LOCUS       NM_175375               8251 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ankyrin repeat and KH domain containing 1 (Ankhd1),
            mRNA.
ACCESSION   NM_175375
VERSION     NM_175375.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8251)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8251)
  AUTHORS   Sidor,C., Borreguero-Munoz,N., Fletcher,G.C., Elbediwy,A.,
            Guillermin,O. and Thompson,B.J.
  TITLE     Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import
            and stability
  JOURNAL   Elife 8, e48601 (2019)
   PUBMED   31661072
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8251)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   4  (bases 1 to 8251)
  AUTHORS   Poulin,F., Brueschke,A. and Sonenberg,N.
  TITLE     Gene fusion and overlapping reading frames in the mammalian genes
            for 4E-BP3 and MASK
  JOURNAL   J Biol Chem 278 (52), 52290-52297 (2003)
   PUBMED   14557257
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ165547.1, BG804884.1, CD538664.1, AC115631.4, CF742822.1,
            AK029322.1, AK042754.1 and BC091647.1.
            
            On Oct 27, 2007 this sequence version replaced NM_175375.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               CJ165547.1         2-401
            401-687             BG804884.1         112-398
            688-979             CD538664.1         350-641
            980-1057            AC115631.4         50867-50944
            1058-1128           AC115631.4         56533-56603
            1129-1585           CF742822.1         1-457
            1586-4159           AK029322.1         1-2574
            4160-4543           AK042754.1         1135-1518
            4544-4765           AK029322.1         2959-3180
            4766-8251           BC091647.1         191-3676
FEATURES             Location/Qualifiers
     source          1..8251
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..8251
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /note="ankyrin repeat and KH domain containing 1"
                     /db_xref="GeneID:108857"
                     /db_xref="MGI:MGI:1921733"
     exon            1..453
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..7782
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /note="multiple ankyrin repeats, single KH-domain homolog"
                     /codon_start=1
                     /product="ankyrin repeat and KH domain-containing protein
                     1"
                     /protein_id="NP_780584.2"
                     /db_xref="CCDS:CCDS50256.1"
                     /db_xref="GeneID:108857"
                     /db_xref="MGI:MGI:1921733"
                     /translation="MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTV
                     RLFGEAGPAPGVGGGGGGGGGSSSSSSAGGGDAALDFKLAAAVLRTGGGGGASGSDED
                     EVSEVESFILDQEDLDNPVLKTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGK
                     LSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAENTHSTGQVDTRSLAEACSD
                     GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI
                     TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFIDIVKVLLNEGANI
                     EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR
                     FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC
                     GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ
                     ETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAAGANVHA
                     TTATGDTALTYACENGHTDVADVLLQAGAHLEHESEGGRTPLMKAARAGHLCTVQFLI
                     SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG
                     HTNVVSYLLDYPNNVLSVPTTDVSQLTSPSQDESQVPRVPIHTLAMVVPPQEPDRTSQ
                     ETSTALLGVQKGASKQKSSSLQVADQDLLPPFHPYQPLECIVEETEGKLNELGQRISA
                     IEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQF
                     TKEYLETKGQRDTESPHQQCSNRGVFMAGEEDGSLPQDHSSESPQLDTVLFKDHDIDD
                     KQQSPPSAEQIDFVPVQPLSSPQCNFFSDLGSNGTNSLVLQKVSGNQQIVGQPQIAIA
                     GHEQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPVGSNNPSQTTECPTPESCY
                     QTPSNMATPSTPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRD
                     KKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLA
                     RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG
                     HVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT
                     PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLINRGAH
                     IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQ
                     YLVKEVSQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLK
                     ELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEDEENKPKENSEQPEGEDEE
                     NDEDVEQEIPIEPPSATTTTTIGISATSTTFTNVFGKKRANVVTTPSTNRKNKKNKTK
                     ESPPTAHLILPEPHISLAQQKADKNKINGEPRGGGAGGNSDSDNIDSTDCNSESSSGG
                     KSQEFSFPVDVNPASDKRCSTVVSSQEEKAVTTTSKTQTRLDGEVNSMSTSYKSLPLS
                     SPTMKLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGA
                     HIDVDKQKDKNGERMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPAST
                     KSIHTNFSSGVGTTATSSKNAFPLGAPALVTSQATTLSTFQPTNKLSKNVPTNVRSPF
                     PVSLPLAYPHPHFALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNT
                     SSSPKHNNTARLPNQNGPVLPSESPGLATTGCPITVSSVVAASQQLCMTNSRTPSSVR
                     KQLFACVPKTSPPATVISSVTSTSSSLPSVSSTSITSGHVTTTFMPAPTQVPLSSQKV
                     ESFSVIPPPKEKVSTQDQPLTNLCTPSPAATSCNSSASNTSGAPEAHPSSTPPPPPGN
                     TQEEGQPSKASDLSPVSMPFASNSETAPLTLASPRLVAADNRDTGSLPQLTVPAPRVS
                     HRMQPRGSFYSVVPNATMHQDPQSIFVTNPVPLTPPQGPPAAVQLSSAVNIMNGSQVH
                     INPANKSLQPTFGPATLFNHFSSLFDSGQVPANQGWGDGPLPSRVAADASFTVQSAFL
                     SNSVLGHLENVHPDNSKAPGFRPPSQRVSTSPVGLPSIDPSGNSPSAAAPLTSFSGIP
                     GTRVFLQGPAPVGTPSFNRQHFSPHPWTSASNTCDSPIPSVSSGSSSPLSATSAPPTL
                     GQQPKGNSASQDRKIPPPIGTERLARIRQGGSVAQAPVGTSFVAPVGHGGIWSFGVNA
                     MSEGLSGWSQSVIGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPTNIFHQPMGLPISM
                     YGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSAECTEAQQIWPGTWAPH
                     IGNMHLKYVN"
     exon            454..604
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            605..761
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            762..909
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1057
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1291
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1386
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1624
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1816
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1926
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2014
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2142
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2286
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2389
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..3148
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3294
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3406
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3552
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3695
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3909
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            3910..4085
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4248
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            4249..4344
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            4345..4461
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            4462..4630
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            4631..5084
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            5085..5219
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            5220..5369
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            5370..6979
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            6980..7153
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            7154..7408
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            7409..7557
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            7558..7722
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     exon            7723..8231
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8213..8218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /note="hexamer: AATAAA"
     polyA_site      8231
                     /gene="Ankhd1"
                     /gene_synonym="1110004O12Rik; 4933432B13Rik;
                     9130019P20Rik; A530027J04Rik; A630021B20Rik; Mask;
                     mFLJ00246; mKIAA1085"
                     /note="major polyA site"
ORIGIN      
        1 agtgagaagt tagtggcgct gctgggacgg gggggaagag acgcttcttc ctcctgctgc
       61 tcctcacctt cccgggatca gccgcggcgg tggccgcgag tgactcggca gcgtctccgg
      121 ctccgcgtga gaaccatgct gacggacagc gggggcggcg gcacctcctt tgaggaggat
      181 ttggactccg tagctccgcg atccgcccca gctggggcct cggagccgcc tccgccggga
      241 ggggtcgggc tgggaatccg caccgtgagg ctctttgggg aggctgggcc cgcgccggga
      301 gtcggtggcg gcggcggcgg cggcggcggc agcagcagca gcagcagcgc gggcggaggg
      361 gacgcagcgc tggatttcaa gttggccgct gctgtgctga ggacgggcgg cggaggtggt
      421 gcctctggga gcgacgagga cgaggtgtcc gaggtagaat catttatttt ggaccaagaa
      481 gatttggata acccagtcct taaaacatca gagatattct tatcaagtac agcagaagga
      541 gcagatttgc gcacagtgga tccagagacc caagcgagac tggaagcatt gctagaagca
      601 gcaggaattg gcaaattgtc aactgctgat ggtaaagctt ttgcagatcc tgaagtactc
      661 cggagactga catcctcagt tagctgtgcc ctggatgaag ccgctgctgc actgacacgg
      721 atgagagcag agaacacaca cagtacagga caagtggata ctcgcagtct ggcagaagct
      781 tgttcagatg gagatgtgaa tgctgttcgt aaattactag atgaaggcag aagtgtaaat
      841 gaacatacag aagaaggaga aagcctgctg tgtttggctt gttcagcagg atattatgaa
      901 ctagcacaag tactactagc tatgcatgct aatgttgaag atagagggaa taaaggagat
      961 ataactcctt tgatggcagc ttctagtgga ggttatttag atattgtgaa attattactt
     1021 cttcatgatg cagatgtcaa ctcccagtcg gcaacaggga acactgcact gacttatgct
     1081 tgtgctggag gatttattga cattgtaaaa gtgcttctta atgagggtgc gaatatagaa
     1141 gaccataatg aaaatggaca cactccccta atggaagcag ccagtgccgg tcatgtagaa
     1201 gttgccagag ttcttctaga tcacggtgca ggcatcaaca ctcattctaa tgagtttaaa
     1261 gaaagtgctc tgacacttgc ctgctacaaa ggccatttgg atatggttcg atttttgctt
     1321 gaagctggtg cagatcaaga gcacaaaacc gatgagatgc acactgcctt aatggaagct
     1381 tgcatggatg gacatgtaga ggtggcacgt ttgcttttag acagtggtgc tcaggtgaat
     1441 atgcctgcgg attcctttga gtctccattg actctagctg cctgtggtgg acatgttgaa
     1501 ttagcagcac tgcttattga aagaggagca aatcttgaag aagttaatga cgaaggatac
     1561 acgcctttga tggaagctgc tcgagaagga catgaagaga tggtggcact tctattggca
     1621 caaggtgcaa atataaatgc ccagacagaa gaaactcaag aaactgctct taccttggct
     1681 tgctgtggag gcttttctga agttgcagat ttcttgatta aggcaggggc tgacatagaa
     1741 cttggctgtt ctacacctct catggaggct tctcaggagg gacacctgga gttggttaaa
     1801 tatttgttgg ctgctggtgc taatgtgcat gctaccacag ctacaggaga cacagctcta
     1861 acctatgctt gtgaaaatgg acatacagat gttgcagatg ttctacttca agcaggggcc
     1921 catttagaac atgaatctga aggtggaaga acacctttga tgaaagctgc aagagcgggt
     1981 catttgtgca ctgttcagtt tcttattagc aaaggtgcca atgtgaatag ggctacagcc
     2041 aataatgatc acacagtagt gtcactggca tgtgcaggag gccatttggc agtggttgaa
     2101 ctgctcttgg ctcatggagc tgaccctact catcgactca aggatggatc aacaatgctt
     2161 attgaagctg caaaaggtgg ccatactaat gttgtttctt atctgttgga ttatccaaat
     2221 aatgttctgt cagttcccac cacagatgta tctcaactta cctctccgtc acaagatgag
     2281 tctcaggttc cacgagtacc catacacaca cttgccatgg ttgtgcctcc ccaggaacct
     2341 gacagaactt cccaggagac atctactgcc cttttaggag tacaaaaagg tgcatccaag
     2401 cagaagtcca gttctctgca ggtagcagat caggacctac tgccaccttt tcacccatac
     2461 cagcctttgg agtgcatagt agaagagact gaaggcaagc tgaatgaact ggggcaaaga
     2521 attagtgcta ttgaaaaagc acagcttaag tcattggagt taattcaagg tgagcctcta
     2581 aacaaggata agatagaaga acttaaaaag aacagagaag agcaagtcca gaagaagaag
     2641 aaaatactga aagaactaca gaaggtggaa aggcagttac agatgaaaac acagcagcaa
     2701 tttaccaaag aatacttgga aacaaaaggt cagagagaca cagagtctcc acaccagcaa
     2761 tgttctaata gaggagtctt catggcaggg gaagaagatg gcagtctccc acaggatcac
     2821 tcttcagaat caccccagct tgatacagtc ttatttaagg atcatgatat tgatgataag
     2881 caacagtctc caccatcggc agaacaaatt gactttgtcc cagtccagcc tctatcatct
     2941 ccacaatgta actttttcag tgacttaggt tctaatggga caaattctct tgtgcttcag
     3001 aaagtatcag gtaaccagca gattgtagga cagcctcaga ttgcgattgc tggacatgag
     3061 caggggctat tagttcaaga gccagatgga ctcatggttg caactccagc ccagacgctt
     3121 accgacactc ttgatgacct gatagcagct gtgagtacca gagtgcctgt tggttcaaac
     3181 aatccctctc agaccacaga atgtcctaca cctgaatcct gttatcagac tccaagcaat
     3241 atggctaccc catccactcc acctgtgtat ccttcggttg acattgatgc acatacggaa
     3301 agcaatcatg acacagcttt aacactggcc tgtgcaggtg gtcatgaaga actcgtatct
     3361 gttctcattg ctcgggatgc taaaattgag catagagaca aaaaaggttt taccccactg
     3421 atcctggcgg caacagcagg gcatgttgga gttgttgaaa tccttttgga taaaggtgga
     3481 gatatagagg cacaatctga acgaactaaa gatactccac tttctttggc atgttctggt
     3541 ggacggcagg aggtggtaga tttgctgctg gcccgaggag ccaataaaga acataggaat
     3601 gtgtctgatt atacaccact gagtctggct gcatctggag gatacgtgaa tattattaag
     3661 attttactta atgctggggc agaaattaat tcaaggactg gaagtaaact aggtatttct
     3721 ccattgatgt tggctgcaat gaatggacat gttcccgcag tgaaattgct gcttgatatg
     3781 ggttcagaca ttaatgctca gatagagacc aaccggaaca cagctctcac cctggcctgt
     3841 ttccagggtc gagcagaagt agtgagtttg cttttggacc gcaaagccaa tgttgaacac
     3901 agggcaaaga ctggtcttac acccttgatg gaagcagctt ctggaggata tgcagaggtt
     3961 ggaagagttc tccttgataa aggagcagat gtcaatgcac ctcctgtgcc ttcctcaaga
     4021 gacactgctt taaccatagc agcagacaaa ggccactaca aattctgtga gctcctgatt
     4081 aacaggggag cacatattga tgttcgtaac aagaagggaa atacaccact ttggctggca
     4141 tccaatggtg gtcattttga tgtagtacaa ttgctagtgc aagcaggtgc tgatgtggat
     4201 gcagcagaca accgaaaaat cacacctctt atgtcagcat ttcgcaaggg tcatgtaaaa
     4261 gttgttcagt atttggtgaa ggaagtcagt cagtttccat ctgatataga atgcatgaga
     4321 tacatagcaa caattacaga taaggaactg ctgaagaagt gtcaccaatg tgttgagaca
     4381 attgtgaagg ctaaagatca gcaggctgca gaagcaaata aaaatgcaag cattctccta
     4441 aaagagctgg atctagaaaa gtcaagagaa gagagcagaa agcaagctct tgctgctaaa
     4501 agagagaagc gaaaagaaaa gaggaaaaag aaaaaagagg aacagaaaag gaaacaggaa
     4561 gatgaggaga acaaacctaa ggagaattca gaacaaccag agggtgaaga tgaagagaat
     4621 gatgaagatg tggagcaaga aattcccata gagcctccga gtgcaaccac cactactaca
     4681 attggaatct ctgctacatc taccacgttt acaaatgtat ttggcaaaaa aagagccaat
     4741 gtagtgacaa cccccagcac caatcggaaa aataagaaga ataagacaaa agagtcccct
     4801 cccacagcgc atttaatttt acctgagcca catatatctt tagcacaaca aaaagcagat
     4861 aaaaataaaa taaatggaga gcctagaggt ggcggcgcag gtggaaatag tgactcggat
     4921 aacatagata gcacagactg caacagtgag agcagcagtg gtgggaagag ccaagagttc
     4981 agtttccctg tggatgtgaa tcccgccagt gacaagaggt gctccacagt tgtcagttct
     5041 caagaggaaa aggcagttac caccacttcc aagactcaga cacgccttga tggtgaagta
     5101 aattccatgt caacaagcta caaatctttg ccattaagtt ctccaaccat gaaactgaat
     5161 ctcactagtc ctaaaagggg tcaaaaaaga gaagaagggt ggaaagaagt tgttagaagg
     5221 tcaaagaaat tatctgttcc agcctcagtg gtgtcgagaa taatgggaag aggaggatgc
     5281 aacattacag caatacaaga tgttactggt gcccatattg atgtggataa acaaaaagat
     5341 aagaatggag agagaatgat tacaataagg ggtggtacag aatcaacaag atatgcagtt
     5401 caacttatca atgcacttat tcaagatcct gcaaaggaac tagaagactt gattcctaaa
     5461 aaccatatca ggacacctgc cagcaccaag tccattcata caaacttctc atctggagta
     5521 ggcaccacag caacttccag caagaatgca tttcccttgg gtgctccagc tcttgtgaca
     5581 tcacaggcaa caacattatc tacgttccag cccactaata aacttagtaa gaacgtgcca
     5641 acaaatgtac gctctccttt cccggtgtct cttcccttag cttatcctca tcctcatttt
     5701 gctctcttgg ctgctcaaac tatgcaacag attcggcatc ctcgcttacc tatggcacaa
     5761 tttggaggaa ccttctcacc ttcacctaac acctggggac cattccccgt gagacctgtg
     5821 aatcctggga atactagtag ttctccaaag cataataata cagcccgtct acctaatcag
     5881 aatgggcctg ttttaccatc agaatctcct ggactggcta ctaccggttg tcctatcact
     5941 gtctcttctg tagttgctgc cagtcagcaa ctatgcatga ctaattcccg gactccttca
     6001 tccgtcagaa agcagttgtt tgcttgtgtg cctaagacca gtcctccagc aacagtgatt
     6061 tcctccgtga caagcactag tagttccttg ccttctgtgt cttccacatc tatcactagt
     6121 ggacacgtta ccaccacatt tatgcctgca cctactcaag taccactttc ttcacaaaag
     6181 gtggagtctt tctctgtcat accgcctccc aaagagaaag tgtccacaca ggaccagccc
     6241 ttgacaaacc tatgtacacc atctccagca gctaccagtt gtaatagctc tgccagcaac
     6301 acctcaggag ctccagaggc tcatccatcc agtacccctc ctcctcctcc gggtaataca
     6361 caagaggagg gacagccgtc caaggcatct gatttaagtc ctgtgtcaat gccttttgcc
     6421 tcgaactcag aaactgctcc attgactttg gcatcaccca gattggttgc tgctgataat
     6481 cgggacactg gtagtttacc tcagttaact gtaccggcac ctcgagtttc tcatcgaatg
     6541 cagcccagag gttcttttta ctcagtggta ccaaatgcaa ctatgcacca ggatccccag
     6601 tcaatttttg ttaccaatcc agttccttta acaccacctc aaggtccacc ggctgcagtg
     6661 cagctttcct cagctgtgaa cattatgaat ggttctcaag tgcacataaa cccagcaaat
     6721 aagtctttgc aaccaacatt cggcccagcc acacttttta atcacttcag tagtcttttt
     6781 gatagtggtc aggtgccagc taaccaaggg tggggagatg gacctctgcc ctcaagagtt
     6841 gctgcagatg cctctttcac tgttcagtca gctttcctga gtaactctgt acttggacac
     6901 ttggaaaatg tgcaccctga caactccaaa gcacctggct tcagaccacc gtcacagaga
     6961 gtttccacta gtccagttgg gttgccatct attgacccat caggcaattc cccatctgct
     7021 gctgctcctc tgacaagttt ctctggcata ccagggacaa gagtttttct gcaagggcca
     7081 gcacctgtcg gcactcctag tttcaacaga caacattttt ctccccaccc ttggacaagc
     7141 gcctcaaaca catgtgactc tcctattcca tctgtttctt cgggatcatc ttcacctctt
     7201 tcagccactt cagcacctcc aacattgggc caacaaccaa aaggaaacag tgccagtcag
     7261 gatcgaaaga tacctcctcc cattggaaca gagaggctgg ccaggattcg gcaaggaggc
     7321 tctgttgcac aagcacctgt agggaccagt tttgttgctc ctgttggaca cggtgggatc
     7381 tggtcatttg gtgtcaatgc tatgtcagaa ggcttatcag gttggtcaca atctgttata
     7441 ggaaaccatc caatgcatca acagttatca gacccaagca cattctccca gcatcagcca
     7501 atggagagag atgattcagg aatggtagct cccactaaca tttttcacca gccaatgggc
     7561 ctgccgattt ccatgtatgg aggcaccatt ataccctctc accctcagct tgctgacgtt
     7621 ccagggggcc cactgttcaa tggacttcac aacccagatc ctgcttggaa tcctatgata
     7681 aaagttatcc agaattcagc tgaatgcact gaagcccagc agatttggcc tggcacgtgg
     7741 gcacctcata ttggaaacat gcatctcaaa tatgtcaact aagttagaag gtctttcctc
     7801 ttttagcctt gtttgggaaa cctatgacta tggaagaact ctgggttttt tcgttttgtt
     7861 ttgttttttt aatgtgccta tctaaaatac tctctgaggc tttagcaatg gaaaattgat
     7921 tgcccattgt gtaagaacaa aaaatgattt cctatccacc tgaatatgtt ctctggttag
     7981 ttaagccact tttgacttga gatcagatga acctagtgct tttggctaaa catatgaatg
     8041 ctacttgtgt acagaagaga attagataat tacatgtttc aactttttag ggtggtaaat
     8101 acatgtataa ttgtttacat acttaaaagg aaaaaaatga gtaaatttct tgtcatatag
     8161 cggctctact taatgtagcc tgtattaatg tgaaatattt accagaatat tcaataaaaa
     8221 aatgaacagt gaaaaaaaaa aaaaaaaaaa a
//
