LOCUS       NM_026187               2752 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ankyrin repeat and zinc finger domain containing 1
            (Ankzf1), transcript variant 1, mRNA.
ACCESSION   NM_026187
VERSION     NM_026187.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2752)
  AUTHORS   Miao,D., Shi,J., Lv,Q., Tan,D., Zhao,C., Xiong,Z. and Zhang,X.
  TITLE     NAT10-mediated ac4C-modified ANKZF1 promotes tumor progression and
            lymphangiogenesis in clear-cell renal cell carcinoma by attenuating
            YWHAE-driven cytoplasmic retention of YAP1
  JOURNAL   Cancer Commun (Lond) 44 (3), 361-383 (2024)
   PUBMED   38407929
  REMARK    GeneRIF: NAT10-mediated ac[4]C-modified ANKZF1 promotes tumor
            progression and lymphangiogenesis in clear-cell renal cell
            carcinoma by attenuating YWHAE-driven cytoplasmic retention of
            YAP1.
REFERENCE   2  (bases 1 to 2752)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2752)
  AUTHORS   Heo,J.M., Livnat-Levanon,N., Taylor,E.B., Jones,K.T., Dephoure,N.,
            Ring,J., Xie,J., Brodsky,J.L., Madeo,F., Gygi,S.P., Ashrafi,K.,
            Glickman,M.H. and Rutter,J.
  TITLE     A stress-responsive system for mitochondrial protein degradation
  JOURNAL   Mol Cell 40 (3), 465-480 (2010)
   PUBMED   21070972
REFERENCE   4  (bases 1 to 2752)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 2752)
  AUTHORS   Ling,K.H., Hewitt,C.A., Beissbarth,T., Hyde,L., Banerjee,K.,
            Cheah,P.S., Cannon,P.Z., Hahn,C.N., Thomas,P.Q., Smyth,G.K.,
            Tan,S.S., Thomas,T. and Scott,H.S.
  TITLE     Molecular networks involved in mouse cerebral corticogenesis and
            spatio-temporal regulation of Sox4 and Sox11 novel antisense
            transcripts revealed by transcriptome profiling
  JOURNAL   Genome Biol 10 (10), R104 (2009)
   PUBMED   19799774
REFERENCE   6  (bases 1 to 2752)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 2752)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN717456.1, DV062487.1, BU054541.1, AC166150.2, CX232548.1,
            AW536302.1 and BU755641.1.
            
            On Jun 7, 2012 this sequence version replaced NM_026187.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150879.1, AK156255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               CN717456.1         1-570
            571-822             DV062487.1         595-846
            823-1204            BU054541.1         224-605
            1205-1277           AC166150.2         169672-169744       c
            1278-1568           CX232548.1         1-291
            1569-1987           AC166150.2         167856-168274       c
            1988-2553           AW536302.1         183-748             c
            2554-2752           BU755641.1         1-199               c
FEATURES             Location/Qualifiers
     source          1..2752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.62 cM"
     gene            1..2752
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /note="ankyrin repeat and zinc finger domain containing 1"
                     /db_xref="GeneID:52231"
                     /db_xref="MGI:MGI:1098746"
     exon            1..518
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2539
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and zinc finger domain-containing protein
                     1; tRNA endonuclease ANKZF1"
                     /codon_start=1
                     /product="tRNA endonuclease ANKZF1 isoform 1"
                     /protein_id="NP_080463.3"
                     /db_xref="CCDS:CCDS56632.1"
                     /db_xref="GeneID:52231"
                     /db_xref="MGI:MGI:1098746"
                     /translation="MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAASAPASVSLLS
                     LNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACD
                     QIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSS
                     SEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQIPPEKAEL
                     LLQNLQNGGPRYYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAH
                     GRASRSAGANLRRYNEAMLYKDVRNLLAGPIWSKALGEAETVLFRAPRSGRSLFFGGQ
                     GAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHWKP
                     VREERKKDTEKEKTKVPSDANKPLGQDEEPLKQGSESQEEDGSEVELELVELTLGTLD
                     LREFEVLPKRRRRRKKKERSQEQQCGAHGPLPQQPQDEPFSQPTQEVETPLDTLVYEA
                     KAPGQPELWDTLLAACRAGEVEVLKLQLATGLVDPGVKSLLNAPLGSGGFTLLHAAAA
                     AGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARV
                     PGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEEQRRFAALSDREKRAL
                     AAERRLAAQLGAPSPPVPDSAVASAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHR
                     SQAGRPSS"
     exon            519..625
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            626..728
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            729..922
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1035
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1183
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1412
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1568
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..2049
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2161
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2329
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2415
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2739
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /note="hexamer: AATAAA"
     polyA_site      2739
                     /gene="Ankzf1"
                     /gene_synonym="1300008P06Rik; 2810025E10Rik; D1Ertd161e"
                     /note="major polyA site"
ORIGIN      
        1 cttcgcctct ccgtagccgc cgaattgttg tggtgttgca gaaatccagt tttcgaacgt
       61 ggtcttgcgt gtggctcggc tctcgggaca ttaggggagg cttctgaggg agggtcgagt
      121 gacgaggctt ggtgtcggtg ctagtagttc cgttgggtag actctgactg gtaactcctg
      181 gactcgaatt gggtcttggt gctctccatt tcactcctga agatcctcac gtatttaccg
      241 cagaactgat ttgtgggagc gggtaaaggc tgaagggcat ttctgcgtgg ggatggccaa
      301 accggctggc gatgcggcag taggatctcg ttctggagag ttgtttctgc cctccgtttc
      361 ttcttcagcc acgtcgccag ctccaagtgc agcctcagcc cctgcctccg tttccctgtt
      421 gtccctcaac ggggaagctc cactcattcg gggcctgagc ctggtgagcc aagctcctgg
      481 ggaggctctg gcctgggcgc cgcgtacttc ctgtccagga gagaacacaa gctcgggggg
      541 aaaagtatct ccatattctc tggaaatttc agagaaatta ttttgttcag cctgtgacca
      601 gatcttccag aaccaccagg aacagagaga acattataag cttgattggc atcgctttaa
      661 cttaaaacaa cgtctcaaga acaagcctct cctgtctgct tcagactttg aacagcaaag
      721 ctccacaggg gatctttcca gcatctcagg atcagatgac acagactcca gcagtgaaga
      781 ggacttgctg ccactggatg aggggagggc tgaatccgag aaacctaacc ggccccccgg
      841 attctaccca catcgggtcc ttttcaaaaa cgcccagggc cagtttcttt atgcctatcg
      901 ttgtgtccta ggccctcacc agattccccc agaaaaggca gaattgctac tacaaaacct
      961 acagaatgga ggtcccagat actacgtggt gctcatggct gcggctggac attttgctgg
     1021 tgccattttt caaggaagag aagtggtggc acacaaaacc tttcaccgtt acactgtgcg
     1081 ggccaagcgg ggcacagccc aggggcttca ggatgcccat ggtagggcat cccgctctgc
     1141 tggagccaac ttgaggcgtt acaatgaagc catgctctat aaggatgttc gcaacctgct
     1201 ggcggggcca atctggtcca aggcactagg ggaggcagaa acagtattgt tccgagcacc
     1261 acgctctggc cggtccttgt tctttggagg ccaaggggca cccctacaaa gggatgatcc
     1321 ccgactttgg gatatccctc tcaccacccg cagacccact tttggagagc tccagcgtgt
     1381 actccataag ctgaccacct tgcaggtgta tgatgaagac cctcgagaaa tggtcagatt
     1441 tcactctcct gagacacact ggaaaccagt gagagaagag aggaaaaagg atactgagaa
     1501 agaaaaaaca aaggtcccca gtgatgcaaa taagcccctt gggcaggatg aagaaccact
     1561 caaacaaggt tcagagtctc aggaagaaga tggttccgaa gtagagttgg agctagtaga
     1621 attgaccctg gggaccctgg atcttcgtga atttgaagta ctgcccaagc ggaggaggag
     1681 gaggaagaag aaggagagaa gtcaagagca gcagtgtggg gcacatgggc ctcttcctca
     1741 gcaacctcaa gatgagccgt tctcacagcc aacccaagag gttgaaaccc cattggatac
     1801 tttggtctat gaggccaaag cccctggtca gccagagctc tgggacacgc ttctagctgc
     1861 ttgtcgtgct ggggaagttg aggtgctaaa gctgcagcta gccactgggc tggtagaccc
     1921 tggagttaag tccctgctca atgccccttt gggctccggt ggctttactc tcctgcatgc
     1981 agcagccgca gctggaagag gcttagtagt tcgtttgctg ttggaagcag gtgctgatcc
     2041 tactgtgcag gactctaggg ctcggccacc ttatactgta gcagctgaca aatcaacgcg
     2101 taatgaattc cggaggttca tggagaagaa tcttgatgcc tatgattaca acaaggctcg
     2161 ggtgccaggg ccattgactc aagaaatgga ggcccggcag gctacaagga aaaaagagca
     2221 gaaggcagct cgacggcaac gggagcaaca gcagcggaag cagagggagc aggaagaaca
     2281 agagcaagag gaacaacggc ggtttgctgc cctcagtgac cgggagaaga gagctctggc
     2341 tgcagagcgc cgacttgctg cccagttggg agcccctagc cctccagttc ctgactctgc
     2401 agttgctagt gctggacgct gctggagttg tggagtgtcc ctccaaggcc tcattccctt
     2461 tcactacctc gacttctctt tctgctccac acgttgcctt cgagaccatc gcagtcaggc
     2521 ggggagacct tcatcttgat ttctttcagc acctgggcca actctgggtc ccaagaggac
     2581 acatccagac ctagagctct cttcctcctc atgaagcttg acatttggaa gatgggtggt
     2641 gaaggacacc caggaatcga ggcaaagaca gggccacgaa ggtgtgtgga gccagtactg
     2701 tctttggaat tttaatcata ataaagtttg gcaagaaaaa aaaaaaaaaa aa
//
