LOCUS       NM_001012451            4444 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ankyrin repeat domain 6 (Ankrd6), transcript variant
            3, mRNA.
ACCESSION   NM_001012451
VERSION     NM_001012451.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4444)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4444)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4444)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4444)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 4444)
  AUTHORS   Jones,C., Qian,D., Kim,S.M., Li,S., Ren,D., Knapp,L., Sprinzak,D.,
            Avraham,K.B., Matsuzaki,F., Chi,F. and Chen,P.
  TITLE     Ankrd6 is a mammalian functional homolog of Drosophila planar cell
            polarity gene diego and regulates coordinated cellular orientation
            in the mouse inner ear
  JOURNAL   Dev Biol 395 (1), 62-72 (2014)
   PUBMED   25218921
  REMARK    GeneRIF: Results indicated that mAnkrd6 is a functional homolog of
            the Drosophila diego gene for mammalian planar cell polarity (PCP)
            regulation.
REFERENCE   6  (bases 1 to 4444)
  AUTHORS   Schwarz-Romond,T., Asbrand,C., Bakkers,J., Kuhl,M., Schaeffer,H.J.,
            Huelsken,J., Behrens,J., Hammerschmidt,M. and Birchmeier,W.
  TITLE     The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon
            to the beta-catenin degradation complex and acts in both canonical
            Wnt and Wnt/JNK signaling
  JOURNAL   Genes Dev 16 (16), 2073-2084 (2002)
   PUBMED   12183362
REFERENCE   7  (bases 1 to 4444)
  AUTHORS   Tissir,F., Bar,I., Goffinet,A.M. and Lambert De Rouvroit,C.
  TITLE     Expression of the ankyrin repeat domain 6 gene (Ankrd6) during
            mouse brain development
  JOURNAL   Dev Dyn 224 (4), 465-469 (2002)
   PUBMED   12203740
  REMARK    GeneRIF: These data suggest that ankyrin repeat domain 6 (Ankrd6)
            may be involved in brain development in interaction not only with
            Celsr/Flamingo but also with other signaling pathways.
REFERENCE   8  (bases 1 to 4444)
  AUTHORS   Huelsken,J. and Birchmeier,W.
  TITLE     New aspects of Wnt signaling pathways in higher vertebrates
  JOURNAL   Curr Opin Genet Dev 11 (5), 547-553 (2001)
   PUBMED   11532397
  REMARK    Review article
REFERENCE   9  (bases 1 to 4444)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4444)
  AUTHORS   Uusitalo,M., Heikkila,M. and Vainio,S.
  TITLE     Molecular genetic studies of Wnt signaling in the mouse
  JOURNAL   Exp Cell Res 253 (2), 336-348 (1999)
   PUBMED   10585256
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF533090.1, BC065177.1 and
            AV290829.2.
            
            Summary: This gene encodes a protein which is thought to be
            involved in the Wnt signaling pathway and embryonic axis formation.
            Similar genes have been found in human, rhesus macaque, and
            zebrafish. Three transcript variants encoding the same protein have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-4 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.6290.1,
                                           SRR1660815.153969.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-610               CF533090.1         16-625
            611-4261            BC065177.1         850-4500
            4262-4444           AV290829.2         466-648
FEATURES             Location/Qualifiers
     source          1..4444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 14.42 cM"
     gene            1..4444
                     /gene="Ankrd6"
                     /note="ankyrin repeat domain 6"
                     /db_xref="GeneID:140577"
                     /db_xref="MGI:MGI:2154278"
     exon            1..80
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            81..347
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2366
                     /gene="Ankrd6"
                     /note="diversin"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 6"
                     /protein_id="NP_001012454.1"
                     /db_xref="CCDS:CCDS18018.1"
                     /db_xref="GeneID:140577"
                     /db_xref="MGI:MGI:2154278"
                     /translation="MSQQDAVAALSERLLIAAYKGQTENVVQLINKGAKVAVTKHGRT
                     PLHLAANKGHLSVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEILTALIREGCALD
                     RQDKDGNTALHEAAWHGFSQSAKLLVKAGANVLARNKAGNTALHLACQNSHSQSTRIL
                     LLGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLNAFCSVHEKNQAGDTALHVAAALN
                     HKKVVKVLLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQILRFSRGRSLRK
                     RRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPQKEEARRDCPPASQEPRKD
                     ERRRKSRPEVSALSDPTPAADQQPGHQKNLHSHHHPKKKSRHRCWSPPPPHGFRAYQL
                     YTLYRGEDGKVMQAPIKGCRCEPLINKLENQLEATVEEIRAELGSVQDKVNAKLGQME
                     SKTQHQMCVLDKLMVERLSAERTECMNRLQQHAAAEKQEGEKRQMSLVDELKAWCMLK
                     IQSLELRLSGESRTFRAKSTPPPSDSTPAVDQPVVAAGPGAASDSSSQVVRPKDKALN
                     ASAAHSHQQELPPSDCTGSGLRKIKAPGASRCDQQTGSCVNRGTQTKKSGRSGQTKHR
                     GQQPTASSPSGQQPSAASSDVRDASQALELTQYFFEAVSAQMEKWYERKIEEARSQAS
                     QKAQQDEATLKEHIRSLEEELARLRTKVQK"
     exon            348..446
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            447..545
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            546..644
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            645..743
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            744..842
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            843..941
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1019
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1124
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1256
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1442
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1595
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1709
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1836
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..4444
                     /gene="Ankrd6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4424..4429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd6"
     polyA_site      4444
                     /gene="Ankrd6"
ORIGIN      
        1 gtggggcgag cggctgcggg caaggagcgc agcggcccgc gagctccgtg cggagcggcc
       61 ggccggcgcg ggagcgaaag gacctgaaga tggagtagtg agaaaggcat ccctcaggat
      121 tccgagcacc tttcgctgtg gactccagcc ccacccgagg ctgcatgtgg agctgaggaa
      181 actgacccac cgcttgcttt cctgggagcc cctttctctc ctaattcatg agccagcagg
      241 atgcggtcgc tgcgctttca gaacgcctgc tcatagctgc gtacaaaggc caaacagaga
      301 atgtggttca gctcatcaac aagggtgcca aggtagccgt taccaagcat ggccggaccc
      361 ccttgcacct cgctgccaat aagggtcatc tttctgtggt gcagattttg ctgaaggctg
      421 gctgtgacct cgatgtgcaa gatgatgggg accagacagc cttgcaccgg gccactgtgg
      481 tgggaaacac cgagatcctc acagcgctta tccgggaggg gtgtgccctg gacagacagg
      541 acaaggatgg gaatacagcc ctgcatgaag ccgcctggca cggattcagc cagtcagcca
      601 agctgctcgt taaagccgga gccaatgtgc ttgccagaaa caaggcaggg aacacagctc
      661 tgcacctggc ctgccagaat agtcactccc agagcactcg catcctcctg ctgggcggct
      721 cccgggctga cctcaaaaac aacgcagggg acacctgtct gcacgtggct gcgcggtata
      781 accacttgtc cgtcgtcaga ctcctcctca atgctttctg ctctgtccat gaaaagaacc
      841 aggctggaga cacggccctc catgtggctg ctgccctaaa tcacaagaag gtagttaaag
      901 tcctgctgga agctggtgct gacacaacca ttgtgaacaa tgcaggccag accccgctgg
      961 agactgcccg ctaccacaat aatcctgaag tcgcactact cctcaccaag gctccccaga
     1021 tcttgcgctt cagtcgtggg cgaagcctga ggaaaaggag agagaggctc aaggaagaga
     1081 ggagggccca gtctgtgccc cgagatgagg tggcacagag caagggaagt gtctcagcag
     1141 gagatacccc cagcagtgaa caagcagtac cccaaaaaga ggaagctaga agagattgtc
     1201 caccagcttc ccaggagcca agaaaggatg agaggaggag aaagtcgagg ccagaggtgt
     1261 cagcgttatc tgaccccacc ccagccgcag accaacagcc tggacaccaa aagaacctgc
     1321 acagtcatca ccaccccaaa aagaagagca gacatcggtg ttggtcccca cctccacccc
     1381 acgggttcag ggcgtaccag ctatacacgc tgtaccgggg cgaggatgga aaagtgatgc
     1441 aggcaccaat aaaaggttgt cgctgtgaac ctctaatcaa caagctggag aaccagttgg
     1501 aggcgactgt ggaggaaatc agagctgagt taggctcggt gcaggataaa gtgaacgcga
     1561 agctgggcca gatggagagc aaaacccagc accaaatgtg cgttttggac aaactgatgg
     1621 tggaacggct gtccgcggag agaacagaat gcatgaatcg cctgcaacag catgcagctg
     1681 ctgagaagca ggagggagag aaacgtcaga tgtctttggt agatgaacta aaagcctggt
     1741 gcatgttgaa gatccagagt ctggagctaa gactctctgg agagtctcgg accttcagag
     1801 ctaaatccac accacctccg tctgactcca ctccagctgt agaccaacca gtggtagctg
     1861 cagggccagg agcagcttcc gacagctcct ctcaggttgt gaggcccaag gataaggcgc
     1921 tcaatgcctc ggctgcccac agccaccagc aggagctgcc tccctctgac tgtacagggt
     1981 ctgggttaag gaagatcaag gccccgggtg cttccaggtg tgatcagcag actggatcct
     2041 gtgtcaaccg aggcactcag accaagaagt ctgggagaag tgggcagacc aagcatcgag
     2101 gccagcagcc cactgccagc agccccagtg ggcagcagcc atcagcagca agcagtgatg
     2161 tgcgagacgc ctcacaagcc ctggagctaa ctcagtattt ttttgaggcc gtttctgcac
     2221 agatggaaaa gtggtatgaa cggaaaattg aagaagcacg gagccaagca agtcagaaag
     2281 ctcagcagga tgaggccaca ttgaaggaac acatcagaag tctggaggag gagcttgcca
     2341 ggctgcggac aaaggtgcag aagtaaaagc cagaccctca gctggaccca acagggtttc
     2401 cggcttgata acagccaagt aacggtgtcc caggagttgg ttgtcacgcc caaggtggac
     2461 ttgcctttta gaaagtcacg aatgtgttgc ggacacatat ttcctgtgct ctgaaattac
     2521 aaggccttca ctggttaaaa tgaatcctgg caatatgttc acaaaaagca agctgcaccc
     2581 agatgaggtg tgtacccaag tctgcgattc agtgacatga actatgtcgg cagcaaagca
     2641 gattactctg cgagcccagt agtcattcac agctgctgtg actagacagt ccttctaacg
     2701 gagctgggac gcggatgccg gaagcccctt ttctcccatg tgactcaaga tgctcatctt
     2761 ttaaaggggt gaaaagcgct caggttttga ggaaatacat tgtaatgatc tcagtgtcca
     2821 gtatgtctta aagtaatgtt aagggtcatg taaagaagga gtaattgctg actgtcaaac
     2881 tcgaaaagtt taaaatattg gtcagttact gtggttttag ccaaataact gagcagacta
     2941 atggaaaaaa tccaccaaac aactccagct agttacctta gcttgattgc ctttctaacg
     3001 tcaagacttt tgctggtttg taaataaggc agaatcatga aagtttaatt ttgagttgac
     3061 tcctcactga agaacaccaa gccatcagaa ggctttactt gttcgcggag taagatgtaa
     3121 cagactgagg tggtgacgat atctgggttg ggacctagga tttgtcctcg gatcctttgg
     3181 aacacagaac atggattatg tccgtctcca tgatccacat acacatagga acttctgttt
     3241 ctctaagcct aaggacctca taaatcctgt ccatgaattg tgactaaaat gctgttcatt
     3301 gagccaaaga gaagtgacct ttgtgaaata gtatgcattt atccctttgt caagccaagt
     3361 tcttcctttt tcttatagtg acactccatg gatgtagaca ttcctggaaa catacagggt
     3421 agatatatga gtacagaatc tagtgaggcc agttatttca tgggactgac ccgtcctcag
     3481 cctcttggga ggtgcagatt tttcccattc tccttcactg gagtcctgtc ctcagctcac
     3541 ttgccccatc cctgctatga cactccctgg acaaaatgtc actggacctg cctaatacta
     3601 agtaagagat gaaaccccga gttcagcaag ttatgctcca agcaggagtt attttcacta
     3661 ttagaatact tattacctca agataccctt gacaagaaat gcagacatca actgtaactg
     3721 aacatcaaat ctagaccaca gactaccttg gtggcagtac tttgatgcta tacctcctac
     3781 ccatcagaag caggcagctt atcactgtga atggatgttt ttgtcaagtc attaagcata
     3841 aagccaggct attgaataag gccagtcagc cccttaccca cagggttgac ttctaaggaa
     3901 gtggtggttg gcttgttttg gaaggctcta ctgtgtactc tagactgtct cagccacctg
     3961 agttctggga ttaaaggagt gagcatggct aatcctgtgt tgtttgtaac acccgtctta
     4021 ggtttgttgc aattgtaaag cactgaagat cagctgtgtc ttttcccctt gtgctatgtg
     4081 caaaaacaag caaatatccc agctgtactt ttacagataa ctgtttatat cacatactct
     4141 cacatagatc atgcttcaaa ctgaggccta ggaagcatca acagctgtgg agaaacatgt
     4201 tataaaacag taatgttgta tattatcaat gtccttttta aaaacaagta attgttagca
     4261 catcccttag actgtattct gagtatctgt gatggggtga aagtgttagt ctagcatcgc
     4321 tttttatttg aggagtccgg aatataggtt tttcatgttt agatttgtgt gtgcaaggca
     4381 tgttgtctga ttttatcaca tggaacttgt gtctcctata tgcattaaat gttgttttca
     4441 gttc
//
