LOCUS       NM_024204               1754 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ankyrin repeat domain 22 (Ankrd22), mRNA.
ACCESSION   NM_024204
VERSION     NM_024204.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Liu,J., Wu,J., Wang,R., Zhong,D., Qiu,Y., Wang,H., Song,Z. and
            Zhu,Y.
  TITLE     ANKRD22 Drives Rapid Proliferation of Lgr5+ Cells and Acts as a
            Promising Therapeutic Target in Gastric Mucosal Injury
  JOURNAL   Cell Mol Gastroenterol Hepatol 12 (4), 1433-1455 (2021)
   PUBMED   34217895
  REMARK    GeneRIF: ANKRD22 Drives Rapid Proliferation of Lgr5(+) Cells and
            Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165239.3.
            
            On Apr 29, 2007 this sequence version replaced NM_024204.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017360.1, AK017408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC165239.3         164673-164959       c
            288-479             AC165239.3         148134-148325       c
            480-587             AC165239.3         127668-127775       c
            588-665             AC165239.3         124439-124516       c
            666-764             AC165239.3         122981-123079       c
            765-1754            AC165239.3         121467-122456       c
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.33 cM"
     gene            1..1754
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /note="ankyrin repeat domain 22"
                     /db_xref="GeneID:52024"
                     /db_xref="MGI:MGI:1277101"
     exon            1..287
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..842
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 22"
                     /protein_id="NP_077166.4"
                     /db_xref="CCDS:CCDS37963.1"
                     /db_xref="GeneID:52024"
                     /db_xref="MGI:MGI:1277101"
                     /translation="MGILYSEPICQAAYQNDLGQVWRWAKESNHYVDVQDSFNGDTPL
                     ICACRRGHLRIVSFLLRRNADVNLKNLKERTCLHYAVKKRFTFFDYLLIILLMPVLLI
                     GYFLMVSKTKQNETLVRMLLNAGVEVNATDCDGYTALHYACQMKNQTLIPLLLEAHAD
                     PMIKNKHGESSLDIAQRLKFSQIALMLKRAS"
     exon            288..479
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /inference="alignment:Splign:2.1.0"
     exon            480..587
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /inference="alignment:Splign:2.1.0"
     exon            588..665
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /inference="alignment:Splign:2.1.0"
     exon            666..764
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /inference="alignment:Splign:2.1.0"
     exon            765..1754
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1309..1314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /note="hexamer: AATAAA"
     polyA_site      1332
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /note="major polyA site"
     regulatory      1508..1513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /note="hexamer: ATTAAA"
     polyA_site      1534
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /note="hexamer: CATAAA"
     polyA_site      1607
                     /gene="Ankrd22"
                     /gene_synonym="5430429D21Rik; D19Ertd675e"
                     /note="major polyA site"
ORIGIN      
        1 accggttccc ctggctgtaa cagtgataca gctgggatca ttacctgtaa gccaatgcct
       61 tctcttcata gcctgtctct ctacaaggtg tgttgctgtc acagactgct gaaaaggcat
      121 tcccaggtgt ggaaagagag ggctcgccac cagcttggac ttccagggac cttattttcc
      181 tggaagaaat ttaatattaa ttagaaacgc ctctagaaga ttcactactg cattgtagag
      241 agggtgcgaa tccaggaagg accgggatgg gaatcctata ttctgagccc atctgccagg
      301 cagcctacca gaacgacttg gggcaagtgt ggcggtgggc aaaagaaagc aaccattatg
      361 tggatgttca agatagcttc aatggcgata ctcccctcat ctgtgcctgc aggcggggcc
      421 acctgagaat tgtctccttc cttttaagga gaaatgctga tgtcaacctc aaaaacttga
      481 aggagagaac ctgcttgcac tatgctgtga agaagagatt taccttcttt gattatctac
      541 tcattatcct tttaatgcct gtcttgctaa ttggatattt cctcatggta tcaaagacaa
      601 agcagaatga gactcttgtc cggatgctcc ttaatgctgg cgtagaagtt aatgctactg
      661 actgcgacgg ctacactgcc ctgcactatg cttgccagat gaaaaaccag actctcatcc
      721 ctctgcttct ggaagcccat gcagacccca tgataaagaa caagcatggt gagagttcac
      781 tggatatcgc acagagacta aaattttccc agattgcact aatgctaaag agagcctcct
      841 agacctgtga cttctcatgt ggtgataaag acacagccga aggactggat gttgtccaaa
      901 tcatggatta ttgccctatg ggcactcaag ctggatgcat ccactttgtg acaagcactg
      961 gacttaggat ggttttttac agtggaggtc accaaggcct tcatctctcc aaaggaccca
     1021 ttgctcacgt tggaatctca gttgtcaaaa ctgattttta aagaatgtac aatccagtgt
     1081 cttctaaaaa caagtcagag ttacctgagg tcacagtctc tcgttctagt gatgtcatcc
     1141 ctctgaagac ttggccctac aacctgtctt gggagataaa tggttcatgt caggcccctt
     1201 tacatactaa gcccaaaaat caaagtgtgt gtgcacttgt acagcatggc ttgcatgtat
     1261 ggggagttag agatcccaga gtaaatattc ctttgatgga aaatcttcaa taaaaacata
     1321 tgttggttgt cagtggtgag tttgccaaaa ccatagaaac tggcacatgc cccaccgcag
     1381 aactggtttt tgtcattgtt cccctggggg gtggggcggg gcggggaggg gctagatatg
     1441 tgtaccagca tgtgttttac cagaagttta taactaagtg tctttttagt ttgtaagtta
     1501 tataaacatt aaaaatgtct gttctaaatc cttataagac tggaactgta gttcatgggt
     1561 agaacacatg cttgctatac ataaatcccc ggggtcaccc ccaacaccaa aaataaagac
     1621 tcctttgtga tttattttca acttaacgta caatagctag gcattatcct ctggtaatct
     1681 aattttggtc tgtctgtgac attattggag aacaaggtag gataaataaa aacaactgac
     1741 gtattaattt actg
//
