LOCUS       NM_181413               5823 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ankyrin repeat and SAM domain containing 1 (Anks1),
            transcript variant 3, mRNA.
ACCESSION   NM_181413
VERSION     NM_181413.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5823)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5823)
  AUTHORS   Lee,J., Lee,H., Lee,H., Shin,M., Shin,M.G., Seo,J., Lee,E.J.,
            Park,S.A. and Park,S.
  TITLE     ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated
            cerebrovascular clearance in brain endothelial cells
  JOURNAL   Nat Commun 14 (1), 8463 (2023)
   PUBMED   38123547
  REMARK    GeneRIF: ANKS1A regulates LDL receptor-related protein 1
            (LRP1)-mediated cerebrovascular clearance in brain endothelial
            cells.
            Erratum:[Nat Commun. 2024 Apr 9;15(1):3062. doi:
            10.1038/s41467-024-47249-w.. PMID: 38594263]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5823)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5823)
  AUTHORS   Ryu,H., Lee,H., Lee,J., Noh,H., Shin,M., Kumar,V., Hong,S., Kim,J.
            and Park,S.
  TITLE     The molecular dynamics of subdistal appendages in multi-ciliated
            cells
  JOURNAL   Nat Commun 12 (1), 612 (2021)
   PUBMED   33504787
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5823)
  AUTHORS   Zhang,S.B., Lin,S.Y., Liu,M., Liu,C.C., Ding,H.H., Sun,Y., Ma,C.,
            Guo,R.X., Lv,Y.Y., Wu,S.L., Xu,T. and Xin,W.J.
  TITLE     CircAnks1a in the spinal cord regulates hypersensitivity in a
            rodent model of neuropathic pain
  JOURNAL   Nat Commun 10 (1), 4119 (2019)
   PUBMED   31511520
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5823)
  AUTHORS   Shin,J., Gu,C., Park,E. and Park,S.
  TITLE     Identification of phosphotyrosine binding domain-containing
            proteins as novel downstream targets of the EphA8 signaling
            function
  JOURNAL   Mol Cell Biol 27 (23), 8113-8126 (2007)
   PUBMED   17875921
REFERENCE   7  (bases 1 to 5823)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 5823)
  AUTHORS   Kristiansen,T.Z., Nielsen,M.M., Blagoev,B., Pandey,A. and Mann,M.
  TITLE     Mouse embryonic fibroblasts derived from Odin deficient mice
            display a hyperproliiferative phenotype
  JOURNAL   DNA Res 11 (4), 285-292 (2004)
   PUBMED   15500253
  REMARK    GeneRIF: Odin expression in mice is not essential for any major
            developmental pathway; it could play a significant functional role
            to negatively regulate growth factor receptor signaling pathways.
            [Odin]
REFERENCE   9  (bases 1 to 5823)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5823)
  AUTHORS   Pandey,A., Blagoev,B., Kratchmarova,I., Fernandez,M., Nielsen,M.,
            Kristiansen,T.Z., Ohara,O., Podtelejnikov,A.V., Roche,S.,
            Lodish,H.F. and Mann,M.
  TITLE     Cloning of a novel phosphotyrosine binding domain containing
            molecule, Odin, involved in signaling by receptor tyrosine kinases
  JOURNAL   Oncogene 21 (52), 8029-8036 (2002)
   PUBMED   12439753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126040.3 and AC132460.3.
            
            On Oct 26, 2013 this sequence version replaced NM_181413.3.
            
            Transcript Variant: This variant (3) use an alternate structure at
            the 3' end which results in a frameshift compared to variant 1. The
            encoded isoform (3) is shorter and has a distinct C-terminus
            compared to isoform 2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AC126040.3         33031-33371         c
            342-422             AC132460.3         138865-138945       c
            423-579             AC132460.3         137133-137289       c
            580-642             AC132460.3         135361-135423       c
            643-939             AC132460.3         128488-128784       c
            940-1015            AC132460.3         127523-127598       c
            1016-1117           AC132460.3         127198-127299       c
            1118-1219           AC132460.3         127004-127105       c
            1220-1416           AC132460.3         124934-125130       c
            1417-1509           AC132460.3         122450-122542       c
            1510-1630           AC132460.3         117796-117916       c
            1631-2214           AC132460.3         105418-106001       c
            2215-2281           AC132460.3         75704-75770         c
            2282-2388           AC132460.3         71174-71280         c
            2389-2487           AC132460.3         63186-63284         c
            2488-2640           AC132460.3         62201-62353         c
            2641-2748           AC132460.3         62018-62125         c
            2749-2913           AC132460.3         61047-61211         c
            2914-3039           AC132460.3         59835-59960         c
            3040-3111           AC132460.3         59487-59558         c
            3112-3198           AC132460.3         59094-59180         c
            3199-3336           AC132460.3         56386-56523         c
            3337-3507           AC132460.3         55390-55560         c
            3508-3605           AC132460.3         54459-54556         c
            3606-5823           AC132460.3         51071-53288         c
FEATURES             Location/Qualifiers
     source          1..5823
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.6 cM"
     gene            1..5823
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /note="ankyrin repeat and SAM domain containing 1"
                     /db_xref="GeneID:224650"
                     /db_xref="MGI:MGI:2446180"
     exon            1..341
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..3609
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /note="isoform 3 is encoded by transcript variant 3; Odin;
                     ankyrin repeat and SAM domain-containing protein 1A"
                     /codon_start=1
                     /product="ankyrin repeat and SAM domain-containing protein
                     1A isoform 3"
                     /protein_id="NP_852078.1"
                     /db_xref="CCDS:CCDS37525.1"
                     /db_xref="GeneID:224650"
                     /db_xref="MGI:MGI:2446180"
                     /translation="MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGSGSGGG
                     SGGGGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHRDVVEVLLRNDALT
                     NVADSKGCYPLHLAAWKGDAQIVRLLIQQGPSHTRVNEQNALEIRELKKYGPFDPYIN
                     AKNNDNETALHCAAQYGHTEVVKALLEELTDPTMRNNKFETPLDLAALYGRLEVVKLL
                     LGAHPNLLSCSTRKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGK
                     TDVVQILLAAGIDVNIKDNRGLTALDTVRDLPSQKSQQIAALIEDHMTGKRSVKEVDR
                     TSTAQLPLLSNTDAIAPMSQGSMEKTVTELILHFDTHADEEGPYEALYNAVSCHSLDS
                     TASGRSSDRDSMNKEAEATGTRAAGVRPRERPPPPAKPPPDEEEEERVDKKYFPLAAS
                     EGLAVRPRIQSSAPQEEEEHPYELLLTAETKKLGTTDGRTEDHRQSGSGRSQDSVEGQ
                     DGQVPEQFSGLLHGSSPVCEVGQDPFQLLTAPSQSHPESSQQDACHEASMQLEEPGVQ
                     GTEPPQPGVPDQSKRVGLPAGLTALASRTYLDALTHTVPLRPAGAEEEDQSGPRSRAP
                     PTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFAS
                     EWDEIEKIMSSIGEGIDFSQEQQKISGSRTLEQSVGEWLESIGLQQYESKLLLNGFDD
                     VRFLGSNVMEEQDLREIGISDPQHRRKLLQAARSLPKVKALGYDGVSPTSVPSWLDSL
                     GLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVHLLGHRKRIIASLADRPYEEPPQK
                     PPRFSQLRCQDLISQTSSPLSQNDSCTGRSADLLLPSADTSRRRHDSLPDPGTASRAD
                     RFRVQEEPSETKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLR
                     GTESTQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQ
                     DPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSR
                     TMAASAASMIETKSSKPVPKPRVGMRKSALEPPDSDQEAPSHASVSWIVDPKPDSKRS
                     LSTN"
     exon            342..422
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            423..579
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            580..642
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            643..939
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1015
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1117
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1219
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1416
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1509
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1630
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..2214
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2281
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2388
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2487
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2640
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2748
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2913
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3039
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3111
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3198
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3336
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3507
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3605
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..5823
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5624..5629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /note="hexamer: CATAAA"
     polyA_site      5643
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /note="major polyA site"
     regulatory      5659..5664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /note="hexamer: TATAAA"
     polyA_site      5686
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /note="major polyA site"
     regulatory      5794..5799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /note="hexamer: AATAAA"
     polyA_site      5819
                     /gene="Anks1"
                     /gene_synonym="Anks1a; mKIAA0229"
                     /note="major polyA site"
ORIGIN      
        1 gccgccaggg agtgggggag gccgaggagg cggggggaga gggggtggcg tccccggccg
       61 gtttgagggg tgcgttgccc ggagacggaa agtttcggag ccggagcagg ctctgcaagg
      121 ctccgggttg aggtccgagg ggtggcggtc ctggggatgg ggaaggagca ggagctgctg
      181 gaggcggccc gcaccgggca cctcccggcc gtggagaagc tgctgtccgg gaagcggctc
      241 tcctccggct tcggcggcgg cggcggcggc tcaggcagcg gcggcggctc cgggggcggc
      301 ggcctcggtt cttctagcca cccgctctcc agtctgctga gcatgtggag agggccgaac
      361 gtgaactgtg tagatagcac cggctacacg ccactacacc acgctgcttt gaatggacac
      421 agggatgtgg tcgaggtcct tctgaggaac gacgcgctga ccaacgttgc tgactcgaaa
      481 ggctgctacc cgctgcactt ggcagcgtgg aaaggagacg cccagatagt acgtctgctc
      541 atccagcaag ggccctcaca caccagagtc aacgaacaga atgctcttga gatcagagaa
      601 ctcaaaaagt acggcccctt tgacccttat atcaatgcca agaacaacga caatgagacg
      661 gccctgcact gcgcggccca gtacggccac acggaggtcg tgaaggctct gctggaggag
      721 ctcacggacc ccaccatgcg caacaacaag tttgaaacgc ccctggactt ggcggcgctg
      781 tacgggcggc tggaggtggt gaagctgctg ctgggtgcac accccaatct cctgagctgc
      841 agcactcgga aacacacgcc cctgcacttg gcagcaagga atggccacaa ggccgtggtg
      901 caggtcctgc tggacgccgg catggatagc aactatcaga cggagatggg cagtgctttg
      961 catgaggctg ctttgtttgg caagaccgat gtggtgcaaa tcctgctggc tgcaggaatc
     1021 gatgttaaca taaaggataa ccgtggcctg actgcccttg acactgtccg ggatctgccc
     1081 tctcagaaga gccagcagat agccgccctg attgaagatc acatgaccgg aaaaagaagc
     1141 gtgaaagaag tggacaggac ctccacagcc cagctacctc tcctctccaa cacagacgcc
     1201 atagcaccaa tgtctcaggg gagtatggag aagacagtga ctgagctgat ccttcatttt
     1261 gacacacatg ctgacgagga gggcccctac gaggcactgt acaacgctgt gtcctgccat
     1321 tccttggaca gcacggccag tggacgatca tcagacagag actccatgaa caaggaggcc
     1381 gaggccaccg gaacaagggc tgctggagtg aggcctaggg aacgtccgcc gcctccagca
     1441 aaaccgccac ccgatgaaga ggaggaagaa cgcgtagata agaagtattt tcccttggca
     1501 gcctctgagg gcctggctgt gagacccagg attcagagta gtgctcccca ggaagaggag
     1561 gagcacccat atgagctgct gctcacggca gaaaccaaga agctggggac cacagacggg
     1621 aggactgaag accacaggca gagcggcagc ggccggagcc aggactctgt ggaggggcag
     1681 gacgggcagg tcccagagca gttctcaggt ctcctccacg gctcctcccc agtgtgtgag
     1741 gtggggcagg accctttcca gctgctcacg gcccccagcc agagccaccc ggagtcctcc
     1801 cagcaggacg cctgccacga ggccagcatg cagctagagg agccaggcgt gcaaggcact
     1861 gaacccccgc agcccggcgt ccctgaccaa agcaagagag tgggcttgcc ggcaggcctg
     1921 acagccctgg ccagcagaac atacctcgat gcattgactc acacagtacc tctgcgccct
     1981 gctggtgccg aggaagaaga ccagagcggg cccagaagca gagcccctcc caccagcaag
     2041 cccaaagctg agctcaaact cagccgcagt ttgtctaagt ctgactctga cctcctgacc
     2101 tgctccccca cggaggacgc cacaatgggg agtcgcagcg agtccttgtc caactgcagc
     2161 atcgggaaga agaggttgga gaaatcacct tcctttgcct cagagtggga tgagattgag
     2221 aaaatcatga gctccattgg ggaagggatt gacttctctc aggagcagca gaagatctca
     2281 ggttctcgga cgctggagca gagcgtcggg gagtggctgg agtcgattgg cctgcagcag
     2341 tacgagagca agctgctgct gaacggcttt gatgatgtcc gcttcctggg gtctaatgtg
     2401 atggaagagc aggacctgag ggagattggc atcagtgacc cacagcaccg gcggaagctg
     2461 ctgcaggctg cacgctcctt gcccaaggtg aaggcccttg gctatgacgg ggtcagcccc
     2521 acctcagtgc cctcatggct ggactcgctg gggctgcagg actatgtcca ctctttcctg
     2581 tccagtggct acagctccat cgacactgtg aagaacctct gggagctaga gcttgtcaat
     2641 gtcctgaaag ttcacctgct gggccaccgc aagcgcatta tcgcctctct agcagacagg
     2701 ccctatgagg agccacccca gaagcctcca aggttttccc agctaagatg ccaggattta
     2761 atctcccaga catcgtcccc gctgagccag aatgattcct gcacagggcg gtcggcagac
     2821 ctgctgctgc cctcagcaga cacaagcagg aggcggcacg acagcctgcc cgaccctggg
     2881 accgcctccc gagcagaccg cttccgagtc caggaggagc ccagtgagac caagctgacc
     2941 ctccgtccac ccagcctagc cgcgccctat gctcctgttc agagctggca gcaccagcca
     3001 gaaaagctca tctttgagtc ctgcggttat gaggccaatt atctgggttc catgctgatc
     3061 aaagatctgc gagggacaga gtccacccaa gatgcctgtg ccaaaatgcg gaagtcaacg
     3121 gagcacatga agaagatccc caccatcatc ctgtccatca cgtacaaagg tgtcaagttc
     3181 atcgatgctt ccaacaagaa cgtcattgcg gagcacgaga tccggaacat ttcctgcgcc
     3241 gcgcaggacc cagaggacct gtgtaccttc gcgtacatca ccaaggacct gcagacgagc
     3301 caccactact gccacgtttt cagcacagtg gatgtgaacc tgacctacga gatcatcctg
     3361 accctggggc aggcatttga ggtggcctat cagctggccc tccaagccca gaaatccagg
     3421 accatggcgg cctctgcagc ttcgatgatt gagacaaaat cctccaaacc agtgcctaag
     3481 cctcgggtcg gcatgaggaa gtctgcactg gaaccacctg attctgacca agaggccccg
     3541 tcccacgcta gtgtttcctg gatcgtggac ccaaagccag actcgaagcg gagcctcagc
     3601 accaactgag ccactgagga gccaccctgc tttgcagaag tagccgtggg gcgcaggctc
     3661 ctgccccagc cccgagagcc tcatctgcaa cactgaagac ccaggcccag tcctgctgta
     3721 ggacctcctg tcgcctgctc ggcctgggcc tgccgacacc tgcaggaccc tgccctggag
     3781 gcagcgaaga cgccaggcat ctagcagagg agaccggaac tctggatggc ccaagaagtg
     3841 gcctgtccag gacatgtgtt tttgataaga aacataatcc tttttataca tttttaacac
     3901 ttggctccgg cctctcggta aagctgccaa tctttaaaca agacaggacc tgagatgggc
     3961 ctgaaaccct caggcagcct ctgccttcac aatgggctct tggcctggct agagccatga
     4021 ggacacgccc gaggcttcct catctactga ggtgatgaca cagatgtttc tggggttccc
     4081 agtggggata agcaagtagt ttctggtgtg ggggactccg gagtactcac ctgtccccat
     4141 tagcactgcc gcaggcagct gtccccatgc tgctgctggg ccaatggagc catgttggaa
     4201 gggagaagtg gctttgttgg ggcattgata gcaatgccag ttatgactgc agcttgccag
     4261 ctggggactg gatctgcctc tctctgatgc ttgttgactg ttgtatcctg tgtggcaggc
     4321 tgggcacatc tgttccagat gtgggaaagg ctagtcaggc aacagtctta tcccctccac
     4381 cccacccccg ccccgctacg gtcttgaagt caagctggtg ttgctttagc tcttctgcta
     4441 gcttgctttg ctttttaaag tgacttgggt ggagagccac ctcctgggct taaggagcag
     4501 tgaggggcag gctgctgggg tcgggggacc aaccaggcct ctctcaccag cttttccaga
     4561 gtagggagca aaaaagagaa gccctggccc acaggtacgt gagcaggctt cagggtctcc
     4621 gggcagcacc catcctggtc ctggggacag gaggccaggc ctgaacagcg gttgtgagct
     4681 gcaatcctgg gcactgccac cttgtggctg ctcagagtgg aaagcagggt ttccctctgt
     4741 agacctgcgg gctgtctgcc tgctgcattc agtgcagcag ctgctgggta cagctcctct
     4801 ctgggaagga gccagggcct ccgctgctag gtgcaggtag tacttcctct cctgcctcat
     4861 gctctctgcc ctggaaagcc tccctcggct cacagagaga cccttggtgc ctggctcagt
     4921 tgtgccgagc cccttccctc tgccagaggt gagctcagtg ggctctgcag tgggcgcaaa
     4981 gcccagggaa cactgtagac actacgatga gttcaagctg cactctgttc taaagtcaca
     5041 ggcaggcact tcctcctctt gacgctgcta ggtcttattt attcagggtg ttttctacca
     5101 gaaagtcttg gcttgtctgc tctgcgtccc tttcaagatt ggtttctgaa tagtcaagaa
     5161 attcctctcc tcctccgggt gggtctctcc ttttcaggac aagtgccaca tggaaggctc
     5221 tgcctttggc gcttgtgtga aaccaaggct gtgcctgaac tgtgaaggag ccgttctggt
     5281 gggaatggca agacgtgccc agtccctcat gcagtggcca caggatccct tgcttgcctc
     5341 ttggctggcc tgccgccctg caggccctgt gtcccagcag gggactttgg actctgaggt
     5401 tgcccactgg ggggttctga gaaaccttgg gtttgagcac tcagaacaca tggctgcaat
     5461 catcaagaca gttcacagtt agcttgtgag gtgccgggac cagcgccgca ggtcatggga
     5521 gttactgctc atggtggaca gtgggactgg attgtaagaa aaatgttatt taatctttgt
     5581 ttccatattt tgatacttga attccccctt ttgttttact gtacataaaa ttgttaatct
     5641 gtccgatttt gtttgaatta taaacacctt gtggtaccaa acataaccaa cctgtgcatc
     5701 agcatagacc acctcactgc acagtgtgca ccccctgggc ttccagctcg gtttctcact
     5761 tccatagctg tacagcttag gactgactaa gctaataaag gagagcgcta gaaaccggcc
     5821 ata
//
