LOCUS       NM_020033               1111 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus ankyrin repeat domain 2 (Ankrd2), mRNA.
ACCESSION   NM_020033
VERSION     NM_020033.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1111)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1111)
  AUTHORS   Greschik,H., Duteil,D., Messaddeq,N., Willmann,D., Arrigoni,L.,
            Sum,M., Jung,M., Metzger,D., Manke,T., Gunther,T. and Schule,R.
  TITLE     The histone code reader Spin1 controls skeletal muscle development
  JOURNAL   Cell Death Dis 8 (11), e3173 (2017)
   PUBMED   29168801
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1111)
  AUTHORS   Andrade,E.C., Musante,V., Horiuchi,A., Matsuzaki,H., Brody,A.H.,
            Wu,T., Greengard,P., Taylor,J.R. and Nairn,A.C.
  TITLE     ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A
            Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast
            3 Kinase)
  JOURNAL   J Neurosci 37 (10), 2709-2722 (2017)
   PUBMED   28167675
  REMARK    GeneRIF: We describe a novel mechanism of signal transduction
            enriched in medium spiny neurons of striatum that likely mediates
            effects of the neurotransmitter dopamine acting on these cells. We
            find that the protein ARPP-16, which is highly expressed in
            striatal medium spiny neurons, acts as a selective inhibitor of
            certain forms of the serine/threonine protein phosphatase, PP2A,
            when phosphorylated by the kinase, MAST3.
REFERENCE   4  (bases 1 to 1111)
  AUTHORS   Lange,S., Gehmlich,K., Lun,A.S., Blondelle,J., Hooper,C.,
            Dalton,N.D., Alvarez,E.A., Zhang,X., Bang,M.L., Abassi,Y.A., Dos
            Remedios,C.G., Peterson,K.L., Chen,J. and Ehler,E.
  TITLE     MLP and CARP are linked to chronic PKCalpha signalling in dilated
            cardiomyopathy
  JOURNAL   Nat Commun 7, 12120 (2016)
   PUBMED   27353086
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1111)
  AUTHORS   Bang,M.L., Gu,Y., Dalton,N.D., Peterson,K.L., Chien,K.R. and
            Chen,J.
  TITLE     The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not
            essential for normal cardiac development and function at basal
            conditions and in response to pressure overload
  JOURNAL   PLoS One 9 (4), e93638 (2014)
   PUBMED   24736439
  REMARK    GeneRIF: CARP, Ankrd2, and DARP are not essential for normal
            cardiac development and function at basal conditions and in
            response to mechanical pressure overload.
            Erratum:[PLoS One. 2015 Mar 06;10(3):e0118523. doi:
            10.1371/journal.pone.0118523.. PMID: 25747160]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1111)
  AUTHORS   Mckoy,G., Hou,Y., Yang,S.Y., Vega Avelaira,D., Degens,H.,
            Goldspink,G. and Coulton,G.R.
  TITLE     Expression of Ankrd2 in fast and slow muscles and its response to
            stretch are consistent with a role in slow muscle function
  JOURNAL   J Appl Physiol (1985) 98 (6), 2337-43 (2005)
   PUBMED   15677738
  REMARK    GeneRIF: We suggest that Ankrd2, which is also a titin binding
            protein, is a stretch-response gene associated with slow muscle
            function and that it is part of a separate mechanotransduction
            system to the one that regulates muscle mass.
REFERENCE   7  (bases 1 to 1111)
  AUTHORS   Witt,C.C., Ono,Y., Puschmann,E., McNabb,M., Wu,Y., Gotthardt,M.,
            Witt,S.H., Haak,M., Labeit,D., Gregorio,C.C., Sorimachi,H.,
            Granzier,H. and Labeit,S.
  TITLE     Induction and myofibrillar targeting of CARP, and suppression of
            the Nkx2.5 pathway in the MDM mouse with impaired titin-based
            signaling
  JOURNAL   J Mol Biol 336 (1), 145-154 (2004)
   PUBMED   14741210
REFERENCE   8  (bases 1 to 1111)
  AUTHORS   Fujiwara,M., Tsukamoto,Y., Miyazaki,A., Moriyama,M. and Satoh,H.
  TITLE     Assignment of the murine ankyrin-repeated protein gene (Ankrd2) to
            mouse chromosome 19C3-->D1 and rat chromosome 1q51-->q53 by
            fluorescence in situ hybridization
  JOURNAL   Cytogenet Genome Res 105 (1), 159 (2004)
   PUBMED   15222314
  REMARK    GeneRIF: assignment to mouse chromosome 19C3
REFERENCE   9  (bases 1 to 1111)
  AUTHORS   Tsukamoto,Y., Senda,T., Nakano,T., Nakada,C., Hida,T., Ishiguro,N.,
            Kondo,G., Baba,T., Sato,K., Osaki,M., Mori,S., Ito,H. and
            Moriyama,M.
  TITLE     Arpp, a new homolog of carp, is preferentially expressed in type 1
            skeletal muscle fibers and is markedly induced by denervation
  JOURNAL   Lab Invest 82 (5), 645-655 (2002)
   PUBMED   12004005
REFERENCE   10 (bases 1 to 1111)
  AUTHORS   Kemp,T.J., Sadusky,T.J., Saltisi,F., Carey,N., Moss,J., Yang,S.Y.,
            Sassoon,D.A., Goldspink,G. and Coulton,G.R.
  TITLE     Identification of Ankrd2, a novel skeletal muscle gene coding for a
            stretch-responsive ankyrin-repeat protein
  JOURNAL   Genomics 66 (3), 229-241 (2000)
   PUBMED   10873377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133503.4.
            
            On Jul 24, 2018 this sequence version replaced NM_020033.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB076256.1, AJ245514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC133503.4         112178-112273       c
            97-198              AC133503.4         108349-108450       c
            199-357             AC133503.4         108058-108216       c
            358-465             AC133503.4         107857-107964       c
            466-564             AC133503.4         106250-106348       c
            565-663             AC133503.4         105833-105931       c
            664-762             AC133503.4         104449-104547       c
            763-861             AC133503.4         104159-104257       c
            862-1111            AC133503.4         103190-103439       c
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.65 cM"
     gene            1..1111
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /note="ankyrin repeat domain 2"
                     /db_xref="GeneID:56642"
                     /db_xref="MGI:MGI:1861447"
     exon            1..96
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1008
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /note="skeletal muscle ankyrin repeat protein; ankyrin
                     repeat domain 2 (stretch responsive muscle)"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 2"
                     /protein_id="NP_064417.2"
                     /db_xref="CCDS:CCDS50437.2"
                     /db_xref="GeneID:56642"
                     /db_xref="MGI:MGI:1861447"
                     /translation="MEGTMEGPEAVQRATELIEQRLAQEEETEKLRRSAPGKLSMDML
                     VLEEEKRLGVQSPALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDA
                     LAAAQEPPPEPEEITGPVNEETFLKAAVEGKMKVIDKYLADGGSADTCDEFRRTALHR
                     ASLEGHMEILEKLLENGATVDFQDRLDCTAMHWACRGGHLEVVRLLQSRGADTNVRDK
                     LLSTPLHVAVRTGHVEIVEHFLSLGLDINAKDREGDSALHDAVRLNRYKIIKLLLLHG
                     ADMMAKNLAGKTPTDLVQLWQADTRHALEHPEPESEQNGLERPGSGRETPQPIPAQ"
     exon            97..198
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
     exon            199..357
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
     exon            358..465
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
     exon            466..564
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
     exon            565..663
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
     exon            664..762
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
     exon            763..861
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1111
                     /gene="Ankrd2"
                     /gene_synonym="Arpp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaacagtca tggagggtac catggagggg cccgaggcgg tgcagagagc cacagagctc
       61 atcgagcagc ggcttgccca ggaggaagag actgagaaac ttcgaagatc cgctcctggg
      121 aagctgtcca tggacatgct agtgctagag gaagagaagc gcctcggggt tcagagtcct
      181 gctttacaaa aggttaaggg ccaagagcgc gtgcgcaaga catccctgga cctgcgacgt
      241 gagatcattg atgtgggtgg gatccagaac ctcattgaac tgaggaaaaa acgcaagcag
      301 aaaaagcgag atgccctggc tgcagcccag gagcctcctc cagagccaga ggagatcacc
      361 ggccctgtga atgaggagac attcctgaaa gctgcagtgg aggggaaaat gaaagtcatt
      421 gacaagtacc tggcggacgg aggttcagcg gacacctgtg atgagttccg tcggacagca
      481 ctgcatcggg cctccctgga gggacacatg gagatactgg agaaacttct ggagaatggg
      541 gccaccgtgg acttccagga tcggctggac tgcacagcca tgcactgggc ctgccgtggg
      601 ggccacctgg aggtggtgag actcctgcaa agccgggggg ccgacaccaa cgtgagagac
      661 aagctactga gcactcccct gcatgtggcc gtccgtactg gacacgtgga gattgtggaa
      721 cattttcttt ccctgggctt ggatatcaat gccaaagaca gagaagggga cagtgcccta
      781 catgatgccg tgagactcaa ccgctacaaa atcatcaaac tgctgctctt gcatggggcg
      841 gacatgatgg ctaagaacct ggcgggaaag acccccacgg acctggtcca gctctggcaa
      901 gcagacaccc ggcatgccct ggagcatccc gagccagaat cagagcagaa cggactggag
      961 aggcctggga gtggccgtga gacacctcag cctataccag cccagtaaat acctacccgg
     1021 agctgggcac ccaaccccct actatgagct gcctgcagcc agtctagcag gaacacccct
     1081 agatgcaaca caataaagtg ctggctttgc t
//
