LOCUS       NM_177268               2356 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ankyrin repeat domain 16 (Ankrd16), transcript variant
            1, mRNA.
ACCESSION   NM_177268 XM_001003042 XM_001003050 XM_001003055 XM_001003061
            XM_001003070 XM_001003077
VERSION     NM_177268.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Vo,M.N., Terrey,M., Lee,J.W., Roy,B., Moresco,J.J., Sun,L., Fu,H.,
            Liu,Q., Weber,T.G., Yates,J.R. 3rd, Fredrick,K., Schimmel,P. and
            Ackerman,S.L.
  TITLE     ANKRD16 prevents neuron loss caused by an editing-defective tRNA
            synthetase
  JOURNAL   Nature 557 (7706), 510-515 (2018)
   PUBMED   29769718
  REMARK    GeneRIF: results identify an amino-acid-accepting co-regulator of
            tRNA synthetase editing, ANKRD16, as a new layer of the machinery
            that is essential to the prevention of severe pathologies that
            arise from defects in editing
            Erratum:[Nature. 2018 Aug;560(7720):E35. doi:
            10.1038/s41586-018-0271-3.. PMID: 29925958]
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845548.7.
            
            On Jun 25, 2009 this sequence version replaced NM_177268.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2884966.1,
                                           SRR7652917.419379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1150              AL845548.7         33206-34355
            1151-1371           AL845548.7         35130-35350
            1372-1414           AL845548.7         36930-36972
            1415-1523           AL845548.7         39094-39202
            1524-1685           AL845548.7         39744-39905
            1686-1764           AL845548.7         41677-41755
            1765-2356           AL845548.7         45187-45778
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 9.05 cM"
     gene            1..2356
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /note="ankyrin repeat domain 16"
                     /db_xref="GeneID:320816"
                     /db_xref="MGI:MGI:2444796"
     exon            1..1150
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             837..1922
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing protein 16"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 16
                     isoform 1"
                     /protein_id="NP_796242.2"
                     /db_xref="CCDS:CCDS50502.1"
                     /db_xref="GeneID:320816"
                     /db_xref="MGI:MGI:2444796"
                     /translation="MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCA
                     ARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKK
                     ADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVC
                     PDAWKTESNIRRTPLHTAAMHGCLEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHV
                     SIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLT
                     ALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDS
                     EDLTGTLAQQLTRSVDILQDFDHDVKS"
     exon            1151..1371
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1414
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1523
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1685
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1764
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2356
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2327..2332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2356
                     /gene="Ankrd16"
                     /gene_synonym="2810455F06Rik; D430029B21Rik"
                     /note="major polyA site"
ORIGIN      
        1 accgcggagg aggcgaagga aactttccca gagttcctta gagctccctg ggtccccgcg
       61 ggggcccagg agacagcagc gggcggggag ggggctgggg tcggctgcgg attgggtgag
      121 gatcgggcgg agcacaagga caccgttcca gctctgagag gccccagaaa cccttgctgt
      181 tgtgagcctg gtcagccgaa ggatgcggct gtcagtccgg cagacatcct caggccaggg
      241 gtgggccagc taggttccag ggtggtgggc agcgtgctct cgactgcctg tgcagctacc
      301 accggagcag cccagcaaac attcccagaa gctgtccggt ggagagcaga ccacatctgg
      361 gatgcgaggc cagaagtccc gcgtgcagga cttcgcggta cactggcacc ctccattctg
      421 ataggtcttc cgttcccagt tcactcgggt gcaagggaca gctccaggat gtcaggtgca
      481 cacagcctta ccccaagccc tgggagcccg aggccccacc ctgacgagta cgcgtgtgtg
      541 atgcgcggta accagaatga cctacgagtg tgcatgttgt cgcctgaggg gacaccattc
      601 tacatttgga gactgtgact tccaaaccag ggcaagaagc attaaagacg ctagcggaga
      661 gaatctggct gggggcgggc agggggcggt gccgagagtc ggggaaaagg gtcacgtgga
      721 ggaagcggaa gcggaagcgc cagccttctc tcacctccca acctatcata gcacagatct
      781 gctctaagac tgaacctggg tcttcctcct acttttgtcc atcctggtcc agggcgatgg
      841 ctctgcctgg ggatccgcgg cgcctctgca ggctggtgca agagggccga ctgcgtgacc
      901 ttcaggagga actggcggta gctagaggtt gccgggggcc agccggagac acccttctcc
      961 actgtgcagc acgccacgga cgccaggata tcctagcgta cctagtggag gcttggagta
     1021 tggacatcga ggctaccaac cgagactaca agcggcctct gcacgaagct gcctctatgg
     1081 gccaccggga ctgcgtgcgc tacctcctgg gccgaggtgc agtcgtggac tccttgaaga
     1141 aggcggactg gactcctctg atgatggcgt gcacaaggaa gaaccttgat gtgatccagg
     1201 accttgtaga acacggtgcc aatccactcc tgaagaacaa ggatggctgg aacagtttcc
     1261 acattgccag tagagaaggc caccctgtga tcctccggta cttgctcact gtctgccctg
     1321 atgcttggaa aacagagagc aacattagaa gaaccccttt acacactgca gcaatgcacg
     1381 gctgtttgga agcagtccag gtgcttcttg aaaggtgtca ctatgaacca gactgtcgag
     1441 acaactgtgg tgtcacgccc ttcatggatg caattcagtg tggccatgtt agtatagcca
     1501 agctgctcct tgaacagcat aaggcttgct cttcagctgc agatagcatg ggggcccagg
     1561 ctctacaccg cgcagcagtc actgggcagg atgaagccat acggttcctg gtatgcggtc
     1621 ttggcatcga tgtagatgta agagcaaagt caagccagct cacagcactt cactatgcag
     1681 caaaggaagg acagacgaat acagttcaaa ctctgttgtc cttgggtgcc gacatcaact
     1741 ctacagatga aagaaatcgc tcagtcctgc atctggcctg cgcaggtcag catgtggctt
     1801 gcaccaggct cctcctacag tcgggactga aggattccga agacctcaca ggcaccttgg
     1861 cccagcagct cacgagaagc gtagatatcc ttcaggactt tgaccatgac gtgaaatcgt
     1921 aggatgcttg aagaaggagg cgatggagtt caaggccgtt catattctgc tccttctgtt
     1981 gctgagagac agggtatcga gttccttctc ggccagcgtt ttcatctcct cctgctgcct
     2041 ttccttctgc atgctcttcg gtcgaatgac caggagtctg gattcctggc atgttgtgtg
     2101 atcttgaacg tagccatttg ttttttcatt tttaaactgt aatgagggtt aaactgagaa
     2161 ctttcacaca ctcagcaagt gctatgccac tgaagcacat caccagcccc ggatcttggc
     2221 ttttctacgc tgcaaggaga atcaggttaa acatagaggt ttgtgtatcc ttagggagtg
     2281 aatgtaatat atgtgtcttt aaatatataa aaatctaata aaacaatata aactgatgtt
     2341 tattcaagct ctaaaa
//
