LOCUS       NP_001363880             746 aa            linear   ROD 12-FEB-2025
DEFINITION  ankyrin repeat and protein kinase domain-containing protein 1
            isoform 1 [Mus musculus].
ACCESSION   NP_001363880
VERSION     NP_001363880.1
DBSOURCE    REFSEQ: accession NM_001376951.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 746)
  AUTHORS   Rubio-Solsona,E., Marti,S., Vilchez,J.J., Palau,F. and Hoenicka,J.
  TITLE     ANKK1 is found in myogenic precursors and muscle fibers subtypes
            with glycolytic metabolism
  JOURNAL   PLoS One 13 (5), e0197254 (2018)
   PUBMED   29758057
  REMARK    GeneRIF: Study characterized the ANKK1 localization in vivo and in
            vitro, by using immunolabeling, quantitative real-time PCR and
            Western blot in the myogenic lineage. Histologic investigations in
            mice and humans revealed that ANKK1 is expressed in precursors of
            embryonic and adult muscles. Results show a relationship between
            ANKK1 gene regulation and the metabolism of muscles during
            development and in adulthood.
            Erratum:[PLoS One. 2018 Jun 6;13(6):e0198880. doi:
            10.1371/journal.pone.0198880.. PMID: 29874274]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 746)
  AUTHORS   Espana-Serrano,L., Guerra Martin-Palanco,N., Montero-Pedrazuela,A.,
            Perez-Santamarina,E., Vidal,R., Garcia-Consuegra,I., Valdizan,E.M.,
            Pazos,A., Palomo,T., Jimenez-Arriero,M.A., Guadano-Ferraz,A. and
            Hoenicka,J.
  TITLE     The Addiction-Related Protein ANKK1 is Differentially Expressed
            During the Cell Cycle in Neural Precursors
  JOURNAL   Cereb Cortex 27 (5), 2809-2819 (2017)
   PUBMED   27166167
REFERENCE   3  (residues 1 to 746)
  AUTHORS   Hoenicka,J., Quinones-Lombrana,A., Espana-Serrano,L.,
            Alvira-Botero,X., Kremer,L., Perez-Gonzalez,R.,
            Rodriguez-Jimenez,R., Jimenez-Arriero,M.A., Ponce,G. and Palomo,T.
  TITLE     The ANKK1 gene associated with addictions is expressed in
            astroglial cells and upregulated by apomorphine
  JOURNAL   Biol Psychiatry 67 (1), 3-11 (2010)
   PUBMED   19853839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167980.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.83 cM"
     Protein         1..746
                     /product="ankyrin repeat and protein kinase
                     domain-containing protein 1 isoform 1"
                     /EC_number="2.7.11.1"
                     /note="ankyrin repeat and protein kinase domain-containing
                     protein 1"
                     /calculated_mol_wt=82420
     Region          37..305
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(40..43,46,48,61,63,96,110..113,157,161..162,164,
                     174..175)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          353..630
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          370..399
                     /region_name="ANK 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          373..401
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(403,405,409..410,413..415,417..418,422,425,434,436,
                     438,442..443,446..448,450..451,455,458,467,469,471,
                     475..476,479..481,483..484,488,491)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          403..434
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          403..432
                     /region_name="ANK 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          436..467
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          436..465
                     /region_name="ANK 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          469..498
                     /region_name="ANK 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          469..497
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          502..532
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          502..531
                     /region_name="ANK 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          535..564
                     /region_name="ANK 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          537..566
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          555..>744
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          568..599
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          568..597
                     /region_name="ANK 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          601..630
                     /region_name="ANK 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          602..632
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(634,636,640..641,644..646,648..649,653,656,665,667,
                     669,673..674,677..679,682..683,689,698,700,702,706..707,
                     710..712,714..715,719,722)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          634..665
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          634..663
                     /region_name="ANK 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          667..698
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          667..696
                     /region_name="ANK 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     Region          700..730
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          700..729
                     /region_name="ANK 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ25.1)"
     CDS             1..746
                     /gene="Ankk1"
                     /gene_synonym="9930020N01Rik"
                     /coded_by="NM_001376951.1:51..2291"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:244859"
                     /db_xref="MGI:MGI:3045301"
ORIGIN      
        1 mvphrarrll npmavgplaq qlgsltvftr ddfeeewhlv asggfskvfq arhkrwrtqy
       61 aikcspclqk ettssevtcl feeavkmeki kfqhivsiyg vckqplgivm efmasgslek
      121 tlpthslcwp lklriihets lamnflhsik ppllhldlkp gnilldnnmh vkisdfglsk
      181 wmeqstqkqy iersalrgtl syippemfle nnkapgpeyd vysfaiviwe iltqkkpyag
      241 lnmmtiiirv aagmrpslqd vsdewpeevh qmvnlmkrcw dqdpkkrpcf lnvavetdml
      301 lslfqspmtd pgcealtqkv sckpslsqph kvskevnqei adsavssdsl kwilqlsdsk
      361 slvasdvyen rvtplhflva ggsleqvrll lshdvdvdcq tasgytplli atqdqqpdlc
      421 alllahgadt nladedgwap lhfaaqngdd htarllldhg alvnareheg wtplhlaaqn
      481 nfenvarllv srqadlsphe aegktplhva ayfghiglvk llsgqgaeld aqqrnlrtpl
      541 hlavergkvr aiqhllkcga lpdaldhsgy splhiaaarg kdlifkmllr ygaslelrtq
      601 qgwtplhlat ykghleiihq lakshvdlda lgsmqwtplh laafqgeegv mlallqcgan
      661 pnaaeqsgwt plhlavhkgt flgithlley gadihacnkv gwtpahlaal kgntailkvl
      721 vkaaaqvdvk ggvsctplql aihspk
//
