LOCUS       NM_001081379            8719 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ankyrin repeat domain 11 (Ankrd11), transcript variant
            1, mRNA.
ACCESSION   NM_001081379 NM_183118 XM_902618
VERSION     NM_001081379.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8719)
  AUTHORS   Kibalnyk,Y., Afanasiev,E., Noble,R.M.N., Watson,A.E.S.,
            Poverennaya,I., Dittmann,N.L., Alexiou,M., Goodkey,K.,
            Greenwell,A.A., Ussher,J.R., Adameyko,I., Massey,J., Graf,D.,
            Bourque,S.L., Stratton,J.A. and Voronova,A.
  TITLE     The chromatin regulator Ankrd11 controls cardiac neural crest
            cell-mediated outflow tract remodeling and heart function
  JOURNAL   Nat Commun 15 (1), 4632 (2024)
   PUBMED   38951500
  REMARK    GeneRIF: The chromatin regulator Ankrd11 controls cardiac neural
            crest cell-mediated outflow tract remodeling and heart function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8719)
  AUTHORS   Goodkey,K., Wischmeijer,A., Perrin,L., Watson,A.E.S., Qureshi,L.,
            Cordelli,D.M., Toni,F., Gnazzo,M., Benedicenti,F.,
            Elmaleh-Berges,M., Low,K.J. and Voronova,A.
  TITLE     Olfactory bulb anomalies in KBG syndrome mouse model and patients
  JOURNAL   BMC Med 22 (1), 158 (2024)
   PUBMED   38616269
  REMARK    Erratum:[BMC Med. 2024 Jul 11;22(1):292. doi:
            10.1186/s12916-024-03519-4.. PMID: 38992656]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8719)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 8719)
  AUTHORS   Yuan,M., Barefoot,M.E., Peterson,K., Campbell,M.J., Blancato,J.K.,
            Chen,M., Schmidt,M.O., Kiliti,A.J., Fang,H.B., Wellstein,A.,
            Riegel,A.T. and Sharif,G.M.
  TITLE     Loss of ANCO1 Expression Regulates Chromatin Accessibility and
            Drives Progression of Early-Stage Triple-Negative Breast Cancer
  JOURNAL   Int J Mol Sci 24 (14), 11505 (2023)
   PUBMED   37511268
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8719)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8719)
  AUTHORS   Barbaric,I., Perry,M.J., Dear,T.N., Rodrigues Da Costa,A.,
            Salopek,D., Marusic,A., Hough,T., Wells,S., Hunter,A.J.,
            Cheeseman,M. and Brown,S.D.
  TITLE     An ENU-induced mutation in the Ankrd11 gene results in an
            osteopenia-like phenotype in the mouse mutant Yoda
  JOURNAL   Physiol Genomics 32 (3), 311-321 (2008)
   PUBMED   17986521
  REMARK    GeneRIF: A Glu->Lys missense mutation in a highly conserved region
            causes osteopenia and craniofacial abnormalities. Homozygosity
            causes embryo death. Ankrd11 is a genetic regular of bone
            homeostasis.
REFERENCE   7  (bases 1 to 8719)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 8719)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 8719)
  AUTHORS   Nolan,P.M., Peters,J., Strivens,M., Rogers,D., Hagan,J., Spurr,N.,
            Gray,I.C., Vizor,L., Brooker,D., Whitehill,E., Washbourne,R.,
            Hough,T., Greenaway,S., Hewitt,M., Liu,X., McCormack,S.,
            Pickford,K., Selley,R., Wells,C., Tymowska-Lalanne,Z., Roby,P.,
            Glenister,P., Thornton,C., Thaung,C., Stevenson,J.A., Arkell,R.,
            Mburu,P., Hardisty,R., Kiernan,A., Erven,A., Steel,K.P.,
            Voegeling,S., Guenet,J.L., Nickols,C., Sadri,R., Nasse,M.,
            Isaacs,A., Davies,K., Browne,M., Fisher,E.M., Martin,J., Rastan,S.,
            Brown,S.D. and Hunter,J.
  TITLE     A systematic, genome-wide, phenotype-driven mutagenesis programme
            for gene function studies in the mouse
  JOURNAL   Nat Genet 25 (4), 440-443 (2000)
   PUBMED   10932191
REFERENCE   10 (bases 1 to 8719)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121819.3 and AC132287.3.
            
            On or before Feb 15, 2011 this sequence version replaced
            NM_183118.1, NM_001081379.1.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               AC121819.3         90566-90901         c
            337-400             AC132287.3         152256-152319       c
            401-545             AC132287.3         93428-93572         c
            546-684             AC132287.3         86195-86333         c
            685-855             AC132287.3         77506-77676         c
            856-1059            AC132287.3         77131-77334         c
            1060-1202           AC132287.3         76101-76243         c
            1203-1350           AC132287.3         74087-74234         c
            1351-7868           AC132287.3         67166-73683         c
            7869-7967           AC132287.3         65055-65153         c
            7968-8111           AC132287.3         64841-64984         c
            8112-8204           AC132287.3         63177-63269         c
            8205-8719           AC132287.3         61349-61863         c
FEATURES             Location/Qualifiers
     source          1..8719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.0 cM"
     gene            1..8719
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /note="ankyrin repeat domain 11"
                     /db_xref="GeneID:77087"
                     /db_xref="MGI:MGI:1924337"
     exon            1..336
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            337..400
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            401..545
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     CDS             459..8390
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /codon_start=1
                     /product="ankyrin repeat domain-containing protein 11"
                     /protein_id="NP_001074848.2"
                     /db_xref="CCDS:CCDS40507.2"
                     /db_xref="GeneID:77087"
                     /db_xref="MGI:MGI:1924337"
                     /translation="MPKGGCSKTPQQEDFALSNDMVEKQTGKKDKDKVSLTKTPKLDR
                     SDGGKEVRERATKRKLPFTVGANGEQKDSDTEKQGPERKRIKKEPVARKSGLLFGMGL
                     SGIRAGYPLSERQQVALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSASKTKDK
                     VNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDIAK
                     QLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANS
                     PTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKLKAKNP
                     EPQKTVTPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKEAKANSFISIPKMEVKSYS
                     KNNTLAPKKAAHRILSDTSDEEDVSVSIGAGEKLRLSAHTMLPGSKARESSSSRQQKE
                     KNKLKKKRKKETKGKEVRFGKRSDKFCSSGSESESSESEEDDGDSVGSSGCLKGSPLV
                     LKDPSLFSSLSASSTSSHGSAVAQKHGSGHTDQHTKHWRTDNWKAISSPAWSEVSSLS
                     DSSRTGLTSESDCSSEGSSVESLKPTRRKQEHRKRGVLQSAPSEKRSSFHPCTDGAVP
                     KLDKEGKVVKKHKTKHKHKHKEKGQCSVSQELKLKSFTYEYEDSKQKSDKAILLESDL
                     STENKLKVLKHDREHLKKEDKLGRMKPEDKDWLFKDEKVLKRIKDANKDMSRAFREDK
                     DRASKAERERATKDKSPKEEKLRLYKEERKKKSKDRASRLERKNDMKEDKLSKEKEKA
                     FKEDKEKLKKEKLYREDAAFDDYCNKSQFLDHEDTKFSLSDDQQERWFSDLSDSSFDF
                     KGEDSWDSVTDYRDIKNDSVAKLILETVKEDSKEKKRDNKIREKRDFKDSFFRKRDRD
                     CLDKNSEKRRDQTEKHKSIPSYLSEKDKKRRESAEGGRDRRDGRIRSEEVHREDLKEC
                     GFESSFKDKSDCDFPKNLEPWERPHAAREKEKKDALEKERKEKGRADKYKEKSSERER
                     SDKSTLDKCQKDKEFEKCFKEKKDGKEKHKDIHSKDRKASFDQLREKKEKVFSSIISE
                     DFSERKDDRKGKEKSWYIADIFTDESEDEKDDCVAGSFKATEASDTQRVDGLPEKEEG
                     REHPSDRHRKSSSDRQHTEKPRDKEPKEKKKDRGASEGGKDKKEKMEKIFEKHKEKKD
                     KECAERYKDRKERASADSAPEKKNKQKLPEKVEKKHFAEDKVKSKHKEKPEKEHSRER
                     ERKPSRGPDVEKSLLEKLEEEALHDYREDSNDKISEVSSDSFADHGQEPSLSTLLEVS
                     FSEPPAEDKARDSACLSEKLREKERHRHSSSSSKKSHERERAKKEKAEKKEKSEDYKD
                     SISSVRKDASQFEKDFLDAETYGVSYPTKADVEEELDKAIELFSSEKKDRSDPEREPA
                     KRIEKELKPYGSSAISILKEKKKREKHRERWREEKERHRDKHVDGFLRHHKDEPKPAA
                     KDKDNPPNSFKEKSREESLKLSETKLKEKFKENTEREKGDSIKMSNGNDKLVPSRDSG
                     KKDSRPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKMRHRSGDPKL
                     KEKKPTEDGRKKSLDFPSKKALGLDKKVKEPAPTLTTGESKPHSGPGTESKDWLSGQP
                     LKEVLPASPRTEQSRPTGVPTPTSVVSCPSYEEVMHTPRTPSCSADDYPDLVFDCTDS
                     QHSMPVSTASTSACSPPFFDRFSVASSVVSENAAGQTPTRPISTNLYRSISVDIRRTP
                     EEEFSAGDKLFRQQSVPAPSSFDSPVQHLLEEKAPLPPVPAEKFACLSPGYYSPDYGI
                     PSPKVDTLHCPPTAVVSATPPPDSVFSNLPPKSSPSPRGELLSPAIEGTLPPDLGLPL
                     DATEDQQATAAILPQEPSYLEPLDEGPFTTVITEEPVEWTHTAAEQGLSSSSLIASAS
                     ENPVSWPVGSELMLKSPQRFAESPKHFCPGESLHSTTPGPYSAAEPTYPVSPGSYPLP
                     APEPALEEVKDGGTGAIPVAISAAEGAAPYAAPARLESFFSNCKSHPDAPLDTAPEPT
                     GVTAVAQVEALGPLESSFLDSNPSISTLSQVEPVSWHEAFTSPEDDLDLGPFSLPELP
                     LQAKDASDVEAEAAKASPVPPAESPPGPTGVLGGGDVPAPAAEEPPAPPPQEASPQLS
                     TEPEPSEEPKLDVVLEATVETEVLADDSAPEASISNSVPAPSPPQQQPPGGGDEEAET
                     EDPSATPCCAPDGPTTDGLAQAHNSAEASCVVAAAEGPPGNVQAEATDPEPKPTSEVP
                     KAPKVEEVPQRMTRNRAQMLASQSKQGIPAAEKDPMPTPASRAKGRASEEEDAQAQHP
                     RKRRFQRSSQQLQQQLNTSTQQTREVIQQTLAAIVDAIKLDAIEPYHSDRSNPYFEYL
                     QIRKKIEEKRKILCCITPQAPQCYAEYVTYTGSYLLDGKPLSKLHIPVIAPPPSLAEP
                     LKELFKQQEAVRGKLRLQHSIEREKLIVSCEQEILRVHCRAARTIANQAVPFSACTML
                     LDSEVYNMPLESQGDENKSVRDRFNARQFISWLQDVDDKYDRMKTCLLMRQQHEAAAL
                     NAVQRMEWQLKAQELDPAGHKSLCVNEVPSFYVPMVDVNDDFVLLPA"
     exon            546..684
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            685..855
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1059
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1202
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1350
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..7868
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            7869..7967
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            7968..8111
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            8112..8204
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
     exon            8205..8719
                     /gene="Ankrd11"
                     /gene_synonym="2410104C19Rik; 3010027A04Rik;
                     6330578C09Rik; 9530048I21Rik; Gm176; Yod"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccgcagc caccgctggg tcctggagcc agaggccgcc cgcgacagag cgcgatggac
       61 cgagggcccc agccggggag gcgccgcggc ggagtccgcg gccagacgcc cccgcagtag
      121 cgtccgcgcg agcgccgcgg ccccgcgtga gctcctgcac gccgagggcg ggcttgcatc
      181 ccgccggccc cgcactcgcc gcagcctcca gcccgcgcgc cgacgccgcc ttcccgcccg
      241 ggccgcgcgg cccgggaaac gcggccgcgg gctgcatggg cagcgcccgc gccccgccgc
      301 cgttccgccg cggagccgcg tcgccctcgg agccggagca tactgccctg ctggagttca
      361 tacccattcc tgagcaacac tggtttttgc catggaatcc acagttgatg atgaagcaat
      421 agcagcataa atgaagatca agtaagggga ggagaacgat gcccaagggt gggtgttcta
      481 aaacaccaca gcaagaagac tttgctctca gcaacgacat ggtggagaaa caaactggga
      541 aaaaggataa agataaagtt tctctaacca agactcccaa gctggaccgc agtgatggcg
      601 ggaaggaggt gagagaacga gccaccaagc ggaagctgcc cttcaccgtg ggggccaatg
      661 gagagcagaa ggactcggac acagagaagc agggtcccga gcggaagagg atcaagaagg
      721 agcctgttgc ccggaagtcc gggctgttgt tcggcatggg gctgtctggg atccgagctg
      781 gataccctct ctctgagcgt cagcaggtgg ctctgctcat gcagatgact gctgaggagt
      841 ctgcaaatag tccggtagac acaacaccaa agcacccttc ccagtctaca gtgtgtcaga
      901 aggggacccc caactctgcc tcaaaaacca aagataaggt gaacaagaga aatgaacgcg
      961 gagagacccg cctgcaccga gcagctatcc gaggggatgc ccggcgcatc aaggaactca
     1021 tcagtgaggg cgcggacgtg aacgtcaagg actttgcagg ctggactgca ctgcacgagg
     1081 cgtgtaaccg gggctattac gacatcgcca agcaactgtt agccgctggt gcagaggtga
     1141 acactaaggg cctggatgat gacacacctt tgcatgatgc cgccaacaac gggcactaca
     1201 aggtggtgaa gttgttgtta cggtatggcg gaaatcctca acaaagcaac agaaaaggag
     1261 agacaccgtt gaaagtagcc aattcgccaa cgatggtgaa cctcctgtta ggcaaaggca
     1321 catacacttc cagtgaggag agctctactg agagctcgga agaagaggac gccccgtcat
     1381 tcgcaccttc cagctccgtc gatggcaata acacagactc tgagtttgag aaaggcctca
     1441 agcttaaggc taagaaccca gagccccaga agactgtgac ccccgtcaag gatgagtacg
     1501 agtttgatga ggacgacgag caggacaggg tccccccggt ggacgacaag cacctgctga
     1561 agaaagacta caggaaggag gctaaggcca acagcttcat ttccataccc aagatggaag
     1621 tgaagagcta ctcaaaaaac aacacgcttg caccaaagaa ggcggcccat cgcatcctgt
     1681 cagacacatc cgacgaggag gacgtgagtg tttccatagg ggctggagag aaactgaggc
     1741 tgtcagcaca cacaatgctc cctggtagta aggcacgaga gtcttctagt tctaggcagc
     1801 aaaaagaaaa gaataaattg aaaaagaagc gaaagaaaga aacgaagggg aaagaagttc
     1861 ggtttggaaa gaggagtgac aagttctgtt cctctgggtc agaaagtgag tcctcagaga
     1921 gcgaggagga cgacggggac tctgtgggga gctcaggctg cctcaagggg tccccgctgg
     1981 tgctgaagga cccttccctg ttcagctcac tgtctgcctc ctccacctca tctcatggta
     2041 gcgctgtggc ccagaagcac ggctccggcc acaccgacca gcacacgaag cactggcgca
     2101 ctgacaattg gaaagccatt tcttctccag cctggtctga ggtgagttct ttgtcagact
     2161 cctcaaggac gggactgacc agtgagtctg actgctcctc cgagggctct agtgtggaat
     2221 ctctgaagcc tacgagaagg aagcaggaac accgaaaaag gggtgtcctg cagagcgcgc
     2281 cgtcagagaa gaggagctcc ttccacccct gtacggatgg cgctgtcccc aagctggaca
     2341 aggaagggaa ggtagtcaaa aaacacaaaa ccaaacacaa acacaaacac aaggagaagg
     2401 gacagtgttc cgtcagccaa gaacttaaac tgaaaagctt tacctacgaa tatgaggact
     2461 ccaagcaaaa gtcagataag gccatccttt tagagagtga cctctccact gagaataagc
     2521 tgaaggtatt gaaacacgac agagagcacc ttaagaaaga agataagctc ggtaggatga
     2581 agccggagga taaggactgg ctctttaagg atgagaaggt gctgaagaga atcaaggatg
     2641 ccaacaaaga catgagcaga gccttccggg aagacaaaga ccgtgccagc aaagcagaga
     2701 gggagagggc cacgaaggac aagtccccga aggaagaaaa gctcagactg tacaaagagg
     2761 aaaggaagaa aaagtccaaa gaccgagctt ccagactcga aaggaagaat gacatgaaag
     2821 aggacaagct ctccaaggag aaggagaagg ccttcaaaga ggacaaagag aaactcaaaa
     2881 aggaaaagct gtacagggag gacgctgcct ttgatgacta ttgtaacaaa agtcagtttc
     2941 tggaccatga ggacaccaag ttcagcctct ctgatgacca acaagagagg tggttttctg
     3001 acctgtctga ttcctctttt gatttcaaag gagaggacag ctgggactca gtaacagact
     3061 atagagacat caagaatgac tcggtggcca aacttatcct ggaaactgtc aaagaagaca
     3121 gtaaggaaaa gaagcgcgac aacaaaatcc gggagaagcg agattttaaa gactctttct
     3181 tccgaaagag agacagggac tgtctagaca agaattctga gaaaaggaga gaccaaacgg
     3241 aaaagcataa aagcatccct agctatcttt ctgagaaaga caagaaaagg cgagagtctg
     3301 cagaaggggg ccgggacagg agggatgggc ggattcggtc tgaagaagtg cacagggagg
     3361 acctaaagga gtgtgggttc gagagcagct tcaaggacaa gtcagactgt gacttcccca
     3421 agaacctgga gccctgggaa cggccccatg cagcgcggga aaaggagaaa aaggatgccc
     3481 tggaaaagga aaggaaggaa aagggcaggg cagacaagta caaagagaag tccagcgaga
     3541 gggagagaag tgacaagtcc acccttgaca agtgtcagaa agacaaagaa tttgaaaaat
     3601 gctttaaaga gaagaaagac ggcaaggaaa agcataaaga catacacagc aaagacagaa
     3661 aagcatcctt tgaccaactg agagagaaga aggagaaggt gttctctagc atcatctcag
     3721 aagacttctc agagagaaag gatgacagga aggggaagga gaagagctgg tacattgcag
     3781 acattttcac agatgagagc gaggacgaga aggacgattg cgtggccggc agcttcaagg
     3841 ccacagaggc cagcgacacc cagcgagtgg acggcctccc agaaaaggag gaaggacgag
     3901 aacacccctc ggacaggcac cggaagtcct cttctgacag gcagcacaca gagaagccaa
     3961 gagacaaaga gcccaaggaa aagaagaagg acagaggagc ttcggaagga ggaaaggaca
     4021 agaaggaaaa aatggaaaag atctttgaga agcacaaaga aaagaaagac aaggagtgtg
     4081 cagagagata caaggacagg aaagagcgag cctcggctga ctctgcccca gaaaagaaaa
     4141 acaaacagaa gctccccgaa aaggtagaga agaagcactt cgctgaggac aaggtgaaga
     4201 gtaaacacaa ggagaagcca gagaaggagc actcccggga gagggagcgg aagccttccc
     4261 gaggccccga tgtcgagaag agcctgctgg agaagctgga ggaagaggct ctgcacgact
     4321 accgggagga ctccaacgac aagatcagcg aggtctcctc ggacagcttt gcggaccacg
     4381 gccaggagcc cagcctgagc acgctcctgg aagtctcctt ctctgagccc ccagcagagg
     4441 acaaggccag ggacagtgcc tgcctctccg agaaactgag ggagaaggag aggcatcggc
     4501 attcctcttc ctcctctaag aaaagccacg agcgtgaaag agccaagaag gaaaaggcag
     4561 aaaagaagga gaagagcgaa gactacaagg acagcatcag cagcgtcagg aaggatgcca
     4621 gccagttcga gaaagacttc ctggatgcag agacttacgg ggtttcttac cccacaaaag
     4681 ctgacgtgga ggaggagctg gataaggcca ttgagttgtt ctcctcagaa aagaaagaca
     4741 ggagtgatcc tgaacgagag cctgccaaga ggatagagaa ggagttaaag ccgtacggct
     4801 cgagtgccat cagcatctta aaggagaaga agaagagaga aaaacacagg gagagatgga
     4861 gggaggagaa ggagagacac agggacaagc atgtggacgg cttcctgaga caccacaagg
     4921 acgagccaaa gcctgcagcc aaagacaagg acaaccctcc caactccttc aaggagaagt
     4981 ccagggagga aagcctgaaa ctcagcgaga ctaagctgaa ggaaaagttc aaggagaaca
     5041 cagagcgaga aaagggcgac tccataaaga tgagcaacgg gaacgacaaa cttgtgccat
     5101 ccagagactc cggcaagaaa gacagcagac cccgggagaa gctcctggga gatggcgacc
     5161 tcatgatgac aagttttgag aggatgctgt cccagaaaga cctcgagatt gaggagcggc
     5221 acaagcgaca caaggagcgc atgaagcaga tggagaagat gcggcatcgg tctggagacc
     5281 ccaagctcaa agagaagaag cccacggagg acgggcgcaa gaagagcctg gactttcctt
     5341 ccaagaaggc tctggggctg gacaaaaagg tcaaggagcc ggctcccacg ctgaccacgg
     5401 gtgaaagcaa gccacactct ggaccgggta cagagtccaa agactggctg tctggacagc
     5461 ccctgaagga ggttctccct gcttcacccc gcactgagca gagccgaccc actggggtgc
     5521 ccacgcccac ctcagtagtg tcgtgcccca gctacgaaga ggtgatgcac acacccagaa
     5581 ccccgtcctg cagtgctgac gattaccccg acctggtgtt cgactgcacc gactcccagc
     5641 actcgatgcc cgtctccacc gcgtccacca gcgcctgctc gccgcccttt tttgacaggt
     5701 tttctgtggc ttccagtgtg gtctcagaaa acgcagcagg ccagacaccc accaggccta
     5761 tctccacaaa cctttatcgc tcgatatctg tggatatcag aaggacaccc gaggaggagt
     5821 tcagtgctgg ggacaagctg ttcaggcagc agagtgtccc tgcgccctct agttttgact
     5881 ccccagtaca gcacttgctg gaagagaaag ctcctctgcc acccgttcct gcagaaaagt
     5941 ttgcctgcct gtcccctggc tactactccc cagactatgg tatcccctcg cccaaggtgg
     6001 acacgttaca ctgtccacca acagctgtgg tcagtgccac accaccccca gacagcgtct
     6061 tctccaatct accaccaaag tcttcccctt cccctagagg tgaactgctg agcccagcca
     6121 ttgaagggac cctgccccca gatctaggcc tacctctgga tgccacagag gaccagcagg
     6181 ccacagctgc catcctcccc caggagccca gctatctgga gcctctggat gagggtccct
     6241 tcaccacagt catcacggag gaacctgttg agtggacaca caccgctgct gagcagggcc
     6301 tgtcttcctc ctcccttatt gccagtgcct ctgaaaaccc tgtcagctgg cctgttggct
     6361 ctgagcttat gctaaagtct ccacagaggt ttgcagaatc cccaaaacat ttttgccctg
     6421 gagaatccct ccattccacc accccaggac cctacagtgc tgcagagccc acctaccctg
     6481 tctctccagg atcttaccct ttgccggccc ctgagccagc cctagaagaa gtcaaagacg
     6541 gtgggacagg agcaatccca gtggccatct ctgctgcaga aggggctgct ccttatgctg
     6601 ctcctgctag gctggagtcg tttttcagca actgcaagtc acacccagat gcacccctgg
     6661 acacagcccc tgaacctacg ggtgttactg ctgtggctca ggtagaggct ctgggacccc
     6721 tggagagcag cttcctagac agcaatccta gcatatctac cctcagccag gtggaaccag
     6781 tctcatggca tgaagccttt accagccctg aggatgacct cgacctgggg cccttctcac
     6841 tgccagagct tcctctccag gccaaagatg cttcagatgt tgaggcagaa gccgcaaagg
     6901 ccagtcctgt tcctccggcg gagagccctc caggccccac gggggttctc ggcggagggg
     6961 atgtccctgc cccagcagct gaggagccac cagccccacc gcctcaggaa gcatcgcctc
     7021 agctctccac agagcccgag ccctcagagg agccaaagct ggatgtggtt ctagaagcta
     7081 cagtggaaac agaggtccta gcagacgaca gtgcccctga agcctcaatc tccaattcgg
     7141 tgccagcacc cagtccccct caacagcagc ctccgggagg tggcgatgaa gaagctgaaa
     7201 ctgaagatcc ttctgccact ccctgctgtg cacctgatgg acccaccaca gatggcttgg
     7261 cacaggcaca caacagtgca gaggcctcct gtgttgtggc tgcggccgag gggcccccag
     7321 gcaacgttca agcagaagct acagatccag agcccaagcc tacatctgag gtccctaagg
     7381 cccccaaggt ggaagaagtt cctcagcgta tgaccaggaa ccgtgcccag atgctggcaa
     7441 gccagagcaa gcagggcata cctgcagcag agaaggaccc aatgcccacc ccagcctcta
     7501 gagccaaggg tcgagcctct gaggaggaag atgcccaggc ccaacatccc cgcaagcggc
     7561 gcttccagcg gtctagtcag cagctgcagc agcagctgaa cacatccaca cagcagaccc
     7621 gggaggttat ccagcagacg ctggcagcca ttgtggatgc cataaagctg gatgccattg
     7681 agccctacca cagtgacagg tccaatccct actttgagta ccttcaaatc cggaagaaga
     7741 tcgaagagaa gcgaaagatc ctctgctgca tcacgccgca ggcaccccag tgctacgcgg
     7801 agtatgtcac ctacacgggg tcctacctcc tggacggcaa gcccctcagc aagctgcaca
     7861 tccctgtgat tgcaccccct ccctctctag ctgagcccct gaaggagctg ttcaagcaac
     7921 aagaggctgt gcggggtaag ctgcgcctgc agcacagcat cgagagggag aagctgattg
     7981 tgtcctgtga gcaagagatt cttcgggttc attgccgggc agccaggacc attgccaacc
     8041 aggcagtgcc attcagtgca tgcacaatgc tcttggactc cgaggtctac aacatgcctc
     8101 tggaaagcca gggggatgag aacaagtctg tgcgagaccg cttcaatgcc cgccagttca
     8161 tctcctggct tcaggacgtc gacgacaagt acgaccgcat gaagacatgt ttgctgatgc
     8221 ggcagcaaca tgaggctgca gccctcaatg ccgtgcaaag aatggagtgg cagctgaagg
     8281 cccaggagct ggaccccgct gggcacaagt ccctgtgtgt aaatgaggtg ccatccttct
     8341 acgtgcccat ggttgacgtc aacgatgact tcgtattgtt gccagcatga cactcggagg
     8401 aaggtcacag gacacaaaca agggccacat aggtcgccca gtgctgccga tgagtcccgg
     8461 cagcggagga gggagcaccg cgtccatcaa gtgggaggag cccagagact gcacctggcc
     8521 gtgtgtctcc cctccagatg cagtgaggta gaaagcatct ccttttacca gttgctgtgg
     8581 gagcacaagg cccagacact gcagagcttt gccaggcctt gggacaagga gaccgtggcc
     8641 acagacaagg tggctctgtg tcagccatgc cctctgggtt ttcttccagc tgatgacagg
     8701 gcacttgagg agtcgcaga
//
