LOCUS       NM_001368766            3671 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ankyrin repeat domain 45 (Ankrd45), transcript variant
            2, mRNA.
ACCESSION   NM_001368766
VERSION     NM_001368766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3671)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138640.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.26782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC138640.7         47372-47393         c
            23-77               AC138640.7         45726-45780         c
            78-430              AC138640.7         38773-39125         c
            431-598             AC138640.7         34677-34844         c
            599-693             AC138640.7         29329-29423         c
            694-832             AC138640.7         26685-26823         c
            833-875             AC138640.7         25876-25918         c
            876-3671            AC138640.7         19583-22378         c
FEATURES             Location/Qualifiers
     source          1..3671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.75 cM"
     gene            1..3671
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /note="ankyrin repeat domain 45"
                     /db_xref="GeneID:73844"
                     /db_xref="MGI:MGI:1921094"
     exon            1..22
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            23..77
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            78..430
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..852
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ankyrin repeat domain-containing protein 45"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 45
                     isoform 2"
                     /protein_id="NP_001355695.1"
                     /db_xref="CCDS:CCDS87902.1"
                     /db_xref="GeneID:73844"
                     /db_xref="MGI:MGI:1921094"
                     /translation="MEPEETLESESSEKSLFSSQQEYEESQEAEETGAENPLLQPTLT
                     GDVEGLQKIFEDPEHPHHEHAVQLLLEEDIVGRNLLYAACMAGKSDVIKALAKYGVNL
                     NEATARGYTLLHCAAAWGRLETLKALVELDVDIEALNFRGEKARDVAARYSQVECVNF
                     LDWADARLILKKIITKSSLIITDPEKGPGKLFKEDKSTILNACRLKNEWLESHPEASI
                     SEIFEQKQQLEDIVSPILAKMSTPRHFAAS"
     exon            431..598
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            599..693
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..832
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..875
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            876..3671
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3641..3646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /note="hexamer: AATAAA"
     regulatory      3645..3650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /note="hexamer: AATGAA"
     polyA_site      3661
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
     polyA_site      3664
                     /gene="Ankrd45"
                     /gene_synonym="4933409K03Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcctgg gccctgagtg agcaccatga ttggagggaa ccttggactg gaagaaactc
       61 agtaggcact gacttgggta tttttttttt ttttttttgg agttaatgga gccagaagaa
      121 actctagaat cggagagttc agaaaagtca ctattttcct cacagcaaga gtatgaagag
      181 tcgcaagaag cagaagaaac aggcgctgag aacccccttc tgcagcccac tctcactggg
      241 gacgtggaag gtttgcagaa gatttttgag gaccctgaac atcctcacca tgagcacgct
      301 gtgcagctgc ttttggaaga agacattgtt gggagaaatc tgttgtatgc agcttgcatg
      361 gctggcaaaa gtgacgtaat taaagccttg gcaaagtatg gggtgaatct gaatgaggca
      421 actgccagag ggtacacgct cttacactgc gctgcagcct ggggccgtct ggaaactttg
      481 aaggccctgg tggaactgga tgttgacata gaggctttga acttccgggg agagaaagct
      541 cgggatgttg ctgctcgtta ttctcaggtt gaatgtgtta attttctgga ctgggcagat
      601 gcaaggctga ttctgaaaaa aattattaca aagtcctccc tcatcattac tgacccagaa
      661 aagggaccgg ggaaactctt caaggaagac aagagcacca tcctcaatgc gtgccgtctg
      721 aaaaacgagt ggttggaaag ccatccagag gcttccatta gtgagatttt tgagcagaaa
      781 caacaattgg aagatatcgt ctcccccatc ctagcaaaaa tgtctacacc acgtcatttt
      841 gctgcctcat aaagagacct tacacttatc aacaggccaa gtgaagagtg ccaaatcgat
      901 aacctaagcc gtggtcacca gagaagtcaa ggatgtgcct tttacagatg ccacatggtg
      961 tagaaggcta cattacattt cagtattaaa tacgacaaac ctgttcctcg ttcctgccaa
     1021 gttcaagaaa tagatccagg gttttgcaga aatgtctggg tacaaattca gttacctggc
     1081 tttgtgttag actgttcaga agactcacac ctggctcagg ggctgggcct ctgctcctcc
     1141 aagctgggct cctcctgagt cctccaagct gggctcctcc tgagtcctcc aagctgggct
     1201 cctcctgagt cctccaagct gggctcctcc tgagtcctcc aagctcagtc ctcctgagtc
     1261 ctccaagctc agtcctcctg agtcctccaa gttcagtcct ccttagtcct ccaagctcag
     1321 ttctactgag tcctccaagc tcagttctac tgagtcctcc aagcatacaa gcacacagag
     1381 aagctaatag ttttctgttt aactgaggca agaaatttcc acttgactag gggattctat
     1441 ttttaaaaga tgcatgaagc catttgtaaa agaaaagcag gtgttccctc tctttcaaaa
     1501 agcaaatact aagaattgaa gtcccccctc cccgagaggt ggggtcctct ggttttagct
     1561 gtctgaatta aaattcaccc ggaaggtggg atatagtttc tgaggaaagc ccacaaatct
     1621 gtggtttccc ctctcagggt ttggcagtac acggtaactg ccactgtgct gagtcccacc
     1681 ggtctccctt acattgcctg tgttttaaag gccatggcga cagaaagggt cctcagaaag
     1741 tactcttggt agtaaaatca agcaggaccg cgaacttcct attactttcc aactttctgg
     1801 gggaagtttt ttatagaaaa tagaacatgt atacttaaaa taggagaatc attttatcac
     1861 tttctcctca ttgtcttgct atgcaaacta tttttcactt tagaggagaa agaaaacagg
     1921 ggagccattc agtcatactt gtcaggtgat gttctcttgg tcatgctatt gaggtcatct
     1981 tgttttaaaa tgtttcccca agtttccact tctgagatct tttctctata ggagcgattg
     2041 ccattcagca gaaacccgaa cactagcccg tctctgcggc acccagagta tttgctgctc
     2101 gtggtaggca gagctctgtg cttggtcctt ttaggacaat ctttcaagac acttggtgca
     2161 catgagcact gagatcatta ggaagagcct tggtgccatt gggggatggg tggtgttgtc
     2221 atttttattc taagccacgt tttctgagcc ttgatcatga acacagcagt ggtctcgagg
     2281 tctctgctcc tcgtaactag gaggggaggc tttaaacgta cttttagtcc caggtgagac
     2341 aagcatttta aaccatctgc tagaacagtt tctctctccc tctttgcctc acactctttg
     2401 tcctcagatg ttttatagcc tttgatacac ttgctagcac agtatttgta cagttccttg
     2461 aattgggacc tttataccaa ctttctcata gtctcctttt ctaatgaatg ccccatcggc
     2521 ttctcctctt cttgaccctc attgtcagat cctctcagga ttccattagg attcttggtc
     2581 ggacaatggt ggttctccac cctatgacta tccccatctt caatattaca aagatccaac
     2641 ctttccttct tggggacatt tacagcgcca gaagcctcat tctgtgtcct gtgtaactta
     2701 gcctcattcg gtgtcctgta taatttactc acatgcttct ctctccatgt gaatgaatat
     2761 agatctttat gaaaggaaga catttttgtt gaaaatcctt tattttcaac aattttgttg
     2821 acatccttta tgaaaggagg cctctttttt gttgggggcc ttcctcatac ctaaagagct
     2881 tgtaaaatag taagtcgggg aatagaagtt gaattgacgc acttagtact accttactct
     2941 cagtacctag aattgcttag tcctaccttg tactcagaac tcactccctc ttcattcatt
     3001 tacgaagttg gattaccatt atagaaatgc tcccaacctt agcttatgcc ttgcctatgt
     3061 cagtgtacca cagacaagcc atacgcacag caaacattgt ggctctctgt ctgcccgctc
     3121 ccaactgtgt agttctgaat gtcatggacc tggtggcccc atggcatcct tgtatcttat
     3181 ttcagagact cctttgatgt ggggtctgaa tacttactta aatctgtgta tgtataactt
     3241 ctgttttgct agagatgata tcaattatta cctattgttg cactgactta tacgtagatc
     3301 aataggagat ttagatgccc ttatgctgtg agtttgatgt gatttcatta gctgcatggt
     3361 gctttctgac cttgcataga ctaatgactt tttaaaaagc acacacttaa cagttcagga
     3421 acgcctccac agtatttgaa agggaggcaa tttaatgtta tgatcagttc tagttggtag
     3481 ttctttaggt tttgtgtttc attggtcata aaaatgtaaa aatataaagg tatggtatta
     3541 atgtaacatt aaaatagcaa ctgctgcctg ttatcactgt catgtaacaa aagacatttt
     3601 aactccaaaa agtagggcta cgtggtgaca gtatgatccg aataaatgaa gcttcattac
     3661 agaattttat g
//
