LOCUS       NM_001376951            2737 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus ankyrin repeat and kinase domain containing 1 (Ankk1),
            transcript variant 1, mRNA.
ACCESSION   NM_001376951
VERSION     NM_001376951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Rubio-Solsona,E., Marti,S., Vilchez,J.J., Palau,F. and Hoenicka,J.
  TITLE     ANKK1 is found in myogenic precursors and muscle fibers subtypes
            with glycolytic metabolism
  JOURNAL   PLoS One 13 (5), e0197254 (2018)
   PUBMED   29758057
  REMARK    GeneRIF: Study characterized the ANKK1 localization in vivo and in
            vitro, by using immunolabeling, quantitative real-time PCR and
            Western blot in the myogenic lineage. Histologic investigations in
            mice and humans revealed that ANKK1 is expressed in precursors of
            embryonic and adult muscles. Results show a relationship between
            ANKK1 gene regulation and the metabolism of muscles during
            development and in adulthood.
            Erratum:[PLoS One. 2018 Jun 6;13(6):e0198880. doi:
            10.1371/journal.pone.0198880.. PMID: 29874274]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Espana-Serrano,L., Guerra Martin-Palanco,N., Montero-Pedrazuela,A.,
            Perez-Santamarina,E., Vidal,R., Garcia-Consuegra,I., Valdizan,E.M.,
            Pazos,A., Palomo,T., Jimenez-Arriero,M.A., Guadano-Ferraz,A. and
            Hoenicka,J.
  TITLE     The Addiction-Related Protein ANKK1 is Differentially Expressed
            During the Cell Cycle in Neural Precursors
  JOURNAL   Cereb Cortex 27 (5), 2809-2819 (2017)
   PUBMED   27166167
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Hoenicka,J., Quinones-Lombrana,A., Espana-Serrano,L.,
            Alvira-Botero,X., Kremer,L., Perez-Gonzalez,R.,
            Rodriguez-Jimenez,R., Jimenez-Arriero,M.A., Ponce,G. and Palomo,T.
  TITLE     The ANKK1 gene associated with addictions is expressed in
            astroglial cells and upregulated by apomorphine
  JOURNAL   Biol Psychiatry 67 (1), 3-11 (2010)
   PUBMED   19853839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167980.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC167980.3         185365-185635       c
            272-566             AC167980.3         180261-180555       c
            567-718             AC167980.3         178919-179070       c
            719-768             AC167980.3         178585-178634       c
            769-924             AC167980.3         177960-178115       c
            925-1043            AC167980.3         177255-177373       c
            1044-1080           AC167980.3         176637-176673       c
            1081-2737           AC167980.3         173788-175444       c
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.83 cM"
     gene            1..2737
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /note="ankyrin repeat and kinase domain containing 1"
                     /db_xref="GeneID:244859"
                     /db_xref="MGI:MGI:3045301"
     exon            1..271
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2291
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and protein kinase domain-containing
                     protein 1"
                     /codon_start=1
                     /product="ankyrin repeat and protein kinase
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_001363880.1"
                     /db_xref="GeneID:244859"
                     /db_xref="MGI:MGI:3045301"
                     /translation="MVPHRARRLLNPMAVGPLAQQLGSLTVFTRDDFEEEWHLVASGG
                     FSKVFQARHKRWRTQYAIKCSPCLQKETTSSEVTCLFEEAVKMEKIKFQHIVSIYGVC
                     KQPLGIVMEFMASGSLEKTLPTHSLCWPLKLRIIHETSLAMNFLHSIKPPLLHLDLKP
                     GNILLDNNMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPE
                     YDVYSFAIVIWEILTQKKPYAGLNMMTIIIRVAAGMRPSLQDVSDEWPEEVHQMVNLM
                     KRCWDQDPKKRPCFLNVAVETDMLLSLFQSPMTDPGCEALTQKVSCKPSLSQPHKVSK
                     EVNQEIADSAVSSDSLKWILQLSDSKSLVASDVYENRVTPLHFLVAGGSLEQVRLLLS
                     HDVDVDCQTASGYTPLLIATQDQQPDLCALLLAHGADTNLADEDGWAPLHFAAQNGDD
                     HTARLLLDHGALVNAREHEGWTPLHLAAQNNFENVARLLVSRQADLSPHEAEGKTPLH
                     VAAYFGHIGLVKLLSGQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKCGALPDALD
                     HSGYSPLHIAAARGKDLIFKMLLRYGASLELRTQQGWTPLHLATYKGHLEIIHQLAKS
                     HVDLDALGSMQWTPLHLAAFQGEEGVMLALLQCGANPNAAEQSGWTPLHLAVHKGTFL
                     GITHLLEYGADIHACNKVGWTPAHLAALKGNTAILKVLVKAAAQVDVKGGVSCTPLQL
                     AIHSPK"
     exon            272..566
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            567..718
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            719..768
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            769..924
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1043
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1080
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..2737
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      2737
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /note="major polyA site"
ORIGIN      
        1 acccagctcg ctgccagagt aaggtgcggt gcagaggcac aggggagtgt atggtgccac
       61 acagagccag gaggcttctg aaccccatgg cagtcggtcc cttggcgcag cagctgggca
      121 gcctcaccgt cttcacgagg gatgattttg aggaagaatg gcacctagta gccagtggtg
      181 gcttcagcaa ggtgttccag gcgaggcaca agcgctggag gacccagtac gccatcaagt
      241 gctccccgtg cctccagaag gaaaccacca gctctgaggt gacctgcctc tttgaagaag
      301 cagtcaaaat ggagaagatt aagtttcaac acatcgtgtc catctatggg gtctgtaagc
      361 agcccctggg cattgtgatg gagttcatgg ccagtggttc cctggagaag acactaccta
      421 cccacagcct ctgctggcca ctcaagctcc gcatcatcca tgagaccagc ttggccatga
      481 acttcctcca cagcattaag ccacccctgc tccacctgga ccttaagcca ggcaacatcc
      541 tgctggacaa caacatgcat gtcaagattt ccgattttgg cctgtccaag tggatggagc
      601 agtcaactca gaagcagtac attgagagat cagctctgag ggggacactc agctacatcc
      661 ctcctgaaat gttcctggag aataacaagg ctccggggcc tgaatatgat gtgtacagct
      721 ttgcaattgt catctgggag attctcactc agaagaaacc ctatgcaggg ctcaatatga
      781 tgactattat catccgggta gctgcaggca tgaggccctc cttgcaggat gtctctgatg
      841 agtggccaga ggaggtacat caaatggtga acctgatgaa gcgctgttgg gaccaagacc
      901 ccaagaagag gccatgtttc ctaaatgtgg ccgtcgagac agacatgcta ctgtccctgt
      961 tccagagccc catgacagac cctgggtgtg aagccctgac ccagaaggtg tcttgcaagc
     1021 catcgctgag ccaaccccac aaggtcagca aggaggtcaa ccaggagatt gcagacagtg
     1081 cagtctcaag tgactccttg aagtggatcc tacagctctc tgacagcaag agcttggtcg
     1141 caagtgatgt ctacgagaat agggtgactc ccctacactt tctagtggcc ggaggcagct
     1201 tggaacaggt gaggctgctg ctgtcccacg acgttgatgt agattgccag acagcctctg
     1261 gctatacgcc actcctcatt gccacccagg accagcagcc tgacctctgt gccctgctcc
     1321 tggcacatgg tgctgatacc aacctggcag acgaagatgg ctgggcccca ctgcattttg
     1381 cagcccagaa tggggatgac cacactgccc gtctgctcct ggaccacggg gccctggtga
     1441 atgcacggga gcacgagggc tggaccccac tccacctggc tgcacagaac aactttgaga
     1501 atgtggcacg gcttctggtc tcccgtcagg ctgacctcag cccacacgag gctgaaggca
     1561 agactcccct tcatgttgca gcctactttg gtcacattgg cttggtcaag cttctgtcag
     1621 gacagggagc agagctggat gctcagcaga gaaacctgag gacacccctg cacctagcag
     1681 tggagagggg gaaagtgaga gccattcagc acctgctaaa atgtggggca ctccctgatg
     1741 cccttgacca cagcggctac agccctttgc acattgctgc agccaggggc aaggacctta
     1801 tctttaagat gcttctcaga tatggagcca gccttgagct acgcacacaa cagggatgga
     1861 cacccctgca cctagccact tacaagggtc acctggagat catccatcag ttggccaaga
     1921 gccatgtaga cctagatgct cttggaagta tgcaatggac tcccctgcac ctggctgcct
     1981 tccaagggga ggagggggtg atgctggcac tgctacagtg tggggccaac cccaatgctg
     2041 ctgagcagtc aggctggact cctctccatc tggcagtgca taaaggaacc ttcctgggca
     2101 tcacccacct tctggagtat ggtgctgaca tccatgcttg caacaaggtg ggctggacac
     2161 ctgcccacct ggctgctctc aagggcaaca cagccatcct caaagttcta gttaaagctg
     2221 ctgcacaggt ggatgtcaag ggtggagtta gctgcacacc cctgcagctg gccatccaca
     2281 gcccaaagta gagcatagtg accttcttgc aggacaagga gccttcacta gccattctgg
     2341 aagtttctaa gcctgaaccc caggcagaag attaggtgga ccagggttcc tttgcttgga
     2401 aggagagaag tttatgaaag tgaaacttgt catcttaggg gtcacttccc agctgcccct
     2461 ttgaccttga gaggaaccag tatcctaagt gacagaagaa agcccagggg ttccagtgag
     2521 ctggagaagc tactgactgc ctgggaaact gatcctagct cctgtccagt catctccaga
     2581 caagccatgt tctccctttt ctttagatga gttcatgtgt cccagataag cttcatctct
     2641 agtctcaaga cgtctgccac catttgttgc tttcctttga ataatggagc cctgtttccc
     2701 aagaaactca aaataaagaa aaaaaaaaaa ctcaaaa
//
