LOCUS       NM_146005              10025 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus ankyrin 3, epithelial (Ank3), transcript variant 2,
            mRNA.
ACCESSION   NM_146005
VERSION     NM_146005.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10025)
  AUTHORS   Ding,X., Wu,Y., Vainshtein,A., Rodriguez,V., Ricco,E., Okoh,J.T.,
            Liu,Y., Kraushaar,D.C., Peles,E. and Rasband,M.N.
  TITLE     Age-dependent regulation of axoglial interactions and behavior by
            oligodendrocyte AnkyrinG
  JOURNAL   Nat Commun 15 (1), 10865 (2024)
   PUBMED   39738113
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10025)
  AUTHORS   Melton,A.J., Palfini,V.L., Ogawa,Y., Oses Prieto,J.A.,
            Vainshtein,A., Burlingame,A.L., Peles,E. and Rasband,M.N.
  TITLE     TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not
            Axon Specification or Axon Initial Segment Formation
  JOURNAL   J Neurosci 44 (42), e0976242024 (2024)
   PUBMED   39251352
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10025)
  AUTHORS   Escobedo,G. Jr., Wu,Y., Ogawa,Y., Ding,X. and Rasband,M.N.
  TITLE     An evolutionarily conserved AnkyrinG-dependent motif clusters
            axonal K2P K+ channels
  JOURNAL   J Cell Biol 223 (10) (2024)
   PUBMED   39078369
REFERENCE   4  (bases 1 to 10025)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 10025)
  AUTHORS   Villacres,J.E., Riveira,N., Kim,S., Colgin,L.L., Noebels,J.L. and
            Lopez,A.Y.
  TITLE     Abnormal patterns of sleep and waking behaviors are accompanied by
            neocortical oscillation disturbances in an Ank3 mouse model of
            epilepsy-bipolar disorder comorbidity
  JOURNAL   Transl Psychiatry 13 (1), 403 (2023)
   PUBMED   38123552
  REMARK    GeneRIF: Abnormal patterns of sleep and waking behaviors are
            accompanied by neocortical oscillation disturbances in an Ank3
            mouse model of epilepsy-bipolar disorder comorbidity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10025)
  AUTHORS   Bryda,E.C., Ling,H., Rathbun,D.E., Burmeister,M. and Flaherty,L.
  TITLE     Fine genetic map of mouse chromosome 10 around the polycystic
            kidney disease gene, jcpk, and ankyrin 3
  JOURNAL   Genomics 35 (3), 425-430 (1996)
   PUBMED   8812475
REFERENCE   7  (bases 1 to 10025)
  AUTHORS   Barisoni,L., Trudel,M., Chretien,N., Ward,L., van Adelsberg,J. and
            D'Agati,V.
  TITLE     Analysis of the role of membrane polarity in polycystic kidney
            disease of transgenic SBM mice
  JOURNAL   Am J Pathol 147 (6), 1728-1735 (1995)
   PUBMED   7495297
REFERENCE   8  (bases 1 to 10025)
  AUTHORS   Peters,L.L., John,K.M., Lu,F.M., Eicher,E.M., Higgins,A.,
            Yialamas,M., Turtzo,L.C., Otsuka,A.J. and Lux,S.E.
  TITLE     Ank3 (epithelial ankyrin), a widely distributed new member of the
            ankyrin gene family and the major ankyrin in kidney, is expressed
            in alternatively spliced forms, including forms that lack the
            repeat domain
  JOURNAL   J Cell Biol 130 (2), 313-330 (1995)
   PUBMED   7615634
REFERENCE   9  (bases 1 to 10025)
  AUTHORS   Kapfhamer,D., Miller,D.E., Lambert,S., Bennett,V., Glover,T.W. and
            Burmeister,M.
  TITLE     Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human
            10q21 and mouse 10
  JOURNAL   Genomics 27 (1), 189-191 (1995)
   PUBMED   7665168
REFERENCE   10 (bases 1 to 10025)
  AUTHORS   Bahou,W.F., Nierman,W.C., Durkin,A.S., Potter,C.L. and
            Demetrick,D.J.
  TITLE     Chromosomal assignment of the human thrombin receptor gene:
            localization to region q13 of chromosome 5
  JOURNAL   Blood 82 (5), 1532-1537 (1993)
   PUBMED   8395910
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129018.4, L40632.1,
            AC156836.6 and AC132435.3.
            
            On Oct 18, 2006 this sequence version replaced NM_146005.2.
            
            Summary: This gene encodes a member of the ankyrin protein family.
            Ankyrins link integral membrane proteins to the spectrin-based
            cytoskeleton. Ankyrin family members share a protein structure
            which includes three independently folded domains: the N-terminal
            ankyrin repeat domain, the central spectrin-binding domain, and the
            C-terminal rod domain. This ankyrin functions as the major ankyrin
            in the kidney and may play a role in the polarized distribution of
            many integral membrane proteins to specific subcellular sites.
            Alternative splicing of this gene results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849385,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-458               AC129018.4         83107-83564         c
            459-2352            L40632.1           1-1894
            2353-2353           AC156836.6         115881-115881       c
            2354-5322           L40632.1           1896-4864
            5323-5323           AC156836.6         6233-6233           c
            5324-6570           L40632.1           4866-6112
            6571-10025          AC132435.3         177889-181343       c
FEATURES             Location/Qualifiers
     source          1..10025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 36.1 cM"
     gene            1..10025
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /note="ankyrin 3, epithelial"
                     /db_xref="GeneID:11735"
                     /db_xref="MGI:MGI:88026"
     exon            1..577
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..6400
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /note="isoform b is encoded by transcript variant 2;
                     brain-specific ankyrin-G"
                     /codon_start=1
                     /product="ankyrin-3 isoform b"
                     /protein_id="NP_666117.2"
                     /db_xref="CCDS:CCDS23909.1"
                     /db_xref="GeneID:11735"
                     /db_xref="MGI:MGI:88026"
                     /translation="MSEEPKEKPAKPAHRKRKGKKSDANASYLRAARAGHLEKALDYI
                     KNGVDVNICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ
                     AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPL
                     AVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDTNADVESKSG
                     FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK
                     IDAKTRDGLTPLHCGARSGHEQVVEMLLDRSAPILSKTKNGLSPLHMATQGDHLNCVQ
                     LLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKASPNAKALNGFTPLHIACK
                     KNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE
                     TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP
                     NAATTSGYTPLHLAAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASL
                     LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKK
                     NQMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKSGLT
                     PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN
                     AKTKNGYTALHQAAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTL
                     KVVTEEIMTTTTITEKHKMNVPETMNEVLDMSDDEVRKASAPEKLSDGEYISDGEEGD
                     KCTWFKIPKVQEVLVKSEDAITGDTDKYLGPQDLKELGDDSLPAEGYVGFSLGARSAS
                     LRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLD
                     NVNLVSSPVHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHK
                     LANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGET
                     WKEHQFDSKNEDLAELLNGMDEELDSPEELGTKRICRIITKDFPQYFAVVSRIKQESN
                     QIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPEETVKKILGNKATFSPIV
                     TVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDATPNLRLLCSITGGTSPAQWEDIT
                     GTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLASQLYRELICVPYMAKFVVFAK
                     TNDPVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLT
                     KGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNIT
                     LPAHKKAEKADRRQSFASLALRKRYSYLTEPSMSPQSPCERTDIRMAIVADHLGLSWT
                     ELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRI
                     DIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGHPSFQVELETPMGLYCTPPNPFQ
                     QDDHFSDISSIESPFRTPSRLSDGLVPSQGNIEHPTGGPPVVTAEDTSLEDSKMDDSV
                     TVTDPADPLDVDESQLKDLCQSECAQCWASVPGIPNDGRQAEPLRPQTRKVGMSSEQQ
                     EKGKSGPDEEVTEDKVKSLFEDIQLEEVEAEEMTEDQGQAMLNRVQRAELAMSSLAGW
                     QNETPSGSLESPAQARRLTGGLLDRLDDSSDQARDSITSYLTGEPGKIEANGNHTAEV
                     IPEAKAKPYFPESQNDIGKQSIKENLKPKTHGCGRTEEPVSPLTAYQKSLEETSKLVI
                     EDAPKPCVPVGMKKMTRTTADGKARLNLQEEEGSTRSEPKQGEGYKVKTKKEIRNVEK
                     KTH"
     exon            578..679
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            680..778
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            779..877
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            878..976
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1162
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1261
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1360
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1459
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1657
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1756
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1855
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1954
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2152
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2251
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2350
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2548
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2647
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2746
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2845
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2941
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3014
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3077
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3131
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3255
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3358
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3465
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3690
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3845
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..4057
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4265
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4362
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            4363..4591
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..4717
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            4718..4840
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            4841..4922
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            4923..4997
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            4998..5129
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            5130..5273
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            5274..5952
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            5953..6334
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            6335..6420
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     exon            6421..10025
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7944..7949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /note="hexamer: AATAAA"
     polyA_site      7970
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /note="major polyA site"
     regulatory      9844..9849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
                     /note="hexamer: AATAAA"
     polyA_site      9865
                     /gene="Ank3"
                     /gene_synonym="2900054D09Rik; Ank-3; AnkG; Ankyrin-3;
                     Ankyrin-G"
ORIGIN      
        1 agagattcgt cagcagtcta gcttattcct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
       61 gtgtgtgtgt gtgtgtgcag cgcacatgca cgtatgcctc cccctttctc tctctcacca
      121 tttccaagct agaatcaccg tggagaagca agccctgaaa tgttgtcaag atcttttctc
      181 ggggtaacga ctggctaaaa aaacaaataa aaagagagag aaaggaagaa aaagaaagaa
      241 ggaagaaagg aaggaagaaa acaaagggtt ggaatattga tttttctttg gaggaataac
      301 cagggctttg ctggagagaa cacccagttc ctccctgagg cgagctgagt tgcccgtgac
      361 agcagccagg gctggcttga agcagccgct ctgcctgggg agttccctaa atggactttg
      421 gtctcaatgc tgtgactctt tgccgtgggt ttggatgtgg gaacacggaa ggtgatctcc
      481 tgcctcgtct caactcccct gatctcaagg aaagatgagt gaagagccaa aggagaagcc
      541 cgccaagcct gctcatagga agaggaaagg aaaaaagtct gatgccaacg caagttactt
      601 aagagcagct cgggcagggc acctggaaaa ggcccttgac tacatcaaaa atggagtgga
      661 cgtcaacatc tgtaaccaga atggattgaa tgcactccat cttgcttcca aagaaggcca
      721 tgtggaagtg gtctctgagc tgctgcagag ggaagccaat gttgatgccg ccacaaagaa
      781 aggaaacacg gccttacaca tcgcatcttt ggctgggcaa gcggaagtgg tcaaggtctt
      841 ggttacgaac ggagcgaatg tcaacgcaca atctcagaat ggcttcacac cattgtatat
      901 ggcagcccag gagaaccacc tggaagtcgt caggtttctt ctggacaatg gcgccagcca
      961 aagcctggcc acagaggacg gcttcacgcc attggccgtg gctctgcaac aaggtcatga
     1021 ccaagtcgtg tccctcctgc tcgagaacga cacgaaggga aaagtgcgcc tcccagccct
     1081 ccacatcgca gcccggaaag acgacaccaa ggcagcagct ctgctcctgc agaatgacac
     1141 aaacgcggac gtggagtcaa agagtggctt caccccgctc cacatagctg cccactatgg
     1201 gaacatcaat gtggccacgt tgctgttaaa ccgagcggct gctgtggact tcaccgcacg
     1261 gaatgacatc actcccttac acgttgcctc gaagcgagga aatgcaaata tggtgaagct
     1321 attgctggac cggggtgcga agatcgatgc caagaccagg gacggtctga ctccgttgca
     1381 ctgtggggcg agaagtggcc atgagcaggt ggtagagatg ttgcttgaca gatccgcccc
     1441 catcctttca aaaaccaaga atggattgtc gccactgcac atggccacac aaggagacca
     1501 tttaaactgc gtccaactcc tcctccagca caacgtgccc gtggacgacg tcaccaacga
     1561 ctacctgact gccctccatg tggctgccca ctgcggccat tacaaagttg ccaaggttct
     1621 tttggataag aaagctagcc ccaatgccaa agccctgaat ggcttcaccc ctctccatat
     1681 cgcctgcaaa aagaaccgca tccgagtaat ggaactcctt ttgaagcacg gtgcatctat
     1741 tcaagccgta accgagtcgg gccttacccc aatccatgtt gctgccttca tgggacatgt
     1801 aaatatcgtg tcacagctaa tgcatcatgg agcctcccca aacaccacca atgtgagagg
     1861 agagacggca ttgcatatgg cggctcggtc cggacaagca gaagtggtgc ggtatctggt
     1921 ccaagatggg gctcaggtag aagcaaaagc taaggatgac cagactccac tccacatctc
     1981 agcccgactt gggaaagctg acatagtgca acaactgtta cagcaaggag catcccccaa
     2041 tgcagcaaca acttctgggt acacccccct tcaccttgcg gccagagagg ggcatgagga
     2101 tgtagctgcg ttcctcctgg atcatggagc atctttatcc ataacaacaa agaagggatt
     2161 cacccctctg cacgtggcag ccaaatacgg aaagcttgaa gtcgcaagtc tcctgctgca
     2221 gaagagtgcg tctcccgatg ccgcagggaa gagcgggcta actccactgc atgtagcagc
     2281 gcattacgat aatcagaaag tggcccttct gctcttggac cagggagcct caccccacgc
     2341 agccgcaaag aatggctata caccactgca catcgcggcc aagaagaacc agatggacat
     2401 agccacgtcc ctgctggagt acggtgctga tgcaaacgcg gttacccggc aagggattgc
     2461 gtccgtccat cttgcggcac aggaagggca cgtggacatg gtgtcgctgc tcctgagtag
     2521 aaacgcgaat gtcaacctga gcaataagag cggtctcacc ccactccacc tggctgctca
     2581 agaagaccga gtgaatgtgg ccgaggtcct tgtcaaccag ggggcccatg tggatgctca
     2641 gacaaagatg ggctacaccc cgctccatgt gggctgtcac tatggaaata tcaaaatagt
     2701 caattttctg ctgcagcatt ctgcaaaagt taatgccaag acgaagaatg gatacacagc
     2761 actgcaccag gctgctcagc agggccacac gcatatcatc aatgtcttgc ttcagaacaa
     2821 cgcctccccc aatgaactca ctgtgaatgg gaacacagct ctggccatcg cccggcgcct
     2881 tggttacatc tcggtggttg acacactgaa ggtcgtgacg gaggaaatta tgaccaccac
     2941 taccatcacg gagaagcaca aaatgaatgt cccagaaacg atgaatgaag tcctcgatat
     3001 gtcagacgat gaagtaagga aagccagcgc ccccgaaaag ctcagtgatg gggaatatat
     3061 ctcagacggt gaagaaggtg ataaatgcac atggttcaaa attcccaaag tacaggaggt
     3121 tttggtgaaa agtgaagatg ccatcacagg ggacactgac aagtatctcg ggccacagga
     3181 ccttaaggag ctaggtgatg actccctgcc agcagaaggt tacgtaggct tcagtcttgg
     3241 agcccgttct gccagcctcc gctccttcag ttcggatagg tcctacacct tgaacagaag
     3301 ctcctacgca agggacagca tgatgataga ggaacttctg gtaccatcca aagagcagca
     3361 cctgacgttc acgagggagt ttgattctga ctccctcaga cactacagtt gggcagcgga
     3421 cacgttagat aatgtgaacc tggtctcaag cccggtgcat tctgggtttc tggttagctt
     3481 tatggtggac gcgagagggg gctccatgcg aggaagccgc caccacggga tgcggatcat
     3541 catccctccg cgaaagtgta cggcccccac ccgcatcacg tgccgcctgg taaagagaca
     3601 taaactggcc aacccacccc ccatggtgga aggagaggga ttagccagta ggctggtaga
     3661 aatgggtcct gcgggggcac aatttttagg ccccgtcatt gtggaaatcc ctcattttgg
     3721 gtccatgagg gggaaggaga gagaacttat cgtccttcgg agcgagaacg gagagacctg
     3781 gaaggaacat cagtttgaca gtaaaaacga agacctcgcg gagcttctca atggcatgga
     3841 tgaagaactc gacagcccgg aagagttggg tacaaagcgc atctgcagaa ttatcacaaa
     3901 ggatttcccc cagtattttg ccgtggtttc ccggattaag caggaaagca accagatcgg
     3961 tcctgagggt gggattctga gcagcaccac cgtgcccctc gtccaggcct ccttcccaga
     4021 gggcgcctta accaagagga tccgtgtggg tctccaggct cagcccgtgc cagaggaaac
     4081 ggtaaaaaaa atccttggga acaaagcaac atttagccca attgtcacgg tagagccgag
     4141 gagaaggaag ttccataagc cgatcaccat gaccattccg gtgcccccgc cctcgggaga
     4201 aggcgtgtcc aatgggtaca agggggatgc cacgcccaac ctgcggctcc tctgcagcat
     4261 cacaggaggc acctcaccag ctcaatggga agacatcaca ggaacaaccc ctctgacgtt
     4321 cataaaggat tgtgtgtctt tcacaaccaa cgtttcagcc agattctggc tggcggactg
     4381 ccatcaggtg ttagagaccg tagggctagc ctcccagctg tacagagagc tgatatgcgt
     4441 tccctacatg gccaagttcg ttgtgtttgc caaaacaaac gacccggtgg agtcctcgct
     4501 gaggtgcttc tgtatgacag acgacagggt ggacaaaacc ctggagcagc aggagaactt
     4561 cgaggaggtt gccagaagca aagacattga ggttctggaa ggaaagccca tctacgttga
     4621 ttgctatgga aacctggccc ctctgaccaa aggaggacag cagcttgttt ttaactttta
     4681 ttctttcaaa gaaaacagac tgccattttc catcaagatc agagacacca gtcaagagcc
     4741 ctgtggccgc ctgtctttcc tgaaggagcc aaagacaaca aagggattac cccaaacagc
     4801 tgtttgcaac ttaaatatta ctctgccggc acataaaaag gctgagaagg cagacagacg
     4861 ccagagcttt gcctccctag ctttacgtaa gcgctacagc tacttgactg aacccagcat
     4921 gagtccgcag agtccttgtg agcggacgga tatcaggatg gcgatagtag ccgatcacct
     4981 gggacttagt tggacagagc tggcaaggga actgaatttt tcagtggatg aaatcaacca
     5041 aatacgtgtg gaaaatccca attctttaat ttctcagagc ttcatgttat taaaaaagtg
     5101 ggtgaccaga gacggaaaga atgccacaac tgatgcctta acttcggtct taacgaagat
     5161 taaccggata gacattgtaa ctctgctgga aggaccaata tttgattatg ggaatatttc
     5221 aggcaccaga agctttgcag atgaaaacaa tgttttccat gacccagttg atggtcaccc
     5281 ttcctttcaa gtggagctgg agacccccat ggggttgtac tgcacaccac ccaacccttt
     5341 ccagcaagat gaccatttta gtgatatctc tagcatagag tctcccttta ggacccccag
     5401 tagactgagt gacgggctgg tgccttccca gggaaacata gagcatccaa caggtggacc
     5461 tccagtggta accgcagagg acacttcttt agaagacagc aaaatggacg attctgtaac
     5521 tgtaacagac ccggccgacc cactggacgt agatgagagc cagttgaagg acctgtgtca
     5581 gagcgagtgt gctcagtgct gggcgagtgt gcccgggatc ccaaacgacg gtcggcaggc
     5641 agagccactg agaccgcaga ctagaaaagt aggcatgagc tctgaacagc aggaaaaagg
     5701 aaaatctggt cctgatgagg aagtgacaga agacaaggtc aaatctctgt ttgaggacat
     5761 tcaacttgaa gaagtagagg ctgaggagat gacagaagac caggggcagg ctatgcttaa
     5821 ccgtgttcag cgagcagaac tggcaatgtc ttcacttgca ggttggcaga acgagacgcc
     5881 aagtggaagc ctagagtccc cagcgcaagc tcgaagacta actggtgggt tactggaccg
     5941 tctggatgac agctctgacc aggctcggga ttctattacc tcatacctca cgggagaacc
     6001 tgggaagatc gaagcaaatg gaaaccacac agcggaagtc attccagaag caaaggcaaa
     6061 accctacttc ccggaatccc aaaacgatat agggaaacag agcatcaagg agaacctgaa
     6121 accaaaaaca cacggatgtg gtcgcactga ggaaccagtg tcgcccctca cagcctacca
     6181 gaaatctctg gaagaaacca gcaagcttgt catagaagac gcacctaaac cctgtgtgcc
     6241 tgtcggcatg aaaaagatga ccaggactac ggctgacggc aaagccaggc tcaacctcca
     6301 ggaagaagag gggtccacca ggtcagagcc taagcaggga gaaggctata aggtgaagac
     6361 gaagaaggaa atccggaacg tggagaagaa aacccactag tgacagtgac gtcagtccag
     6421 gaccacttgg tcatactgcc agtattgaga aactcaccag agatcagcag gaagaaaaat
     6481 agtcaccaag agtggagtgt gggtcagctg cttccaccac acgtcagtga cacgattttt
     6541 tttttgtaaa cgcagaagga aaacgaaaat cacatttttt ctttcattta gcatgagccg
     6601 atctacaaag catggaaact cacattcatt cccggcactg aaatgcacac tgagcaagtg
     6661 cagtgtacga cacaggaagc catgttcttc agacccggtc tcaagtaatt tagtgtcatt
     6721 ttcaaagaag acagacaaaa caacacctgt gccacccagg aggaggggca gcagaggacg
     6781 gaatgatcaa atcaagaaga cacactaaaa ttactaaatt cacaacagct cgccttattt
     6841 ttctcggacc caaactaact gtcagggtat aaacactgtt cctttctttc tttctttctt
     6901 tctttctttt tttttttaaa gaaaaataat aataataata atgaaaaaaa tcaatagttt
     6961 tgctgtaaat aataacactg taaattctaa cagaagaaac tacaataaag aattataagg
     7021 cacccgcctc acagaacaca aagatatcac aaatgcatcc aaggacaggc gtcccaagtg
     7081 acttcaccct ggacaaggat ggggatccag cgctctcggg actctttcac tgactcttgt
     7141 atattagcaa ttatgtttgt acacgcaaaa ctgctagctt gattttaaaa gaaaaaaaat
     7201 gcaaatcttt aaaaaggaaa aaaaaaaaaa aacctgctgc aaatttaaat aattccccaa
     7261 acgaggaatt ctgtagttct gtgaaaaaaa attttttttt cttcagaata ttaatatttt
     7321 gatgcatgca tatcacctta ttttgattaa atcttttcca attttgcaaa cactacagtc
     7381 tcctgcaaca tgggagattt tatctgtaaa cacaaagccc ttcatctaat atttattgct
     7441 attgccaatt tttcaatgaa atgaccaaaa atggaaaaaa aaataactat acagtagttt
     7501 gcttgggggt ggggggaggg gcgctgttag tgcttacagg ggggaaatgc ttgccactgt
     7561 agaagtggat ggtgctcaca agaggcccca gtcgtgggta tttaaaaaaa tggactgacc
     7621 ggaaatccgt atctagcagg atcgaagcgc actgtaaaaa aaaaaaaaaa gacaaaaaaa
     7681 aaaaaaaaaa agatcgctgt attgtgtact ggctctgaga tgtagacccc tttcagcaag
     7741 ccaatcacta gtaaccatcc cagcagtgcc cccattaggt tagcggggct gccgcgtttt
     7801 atagagcatt tttctttggg tttggtgagg ttccttcatt cactatctta acttgaaatc
     7861 gacctccacg gacacctagc tctaaatgac atgtatgaga aaagcagacg ccggataagc
     7921 tagtcgatta tttaagcata taaaataaac tgtgttcaac tcttcaccta cttgggttcc
     7981 acagtgttct tgtatcctct ggcaaaacct agctgtctaa tccccagtca caggggccct
     8041 gtctgtgcct ccagtcacta aagccatact ctggaacgtt ctgctctctc ccgaaaacac
     8101 ccaccttgca taaactctgt gcactttgtg ggggagctaa gaatttaaag atgaagtaat
     8161 cttcgtctat ttaggctctt ctgccccata gaagaagatg ggatttataa ggccagtgtg
     8221 tcaagaagtt atgctgttcc cagggagcat ctatctgtgg ttgatttttt tttttttttt
     8281 taccccccag gaagcattgg tttaggtttt gtgtcattag tttgcgggct tggagatttt
     8341 gtcatcactg ttcttgagac aaggtctcaa aatgtctgct tagtttctta actgatatgt
     8401 tgtcagagct tacagattga gaaattttgc taataactcg agattttttt attttaccag
     8461 tttattttgg tactggtcat catgcatgct aaaagatgtg aactaccact aagcagcacc
     8521 ctcggccttc cctggatatt tctgagacgg cctcactagc tggtccaagc tggccttgac
     8581 tttccgaggc ttctgccctg tttacttaag agggctgcgc caccagactg aacaggggtt
     8641 ctcttgtgaa gcaacctccg gcaacagcag accgcccact ccaaaagacg ttgtaggtgt
     8701 gacccctact ctctccagct acatttgtga tccccgtcat cctagcctta tttcctacct
     8761 aaccctgaga ggcacttgga gtttggggcc cactgatttc ataactcaaa gagttcaaag
     8821 atctcatgcc tttgattcaa cttttacccc ggcccacagc caggcatggc acattagggg
     8881 tggtatctct caccatccta aacttcaagt ccacactata acatttttct tctaaataca
     8941 ttccattcat tgactcggtc cttaccacca ctgtgtgagt tagatactat ctttgatgta
     9001 acaggcccca tatagtatta atgaatgctt aatgtcattc aaggctgtta ttgcctgtcc
     9061 tatgggatga atattctcca gaattccagc cagaagacaa gtaccagaga gcctatttgg
     9121 tctagagaag ccgctttcaa taaacaaaga ggcagagagt acatttgcat gtcatttgca
     9181 tgatgtctgt gtctacaccc ccaacccctg ccaatcagaa acatctaaac gacaagctgc
     9241 cacacctgaa agttttttta aaagtcccca aagcttctac ataactaata acagaatata
     9301 agaatgttaa catctcattt aagagctatg aattccagac cctctggcgt tgctagagat
     9361 tattcagatt tagaaactta atggggttat gttacatgcc tggaaatgtg acttcaggaa
     9421 caggttgaga ggttcagatg acaccaaagc catgagttga cccagaagtc tctgaagtac
     9481 gatagatttt atttacgcct ctaacttctg tatatactgc accgaaatgg gacataatgt
     9541 ttgtatttcc ctgtcagctc acttaaatgt attaagattt ttctttgaca tttttgtaaa
     9601 gagagagaga gagagagaaa gaaagaaaga actgtgactg ataaaatcct gagatttgcc
     9661 acttctcctt tatacatttt tacccatttg ttaacatgaa agggttgttt ctagaaggga
     9721 ctctcttcac tggccactca agcaacagag ctggctctct cacactggta tcccagcatc
     9781 ccaccatgtt cttcttagcc gtcaccttgg ggctccatac aatggaagtt tctctccatg
     9841 gttaataaac gtcgatggaa aagtggtttg cttgactttc ttcaaagcct cccgctcaca
     9901 tttgaccgtg aggagcccag aaagaagcca caggaacagc aactatagaa cttcgtgcct
     9961 catccagggg catctgggta tttgttggcc aggcaactgg catattaaaa ggtgtatcat
    10021 ttcct
//
