LOCUS       NM_153502               2319 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ankyrin repeat domain 23 (Ankrd23), transcript variant
            1, mRNA.
ACCESSION   NM_153502
VERSION     NM_153502.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2319)
  AUTHORS   Farrell,E., Armstrong,A.E., Grimes,A.C., Naya,F.J., de Lange,W.J.
            and Ralphe,J.C.
  TITLE     Transcriptome Analysis of Cardiac Hypertrophic Growth in
            MYBPC3-Null Mice Suggests Early Responders in Hypertrophic
            Remodeling
  JOURNAL   Front Physiol 9, 1442 (2018)
   PUBMED   30410445
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2319)
  AUTHORS   Wang,X., Zeng,R., Xu,H., Xu,Z. and Zuo,B.
  TITLE     The nuclear protein-coding gene ANKRD23 negatively regulates
            myoblast differentiation
  JOURNAL   Gene 629, 68-75 (2017)
   PUBMED   28754631
  REMARK    GeneRIF: Results showed expression of myoblast differentiation
            marker genes were increased by interference and reduced by ANKRD23
            overexpression, indicating that ANKRD23 played a negative role in
            the myoblast differentiation; discovered a long non-coding
            RNA-AK004293 which was overlapped with the 3'UTR of ANKRD23 gene.
            Thus, AK004293 had no significant effect on the expression of
            myoblast differentiation maker genes and ANKRD23.
REFERENCE   3  (bases 1 to 2319)
  AUTHORS   Laughlin,M.H., Yang,H.T., Tharp,D.L., Rector,R.S., Padilla,J. and
            Bowles,D.K.
  TITLE     Vascular cell transcriptomic changes to exercise training differ
            directionally along and between skeletal muscle arteriolar trees
  JOURNAL   Microcirculation 24 (2) (2017)
   PUBMED   27889934
  REMARK    GeneRIF: Ankrd23(-/-) mice exhibit limited ability to form
            collateral arteries following femoral artery occlusion compared to
            WT mice.  Further research will be required to determine whether
            Ankrd23 plays an important role in mechanically induced vascular
            remodeling of the arterial tree in skeletal muscle.
            Review article
REFERENCE   4  (bases 1 to 2319)
  AUTHORS   Lange,S., Gehmlich,K., Lun,A.S., Blondelle,J., Hooper,C.,
            Dalton,N.D., Alvarez,E.A., Zhang,X., Bang,M.L., Abassi,Y.A., Dos
            Remedios,C.G., Peterson,K.L., Chen,J. and Ehler,E.
  TITLE     MLP and CARP are linked to chronic PKCalpha signalling in dilated
            cardiomyopathy
  JOURNAL   Nat Commun 7, 12120 (2016)
   PUBMED   27353086
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2319)
  AUTHORS   Shimoda,Y., Matsuo,K., Kitamura,Y., Ono,K., Ueyama,T., Matoba,S.,
            Yamada,H., Wu,T., Chen,J., Emoto,N. and Ikeda,K.
  TITLE     Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies
            Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle
  JOURNAL   PLoS One 10 (9), e0138624 (2015)
   PUBMED   26398569
  REMARK    GeneRIF: DARP regulates glucose disposal in skeletal muscle and
            thus modifies the glucose homeostasis by modulating AMPK activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2319)
  AUTHORS   Bang,M.L., Gu,Y., Dalton,N.D., Peterson,K.L., Chien,K.R. and
            Chen,J.
  TITLE     The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not
            essential for normal cardiac development and function at basal
            conditions and in response to pressure overload
  JOURNAL   PLoS One 9 (4), e93638 (2014)
   PUBMED   24736439
  REMARK    GeneRIF: CARP, Ankrd2, and DARP are not essential for normal
            cardiac development and function at basal conditions and in
            response to mechanical pressure overload.
            Erratum:[PLoS One. 2015 Mar 06;10(3):e0118523. doi:
            10.1371/journal.pone.0118523.. PMID: 25747160]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2319)
  AUTHORS   Virtanen,C., Paris,J. and Takahashi,M.
  TITLE     Identification and characterization of a novel gene, dapr, involved
            in skeletal muscle differentiation and protein kinase B signaling
  JOURNAL   J Biol Chem 284 (3), 1636-1643 (2009)
   PUBMED   19028694
  REMARK    GeneRIF: Dapr is involved in the PI3K signaling cascade,
            potentially acting as a scaffold protein for PKB and coordinating
            its compartmentalization during differentiation.
REFERENCE   8  (bases 1 to 2319)
  AUTHORS   Barash,I.A., Bang,M.L., Mathew,L., Greaser,M.L., Chen,J. and
            Lieber,R.L.
  TITLE     Structural and regulatory roles of muscle ankyrin repeat protein
            family in skeletal muscle
  JOURNAL   Am J Physiol Cell Physiol 293 (1), C218-C227 (2007)
   PUBMED   17392382
  REMARK    GeneRIF: DARP plays important structural and gene regulatory roles
            in skeletal muscle.
REFERENCE   9  (bases 1 to 2319)
  AUTHORS   Witt,C.C., Ono,Y., Puschmann,E., McNabb,M., Wu,Y., Gotthardt,M.,
            Witt,S.H., Haak,M., Labeit,D., Gregorio,C.C., Sorimachi,H.,
            Granzier,H. and Labeit,S.
  TITLE     Induction and myofibrillar targeting of CARP, and suppression of
            the Nkx2.5 pathway in the MDM mouse with impaired titin-based
            signaling
  JOURNAL   J Mol Biol 336 (1), 145-154 (2004)
   PUBMED   14741210
REFERENCE   10 (bases 1 to 2319)
  AUTHORS   Ikeda,K., Emoto,N., Matsuo,M. and Yokoyama,M.
  TITLE     Molecular identification and characterization of a novel nuclear
            protein whose expression is up-regulated in insulin-resistant
            animals
  JOURNAL   J Biol Chem 278 (6), 3514-3520 (2003)
   PUBMED   12456686
  REMARK    GeneRIF: investigation of potential role in energy metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132370.1, AF492400.1 and BC022973.1.
            
            On Jul 15, 2015 this sequence version replaced NM_153502.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138797.1, AF492400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BC132370.1         1-10
            11-952              AF492400.1         1-942
            953-2319            BC022973.1         904-2270
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2319
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /note="ankyrin repeat domain 23"
                     /db_xref="GeneID:78321"
                     /db_xref="MGI:MGI:1925571"
     exon            1..58
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..952
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     diabetes-realted ankyrin repeat protein; ankyrin repeat
                     domain-containing protein 23; diabetes-related ankyrin
                     repeat protein"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 23
                     isoform 1"
                     /protein_id="NP_705722.2"
                     /db_xref="CCDS:CCDS14882.1"
                     /db_xref="GeneID:78321"
                     /db_xref="MGI:MGI:1925571"
                     /translation="MDFISIEQLVSGERVDRKALEFGRGVPDPGGWPSGWTLGPQEAV
                     AREKLKLEEEKRKKLERFNSSRLTLDNLTDLENLVQRRRKKRQRHKVPPREPESGAEP
                     QPQVPLEPVGLEMFLKAAAENQEALIDKYLADGGDPNAHDKLHRTALHWACLKGHRQL
                     VNKLLAAGAAIEVRDLLDRTPVFWACRGGHLDILKRLLNQGAQVNAQDKIWSTPLHVA
                     VRMGHSDCLEHLIECGAHINAQDKEGDTALHEAVRYGHHKATKLLLLYGAKLGVKNVA
                     SQTPVQLARDWQRGIRDALQAHVGHPRTRC"
     exon            59..205
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            206..334
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            335..460
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            461..559
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            560..658
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..757
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..856
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            857..2305
                     /gene="Ankrd23"
                     /gene_synonym="1110058D09Rik; 2310041C05Rik; Darp;
                     Gm42417; MARP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgctaggtg catggagagc aaggggggac catggacttc atcagcattg agcagttggt
       61 aagtggagaa agagttgata ggaaagcgtt ggagtttgga cgtggagttc ctgatcctgg
      121 aggctggcct agtggctgga cgctgggacc ccaagaggct gtggcccggg agaaactaaa
      181 gttggaggaa gagaaaagga agaaactgga aagatttaac agctccagac tgactctgga
      241 caatctgaca gacttggaaa acttggttca aagacgaaga aaaaaacgac agagacacaa
      301 agtccccccc agggaacctg agtctggggc tgagcctcag ccccaggtcc cactggagcc
      361 cgtgggcctg gaaatgttcc tgaaggcagc tgctgagaac caggaggccc tgattgacaa
      421 gtacctggcg gacggagggg accccaatgc ccatgacaag ctccaccgca cagccttgca
      481 ctgggcctgt ctgaagggcc acagacagct ggtgaacaag ctgctggcgg caggagctgc
      541 tatagaagta cgggatttgc tggacaggac gcccgtgttc tgggcctgcc gcggaggaca
      601 cctggacatt ctcaaacggc tgcttaacca gggagctcag gtcaacgcac aagacaagat
      661 ctggagcacc cctctccatg tggcagtgcg catgggccac tccgactgcc tagagcacct
      721 tatcgagtgt ggcgcccaca tcaacgcaca ggataaggaa ggggacacag cactccacga
      781 ggccgtgcgc tatgggcacc acaaagcaac gaaactgctg ctgctctatg gagccaagct
      841 gggtgtgaag aatgtggctt cccagacacc agtgcagctg gctcgagact ggcagcgggg
      901 catccgggac gcactccagg cccacgtggg ccatccccgt acccggtgct gatgactggc
      961 acctgtggat cacccacggc caccattcca cacccatcca ccagtcctaa atagttcttt
     1021 atcccagtcc taatttctct ctggctttgc ttcctccggc ctgaagcaac aggtagagca
     1081 gcctcctggg tttcagtgag gaaccctgtt ccctgccagg gctggagccg aggaccacag
     1141 ggcagcaaga aacaaagggg tccagatgag ggccaaggcc agagcacaag tgagctgacc
     1201 agtgctaccc tcagctgggt ctaggcctcc gtctaccagt ccttagacca cggactggtc
     1261 ttggcctatt ctcatctaag tagacattca gatgtggcca gcagctgcat ccagggcatg
     1321 agagaagcag gctgagtgcc aggcaccgtg caggtcactt ccgtcctctg ggcagcgttt
     1381 ctcctgggac ttcatttcta ccagtagcag ccctggtagt gtctggcagt tctagccatc
     1441 tcgtcttcag agctctgaag gtgggattcg gcaggctgag gggcatgtca gcaggactga
     1501 ggccccacag aagccaggat ctaccaggtt gctccagaag ctggagcgtg atgagctgga
     1561 actagctagc gttactctgg ggaagctcta cctaaaggct ccaggcagcc ttgcttaccg
     1621 tatgtgaggt cagggtaccg ggtgctgggg attgcttgtg gcccactcac ctcgtggggc
     1681 ggtggcccgc aaccctggct taccctgagg ctctaatgcc ccctggtgca ggagaaagct
     1741 ccgggactag gctctgtagg ccctacacac tgaggagtcc tgcaccttgc tttgggacaa
     1801 tgccaacagt atacatccct ctctggtccc atgccagctg gtagtgtaaa gaggacttca
     1861 cacaggctcc cgggtggctg ctttctctcc cagctgtttc cagtttcact ggtgtaaacc
     1921 tgtactgcgg gcagggcccc cactgaaggc tgagtgaagg gcaaaaggtg aaggcctctt
     1981 gaacagcccc agctgatgcc cattttgcag cagttatttt ttgattaatt ttggcagcct
     2041 atggccattg ttatgacgac gacttgaaga acctgactaa gtataacctg actaagtgtt
     2101 ccctccaaag gggcatgtat ctttccatgg ggcaggccct gccctgtcat gccagccagc
     2161 gtgcaccttg acactggtgc cgtgggcaac acagacattc aagcctactc aatatgacaa
     2221 ttcctcagaa atgaggacac ttagctgaca cacaaagcac ctttttatac agatcaatgt
     2281 tttctcatta aactgactct attcaaaaaa aaaaaaaaa
//
