LOCUS       NM_133979               2653 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus anoctamin 10 (Ano10), transcript variant 1, mRNA.
ACCESSION   NM_133979
VERSION     NM_133979.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2653)
  AUTHORS   Petkovic M, Oses-Prieto J, Burlingame A, Jan LY and Jan YN.
  TITLE     TMEM16K is an interorganelle regulator of endosomal sorting
  JOURNAL   Nat Commun 11 (1), 3298 (2020)
   PUBMED   32620747
  REMARK    GeneRIF: TMEM16K is an interorganelle regulator of endosomal
            sorting.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2653)
  AUTHORS   Tsuji T, Cheng J, Tatematsu T, Ebata A, Kamikawa H, Fujita A, Gyobu
            S, Segawa K, Arai H, Taguchi T, Nagata S and Fujimoto T.
  TITLE     Predominant localization of phosphatidylserine at the cytoplasmic
            leaflet of the ER, and its TMEM16K-dependent redistribution
  JOURNAL   Proc Natl Acad Sci U S A 116 (27), 13368-13373 (2019)
   PUBMED   31217287
  REMARK    GeneRIF: mediates Ca2+-dependent phosphatidylserine scrambling in
            the endoplasmic reticulum
REFERENCE   3  (bases 1 to 2653)
  AUTHORS   Wanitchakool P, Ousingsawat J, Sirianant L, Cabrita I, Faria D,
            Schreiber R and Kunzelmann K.
  TITLE     Cellular defects by deletion of ANO10 are due to deregulated local
            calcium signaling
  JOURNAL   Cell Signal 30, 41-49 (2017)
   PUBMED   27838374
  REMARK    GeneRIF: mutations in ANO10 cause cellular defects and genetic
            disorders through deranged local Ca(2+) signaling.
REFERENCE   4  (bases 1 to 2653)
  AUTHORS   Schreiber R, Faria D, Skryabin BV, Wanitchakool P, Rock JR and
            Kunzelmann K.
  TITLE     Anoctamins support calcium-dependent chloride secretion by
            facilitating calcium signaling in adult mouse intestine
  JOURNAL   Pflugers Arch 467 (6), 1203-1213 (2015)
   PUBMED   24974903
  REMARK    GeneRIF: Ano10 is essential for Ca2+-dependent Cl- secretion in
            jejunum.
REFERENCE   5  (bases 1 to 2653)
  AUTHORS   Suzuki J, Fujii T, Imao T, Ishihara K, Kuba H and Nagata S.
  TITLE     Calcium-dependent phospholipid scramblase activity of TMEM16
            protein family members
  JOURNAL   J Biol Chem 288 (19), 13305-13316 (2013)
   PUBMED   23532839
REFERENCE   6  (bases 1 to 2653)
  AUTHORS   Duran C, Qu Z, Osunkoya AO, Cui Y and Hartzell HC.
  TITLE     ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are
            intracellular proteins
  JOURNAL   Am J Physiol Cell Physiol 302 (3), C482-C493 (2012)
   PUBMED   22075693
REFERENCE   7  (bases 1 to 2653)
  AUTHORS   Milenkovic VM, Brockmann M, Stohr H, Weber BH and Strauss O.
  TITLE     Evolution and functional divergence of the anoctamin family of
            membrane proteins
  JOURNAL   BMC Evol Biol 10, 319 (2010)
   PUBMED   20964844
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2653)
  AUTHORS   Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins
            JR and Kunzelmann K.
  TITLE     Expression and function of epithelial anoctamins
  JOURNAL   J Biol Chem 285 (10), 7838-7845 (2010)
   PUBMED   20056604
REFERENCE   9  (bases 1 to 2653)
  AUTHORS   Gritli-Linde A, Vaziri Sani F, Rock JR, Hallberg K, Iribarne D,
            Harfe BD and Linde A.
  TITLE     Expression patterns of the Tmem16 gene family during cephalic
            development in the mouse
  JOURNAL   Gene Expr Patterns 9 (3), 178-191 (2009)
   PUBMED   19059364
  REMARK    GeneRIF: during mouse cephalic development: detected in
            subventricular zone and differentiating fields, In organs
            developing through epithelial-mesenchymal interactions, such as the
            palate, tooth and tongue
REFERENCE   10 (bases 1 to 2653)
  AUTHORS   Rock JR and Harfe BD.
  TITLE     Expression of TMEM16 paralogs during murine embryogenesis
  JOURNAL   Dev Dyn 237 (9), 2566-2574 (2008)
   PUBMED   18729231
  REMARK    GeneRIF: Data show the expression of Tmem16k during murine
            embryogenesis with an emphasis on the respiratory, digestive,
            skeletal, and integumentary systems.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121264.8, AK046091.1 and
            AC120394.10.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_133979.4.
            
            On Dec 7, 2012 this sequence version replaced NM_133979.2.
            
            Summary: This gene encodes a member of the anoctamin family, which
            in mammals is comprised of 10 members. Anoctamin proteins are
            proposed to have eight transmembrane domains with both termini
            facing the cytoplasm and a C-terminal domain of unknown function.
            While some members have been characterized as calcium-activated
            chloride channels, this protein is reported to inhibit anion
            conductance. Alternative splicing results in multiple transcript
            variants that encode different protein isoforms. [provided by
            RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046091.1, AK080947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC121264.8         167262-167310       c
            50-2648             AK046091.1         2-2600
            2649-2653           AC120394.10        192561-192565       c
FEATURES             Location/Qualifiers
     source          1..2653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..2653
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /note="anoctamin 10"
                     /db_xref="GeneID:102566"
                     /db_xref="MGI:MGI:2143103"
     exon            1..120
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            121..273
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2114
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 16K"
                     /codon_start=1
                     /product="anoctamin-10 isoform 1"
                     /protein_id="NP_598740.1"
                     /db_xref="CCDS:CCDS23645.1"
                     /db_xref="GeneID:102566"
                     /db_xref="MGI:MGI:2143103"
                     /translation="MRVTLSTLDTCESSFTPLVVIELAQDVKDETKEWLKNRIIAKKK
                     DGGAQLLFRPLLNKYEKETLENQNLYLVGASNVRLLLGAEAVGLVKECTDAAMRAFTY
                     GTRHNFKGFHDNNNDFLTMAECQFIIKHELENLRARDEKMIPGYPQAKLYPGKSLMRR
                     LLTSGIVTQVFPLHDTEALKKLEDTWYTRFALKYQPIDSIRSYFGETIALYFGFLEYF
                     TFALIPMAIIGLPYYLFVWEDYDKYVIFASFNLIWSTVILEVWKRGCANMTYRWGTLV
                     MKRQFEEPRPGFHGVLGINSVTGREEPLYSSYKRQLRIYLVSLPFVCLCLYFSLYVMM
                     IYFDMEDWALSLHEDSGSEWTSLLLYVPSIVYAVVIEIMNRLYRYAAEFLTSWENHRL
                     ESAYQNHLVLKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQVVESL
                     LPYWLQRKYCARVKRKVQALKSEVDTTLYEQVLLEKEMGTYLGTFDDYLELFLQFGYV
                     SLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFAEPSASIGVWQLAFETMSVIS
                     VVTNCALIGMSPQVNAVFPESKTDLVLIVVAVEHALLALKFILAFAIPDKPRHIQQKL
                     ARLEFESLEALKQQQMKLVAENLKEEYQEDGKEAT"
     exon            274..471
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            472..606
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            607..726
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1296
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1352
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1427
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1610
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1802
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1931
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2048
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2653
                     /gene="Ano10"
                     /gene_synonym="Tmem16k"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgttgacgc ctcctgtcgg ccaaggcgcc acgccccggt cgtgtatcca gtccgcctta
       61 gcgccgcggg cctggttctc cccgctcccg cggtccccga ggacgccgcg tgggcggccg
      121 gaggtttgcc aaagatgaga gtgactttat caacgctgga tacttgtgag agctccttca
      181 cacctctagt ggtcatagaa ctcgcccagg atgtcaaaga tgaaaccaaa gaatggctca
      241 aaaacagaat cattgccaag aagaaagatg gaggtgccca gctattgttt agaccactgc
      301 taaataagta tgagaaagaa accctagaaa accagaattt ataccttgtt ggtgcctcca
      361 atgtccgact gttactgggg gcagaagcag tcggtctggt gaaggaatgt acggacgctg
      421 ccatgcgggc cttcacctat ggaacacgcc acaactttaa aggtttccat gataacaata
      481 atgacttcct caccatggct gagtgtcagt tcattatcaa acacgaactt gagaatctta
      541 gagctagaga cgagaagatg atccctggct acccacaggc caaactgtac cctgggaagt
      601 cgctgatgag gagactgctc acgtctggca tcgtgaccca agtgttcccg ctgcatgaca
      661 ctgaagccct gaagaagctg gaggacacgt ggtacactcg gtttgctctc aagtaccagc
      721 ccatagacag cattcgtagc tactttgggg agacaattgc tctgtacttc gggttcctgg
      781 agtacttcac ctttgcctta atccccatgg ccatcattgg actgccctac tacctgtttg
      841 tgtgggaaga ctacgacaag tatgtcatct ttgcctcgtt caacctcata tggtccacag
      901 tgatcctgga ggtgtggaag cgtggctgtg ccaacatgac ctatcgctgg gggactctgg
      961 tcatgaagag gcagtttgag gagccccggc cagggtttca tggagtcctt ggcatcaatt
     1021 cagtcacggg ccgggaggag cccctctact cgagctacaa gagacaactg cgcatctacc
     1081 tagtctctct gccatttgtg tgcctctgcc tttatttctc cctttatgtc atgatgatct
     1141 actttgacat ggaggactgg gccttgagtc tccacgagga cagtgggtct gagtggacca
     1201 gccttctgct gtatgtaccc agcattgttt atgccgttgt gattgagatc atgaaccgcc
     1261 tctatcgata tgctgccgag ttcctaacat cttgggagaa tcacagattg gaatctgcct
     1321 accagaatca tctcgttctg aaagtgttgg tgttcaactt cctgaattgc ttcgcctcac
     1381 tcttctacat tgcctttgtc ctgaaggaca tgaagctttt gcgccagagc ttggccacac
     1441 tcctgatcac ctcccagatt ctgaaccaag tcgtagaatc tcttcttcct tactggctgc
     1501 agcggaagta ctgtgcgagg gtaaagcgga aggttcaggc attaaagtct gaggtcgaca
     1561 caaccttgta tgagcaagtc ctcctggaga aggaaatggg aacgtacctg ggaacctttg
     1621 atgattacct ggagttgttc ctgcagtttg gctatgtgag ccttttctct tgtgtttacc
     1681 cgctagcagc tgcctttgct gtgttaaata acttcactga agtcaactca gatgccttga
     1741 aaatgtgcag ggtcttcaaa cggccatttg cagaaccttc ggccagtatt ggcgtatggc
     1801 agttggcttt tgaaacgatg agcgttatat ccgtggtcac taactgtgct ctgattggaa
     1861 tgtcaccaca agtgaatgca gtctttccag aatccaaaac agaccttgtt ctgattgtgg
     1921 tggccgtaga gcatgcactc ttggctctga agttcatact cgcatttgcc atccctgata
     1981 aaccacggca catccaacag aaactggcca gattggaatt cgaatctttg gaggcactca
     2041 agcaacagca aatgaagctg gtggcagaaa acctgaagga ggagtaccag gaagatggga
     2101 aggaagctac ctgagctgca ccatgctggc cgtcctgtcc cctgtgctga aggacacctg
     2161 catcacacct gcacagggag gggacagcag cctgaactta gccctgatgc tgggctgtgt
     2221 gaagtggcta atatgcagca ggcacaccaa ggtctagctc tgtgggaaaa gtggctgagg
     2281 ctctctctca gtacctcttt ccctggtgcc tctcactcgg accctcccag ggccgcacac
     2341 accctccagc tgtttcatca ctttgctcag gagcctcagc tgcctttgaa cgttatccct
     2401 aaagagtcac cagctttcca catgacattc acagtaggtg ccagtcactt ctaaccccag
     2461 ggaccctatt atggggtggt ggcttagtgt ctgtgcccat tatacccatg gtgggaacca
     2521 tgctgaggca gcggtggtcg gggagtaggg gcacacctga atctcctcct tgcttctgta
     2581 tggtgttatg ttgacacttt gcaactgagc tattaaaggc agcccttggc tccgactcct
     2641 gcttctccaa gac
//
