
            subventricular zone and differentiating fields, patent in the
            submandibular autonomic ganglia, detected in osteoblasts and
            chondrocytes, in palate, tooth and tongue
REFERENCE   8  (bases 1 to 6026)
  AUTHORS   Rock,J.R. and Harfe,B.D.
  TITLE     Expression of TMEM16 paralogs during murine embryogenesis
  JOURNAL   Dev Dyn 237 (9), 2566-2574 (2008)
   PUBMED   18729231
  REMARK    GeneRIF: Data report the expression of Tmem16c during murine
            embryogenesis with an emphasis on the respiratory, digestive,
            skeletal, and integumentary systems.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731700.12, AL731779.12 and BX005257.9.
            
            On Jan 26, 2013 this sequence version replaced NM_001128103.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.34545.1,
                                           SRR1660817.243068.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AL731700.12        103288-103474       c
            188-382             AL731700.12        38081-38275         c
            383-454             AL731700.12        34035-34106         c
            455-573             AL731700.12        16050-16168         c
            574-732             AL731779.12        115032-115190       c
            733-833             AL731779.12        103784-103884       c
            834-878             AL731779.12        101518-101562       c
            879-1010            AL731779.12        95110-95241         c
            1011-1117           AL731779.12        91055-91161         c
            1118-1173           AL731779.12        88932-88987         c
            1174-1295           AL731779.12        81562-81683         c
            1296-1430           AL731779.12        77057-77191         c
            1431-1527           AL731779.12        65940-66036         c
            1528-1588           AL731779.12        58890-58950         c
            1589-1671           AL731779.12        18057-18139         c
            1672-1812           AL731779.12        17520-17660         c
            1813-1977           AL731779.12        17145-17309         c
            1978-2014           AL731779.12        8380-8416           c
            2015-2126           AL731779.12        2783-2894           c
            2127-2184           BX005257.9         48677-48734         c
            2185-2282           BX005257.9         37981-38078         c
            2283-2416           BX005257.9         34582-34715         c
            2417-2569           BX005257.9         33237-33389         c
            2570-2717           BX005257.9         32694-32841         c
            2718-2798           BX005257.9         28286-28366         c
            2799-2904           BX005257.9         28029-28134         c
            2905-6026           BX005257.9         22063-25184         c
FEATURES             Location/Qualifiers
     source          1..6026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.75 cM"
     gene            1..6026
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /note="anoctamin 3"
                     /db_xref="GeneID:228432"
                     /db_xref="MGI:MGI:3613666"
     exon            1..187
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..3087
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="anoctamin-3 isoform 1"
                     /protein_id="NP_001121575.1"
                     /db_xref="CCDS:CCDS50658.1"
                     /db_xref="GeneID:228432"
                     /db_xref="MGI:MGI:3613666"
                     /translation="MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSY
                     AHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDF
                     CLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDG
                     KKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLC
                     KYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEES
                     DCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNG
                     SYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKI
                     GLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCS
                     LQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEE
                     EEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVF
                     AVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNL
                     EYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEEC
                     HPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWEND
                     WNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQW
                     RRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQ
                     NENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARL
                     AFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKS
                     GQPIHHEWP"
     exon            188..382
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            383..454
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            455..573
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            574..732
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            733..833
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            834..878
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1010
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1117
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1173
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1295
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1430
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1527
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1588
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1671
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1812
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1977
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2014
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2126
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2184
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2282
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2416
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2569
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2717
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2798
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2904
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..6026
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6003..6008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /note="hexamer: AATAAA"
     polyA_site      6026
                     /gene="Ano3"
                     /gene_synonym="B230324K02Rik; Tmem16c"
                     /note="major polyA site"
ORIGIN      
        1 aaagcaggtg tcagattgcg atgagcttgg tggctctggg attactcaga gccccaggag
       61 tgtctctgga aagtctggct gcaattcctc tgcatccctc tccgacagct cctcaactcc
      121 tttggatcgc gcagagtgaa aatggtccac cactcaggct ccattcagtc ctttaaacag
      181 caaaaaggta tgaatataag caaaagtgag ataacaactg aagcgtcatt aaaaccatct
      241 aggagatccc tgccttgcct ggcccagagc tatgctcatt caaaaagctt gagtcaatct
      301 gcttcactgt ttcagtcaac tgagagtgaa tctcaggctc caacttctgt aacatttctt
      361 tctgctgata agcctgaaca tgttacttcg gaggagagta gaaaggactc tacccttaag
      421 tgttcctttg ctgacctcag tgacttttgc ttggctctgg ggaaagacaa ggattacctg
      481 gatgaatctg aacatgccaa ctatgatcga tctcgtctcc ttaatgactt tgttaccaaa
      541 gataagcctg catccaagac aaagctgtct aagaatgaca tgagttacat agcatctagt
      601 ggactcttat tcaaagatgg caaaaagcga attgattaca tcctggttta tcgaaaaaca
      661 aatatacaat atgataaaag aaacacattt gaaaagaacc tgagagcaga aggcttgatg
      721 ttggagaagg agccagcaat tgccaacccc gacatcatgt ttattaaaat tcacattcca
      781 tgggacacac tgtgcaagta tgcagagagg ctgaacatca gggtgccctt caggaagaaa
      841 tgttactata ctgaccagaa gaacaaatca aagagcaggg tacaaaacta tttcaaaaga
      901 atcaaaaaat ggatgtccca aaacccaatg gtccttgaca agtcagcgtt tccagagctg
      961 gaggagtcgg actgctatac tggacccttc agcagagcta ggattcacca cttcataata
     1021 aacaataagg acaccttctt cagcaatgct actcgaagca ggatagttta tcacatgctg
     1081 gaacgcacca aatatgaaaa tggaatatca aaagtgggta tccgtaagct tatcactaat
     1141 ggttcataca tagcagcatt tcccccacat gagggagcct acaagagtag ccttccgatc
     1201 aaaacccatg gacctcagaa taacaggcat ctgttgtatg agcgctgggc acgctgggga
     1261 atgtggtaca agcatcagcc tctggactta atcaggatgt actttggtga gaagattggc
     1321 ttatacttcg cctggctggg atggtacacc ggaatgctga ttcctgctgc agttgtcggc
     1381 ctgtgtgttt tcttctatgg attagtcaca atgaacgaaa gccaagtaag ccaagaaatc
     1441 tgtaaagcca ctgaagtctt catgtgtcct ctatgtgaca agaattgctc actgcagaga
     1501 ctcaacgaca gctgcatcta tgccaaggta acatatttgt ttgataatgg agggacagtt
     1561 ttcttcgcta tttttatggc aatatgggcc acagtctttc ttgagttttg gaaaaggaga
     1621 agaagcattc tgacttacac ttgggacctt attgaatggg aagaagagga ggaaacactt
     1681 cgcccccagt ttgaagcaaa atattacagg atggaggtaa taaaccccat cacggggaag
     1741 cctgagcctc atcagccttc atccgacaaa gtcacgcgac ttcttgtgtc tgtctcagga
     1801 atcttcttca tgatctcctt ggtcatcaca gcagtgttcg cagttgtagt gtaccgtctg
     1861 gtagtcatgg aacagtttgc atcattcaag tggaatttcg tcaaacagca ctggcagttt
     1921 gctacatctg gtgctgctgt ctgtatcaat ttcataatca tcatgctgct gaatcttgct
     1981 tatgaaaaaa ttgcatacct cctcactaac ttagaatatc ctcgaactga atcagaatgg
     2041 gaaaacagct ttgccttgaa gatgttcctt ttccagtttg tcaatttgaa cagttctatc
     2101 ttctatattg cattcttttt gggaagattc gtaggccacc caggaaaata caataaactt
     2161 tttgagcggt ggagactgga ggaatgccat cctagtggct gtctgataga cctctgcctc
     2221 cagatgggag tcatcatgtt tttgaagcaa atatggaaca acttcatgga gctgggatat
     2281 ccgttaatcc aaaactggtg gtcacgacac aaaatcaaaa ggggaataca agacgcttcc
     2341 ataccacaat gggaaaatga ctggaacctt cagcctatga acatccatgg gctgatggac
     2401 gagtacttag aaatggtttt gcaatttgga ttcactacca tctttgttgc tgcttttccc
     2461 ctggcccctc tattggcttt gttaaacaat atcatagaaa tcagattgga tgcatataaa
     2521 tttgtgaccc agtggaggag gcctctgcca gcccgagcca ctgacatagg tatctggctt
     2581 ggaattcttg agggaattgg catattggct gtgatcacca atgcatttgt aattgctatt
     2641 acatctgatt acatcccacg ttttgtctat gaatacaaat atggcccttg tgcaaatcat
     2701 gtgaagcaga atgaaaattg cctaaagggc tatgtcaaca atagcttatc cttctttgac
     2761 ctgagtgaac ttggtatggg aaaatctggt tactgcaggt accgagacta tagaggccca
     2821 ccttggagtt ccaaacccta tgaattcacc ttacagtact ggcacatcct ggctgctcga
     2881 ttggccttca ttatcgtgtt tgagcatctt gtttttggca ttaagtcatt cattgcatac
     2941 ctgattcctg atataccaaa gggcctccgt gagcgcatac ggcgagagaa atacttggtc
     3001 caggaaatga tgtatgaggc tgaactggaa catttacaac aacagagaag aaaaagtggt
     3061 cagcctattc accatgaatg gccttaggca gtgcctgcta ctccaaaggg gaggtaccgt
     3121 tagtgtgcag gaatgagaca cttggaaggc agatgggatc caagagaaag gcatacttgg
     3181 taaactatat tgtaaaatgc tacttgggaa tacatcatag cagcctatgg gagttagaat
     3241 gttcagactt ctaaggaaat aaaagacttg tgacctccaa agggctgcaa ctggatggca
     3301 aggagccagg ctctgattct cagagcaagc cttcagggga gttctgtgtt ttgaggccat
     3361 tctgttccaa tagctgcaga acaaatagga aacatagtgg tgaaatttcc agggacaagt
     3421 ttcaacataa atgttcataa actggaaata ctaattggat tctaggattt acacataagc
     3481 tcagatattc acaagaaatg agttaaatca gttgttggct ctgatgtccg aaccccatgt
     3541 ccctttagct tacaggtttg tggaattgtc tttgtctcat tgatatgaat gtatgcacat
     3601 gccatttatg ctgctctatg tcgactatgc atttgaagag ctgaatatca ctatagtagt
     3661 taaaccaaaa atccaagttc cccaaaagag caccactgga ataattctat tatattggct
     3721 atgttcaagt ctcctttatc acccagagcc aagtgcactg cccatttttg ttaacaaatg
     3781 ccaatagctt cacttcgagt atttgaatgg ctattattgt atcattggaa catgactaat
     3841 tcatattttt tgcaaaagtc tatcttctat tctattctat gtgcccctct ctgaatgatt
     3901 acaaatctca cagattgcta tgttgaaact ttgtaaatat gccactgttc cttacatgtt
     3961 tgcactttac actgtgtaac ccgagtccca gcctatggag ctctaagacc atttacacag
     4021 gatgttactg taatttgttc attcaggaaa tctgaagcca aatgttctgc aatacttatg
     4081 ctttttctat aacgtgcatt ctcaactatg agctaatgag aataatgcat gcgtgcagtg
     4141 tattatttac ataaaacacc ttttttggtt tcattttttc atcatggaag ggagatttct
     4201 gttttttgat gggttgactt tatttggttt caaaactctc tagaaacaaa gtcaatttaa
     4261 ttgtaaagat cattaattgt tgtagaatcc ttatttgaat gtcaacttta ccccacattg
     4321 atggagcaca aatgaaagga tattcaacta agagaatctc aaaggaagca ttaattaagg
     4381 gggcgaaata caaagaacgg ccgggagtga aggagcaggg tatgttgtag aaatcagcac
     4441 acatcttttg caaaacagaa atatccaagc ttttctctct gtgcatgctg ggtgaaatta
     4501 cacagaacac acagagagaa cacataagca cataacacac acatgcagag cacataaaca
     4561 cacacagaca tacacacaca tacagaaaac acataaacac agagagaaca caatcacaca
     4621 gagaacacat aaacatgcac agagaacaaa cacataaaca cacagtgaga acataacaca
     4681 tgattgttat gatttctatt atttgttcag tttgattttg ttcaaataag taaaacaaaa
     4741 atatttatac aatgtgaaat attagattag tcacacacac aaaataaaac tactttgcat
     4801 acatattagt gattctcaat caaggaaacc cttttcactt attgaaagaa cactgacccc
     4861 gttctaacac tttgaaagct ctgtttactt gattatggtt gctttatagt ttctgccaag
     4921 ggtattcact tctttacttc ccctatggtt ctgagccagg cagacagcct gggactctaa
     4981 cgtcttccac gtgatctggg gatgtagctc agtggtagtg tgcgtagcat gcatgtggaa
     5041 cacataaact caactatcag caccacaaaa tgaacaaaca tacaaaataa atgaaaatta
     5101 aatgaagtat gaagtgaatt ccaacacaaa tccttgttcc tggggctctt ctactacaga
     5161 tataatggct gatttcatca attatcaaat aagattttca gctcctctgt ttggaagcgt
     5221 ttgtgctcca ttttcttcat taattaatgt atccacatac ctgagcatat tttgtttact
     5281 taacatttac atcttttcca aattagggat gcaagacaga cacgtgtctt acagtaggat
     5341 atacaataat cgccttttcc ttgagaattc tttttctagg gttttctata cagcaatagg
     5401 gtttaaataa tattgattga tatgaacaga gaaagatatt ttaataaatg ttgtagtata
     5461 ttaatttaga aatatcttca ctgatatttt tgagatggac aggagaaaac agaaccaaaa
     5521 aaaaatttat ctgatgtatt tgtttcttaa acagtgcagg acaatcaaac tttgtttcct
     5581 cgtcactgat agcaaaacac agacagcccc tcacagtatg ttagctttat tagatcacac
     5641 tacttaagtt gagagaaatg ttttatacgt gcttttcata tgaatataaa ttctttctcg
     5701 aagatttata gcacacacta ttctcaggaa ttctggatga tgcgaatgct gctcatatat
     5761 tttcatattc ttgttgtctt tttatgctaa caactaatgg atacatgcat gcggtctgcc
     5821 ttgacaagtt gtgtaagccg ttctgagtct tctctgtagt agttctcagt cctctgagtc
     5881 tgtgtatgca cttctaggtg agccactgct gcctggctgc atgatgagat tcaacttgaa
     5941 tgctaaatga ttcttggcac aatctactat acaatggaat gaatagaatc tttttttcac
     6001 tcaataaatt atccttttta ctataa
//
