LOCUS       NM_001271388            2462 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ankyrin repeat family A member 2 (Ankra2), transcript
            variant 1, mRNA.
ACCESSION   NM_001271388
VERSION     NM_001271388.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2462)
  AUTHORS   McKinsey,T.A., Kuwahara,K., Bezprozvannaya,S. and Olson,E.N.
  TITLE     Class II histone deacetylases confer signal responsiveness to the
            ankyrin-repeat proteins ANKRA2 and RFXANK
  JOURNAL   Mol Biol Cell 17 (1), 438-447 (2006)
   PUBMED   16236793
  REMARK    GeneRIF: Class II histone deacetylases (HDACs)4 and HDAC5 interact
            with the ankyrin repeats of ANKRA2 and regulatory factor
            X-associated ankyrin-containing protein and, through association
            with RFXANK, repress MHC II promoter activation
REFERENCE   3  (bases 1 to 2462)
  AUTHORS   Wang,A.H., Gregoire,S., Zika,E., Xiao,L., Li,C.S., Li,H.,
            Wright,K.L., Ting,J.P. and Yang,X.J.
  TITLE     Identification of the ankyrin repeat proteins ANKRA and RFXANK as
            novel partners of class IIa histone deacetylases
  JOURNAL   J Biol Chem 280 (32), 29117-29127 (2005)
   PUBMED   15964851
  REMARK    GeneRIF: ANKRA, RFXANK, and CIITA are novel targets of class IIa
            HDACs which may deacetylases play a role in regulating MHCII
            expression
REFERENCE   4  (bases 1 to 2462)
  AUTHORS   Long,A.B. and Boss,J.M.
  TITLE     Evolutionary conservation and characterization of the bare
            lymphocyte syndrome transcription factor RFX-B and its paralogue
            ANKRA2
  JOURNAL   Immunogenetics 56 (11), 788-797 (2005)
   PUBMED   15655668
REFERENCE   5  (bases 1 to 2462)
  AUTHORS   Rader,K., Orlando,R.A., Lou,X. and Farquhar,M.G.
  TITLE     Characterization of ANKRA, a novel ankyrin repeat protein that
            interacts with the cytoplasmic domain of megalin
  JOURNAL   J Am Soc Nephrol 11 (12), 2167-2178 (2000)
   PUBMED   11095640
REFERENCE   6  (bases 1 to 2462)
  AUTHORS   Rader,K., Boyer,A.D., Farquhar,M.G. and Arden,K.C.
  TITLE     Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to
            human chromosome 5q12-->q13 by radiation hybrid mapping and somatic
            cell hybrid PCR
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 164-165 (2000)
   PUBMED   10965114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161446.1, AK139343.1, AC123056.4 and BE952624.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139343.1, AK054037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AK161446.1         3-120
            119-924             AK139343.1         1-806
            925-925             AC123056.4         159183-159183
            926-2203            AK139343.1         808-2085
            2204-2462           BE952624.1         1-259               c
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 51.89 cM"
     gene            1..2462
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /note="ankyrin repeat family A member 2"
                     /db_xref="GeneID:68558"
                     /db_xref="MGI:MGI:1915808"
     exon            1..401
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            402..783
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..1412
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /note="isoform a is encoded by transcript variant 1;
                     ankyrin repeat family A protein 2; ankyrin repeat, family
                     A (RFXANK-like), 2; RFXANK-like protein 2"
                     /codon_start=1
                     /product="ankyrin repeat family A protein 2 isoform a"
                     /protein_id="NP_001258317.1"
                     /db_xref="CCDS:CCDS70493.1"
                     /db_xref="GeneID:68558"
                     /db_xref="MGI:MGI:1915808"
                     /translation="MATSANLDIGAQLIVEECPSSYISGMPDIKLEHQLDPNPDEGAA
                     QGVAMGMKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIHT
                     SPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSTTPLLANSLSAHQLAAQGE
                     MLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESAL
                     SLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLENGADPTIE
                     TDSGYNSMDLAVALGYRGGEYFRTLGSF"
     exon            784..942
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1008
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1106
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1232
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1299
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..2446
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2418..2423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /note="hexamer: AATAAA"
     polyA_site      2446
                     /gene="Ankra2"
                     /gene_synonym="1110004M18Rik; Ankra"
                     /note="major polyA site"
ORIGIN      
        1 actacaagaa agcgccctgg tgggcggggc cctgggcggg gccccgggcc gctctccaat
       61 gacccggaac tgaggcgatc catggttctc cgagaggatg ggctacgggg cgctagggaa
      121 acaagaagcg atccctggga gtcgtctcgc cttcaccgaa cgctctgggc tttttccaga
      181 ggagataaaa gataggaagt gacgtctggg cccgaagcag gcccggggct cgggaccgat
      241 ctggctaggc caggccagag ccgctctccc gctgagctca gggcgcgtgt accacccgcc
      301 tgaccggccc ctgtccccgg atccgctcgc cgcgtcggag cgggagcggg tgtcaccccg
      361 cggccgtaga gcgggaacgc ccgcccggac acctgtcgcc catattttaa tatcccaatt
      421 ccaggaaaat actggataac acctttgaga aaaaaaaaaa caagaaatca tgaagaagtg
      481 ttttaattat taaagccatg gctacatctg caaatctgga cattggggcc cagctgatcg
      541 tggaagagtg tcccagcagc tatatctctg ggatgccaga catcaagcta gagcaccagc
      601 tagacccaaa cccagatgaa ggagcagccc agggcgtcgc catggggatg aaattcatat
      661 tgccaaaccg atttgatatg aacgtgtgtt ctcgattcgt gaagtcctta aatgaagagg
      721 atagtaaaaa tattcaagat caagttaact ctgacctgga ggtggcatct gtcttattta
      781 aagctgagtg caatatccat acatctcctt ctcctggaat tcaagtaagg catgtctaca
      841 caccatctac aacaaaacat ttctcaccca taaaacagtc aactacttta accaacaagc
      901 acaggggaaa cgaggtctct accacacctc tgttagcaaa ttctctgtct gctcaccagt
      961 tggcagccca gggagagatg ctctacctgg ctactcgtat tgaacaagaa aatgttatca
     1021 atcacacgga tgaagaagga tttacccccc tgatgtgggc tgcggcacat gggcaaatag
     1081 ctgtggtaga gttccttctt cagaatggtg cagatcccca gcttctagga aaaggtcgag
     1141 aaagtgctct gtctcttgcc tgtagcaagg gctacacaga cattgtcaaa atgctgcttg
     1201 actgtggagt tgacgtcaat gaatatgact ggaacggagg gacacctttg ctttacgctg
     1261 tccatgggaa ccacgtgaag tgcgtgaaga tgctgttgga aaatggagct gacccaacaa
     1321 ttgaaacaga ctctggctat aattctatgg acctagctgt agctttgggc tacagaggtg
     1381 gtgagtattt tagaactctc gggtcatttt aggaaagcat catatatagg aatgccagtg
     1441 ctccaaaccg tcttcattgc tttcatgcat aaaacactgt agtattctaa ctccagacat
     1501 aggctttaat gaagtgccaa gtaaacagac cccgtaaagc gaagggcgga gttcacttat
     1561 tgtacttttc cataaactca gatagttact ggaagaaaag tggacagtgt ttgcaagatt
     1621 ttcaaaaatg ttttcattaa aaaattatat aacagcattg cactgtgtaa taaaagctca
     1681 gttcagaaaa ctcggaagct cgggcagcgg ctgaattaga agcagcctta atgtcaaggg
     1741 tagctgtcgc acattgtcct cagatggcga caatcagtcc taacagaaat agcttcattg
     1801 tacagaatcc cagggctcgg ttgagctgac gcagtgactt ttgtgtgctt gctcttgtgt
     1861 ctctgtgtgg tgagcttact gacttaccct tacttactga cgtagtccaa caggccatcg
     1921 agtcccatct gctgaaactc cttcagaaca tcagggagtg aggagactcg ggaaacgccc
     1981 tctgccctcc ctcactcctt ggtccttaat gatagttttg tttacatgta aatttttata
     2041 gttttgtttg ggtatacatt tttatctcag ttgcaatatt tgctgggttt tagtgagttt
     2101 taataaatat tcctctggat aattcacttg tttataataa aattaatcct gatggttttt
     2161 taaataaatg tgttttacta tatattaaaa ttattaatta atgttttgtg gcatgtaacc
     2221 ttttatggta caggtggttg tgagtctttg tatcaagtag cacaatttga cactttaagg
     2281 aaactccaac ttgtttgtct ttactcttgt attcactctt ttgactttgc acagggctta
     2341 ctgtaagtgt gtgggaggga aataatgttc ttgtggaatt aaaaagtaca gtgtgatggt
     2401 ttacaaaatc atgtctaaat aaaatacttt gtctgtttgc attctaaaaa aaaaaaaaaa
     2461 aa
//
