LOCUS       NM_001271392            1126 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ankyrin repeat family A member 2 (Ankra2), transcript
            variant 6, mRNA.
ACCESSION   NM_001271392
VERSION     NM_001271392.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1126)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1126)
  AUTHORS   McKinsey,T.A., Kuwahara,K., Bezprozvannaya,S. and Olson,E.N.
  TITLE     Class II histone deacetylases confer signal responsiveness to the
            ankyrin-repeat proteins ANKRA2 and RFXANK
  JOURNAL   Mol Biol Cell 17 (1), 438-447 (2006)
   PUBMED   16236793
  REMARK    GeneRIF: Class II histone deacetylases (HDACs)4 and HDAC5 interact
            with the ankyrin repeats of ANKRA2 and regulatory factor
            X-associated ankyrin-containing protein and, through association
            with RFXANK, repress MHC II promoter activation
REFERENCE   3  (bases 1 to 1126)
  AUTHORS   Wang,A.H., Gregoire,S., Zika,E., Xiao,L., Li,C.S., Li,H.,
            Wright,K.L., Ting,J.P. and Yang,X.J.
  TITLE     Identification of the ankyrin repeat proteins ANKRA and RFXANK as
            novel partners of class IIa histone deacetylases
  JOURNAL   J Biol Chem 280 (32), 29117-29127 (2005)
   PUBMED   15964851
  REMARK    GeneRIF: ANKRA, RFXANK, and CIITA are novel targets of class IIa
            HDACs which may deacetylases play a role in regulating MHCII
            expression
REFERENCE   4  (bases 1 to 1126)
  AUTHORS   Long,A.B. and Boss,J.M.
  TITLE     Evolutionary conservation and characterization of the bare
            lymphocyte syndrome transcription factor RFX-B and its paralogue
            ANKRA2
  JOURNAL   Immunogenetics 56 (11), 788-797 (2005)
   PUBMED   15655668
REFERENCE   5  (bases 1 to 1126)
  AUTHORS   Rader,K., Orlando,R.A., Lou,X. and Farquhar,M.G.
  TITLE     Characterization of ANKRA, a novel ankyrin repeat protein that
            interacts with the cytoplasmic domain of megalin
  JOURNAL   J Am Soc Nephrol 11 (12), 2167-2178 (2000)
   PUBMED   11095640
REFERENCE   6  (bases 1 to 1126)
  AUTHORS   Rader,K., Boyer,A.D., Farquhar,M.G. and Arden,K.C.
  TITLE     Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to
            human chromosome 5q12-->q13 by radiation hybrid mapping and somatic
            cell hybrid PCR
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 164-165 (2000)
   PUBMED   10965114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161446.1, AK003438.2 and BE952624.1.
            
            Transcript Variant: This variant (6) contains multiple differences
            in the UTRs and coding region, compared to variant 1. These
            differences result in initiation of translation at an alternate
            in-frame downstream start codon, compared to variant 1. The encoded
            isoform (f) has a shorter N-terminus and a distinct C-terminus,
            compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003438.2, BY703695.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AK161446.1         3-161
            160-1102            AK003438.2         79-1021
            1103-1126           BE952624.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 51.89 cM"
     gene            1..1126
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /note="ankyrin repeat family A member 2"
                     /db_xref="GeneID:68558"
                     /db_xref="MGI:MGI:1915808"
     exon            1..401
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            402..560
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            561..626
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..1060
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /note="isoform f is encoded by transcript variant 6;
                     ankyrin repeat family A protein 2; ankyrin repeat, family
                     A (RFXANK-like), 2; RFXANK-like protein 2"
                     /codon_start=1
                     /product="ankyrin repeat family A protein 2 isoform f"
                     /protein_id="NP_001258321.1"
                     /db_xref="CCDS:CCDS88507.1"
                     /db_xref="GeneID:68558"
                     /db_xref="MGI:MGI:1915808"
                     /translation="MLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNG
                     ADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC
                     VKMLLENGADPTIETDSGYNSMDLAVALGYRGGLTVSVWEGNNVLVELKSTV"
     exon            627..724
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            725..850
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            851..917
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            918..998
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1110
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1082..1087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /note="hexamer: AATAAA"
     polyA_site      1110
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /note="major polyA site"
ORIGIN      
        1 actacaagaa agcgccctgg tgggcggggc cctgggcggg gccccgggcc gctctccaat
       61 gacccggaac tgaggcgatc catggttctc cgagaggatg ggctacgggg cgctagggaa
      121 acaagaagcg atccctggga gtcgtctcgc cttcaccgaa cgctctgggc tttttccaga
      181 ggagataaaa gataggaagt gacgtctggg cccgaagcag gcccggggct cgggaccgat
      241 ctggctaggc caggccagag ccgctctccc gctgagctca gggcgcgtgt accacccgcc
      301 tgaccggccc ctgtccccgg atccgctcgc cgcgtcggag cgggagcggg tgtcaccccg
      361 cggccgtaga gcgggaacgc ccgcccggac acctgtcgcc cctgagtgca atatccatac
      421 atctccttct cctggaattc aagtaaggca tgtctacaca ccatctacaa caaaacattt
      481 ctcacccata aaacagtcaa ctactttaac caacaagcac aggggaaacg aggtctctac
      541 cacacctctg ttagcaaatt ctctgtctgc tcaccagttg gcagcccagg gagagatgct
      601 ctacctggct actcgtattg aacaagaaaa tgttatcaat cacacggatg aagaaggatt
      661 tacccccctg atgtgggctg cggcacatgg gcaaatagct gtggtagagt tccttcttca
      721 gaatggtgca gatccccagc ttctaggaaa aggtcgagaa agtgctctgt ctcttgcctg
      781 tagcaagggc tacacagaca ttgtcaaaat gctgcttgac tgtggagttg acgtcaatga
      841 atatgactgg aacggaggga cacctttgct ttacgctgtc catgggaacc acgtgaagtg
      901 cgtgaagatg ctgttggaaa atggagctga cccaacaatt gaaacagact ctggctataa
      961 ttctatggac ctagctgtag ctttgggcta cagaggtggg cttactgtaa gtgtgtggga
     1021 gggaaataat gttcttgtgg aattaaaaag tacagtgtga tggtttacaa aatcatgtct
     1081 aaataaaata ctttgtctgt ttgcattcta aaaaaaaaaa aaaaaa
//
