LOCUS       NM_175134               2480 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus ankyrin repeat domain 46 (Ankrd46), transcript variant
            3, mRNA.
ACCESSION   NM_175134
VERSION     NM_175134.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Li,Z., Jia,J., Gou,J., Zhao,X. and Yi,T.
  TITLE     MicroRNA-451 plays a role in murine embryo implantation through
            targeting Ankrd46, as implicated by a microarray-based analysis
  JOURNAL   Fertil Steril 103 (3), 834-4 (2015)
   PUBMED   25542822
  REMARK    GeneRIF: miR-451 was specifically up-regulated during the
            implantation period, and it may play a major role in embryo
            implantation by targeting Ankrd46.
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Brouns,M.R., De Castro,S.C., Terwindt-Rouwenhorst,E.A., Massa,V.,
            Hekking,J.W., Hirst,C.S., Savery,D., Munts,C., Partridge,D.,
            Lamers,W., Kohler,E., van Straaten,H.W., Copp,A.J. and Greene,N.D.
  TITLE     Over-expression of Grhl2 causes spina bifida in the Axial defects
            mutant mouse
  JOURNAL   Hum Mol Genet 20 (8), 1536-1546 (2011)
   PUBMED   21262862
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 2480)
  AUTHORS   Silvestri,C., Narimatsu,M., von Both,I., Liu,Y., Tan,N.B., Izzi,L.,
            McCaffery,P., Wrana,J.L. and Attisano,L.
  TITLE     Genome-wide identification of Smad/Foxh1 targets reveals a role for
            Foxh1 in retinoic acid regulation and forebrain development
  JOURNAL   Dev Cell 14 (3), 411-423 (2008)
   PUBMED   18331719
  REMARK    Erratum:[Dev Cell. 2008 Apr;14(4):633]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ715954.1 and BC035553.1.
            
            On Dec 12, 2009 this sequence version replaced NM_175134.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086659.1, AB076382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-674               BQ715954.1         1-674
            675-2480            BC035553.1         2253-4058
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.47 cM"
     gene            1..2480
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /note="ankyrin repeat domain 46"
                     /db_xref="GeneID:68839"
                     /db_xref="MGI:MGI:1916089"
     exon            1..65
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            66..182
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            183..515
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..891
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /note="ANK-S; ankyrin repeat small protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 46"
                     /protein_id="NP_780343.1"
                     /db_xref="CCDS:CCDS27429.1"
                     /db_xref="GeneID:68839"
                     /db_xref="MGI:MGI:1916089"
                     /translation="MSYVFVNDSSQTNVPLLQACIDGDFTYSKRLLESGFDPNIRDSR
                     GRTGLHLAAARGNVDICQLLHKFGADPLATDYQGNTALHLCGHVDTIQFLVSNGLKID
                     ICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGAHSKLETMQTAESESAME
                     SHSLLNPNLQQGEGVLSSFRTTWQEFVEDLGFWRVLLLILVIALLSLGIAYYVSGVLP
                     FVDNQPELVH"
     exon            516..674
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            675..2480
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2458..2463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2480
                     /gene="Ankrd46"
                     /gene_synonym="1110054N06Rik"
                     /note="major polyA site"
ORIGIN      
        1 tccgcgcccc gcctgtcgcc gctggagagg aggagctgct gccatcactg ctgccgcggg
       61 cgcagataaa gaagctgagg cacagagtct taagtcaacc tgtccaagcc cagacagttg
      121 gcagactaag tgggaccgga gacgcccaag acttcacgcc agcatccctt taccttgcaa
      181 aggagtggcc gtccaccaca gacgatgtcc tacgtttttg tgaatgattc ttcacagact
      241 aacgtgccct tgctccaagc ttgcatcgat ggggacttca cctattccaa gaggcttttg
      301 gaaagtggct ttgatccaaa tatccgagac agcagaggca gaacgggcct tcacctcgcc
      361 gcggcccgag ggaatgtgga catctgccag ctgctgcata agtttggagc tgatccactg
      421 gccacagatt accaggggaa cacggccctc cacctgtgtg gccatgtgga caccattcag
      481 ttcttagttt ccaacggact caaaattgat atttgcaatc atcaaggtgc taccccttta
      541 gttctggcaa agcgccgggg tgtgaacaaa gatgtcatcc gactgctgga gtctttggaa
      601 gaacaggaag taaagggatt taacagaggc gcgcactcga agctggagac catgcagacg
      661 gcagagagcg aaagtgccat ggaaagccat tctctgctca accccaacct ccagcaaggc
      721 gaaggcgtcc tgtccagctt ccgaaccacg tggcaggagt ttgtggaaga cctgggtttc
      781 tggagggtct tgctgttgat cttggtcatt gctttgctgt ctctgggcat tgcctactac
      841 gtgagtgggg tgttgccctt tgtggataac cagcctgagc tggtgcattg agggctcctg
      901 gggagaggca aggggcctgt cagtgtggct tttcagttct tagactattc cttaggcaag
      961 gcagcgaggc ctgtctgtgt ttaggatttg tatttaccgt gatccttacg gaggaatgac
     1021 gtgtcccact gaacttcgtc ctgccgctgg ttagactcat tctcatgcta ccctctgatg
     1081 ccgcctgtgt ctgaggaagg catccccagg cttgtgtgac ccaagtgtgg tgataaccag
     1141 gtggacactc aaggcagagg cttgggaggc ctcacagtgg ggcccgacct tgatggagga
     1201 gcagtgacag aaagcggatt tctttttcta ggattccatt tgccagtggc tttgttttcc
     1261 ctcgtttgtt ccttttgcaa tagtattctg tttttattta ctttcctggc aagaggaggg
     1321 agtgaaaact ttcaacttga attttaatta cttttacaat ctatatgaca aattagaact
     1381 gttaggaatt ttgactttaa aagtatgtag tcagatagta gacaggtttg gaaagcgagc
     1441 agtcttctct ctgacatgat tgatccgatc agggtttagt tgccatggag cagttttgaa
     1501 tcagtgtaaa ctgattgctt gcagtgtctg aaaaccaatg ttttatgagt tcagctcact
     1561 cttcagtctc ctcccatttt tacttttgag atgtcccatt cagaaaaata ccaggaaatt
     1621 ctttgtagtg aatagtcatt agagagagtc ctgtccttca ttgtcaccaa actcaggagt
     1681 gccaccaaga cagcgacact tgagtctgta agccagccgt gtcatgaggc tcaccacagt
     1741 taaccgtttg tctgaaggga cacattcagg tcagcaggag ttcagcagtg gatgggggag
     1801 catttctgag tacagagtcc tggacgatac tctgctgctg ctgctatgat gtcttccctg
     1861 tgtacaggtg cattcacata atgaatagga atctggaccc tatgtcatag cttctcagcg
     1921 tctctgaaag ccctctttgc ttctgtggta tagaaaccat gtttcttatg atattacaga
     1981 gcatggaggt ttaataatga gtaaaatttg aaacttgcag tgaagggcta acggttctct
     2041 tttctctagc aaaggcaccc ctggccacct gtctgggcaa agtggccctt ctgcaagcct
     2101 ctcgctactg gtatcttctc ctctgctttc agatacatag ccctgacact tttctttcag
     2161 gtggctttat cctgtctgaa ggaactgttt tacaggtctt cactggctgt ttcagaatca
     2221 gcttgcagtg tcttgctttt aactaatcat gtttggtaga cgcaggcttt tgcttttgca
     2281 tggagaacac tagcattcaa gttcaaagca tgttcaggac gagtgctttg gagttagttt
     2341 accctctgta agtcagaata tatgtaatat gtaaatattt tgcctctacg atccctgctt
     2401 cctgcccagc actggtttct gtgcatcatg tgttccacac tgcatttaac tgcttccaat
     2461 aaatgcattt ataaatcctt
//
