LOCUS       NM_001081112            6983 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus ankyrin repeat domain 26 (Ankrd26), mRNA.
ACCESSION   NM_001081112 XM_132817
VERSION     NM_001081112.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6983)
  AUTHORS   Sladky,V.C., Akbari,H., Tapias-Gomez,D., Evans,L.T., Drown,C.G.,
            Strong,M.A., LoMastro,G.M., Larman,T. and Holland,A.J.
  TITLE     Centriole signaling restricts hepatocyte ploidy to maintain liver
            integrity
  JOURNAL   Genes Dev 36 (13-14), 843-856 (2022)
   PUBMED   35981754
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 6983)
  AUTHORS   Raciti,G.A., Spinelli,R., Desiderio,A., Longo,M., Parrillo,L.,
            Nigro,C., D'Esposito,V., Mirra,P., Fiory,F., Pilone,V.,
            Forestieri,P., Formisano,P., Pastan,I., Miele,C. and Beguinot,F.
  TITLE     Specific CpG hyper-methylation leads to Ankrd26 gene
            down-regulation in white adipose tissue of a mouse model of
            diet-induced obesity
  JOURNAL   Sci Rep 7, 43526 (2017)
   PUBMED   28266632
  REMARK    GeneRIF: the methylation of specific CpGs at the Ankrd26 promoter
            occurs in mice during HFD treatment and causes the down-regulation
            of Ankrd26 expression, at least in part, by impairing p300 binding
            to its promoter. We propose that the epigenetic silencing of the
            Ankrd26 gene contributes to VAT inflammation following unhealthy
            dieting.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6983)
  AUTHORS   Acs,P., Bauer,P.O., Mayer,B., Bera,T., Macallister,R., Mezey,E. and
            Pastan,I.
  TITLE     A novel form of ciliopathy underlies hyperphagia and obesity in
            Ankrd26 knockout mice
  JOURNAL   Brain Struct Funct 220 (3), 1511-1528 (2015)
   PUBMED   24633808
  REMARK    GeneRIF: Deletion of the C-terminus of the protein encoded by
            Ankrd26 leads to changes in primary cilia in the brain, resulting
            in the disruption of the function of the melanocortin pathway and
            the HPA axis and leading to excessive food intake and obesity.
REFERENCE   4  (bases 1 to 6983)
  AUTHORS   Liu,X.F., Bera,T.K., Kahue,C., Escobar,T., Fei,Z., Raciti,G.A. and
            Pastan,I.
  TITLE     ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA
            regulate adipogenesis in 3T3-L1 cells
  JOURNAL   PLoS One 7 (5), e38130 (2012)
   PUBMED   22666460
REFERENCE   5  (bases 1 to 6983)
  AUTHORS   Raciti,G.A., Bera,T.K., Gavrilova,O. and Pastan,I.
  TITLE     Partial inactivation of Ankrd26 causes diabetes with enhanced
            insulin responsiveness of adipose tissue in mice
  JOURNAL   Diabetologia 54 (11), 2911-2922 (2011)
   PUBMED   21842266
  REMARK    GeneRIF: Data indicate that Ankrd26 is involved in regulation of
            food intake and in regulation of insulin/insulin receptor signaling
            in white adipose tissue; partial inactivation of Ankrd26 leads to
            obesity and, thus, to diabetes type 2.
REFERENCE   6  (bases 1 to 6983)
  AUTHORS   Fei,Z., Bera,T.K., Liu,X., Xiang,L. and Pastan,I.
  TITLE     Ankrd26 gene disruption enhances adipogenesis of mouse embryonic
            fibroblasts
  JOURNAL   J Biol Chem 286 (31), 27761-27768 (2011)
   PUBMED   21669876
  REMARK    GeneRIF: conclude that Ankrd26 gene disruption promotes adipocyte
            differentiation at both the progenitor commitment and
            differentiation steps and that ERK activation plays a role in this
            process
REFERENCE   7  (bases 1 to 6983)
  AUTHORS   Bera,T.K., Liu,X.F., Yamada,M., Gavrilova,O., Mezey,E.,
            Tessarollo,L., Anver,M., Hahn,Y., Lee,B. and Pastan,I.
  TITLE     A model for obesity and gigantism due to disruption of the Ankrd26
            gene
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 270-275 (2008)
   PUBMED   18162531
  REMARK    GeneRIF: obesity and gigantism may be caused by a disruption of the
            Ankrd26 gene
REFERENCE   8  (bases 1 to 6983)
  AUTHORS   Hahn,Y., Bera,T.K., Pastan,I.H. and Lee,B.
  TITLE     Duplication and extensive remodeling shaped POTE family genes
            encoding proteins containing ankyrin repeat and coiled coil domains
  JOURNAL   Gene 366 (2), 238-245 (2006)
   PUBMED   16364570
REFERENCE   9  (bases 1 to 6983)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 6983)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC036121.11 and AC140192.3.
            
            On Feb 16, 2019 this sequence version replaced NM_001081112.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.156127.1,
                                           SRR9219382.196589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-459               AC036121.11        138238-138696
            460-574             AC036121.11        141124-141238
            575-748             AC036121.11        141398-141571
            749-855             AC036121.11        144207-144313
            856-917             AC036121.11        146244-146305
            918-951             AC036121.11        147730-147763
            952-1024            AC036121.11        148468-148540
            1025-1085           AC036121.11        150811-150871
            1086-1237           AC036121.11        150972-151123
            1238-1367           AC036121.11        151550-151679
            1368-1429           AC036121.11        152134-152195
            1430-1523           AC036121.11        157526-157619
            1524-1622           AC036121.11        159960-160058
            1623-1651           AC036121.11        160634-160662
            1652-1730           AC036121.11        160745-160823
            1731-1795           AC036121.11        165366-165430
            1796-1947           AC036121.11        167043-167194
            1948-2115           AC036121.11        168140-168307
            2116-2149           AC036121.11        170633-170666
            2150-2291           AC036121.11        170934-171075
            2292-2505           AC036121.11        172640-172853
            2506-2689           AC036121.11        174593-174776
            2690-2827           AC036121.11        175427-175564
            2828-3784           AC036121.11        176614-177570
            3785-3937           AC036121.11        178516-178668
            3938-4008           AC036121.11        182098-182168
            4009-4102           AC036121.11        182520-182613
            4103-4215           AC036121.11        184616-184728
            4216-4345           AC140192.3         158983-159112       c
            4346-4636           AC140192.3         155907-156197       c
            4637-4851           AC140192.3         155055-155269       c
            4852-5080           AC140192.3         153793-154021       c
            5081-5126           AC140192.3         153143-153188       c
            5127-6983           AC140192.3         148717-150573       c
FEATURES             Location/Qualifiers
     source          1..6983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 55.86 cM"
     gene            1..6983
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /note="ankyrin repeat domain 26"
                     /db_xref="GeneID:232339"
                     /db_xref="MGI:MGI:1917887"
     exon            1..459
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            460..574
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            575..748
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            749..855
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            856..917
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            918..951
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1024
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1085
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1237
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1367
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1429
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1523
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1622
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1651
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1730
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1795
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1947
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2115
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2149
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2291
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2505
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2689
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2827
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3784
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3937
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4008
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4102
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            4103..4215
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            4216..4345
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            4346..4636
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            4637..4851
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            4852..5080
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            5081..5126
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     exon            5127..6983
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5469..5474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /note="hexamer: AATAAA"
     polyA_site      5490
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /note="major polyA site"
     regulatory      6856..6861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /note="hexamer: AATATA"
     polyA_site      6875
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /note="major polyA site"
     regulatory      6950..6955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /note="hexamer: AATAAA"
     regulatory      6955..6960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /note="hexamer: ATTAAA"
     polyA_site      6975
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
                     /note="major polyA site"
     polyA_site      6983
                     /gene="Ankrd26"
                     /gene_synonym="5730521P14Rik; mKIAA1074"
ORIGIN      
        1 gtgagcatgc gcggcagcaa gaaggcgcgg gttgctagtt tgcagctcgg cttggcgatt
       61 attgtgcttt aaaaacctgc cgggccatgc agcgtctttc ccggtgggat cccgtgcgtc
      121 taggccggct tttcaataag tgccctagct gcgttgtgtt gtcagccaac gttgcgcggg
      181 gaagaaggtg cctgtgaggg gcgtaccctc tgccatgaag aagatttttg gcttcaggag
      241 taagggccca tcgcccttag gcccctctgc ccgcccgcgc agcaactgcg tgggctttgg
      301 acgcgagagt gctagtggct cccacgtgcc caggtaccat attcacgaca aggatatggg
      361 caagatccac aaggctgcaa gcgtgggaga tgtagccaaa gtgcagcata tccttatcct
      421 tggaaaaagt ggcgtgaacg atagagacaa gaaggacagg actgctctac atcttgcctg
      481 tgcttacggc cacccagaag tggtgactct cttagtagag agaaaatgtg agatagatgc
      541 ccgtgacagc gagagcagca cggccctcat taaggccgtg cagtgccagg aggaagaatg
      601 tgcagccata ctgctggacc acggggccga tccaaatgtg atggacagca gcggcaacac
      661 cgccctccac tacgcggtct acagtgagaa cacgtccatg gcagccaaac tgctcgcaca
      721 caatgcaaac atagaagcca aaaacaagga tgacctaaca cctatgttac ttgctgtaaa
      781 ggaaaataaa caacatattg tggaattttt agtaaagaag aaagcaagta ttcacgcagt
      841 tgatcagctt ggaagcaaca ggcaaatgtt tgaatatgat gggaagagac tacaaagatc
      901 tgaaaacagc aatccagtgg ataatggttc tgaagatggc tctttaacca ggtcttataa
      961 cacacctggc cctgctgatt cctggccgac atcagatgag gaggactata actttgacaa
     1021 caagaatgtc cccaaaatta atttgacaga gttgtggaca gctgctcagc agtctaggaa
     1081 aaaccaaaca aaatgtggct ttgaggagct agacaatgga gcccggtttg atgacagtga
     1141 ttcccctagt gaaagtgaag atgccattga ggttgagcct gcgccatcag tcagagtcca
     1201 gaccctctcc ccatcccgtc agtcacctga ccctgtggaa ggagcaaccg agctagcaat
     1261 tgaaggagaa gaaaacggta ctgatgttat tgagagcgct tcacaggagc aaccaaatca
     1321 tgacaattta acccgtgctg atggttggca caaaagtaat aaaagtgaaa tgatgtctgc
     1381 attaggatta ggagaagacg aagatgaaca ctcgccttgg gattctgaga gtatctccga
     1441 gagtgtgtca ctgaaagacg taggtcactt ctctgggact gcagatcaaa cgggaaaaag
     1501 gagagcacat ggacagatag aagatgtgac ttatatacct tcttgcatga gtggatcaag
     1561 aagctttaaa atggctaaac tagaggagtc aagaaatgta ggccttccgg tagcccacat
     1621 ggaggccccc aggaaatatg caatcatgga gcctaccatc gaaaggaggg ctcctgttct
     1681 gaacaaaacg gagacagtgg gaatgacgga tgcacagact ttcaagtcag agccagaatc
     1741 agtatcaaga gaagaacaga caaggctcag tggcagcgag gacagccagc agaaggttga
     1801 agaaaagaga aaatacaaaa ataacgaagc agaaccctca ggaaatctat acagcggtgc
     1861 tgctgacggc ggtgctgatg taaagccaca gagtggagac actgagaacc agcagtctcc
     1921 ccgggagggg agtgagggac gtggcagtgg tcctgccttg cttatgaagg aagcaaagaa
     1981 aatggaaaat gaaaaatggg tatccagaga gcccgcgagg acggcaatga gtgagcgcac
     2041 cggcttacca actggtggct ggccacaaat gcaggatggt tcctgctgga gtgacacgga
     2101 ccaaagtgaa gccaggccca caaagaaaac atctagtaaa cataacaagg acagcgggca
     2161 gacagctgca gtggacaacc ttgacgactt tactgagtcg tctgaaacag cctctgagga
     2221 ccatgagctc cagggccctg attccgagag cattttgtgt gcgatcgagc atctcagact
     2281 ggagtgtaaa gatactgcta gtctattgaa aatccgggat gccgtttatt catataaacg
     2341 attaatagaa cttaaaagaa gccactgtga actacttaca ggaaaactga aaagaatgga
     2401 aaacaaatat aagggattgc agaaggaaat gtcagagaca gaagaagtga agtcacggtt
     2461 ggaacatgaa aaggtcggat gggaacagga gctctgcagg ctgagatttg cactgaaaca
     2521 agaggaagag aagaggagga gtgcagacca gctttctgag aaaacctcgg agcagcttag
     2581 aaggaaaggc gagcagtgtc agagtgaggt ggaagccagg cagcagcttg aagcctctct
     2641 cagaaccctg gagatggagc tgaagacggt gaaaagccat ctcaaccagg tcttagagga
     2701 acgaaatgag actcagaggc agctctcccg agaacagaat gccagaatgt tacaagatgg
     2761 gattcttgca agtcacctct gcaagcaaaa ggagatagaa atgacgcaga agaaaatgac
     2821 ttctgaggtt tctgttagtc atgaaaaaga aaaagatcta ttgcataaaa accagaggct
     2881 gcaggatgaa gttgctgtgt tacgactgga aatggacaca ataaaaagcc ataaccagga
     2941 gaaggaaaag aggtatcttg aggatattaa gattgcaaat gagaagaatg acaaccttca
     3001 aaggatggtc aagctgaatg aagaaacatt tacaaaaacc atattccagt atactggaca
     3061 gcttaatagt cttaaagctg agaacacaat gctgagttct aagctggaca acgaaaaaca
     3121 aaataaggag agactggaaa cagacgttga gtcgttccga tctaggctgg cttctgctct
     3181 gcatgatcac gctgaaattc agacagcaaa aagagaccta gaaattgctt tccagagagc
     3241 gagagatgag tggtttcgtg tgaaagacaa gatgaatttc gatatgtcta acctccgaga
     3301 taacaatgag gttctctccc aacagctttc taaaactgaa aggaagttga atagcctaga
     3361 aattgagttt catcacacga aagatgagct tcgagagaag acgctggcgt taaagcatgc
     3421 gcagagagac ctgagccaga cccagtgcca gatgaaggag gtggagcaca tgtttcagga
     3481 cgaacaaggc aaagtgagca agttcatggg gaagcaggag tccatagagg agaggctggc
     3541 ccagctgcag agtgagaaca cgctgctccg gcagcagctg gacgacgctg ccaacaaggc
     3601 cgagagcaaa gacaagacca tagtcaacat ccaagaccag ttccaggatg tgctaaccag
     3661 gttccaagct gagagtcagc ggcacagcct gaggctagaa gacagaaacc aggagttagt
     3721 cagtgagtgc agccatctaa gagaaagact gtgtcagtac gagaacgaga aagccgaaag
     3781 agaggtagtt gtgaggcaac tccagcaaga attggctgat accctaaaaa agcagtcgat
     3841 gtcagaggct tcgctggaag tctcctcccg ctaccgcagc aatttagaag aagaggcgcg
     3901 agacttaaag aagaaattag gtcagctcag aagtcagttg caggaggcgc gggatcaaca
     3961 cagagaggct gtacaccatg ctgagaagat ggaagaccac ctacaaaagc ttgaacttga
     4021 aaaatccaag ttcgaaatta caattaaaaa gcaatcagag gaaattgatc aacttcagga
     4081 aaacctgtca agggtgaatt tgtctgaaga ggataaggaa aaactgcaga aacttaccga
     4141 gttgaaggag tctctggaat gtactgtgga tcaagaacag aagagaagca gtgcgttaga
     4201 aaaagaactg gcagaattta aggaagtctt aaaaatgacc aaaaaagaat taaatgaata
     4261 tgaaaacaga gaacttaatc ttcgtcaaga tataaaaaac aatcaccttg aaatggatat
     4321 cccagttagt acactaataa aaaagattga tgatcttaca gcaaaactgg aaactgcatc
     4381 ttcaaaatgt ctacatctgg gtaaaaaaaa tcagctgctt cagcaggagt tactattgat
     4441 gaggactata caaaagaagt gtgggaaact agagaagaat aaaaagcaat tggagcagga
     4501 ggtcgtgaac ctcagaagtc acatggagaa gaacatggtg gagcacagcc aagcacagca
     4561 gtacgcgcgg gaggtcgaag agcgagcgag gcaggacttg gtggaaaagt taaaacaggt
     4621 caacctcttc ctgcaggctc aagcagcatc ccaggagagc ttggagcagt taagagagaa
     4681 cagtaacgct tcggttagaa gtcagatgga gctcaggatt aaagacctgg agtcccagct
     4741 ctacagaatg aaagcccagg aagacttcga taaaatagaa ctggaaaagt ataagcagct
     4801 ctaccaggaa gagttcagag ctagaaaatc gctgtcaagt aaactaaaca agaccagtga
     4861 gaagctggag gaggccagca gcaagctgct cctggaggag cagcagaaca ggtccttgct
     4921 gagcactctg agtacaaggc ctgttgtgga gtgtccttgt gttggaagtt tccataatag
     4981 tttggtattc aacagaactc ttattccaag agaaaacata gtggttccta cttcaggcct
     5041 acagccatca aataagagag tggagatcta cctgaccaag atgcatcaag agttggaaaa
     5101 aagtataaat agagaactta aagaagctac tgctgaactt gaatctgagt tctgcagagt
     5161 ttctcccctg ggatctgcta ctaaagcaag ccaagatcaa ctctcagacg catcgcaaga
     5221 atttatagac attctaaaga aaaaatatat gatctgctga atttaaaaag agaaaaagga
     5281 agaaaaagta gaagtgggac tttttgggag agaggatcag agaagttaaa ggggcacgtg
     5341 ctgtgtgtct gaaatgtctc cgtggcctgg gtgtggtggc acgtgtcttt gactccagca
     5401 cttgggaagc agaggctggt agatctctga attcaagggc agtcagagct acatgtctca
     5461 tactgaaaaa taaagtcata atggaaccta ctattttgta caaataatac acattaatat
     5521 acatgatcta aaatataaca ttttgggctg gaaaggtgcc tcaggagttt gagagcactg
     5581 gcagctcttc cctaggtcct gaattcagtt cccagcatcc atatggtggc tctaaccatc
     5641 tataatgtga tctggtgtcc tcttttgatg tgcaggatta tgtgcaaata gaacactcat
     5701 attcataaaa taaatcttta aaaaaagaaa acaaagatat aagtgcttat taaaataaat
     5761 aaaacatatt tattaaactg tttatatttg tattaaccat ataacttgaa agcacgagaa
     5821 aaactttttc gtcatatgta ttagaaatta atatatttac caggagtttt ttggtggtcg
     5881 taagcagatt ttgcaagtat tattgaacca gtattactaa attttactta tgaaaacacc
     5941 ctaaagcgag ttgttcaaac aaccaagtta ccgtgaatac tttggtggga tgaaatacca
     6001 tccttgtgtt tatatttttc tatttttgtc actctgcatg ggccaaaaga tttagccaga
     6061 catcagttca gttcagtagg ctgctgcctt ggccactgtt aatgttttca cggttcccag
     6121 ccatagtgtt gccaccaaac ttaactttaa ttttaagcac tgatcattct tgatcctgtg
     6181 gaacagcacg atgacctaag gcttttcacc aagtctcttt attcatttgc tggttcatcc
     6241 ttgatagttt tttcaagtca taaaattagg gagaagctca ggtaattcta tcccgctcgt
     6301 ctgaaccatt tgagagagcc ttgctgccgg ccattgtcat tccttactac ttcagtattt
     6361 attgtagtta gcaacgctct aagtaactgt agtgtcgcct ttgtaacgag aaggctaaca
     6421 ctaacagatt cctttccagc ttggcttctt ctctacagtg tcctttaata aagactggtc
     6481 ccattcggac cgatgggtcc caggtactga cgttctgaga ctccttcagt ctggaacatt
     6541 gttcagtcct tcctggactt tcacgacctt aaatcttcaa ggggcaattc gtgtagtatg
     6601 ttcttgaatt gaatttttct attttattat gtttcatcgc gcattcttgg cagaagtatt
     6661 acagaagtaa tttttctcac ttaatcctat tatgtgatct ctaatataga tgtttctctg
     6721 ttattatgat gttgatattg atcactagag caattaccta ctgtttttcc tcagtatatt
     6781 tacttttgtt ttgtaataat tgatatgtgg agagataatt tgtgactgta aatatctgct
     6841 tcttatcaaa tgtacaatat attcatttac tagtattcat gtagattaat ggctctttat
     6901 tttatttaat gagatataag ttattgataa caaattattt ttatatttta ataaattaaa
     6961 tttttgagaa tttcatacat gaa
//
