LOCUS       NM_146033               2458 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus ankyrin repeat and MYND domain containing 2 (Ankmy2),
            mRNA.
ACCESSION   NM_146033
VERSION     NM_146033.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2458)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2458)
  AUTHORS   Hwang,S.H., White,K.A., Somatilaka,B.N., Wang,B. and
            Mukhopadhyay,S.
  TITLE     Context-dependent ciliary regulation of hedgehog pathway repression
            in tissue morphogenesis
  JOURNAL   PLoS Genet 19 (11), e1011028 (2023)
   PUBMED   37943875
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2458)
  AUTHORS   Somatilaka,B.N., Hwang,S.H., Palicharla,V.R., White,K.A.,
            Badgandi,H., Shelton,J.M. and Mukhopadhyay,S.
  TITLE     Ankmy2 Prevents Smoothened-Independent Hyperactivation of the
            Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling
  JOURNAL   Dev Cell 54 (6), 710-726 (2020)
   PUBMED   32702291
  REMARK    GeneRIF: Ankmy2 Prevents Smoothened-Independent Hyperactivation of
            the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase
            Signaling.
REFERENCE   4  (bases 1 to 2458)
  AUTHORS   Saita,S., Shirane,M., Ishitani,T., Shimizu,N. and Nakayama,K.I.
  TITLE     Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog
            (Shh) signaling pathway
  JOURNAL   J Biol Chem 289 (37), 25639-25654 (2014)
   PUBMED   25077969
  REMARK    GeneRIF: Our findings thus indicate that the FKBP38-ANKMY2 axis
            plays a key role in regulation of Shh signaling in vivo
REFERENCE   5  (bases 1 to 2458)
  AUTHORS   Jensen,V.L., Bialas,N.J., Bishop-Hurley,S.L., Molday,L.L., Kida,K.,
            Nguyen,P.A., Blacque,O.E., Molday,R.S., Leroux,M.R. and Riddle,D.L.
  TITLE     Localization of a guanylyl cyclase to chemosensory cilia requires
            the novel ciliary MYND domain protein DAF-25
  JOURNAL   PLoS Genet 6 (11), e1001199 (2010)
   PUBMED   21124868
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY069852.1, AK164434.1, AK077556.1 and BF453918.1.
            
            On Nov 20, 2009 this sequence version replaced NM_146033.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077556.1, SRR1660815.13446.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               BY069852.1         13-367
            356-1800            AK164434.1         258-1702
            1801-2444           AK077556.1         1772-2415
            2445-2458           BF453918.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..2458
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.54 cM"
     gene            1..2458
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /note="ankyrin repeat and MYND domain containing 2"
                     /db_xref="GeneID:217473"
                     /db_xref="MGI:MGI:2144755"
     exon            1..300
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1556
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /codon_start=1
                     /product="ankyrin repeat and MYND domain-containing
                     protein 2"
                     /protein_id="NP_666145.3"
                     /db_xref="CCDS:CCDS25885.1"
                     /db_xref="GeneID:217473"
                     /db_xref="MGI:MGI:2144755"
                     /translation="MGHIKKGELTQEEKELLEVIGKGTVQEAGRLLSSKNVHVNCLDE
                     NGMTPLMHAAYKGKLEMCKLLLRHGADASCHQHEHGYTALMFAALSGNKDITWVMLEA
                     GAETDVVNSVGRTAAQMAAFVGQHDCVAIINNFFPRERLDYYTKPQGLDKEPKLPPKL
                     AGPLHKIITTTNLHPVKIVMLVSENPLLADAAALGKCYRVMDLICEKCMKQRDMNEVL
                     AMKMHYISCIFQKCITFLKEGENKLDTLIRSLLKGRASDGFPVYQEKIIRESIRKFPY
                     CEATLLQQLVRSIAPVEIGSDPTAFSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSV
                     CKMVIYCDQTCQKTHWFAHKKMCKSLKDVYEKQQIEAAKHKRQEEKNGNPNVSSNHVN
                     EDQPEAEEGITQENSIPSDSVEGEKEAANDTGLASAQDAPTGPQLSEE"
     exon            301..365
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            366..504
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            505..603
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            604..764
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            765..979
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1115
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1244
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1374
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2446
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /note="hexamer: AATAAA"
     polyA_site      2446
                     /gene="Ankmy2"
                     /gene_synonym="ZMYND20"
                     /note="major polyA site"
ORIGIN      
        1 ggccattgag gcgcgggggc gggacttgtg gagagcgcca gcccggctcg ctcaagctcg
       61 ccgcacccgc cagcccccag ccgtgagacc ctagcgactc tgccacttca ctgggctgct
      121 gctccggcct cgagttgcct tgctgtggcg gtcttccacg acgcatacac gtctcttgtt
      181 tttttaaaaa acctttccaa agaaatagaa taagcgtcaa gctggcggga acgatgggtc
      241 acataaagaa aggcgagctg acccaggagg aaaaggaact gctggaagtg atcgggaaag
      301 gtactgtcca agaagccgga agactgttgt ctagtaagaa tgttcatgtc aactgcttgg
      361 atgagaatgg aatgactcct ttgatgcatg cagcctataa agggaaactc gagatgtgca
      421 agctcctcct gcgccatgga gctgacgcca gttgccatca gcatgagcac gggtacacag
      481 ccctcatgtt tgctgcgctt tccggtaata aagacatcac ttgggtcatg ctggaagcag
      541 gcgcagagac cgatgttgtg aactcggtgg gaagaactgc tgcccagatg gcagcctttg
      601 tgggtcagca cgattgcgtg gctatcatca acaatttctt ccctcgagag agactggatt
      661 attacactaa accccaggga ctggataaag agccaaaact gcctccaaag ttggcaggcc
      721 cgctacacaa aatcatcacc acaacgaatc tccaccctgt caagatcgtg atgcttgtga
      781 gtgagaaccc tctgctggca gacgcagctg ctctcggtaa atgctacagg gtgatggatt
      841 tgatctgtga gaaatgcatg aaacagagag acatgaatga agtgttggct atgaaaatgc
      901 actacatcag ctgcatcttt cagaaatgca ttaccttcct caaagaagga gagaataagc
      961 tggacaccct gatcagaagc ttgttgaaag gccgagcgtc tgatggcttc ccggtgtatc
     1021 aggaaaagat catcagagaa agcatccgga agtttccata ctgtgaagcc acactcctac
     1081 agcagctggt gcgaagcatc gctccagttg aaattggttc tgatcccact gcattctctg
     1141 tgcttaccca agccatcaca gggcaagtgg gctttgtgga tgttgagttt tgtaccacct
     1201 gtggagaaaa aggagcgagc aaaagatgtt cggtttgtaa aatggtaata tattgtgacc
     1261 agacctgcca gaagacacac tggttcgcac ataagaagat gtgtaagagt ctgaaagatg
     1321 tctatgagaa gcaacagatt gaagctgcca aacataagag acaggaggaa aagaatggaa
     1381 accccaatgt cagttctaac catgtcaatg aagatcaacc agaagctgaa gagggcatca
     1441 ctcaagaaaa ttccattcct agcgattctg tggaagggga gaaagaagct gctaatgaca
     1501 ctggactggc cagtgcacaa gacgctccta cagggccaca gttgtccgag gaataaaggc
     1561 tgtcgacagt ggccggcatg ggtggtcttc atcctggccg atagctgcag aactgatgtg
     1621 aatgtacctt catttgctct gacactgcat ggcacagtgg caggattgca catccctaga
     1681 gtagaggctt tcaagcaaag ctgcctcccc cgtcttgatt tcctgttgat ttctattcta
     1741 taattgaaca ggcatttctg tggaatttct ttcttttctt tctttctttt tttttttttt
     1801 caaaatacac aaaaacaggt ccattccttt gctggcttct cagtgattgt acacaaagga
     1861 gaagaaatca ccttaaagaa gaaatctggg tcctagggaa caaagagaag aatagggaag
     1921 atgtagaaag agaggtgata tttaggaaag aaggaatcgt gggcacagag atgggcattc
     1981 agagaaacaa aacttacttg tgaatgttgt cctcaagttg gacatacaaa gccgtaatga
     2041 ggaacaatct ttggtcttaa agctttgcca tagttgagcc tcctgtggta taaccaggaa
     2101 ttgttgagag cactttgaac cctctgttcc ttgcagcgat acgctacttg atttgaacaa
     2161 tcagaaaggt tggatccaac cctggtagtc actgtgttta tttcccgtag aaccacccat
     2221 gcaccatcct ccccacccag aaggccaaca cttaccttcc catcagcctt tcctgaccct
     2281 cctcctatcc agaaactgtg atttcttgct gtcatttcga gaatgtccca ttctgcattt
     2341 tcagtgtcgg ggcatgtaag caaagctgga gtgtcctgtc tcaagaaggt gctgtctttc
     2401 tgttccctct gttggcttta aaataaatct acctacatgc acagttaaaa aaaaaaaa
//
