LOCUS       NM_001356426            3798 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ankyrin repeat and sterile alpha motif domain
            containing 6 (Anks6), transcript variant 1, mRNA.
ACCESSION   NM_001356426 XM_006538332
VERSION     NM_001356426.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3798)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3798)
  AUTHORS   Airik,M., McCourt,B., Ozturk,T.T., Huynh,A.B., Zhang,X.,
            Tometich,J.T., Topaloglu,R., Ozen,H., Orhan,D., Nejak-Bowen,K.,
            Monga,S.P., Hand,T.W., Ozaltin,F. and Airik,R.
  TITLE     Mitigation of portal fibrosis and cholestatic liver disease in
            ANKS6-deficient livers by macrophage depletion
  JOURNAL   FASEB J 36 (2), e22157 (2022)
   PUBMED   35032404
  REMARK    GeneRIF: Mitigation of portal fibrosis and cholestatic liver
            disease in ANKS6-deficient livers by macrophage depletion.
REFERENCE   3  (bases 1 to 3798)
  AUTHORS   Airik,M., Schuler,M., McCourt,B., Weiss,A.C., Herdman,N.,
            Ludtke,T.H., Widmeier,E., Stolz,D.B., Nejak-Bowen,K.N.,
            Yimlamai,D., Wu,Y.L., Kispert,A., Airik,R. and Hildebrandt,F.
  TITLE     Loss of Anks6 leads to YAP deficiency and liver abnormalities
  JOURNAL   Hum Mol Genet 29 (18), 3064-3080 (2020)
   PUBMED   32886109
  REMARK    GeneRIF: Loss of Anks6 leads to YAP deficiency and liver
            abnormalities.
REFERENCE   4  (bases 1 to 3798)
  AUTHORS   Schlimpert,M., Lagies,S., Muller,B., Budnyk,V., Blanz,K.D., Walz,G.
            and Kammerer,B.
  TITLE     Metabolic perturbations caused by depletion of nephronophthisis
            factor Anks6 in mIMCD3 cells
  JOURNAL   Metabolomics 15 (5), 71 (2019)
   PUBMED   31041607
  REMARK    GeneRIF: The Anks6 affects DNA damage responses and proliferation
            and plays a crucial role in physiological amino acid and
            purine/pyrimidine metabolism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3798)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3798)
  AUTHORS   Delestre,L., Bakey,Z., Prado,C., Hoffmann,S., Bihoreau,M.T.,
            Lelongt,B. and Gauguier,D.
  TITLE     ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is
            Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice
  JOURNAL   PLoS One 10 (9), e0136781 (2015)
   PUBMED   26327442
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3798)
  AUTHORS   Bakey,Z., Bihoreau,M.T., Piedagnel,R., Delestre,L., Arnould,C., de
            Villiers,Ad., Devuyst,O., Hoffmann,S., Ronco,P., Gauguier,D. and
            Lelongt,B.
  TITLE     The SAM domain of ANKS6 has different interacting partners and
            mutations can induce different cystic phenotypes
  JOURNAL   Kidney Int 88 (2), 299-310 (2015)
   PUBMED   26039630
  REMARK    GeneRIF: Thus, our data demonstrate the importance of ANKS6 for
            kidney structure integrity and the essential mediating role of its
            SAM domain in the formation of protein complexes.
REFERENCE   8  (bases 1 to 3798)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   9  (bases 1 to 3798)
  AUTHORS   Czarnecki,P.G., Gabriel,G.C., Manning,D.K., Sergeev,M., Lemke,K.,
            Klena,N.T., Liu,X., Chen,Y., Li,Y., San Agustin,J.T., Garnaas,M.K.,
            Francis,R.J., Tobita,K., Goessling,W., Pazour,G.J., Lo,C.W.,
            Beier,D.R. and Shah,J.V.
  TITLE     ANKS6 is the critical activator of NEK8 kinase in embryonic situs
            determination and organ patterning
  JOURNAL   Nat Commun 6, 6023 (2015)
   PUBMED   25599650
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3798)
  AUTHORS   Stagner,E.E., Bouvrette,D.J., Cheng,J. and Bryda,E.C.
  TITLE     The polycystic kidney disease-related proteins Bicc1 and SamCystin
            interact
  JOURNAL   Biochem Biophys Res Commun 383 (1), 16-21 (2009)
   PUBMED   19324013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060663.1 and BC072562.1.
            
            On Oct 4, 2017 this sequence version replaced XM_006538332.2.
            
            Sequence Note: This RefSeq record is inferred based on alignments
            to the orthologous transcript from rat, AY661303.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2414              BC060663.1         1-2414
            2415-2628           BC060663.1         2589-2802
            2629-2804           BC060663.1         2833-3008
            2805-3756           BC072562.1         1192-2143
            3757-3798           BC060663.1         3961-4002
FEATURES             Location/Qualifiers
     source          1..3798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 25.88 cM"
     gene            1..3798
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /note="ankyrin repeat and sterile alpha motif domain
                     containing 6"
                     /db_xref="GeneID:75691"
                     /db_xref="MGI:MGI:1922941"
     exon            1..358
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2678
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and SAM domain-containing protein 6;
                     ankyrin repeat domain 14; sterile alpha motif
                     domain-containing protein 6; sterile alpha motif domain
                     containing 6"
                     /codon_start=1
                     /product="ankyrin repeat and SAM domain-containing protein
                     6 isoform 1"
                     /protein_id="NP_001343355.1"
                     /db_xref="CCDS:CCDS89741.1"
                     /db_xref="GeneID:75691"
                     /db_xref="MGI:MGI:1922941"
                     /translation="MGEGALAPGLQLLLRACEQGDTDTARRLLEPGADPVAGPEAGAE
                     PAGPEAVRAAEAGAPVPVDCSDEAGNSALQLAAAGGHEPLVRFLLRRGASVNSRNHYG
                     WSALMQAARCGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAI
                     VDHHTPSGESPATGGSGDELLGITALMAAVQHGHEAVVRLLMEWGADPNHTARTVGWS
                     PLMLAALLGKLNVAQQLVEKGANPDHLSVLEKTAFEVALDRKYRDLAEYLDPLTTVRP
                     KTDEEKRRPDIFYALKMGNFQLVKEIADEDPNHVNLVNGDGATPLMLAAVTGHLPLVQ
                     LLVEKHADMDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVALRAKNGYTAFDLVM
                     LLNDPDTELVRLLASVCMQVNKDRGRPSHRPPLPHSKARQPWSIPVLPDDKGGLKSWW
                     SRMSNRFRKLKLMQTLPRGLAANQPLPFSDEPELALDSTMRAPPQDRTSHLGPPEAAH
                     ATKDSGPGNPRREKGDVLLTTMLRNGAPFPRLPSDKLKAVIPPFLPPSSFELWSSDRS
                     HTCHNGKADPTKTALPPRASRAHPVGCVGTDGATSRPVKFPSISRSPASPASSGSFNH
                     SPHSSGGASGIGGMSRLGGELHSRSGGSVDSVLSQIAAQRKKAAGLCEQKPRQQSSPV
                     GPATSSSPPELPASLPSSGSGSSSGPSSSKKLDPSKRPPSGTSATSKSTSPTLTPSPS
                     PKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTGILKKLSLEKYQPIFEEQEVD
                     MEAFLTLTDGDLQELGIKTDGSRQQILAAISELNAGKGRERQILQETIHNFHSSFESS
                     ASNTRAPGNGPSMAGWTRPEETVSSRR"
     exon            359..861
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            862..906
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1111
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1218
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1367
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1566
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1616
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1820
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1974
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2162
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2346
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2414
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2531
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2628
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..3776
                     /gene="Anks6"
                     /gene_synonym="2210417J20Rik; Ankrd14; b2b1801.1Clo;
                     Gm635; SamCystin; Samd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcgcg gagcgggcgg tcagcgatgg gcgagggcgc gctggccccc ggcctgcagc
       61 tgctgctccg cgcctgcgag cagggtgaca ccgacacggc gcggcgcctg ctggagccag
      121 gcgcggaccc ggtcgcgggg cccgaggcgg gagcggagcc ggcagggccc gaggcggtcc
      181 gggcagcgga ggccggggcg ccggtgccgg tggactgttc cgatgaggcg ggcaactcgg
      241 cgctgcagct ggcggcggcc ggtggccacg agccactcgt aaggttcctg ctgcgccgcg
      301 gagcctcggt caacagccgc aaccactacg gctggagcgc gctcatgcag gcggccaggt
      361 gtgggcatgt gagcgtggca cacctccttt tggatcatgg agccgatgtc aatgctcaga
      421 atcggctggg tgccagtgtg ctcaccgtgg cttctcgggg tggccacctg ggtgtggtga
      481 agctgctgct agaggcggga gccattgtgg accaccacac cccttctgga gagtcgccag
      541 caacgggagg cagcggggat gaactgctgg gcattacagc cctgatggcc gctgttcagc
      601 atgggcacga ggccgtggta cgtctgctga tggagtgggg tgcggaccct aaccacacag
      661 cccggactgt gggctggagc cctctgatgc tggcagccct ccttgggaag ctgaatgtgg
      721 cgcagcagct ggtggagaag ggagccaacc ctgaccacct cagtgtactg gagaagactg
      781 ccttcgaggt tgctctcgac cgcaagtaca gggatcttgc tgaatacctg gacccactga
      841 ccactgtcag gccaaaaaca gatgaggaga agaggcgacc agatattttc tatgccctga
      901 agatggggaa cttccagctg gtgaaggaga ttgcggacga agaccccaac catgtgaacc
      961 tggtcaacgg ggacggggcg accccactga tgctggctgc tgtcacgggg cacttgcccc
     1021 tggtacagct gctggtggag aagcacgcag acatggacaa gcaggacagc gtgcatggct
     1081 ggacggccct catgcaggcc acctaccacg gaaataaaga aattgtcaag tatctgctaa
     1141 atcaaggggc tgatgttgct cttcgagcca aaaatgggta cacggccttt gacctggtga
     1201 tgctgctgaa cgatcctgac actgaacttg ttcgactgct ggcgtctgtg tgcatgcagg
     1261 tgaataaaga ccgaggtcgg cccagccacc ggccacccct gccccactcg aaggccaggc
     1321 aaccctggag catccctgtg ctgcccgacg acaagggagg cctgaagtcc tggtggagcc
     1381 ggatgtccaa caggttccga aagctcaaac ttatgcagac actgccacgc gggctggctg
     1441 ccaaccaacc tttgcctttc tctgacgagc ctgagctggc gctggactcc accatgcggg
     1501 caccccccca ggacaggact agccaccttg ggccacctga agcagcccat gcaaccaaag
     1561 acagtggtcc tgggaaccca agaagagaga agggagatgt gttactgaca accatgctgc
     1621 gaaacggagc gcccttcccc cggctcccca gtgacaagct aaaggccgtc atcccaccct
     1681 tcctgccccc gtccagcttt gagctgtgga gctctgacag gtcccacaca tgtcacaacg
     1741 ggaaggcaga ccccacgaag actgcactac ccccaagagc cagcagggcc caccccgtgg
     1801 gctgtgtggg cacagacggt gctaccagca ggccagtcaa attccccagc atctccagaa
     1861 gccccgcgtc ccctgccagc tctgggagct ttaaccactc gcctcactcc tcagggggtg
     1921 ccagtggcat tggtggcatg agcaggctgg gtggtgagct gcatagccgc tcaggtggca
     1981 gcgtagacag tgtcctgtcc cagatcgctg ctcagaggaa gaaagcagcc ggcttgtgtg
     2041 agcagaagcc ccgccagcag tccagtcccg tggggccagc caccagctcc agcccgcctg
     2101 agctcccagc ctccctcccg agcagtggta gtggctcttc cagtggccct tccagcagca
     2161 agaaactgga ccccagcaaa cggcctccct ccggaacttc tgctacctct aaaagcacct
     2221 ctcccaccct cacgccctct ccctcgccca aaggccacac tgcagagtct tcggtgtctt
     2281 cctcctcgtc tcaccggcag tctaagagca gtgggggctc cagcagtggc accatcaccg
     2341 atgaggatga actgactgga atccttaaga agttatcact tgagaaatac cagcccatct
     2401 tcgaggaaca agaggtggac atggaagcct tcctcacact caccgacggc gacctgcagg
     2461 agctggggat taagacggat ggctcccggc agcagatcct ggcggccatc tctgagctga
     2521 atgcgggcaa ggggcgtgag aggcagattc tacaggaaac cattcacaac ttccactctt
     2581 cctttgaaag cagtgccagc aacaccagag cccctggcaa tggtccctcc atggccggat
     2641 ggacaaggcc ggaagaaacc gtgtctagca ggaggtagcc acagctttgg tggttccgct
     2701 ggcctcggag ccctgaggca ttgagggttg agcagtgctt ccctgccctt ccatcatttc
     2761 tgctcctggg ttgtttcttc cctgggactc acagcaggtg gacagaaagg aggccgggcg
     2821 acgcatcatc agagctgatg cagtgggcag ggcctgggaa gttctcctct ctgtctctgc
     2881 cttgcggagg cctgagaaca tgcaaggcat gctggaggcc gcatggctgc agatgtaaac
     2941 cctaaccagt ttgtgcaagt acgtgctgcc ctcgaggcgt gagactcttc cagagaagat
     3001 gctacacaga gatgaacccc tgcagaaggt gtggtgaagc accccactgt ggctgccgtg
     3061 gttcatttta agcaatcacc aatagaccct gttcaacaag tgaggaagct cgatgttctc
     3121 cctaatgaag ttggtgcccg gttctgcaga ctgccgagga gagggtgccg agaccctcgg
     3181 gagtttcccg ctcactcaca tgtggcctcc agagaaacag ccaggctccc cactgctcct
     3241 ggggtgctac agacctggac acagccatgc ttgtagtcta gctgcacata accgacagtg
     3301 acatgagggt gcaggaggga ggtctgagga agagccacac gggaagagag ctccaagccc
     3361 acccgcttcc ctcgtcttca gctcttccag gcccataggc ttccttctta aggccaaaac
     3421 catactagct gctggccaga gccctgccgc tgagtagagc cgactcacct cagggcaggg
     3481 tcctgtttcc tgtgtgaacc ttccctctaa gtccggcaga cacggcccca gtcatgtcca
     3541 tcaggatacc cagtggcagg actagaatgt gaccttgtcc cagctcacac tggggtggct
     3601 ccccccatgg tcagagacca cggcgccatc ttgcttcagc cctgcagttg gttttcattt
     3661 ttctcacatc agtcgcagcg ttatttctac acgagggcgt gattcttgga aagatttttc
     3721 cttgccagac tatatctatt aaaaatgggg actgtgtccc ctgagtttgt gctcttaaaa
     3781 aaaaaaaaaa aaaaaaaa
//
