LOCUS       NM_028301               2446 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ankyrin repeat and sterile alpha motif domain
            containing 3 (Anks3), mRNA.
ACCESSION   NM_028301
VERSION     NM_028301.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Rothe,B., Ikawa,Y., Zhang,Z., Katoh,T.A., Kajikawa,E.,
            Minegishi,K., Xiaorei,S., Fortier,S., Dal Peraro,M., Hamada,H. and
            Constam,D.B.
  TITLE     Bicc1 ribonucleoprotein complexes specifying organ laterality are
            licensed by ANKS6-induced structural remodeling of associated ANKS3
  JOURNAL   PLoS Biol 21 (9), e3002302 (2023)
   PUBMED   37733651
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Schlimpert,M., Lagies,S., Budnyk,V., Muller,B., Walz,G. and
            Kammerer,B.
  TITLE     Metabolic Phenotyping of Anks3 Depletion in mIMCD-3 cells - a
            Putative Nephronophthisis Candidate
  JOURNAL   Sci Rep 8 (1), 9022 (2018)
   PUBMED   29899363
  REMARK    GeneRIF: Combined metabolomics successfully identified 155
            metabolites; 48 metabolites were identified to be significantly
            altered by decreasing Ankyrin repeat and sterile alpha motif domain
            containing 3 protein (Anks3) levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Nakajima,Y., Kiyonari,H., Mukumoto,Y. and Yokoyama,T.
  TITLE     The Inv compartment of renal cilia is an intraciliary
            signal-activating center to phosphorylate ANKS6
  JOURNAL   Kidney Int 93 (5), 1108-1117 (2018)
   PUBMED   29395339
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   Delestre,L., Bakey,Z., Prado,C., Hoffmann,S., Bihoreau,M.T.,
            Lelongt,B. and Gauguier,D.
  TITLE     ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is
            Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice
  JOURNAL   PLoS One 10 (9), e0136781 (2015)
   PUBMED   26327442
  REMARK    GeneRIF: ANKS3-ANKS6 direct interaction through their SAM domain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2446)
  AUTHORS   Ramachandran,H., Engel,C., Muller,B., Dengjel,J., Walz,G. and
            Yakulov,T.A.
  TITLE     Anks3 alters the sub-cellular localization of the Nek7 kinase
  JOURNAL   Biochem Biophys Res Commun 464 (3), 901-907 (2015)
   PUBMED   26188091
  REMARK    GeneRIF: Anks3 N-terminal ankyrin repeats, but not SAM domain
            required for Nek7 interaction.Nek7 increased Ser/Thr
            phosphorylation of Anks3 primarily within ankyrin domain.
REFERENCE   7  (bases 1 to 2446)
  AUTHORS   Yakulov,T.A., Yasunaga,T., Ramachandran,H., Engel,C., Muller,B.,
            Hoff,S., Dengjel,J., Lienkamp,S.S. and Walz,G.
  TITLE     Anks3 interacts with nephronophthisis proteins and is required for
            normal renal development
  JOURNAL   Kidney Int 87 (6), 1191-1200 (2015)
   PUBMED   25671767
REFERENCE   8  (bases 1 to 2446)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   9  (bases 1 to 2446)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 2446)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163723.3 and AC240849.2.
            
            On Nov 18, 2022 this sequence version replaced NM_028301.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050929.1, AK012494.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC163723.3         13931-14022         c
            93-264              AC163723.3         10208-10379         c
            265-463             AC240849.2         1368-1566
            464-585             AC240849.2         1772-1893
            586-667             AC240849.2         3595-3676
            668-803             AC240849.2         5580-5715
            804-959             AC240849.2         8766-8921
            960-1097            AC240849.2         11171-11308
            1098-1207           AC240849.2         11776-11885
            1208-1375           AC240849.2         12102-12269
            1376-1500           AC240849.2         13355-13479
            1501-1642           AC240849.2         15834-15975
            1643-1815           AC240849.2         16283-16455
            1816-1901           AC240849.2         16756-16841
            1902-1985           AC240849.2         17240-17323
            1986-2074           AC240849.2         17547-17635
            2075-2446           AC240849.2         17737-18108
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.48 cM"
     gene            1..2446
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /note="ankyrin repeat and sterile alpha motif domain
                     containing 3"
                     /db_xref="GeneID:72615"
                     /db_xref="MGI:MGI:1919865"
     exon            1..92
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            93..264
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2062
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /codon_start=1
                     /product="ankyrin repeat and SAM domain-containing protein
                     3"
                     /protein_id="NP_082577.2"
                     /db_xref="CCDS:CCDS27928.1"
                     /db_xref="GeneID:72615"
                     /db_xref="MGI:MGI:1919865"
                     /translation="MSELSDEASEPELLKRSLSMWHGLGAQGSPEELDVPLDLHTAAS
                     IGQHEVVKECVQRGELDLNKKNGGGWTALMYASYIGHDTIVHLLLEAGVSVNVPTPEG
                     QTPLMLASSCGNESIAYFLLQQGAELEMKDIHGWTALFHCTSAGHQQMVKFLLESGAN
                     ANVREPVYGYTPLMEAAASGHEIIVQYFLNHGVKVDTRDHSGATACMLARQFGHMKIV
                     ALMETHSPVLPKSLYRSPEKYEDLSSSDESWPVPQRQRPCRKKGLSIHEGPRALAKIT
                     AIGLGGKTQTTYEQVPPRGYVTFTSSDENTMESEGLCYRDVTSPINEQDVESSSSSSR
                     EEPTFCASLGPVWRSSSSDGLARAQGLSSEASIESNEDSDHARKSSVRKQTRSYLKNK
                     SRHGNSDGHWPSSTGPASIPGSEPQTEKSPYSGPQDLATLLEQIGCLKYLQVFEEQDI
                     DLRIFLTLTESDLKEIGITLFGPKRKMTSAIARWHSSARPPSDALELAYADRLETEMQ
                     ELAIQLHKCCEEAEALRGQVSQEQELRAVVESCLLEQDSARKDIHAQLQEAQTLAQDA
                     ALVLDQLRACQAELSARLRQHHSPREGTPNPHFLSADSKGWPIPLQALSLPELSGALE
                     DRVHEMGQALCSVTQSLEKLQMLNAKKWREP"
     exon            265..463
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            464..585
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            586..667
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            668..803
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            804..959
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1097
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1207
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1375
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1500
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1642
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1815
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1901
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1985
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2074
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2446
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2419..2424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /note="hexamer: AATAAA"
     polyA_site      2436
                     /gene="Anks3"
                     /gene_synonym="2700067D09Rik; mKIAA1977"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggg tgggccgggc gcagggctgt cggccggtga ggggcgagcc gctgtcgctg
       61 gagggtggcc cgggaacctg aggccttgca agctatgtct gagctcagcg atgaagccag
      121 cgagccggag ctcctgaagc gcagcctgtc catgtggcac gggcttggtg cccagggcag
      181 cccagaggag ctggatgtcc ccttggatct tcacacagct gcctccattg gccagcatga
      241 ggtggtgaag gagtgtgtgc agcggggaga gttagatttg aataagaaga atggtggtgg
      301 ttggacagcg ctgatgtatg cctcctacat tggacacgat accattgttc acttgctgct
      361 tgaggcaggc gtgagtgtga atgtgccaac cccggaagga cagactccac tgatgctggc
      421 ctccagctgt ggcaacgaaa gcattgccta ctttctgctc cagcaaggtg cagagcttga
      481 gatgaaagac atccatggct ggactgcact cttccactgt accagtgccg gccaccaaca
      541 gatggtcaaa tttcttctgg agagtggagc caatgccaac gtgagggagc ctgtatatgg
      601 atacactcct ttgatggaag cagctgcctc tggccatgag ataattgtgc agtattttct
      661 gaatcacgga gtcaaagtgg acacaagaga ccacagtgga gcgacagcct gcatgttagc
      721 caggcagttt ggtcacatga agattgtagc cttgatggaa actcactcac ctgtactgcc
      781 caagagcctc taccgtagcc cagaaaaata tgaagatctg agctcttcag atgagtcctg
      841 gcctgttcct cagcgccaga ggccctgccg aaaaaagggc ctcagtatcc atgaggggcc
      901 gcgtgccctg gccaagatca cagctattgg actcggaggg aagactcaga ccacctatga
      961 gcaagtccct ccacggggct acgtgacctt caccagcagt gatgagaata ccatggaaag
     1021 cgagggcctc tgctacagag acgtcacttc ccccatcaat gaacaggatg tggagagcag
     1081 tagcagcagc agccgggagg aacccacttt ctgtgccagt cttgggcctg tgtggaggag
     1141 cagcagcagt gatggcctag caagagccca gggtctcagc agtgaagcct ccatagaaag
     1201 caatgaggat tctgatcatg cccggaaaag ctcggttcga aaacaaacca ggagttattt
     1261 gaagaataag agtcgtcacg gcaacagtga tggtcattgg ccttccagca cagggcctgc
     1321 ttccattcca gggtctgaac cccaaactga gaagtctcct tactcaggac cccaggacct
     1381 tgccacactg ctggaacaga tcgggtgtct gaagtacctg caagtgttcg aggagcagga
     1441 catagacctg cgtatctttc tgactctcac tgaaagcgat ttgaaggaaa ttggcatcac
     1501 gttgtttggg cccaaaagga aaatgacctc tgccattgcc cgctggcaca gcagtgcccg
     1561 cccacctagt gatgccctag agctggccta tgctgaccgg ctggagactg agatgcagga
     1621 gcttgccatt cagttgcata aatgctgtga ggaggcagag gctctgcgtg gccaggtatc
     1681 ccaggagcag gaattgcggg ctgtagtaga gagctgcctc ctggagcagg atagtgcccg
     1741 aaaggacatc catgcccagc tgcaggaggc ccaaaccctg gcccaggatg ctgcccttgt
     1801 cctggaccag ctgcgggcct gtcaagctga gctgtcagct cgattgcggc agcaccactc
     1861 ccccagggaa ggtactccaa acccacactt tctctcagca gattccaaag gctggcccat
     1921 tcccctgcag gccttgagcc tccctgagtt gtcaggagcc ctggaagacc gtgtccatga
     1981 gatggggcag gcgttatgct ctgtaacaca gagcttggag aaactacaga tgctgaatgc
     2041 aaagaaatgg cgggaaccgt agccaggagg gacgattctg acgttgggtg ataaatccac
     2101 cctgaagtta tgtgccacgc aagacagggc agtgagcaga tggctgcggc agcccaggga
     2161 atagaagacc attccaggga gcagcttatg gacaggaaga caggactgcg gtccccacta
     2221 gggcagcttg ggccagccct gagacaggat ggagggctca gcacccagat cctggtggag
     2281 aggcccatgc tggtaggcag ctttggccca gaccaggcag ggctgtatgg agaggttgtg
     2341 tcctgcacat gcaggtgcca tactgaggtc tgatcttaca gacaaggtct ggggtgccta
     2401 gaaaatgtac tctttgaaaa taaaaattag atgcaagttg gtgggg
//
