LOCUS       NM_001277281            7980 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ankyrin 1, erythroid (Ank1), transcript variant 4,
            mRNA.
ACCESSION   NM_001277281
VERSION     NM_001277281.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7980)
  AUTHORS   Argall,A.D., Sucharski-Argall,H.C., Comisford,L.G., Jurs,S.J.,
            Seminetta,J.T., Wallace,M.J., Crawford,C.A., Takenaka,S.S., Han,M.,
            El Refaey,M., Hund,T.J., Mohler,P.J. and Koenig,S.N.
  TITLE     Novel Identification of Ankyrin-R in Cardiac Fibroblasts and a
            Potential Role in Heart Failure
  JOURNAL   Int J Mol Sci 25 (15), 8403 (2024)
   PUBMED   39125973
  REMARK    GeneRIF: Novel Identification of Ankyrin-R in Cardiac Fibroblasts
            and a Potential Role in Heart Failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7980)
  AUTHORS   Stevens,S.R., van der Heijden,M.E., Ogawa,Y., Lin,T., Sillitoe,R.V.
            and Rasband,M.N.
  TITLE     Ankyrin-R Links Kv3.3 to the Spectrin Cytoskeleton and Is Required
            for Purkinje Neuron Survival
  JOURNAL   J Neurosci 42 (1), 2-15 (2022)
   PUBMED   34785580
REFERENCE   3  (bases 1 to 7980)
  AUTHORS   Zhang,C., Joshi,A., Liu,Y., Sert,O., Haddix,S.G., Teliska,L.H.,
            Rasband,A., Rodney,G.G. and Rasband,M.N.
  TITLE     Ankyrin-dependent Na+ channel clustering prevents neuromuscular
            synapse fatigue
  JOURNAL   Curr Biol 31 (17), 3810-3819 (2021)
   PUBMED   34289389
REFERENCE   4  (bases 1 to 7980)
  AUTHORS   Stevens,S.R., Longley,C.M., Ogawa,Y., Teliska,L.H.,
            Arumanayagam,A.S., Nair,S., Oses-Prieto,J.A., Burlingame,A.L.,
            Cykowski,M.D., Xue,M. and Rasband,M.N.
  TITLE     Ankyrin-R regulates fast-spiking interneuron excitability through
            perineuronal nets and Kv3.1b K+ channels
  JOURNAL   Elife 10, e66491 (2021)
   PUBMED   34180393
  REMARK    GeneRIF: Ankyrin-R regulates fast-spiking interneuron excitability
            through perineuronal nets and Kv3.1b K(+) channels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7980)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7980)
  AUTHORS   Peters,L.L., Birkenmeier,C.S. and Barker,J.E.
  TITLE     Fetal compensation of the hemolytic anemia in mice homozygous for
            the normoblastosis (nb) mutation
  JOURNAL   Blood 80 (8), 2122-2127 (1992)
   PUBMED   1391963
REFERENCE   7  (bases 1 to 7980)
  AUTHORS   Peters,L.L., White,R.A., Birkenmeier,C.S., Bloom,M.L., Lux,S.E. and
            Barker,J.E.
  TITLE     Changing patterns in cytoskeletal mRNA expression and protein
            synthesis during murine erythropoiesis in vivo
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5749-5753 (1992)
   PUBMED   1385865
REFERENCE   8  (bases 1 to 7980)
  AUTHORS   Iolascon,A., Miraglia del Giudice,E. and Camaschella,C.
  TITLE     Molecular pathology of inherited erythrocyte membrane disorders:
            hereditary spherocytosis and elliptocytosis
  JOURNAL   Haematologica 77 (1), 60-72 (1992)
   PUBMED   1356891
  REMARK    Review article
REFERENCE   9  (bases 1 to 7980)
  AUTHORS   White,R.A., Birkenmeier,C.S., Peters,L.L., Barker,J.E. and Lux,S.E.
  TITLE     Murine erythrocyte ankyrin cDNA: highly conserved regions of the
            regulatory domain
  JOURNAL   Mamm Genome 3 (5), 281-285 (1992)
   PUBMED   1386265
REFERENCE   10 (bases 1 to 7980)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ101195.1, M84756.1, AC126445.5, AK147483.1 and AI846810.1.
            
            On Aug 10, 2013 this sequence version replaced NM_001277281.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            represents use of an alternate promoter, initiates translation at
            an alternate start codon, and lacks an alternate in-frame exon
            compared to variant 1. The encoded isoform (4) has a shorter and
            distinct N-terminus and lacks an alternate internal segment
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849388,
                              SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               CJ101195.1         2-435
            435-2164            M84756.1           412-2141
            2165-2165           AC126445.5         87804-87804         c
            2166-2567           M84756.1           2143-2544
            2568-2568           AC126445.5         84166-84166         c
            2569-4752           M84756.1           2546-4729
            4753-4753           AC126445.5         61690-61690         c
            4754-6257           M84756.1           4731-6234
            6258-7963           AK147483.1         6660-8365
            7964-7980           AI846810.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..7980
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..7980
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="ankyrin 1, erythroid"
                     /db_xref="GeneID:11733"
                     /db_xref="MGI:MGI:88024"
     exon            1..147
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..5721
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="isoform 4 is encoded by transcript variant 4;
                     ankyrin-1; erythrocyte ankyrin; normoblastic anemia"
                     /codon_start=1
                     /product="ankyrin-1 isoform 4"
                     /protein_id="NP_001264210.1"
                     /db_xref="CCDS:CCDS72100.1"
                     /db_xref="GeneID:11733"
                     /db_xref="MGI:MGI:88024"
                     /translation="MGFCKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG
                     LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA
                     QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI
                     NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA
                     QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAA
                     RNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDH
                     LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGAS
                     IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK
                     YLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAR
                     EGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGL
                     TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSA
                     NAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVPVADV
                     LIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ
                     GHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKH
                     RMSYPETVDEILDVSEDEGDELVGSKAERRDSRDVGEEKELLDFVPKLDQVVESPAIP
                     RIPCVTPETVVIRSEDQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFM
                     VDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLNTPPPLAEEEGLASRII
                     ALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHKSRYGESYLDQILN
                     GMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLRSKLVPLVQ
                     ATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIP
                     LPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYANECANFTTNVS
                     ARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDAREGRLRCYCMTDDKV
                     DKTLEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLA
                     IPVKVRDSSREPGGFLSFLRKTMKYEDTQHILCHLNITMPPCTKGSGAEDRRRTLTPL
                     TLRYSILSESRLGFTSDTDRVEMRMAVIREHLGLSWAELARELQFSVEDINRIRVENP
                     NSLLDQSTALLTLWVDREGENAKMENLYTALRNIDRSEIVNMLEGSGRQSRNLKPERR
                     HGDREYSLSPSQVNGYSSLQDELLSPASLQYALPSPLCADQYWNEVAVIDAIPLAATE
                     HDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDAIPEWKLEGAHSEDTQGPEL
                     GSQDLVEDDTVDSDATNGLADLLGQEEGQRSEKKRQEVSGTEQDTETEVSLVSGQQRV
                     HARITDSPSVRQVLDRSQARTLDWDKQGSTAVHPQEATQSSWQEEVTQGPHSFQRRIT
                     TIQGPEPGALQEYEQVLVSTREHVQRGPPETGSPKAGKEPSLWAPESAFSQEVQGDEL
                     QNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQVDSSGAIDTQQHEEVELRGSGLQPDL
                     IEGRKGAQIVKRASLKRGKQ"
     exon            148..249
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            250..348
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            349..447
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            448..546
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            547..732
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            733..831
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            832..930
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1029
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1227
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1326
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1425
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1524
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1722
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1821
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1920
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2118
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2217
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2316
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2415
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2508
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2581
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2678
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2757
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2855
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..3080
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3235
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3447
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3652
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3749
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3978
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4104
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4224
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4303
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4304..4378
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4510
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4657
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4658..5195
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5196..5472
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5473..5556
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5557..5622
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5623..5747
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5748..7964
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6395..6400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="hexamer: GATAAA"
     polyA_site      6421
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
     regulatory      6728..6733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="hexamer: AATAAA"
     polyA_site      6748
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="major polyA site"
     regulatory      7942..7947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="hexamer: AATAAA"
     polyA_site      7964
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
ORIGIN      
        1 aaggcctttt ctggttgcag ggtagcagtg gcaagtcccc tagggagaga ctgttcccgc
       61 tgctctgaca gctctccctc tctcccgccc tccagccctc cggccggcag ggtcctggtc
      121 ccgagcaaca agatgggctt ctgtaaagcc gatgctgcta ccagctttct gcgggcggca
      181 cgctcgggga acctggacaa ggctctggat cacctgcgca atggagtgga cattaacacc
      241 tgtaaccaga acgggttgaa cggcctgcat ctggcctcca aagaaggcca tgtgaagatg
      301 gtggttgaac ttctgcacaa agagatcatt ctagaaacga caaccaagaa ggggaacact
      361 gctctgcaca tcgctgccct tgctggtcag gatgaggtgg tccgggagct ggtcaactat
      421 ggagccaatg tcaatgccca gtctcagaaa ggctttactc ccctgtacat ggctgctcag
      481 gagaaccact tggaagtggt gaaatttcta ctggagaatg gagccaatca gaatgtagcc
      541 acagaagatg gcttcacccc actggccgtg gctctacagc agggtcacga gaatgtggtg
      601 gctcacctca tcaactatgg gacgaaaggg aaagtgcgcc tccctgccct gcacatcgcg
      661 gcccgcaacg atgacacacg gacagccgca gtccttctgc agaatgaccc caacccagat
      721 gtgctttcca agacgggatt cacacccctc cacatcgcag ctcactatga gaacctcaac
      781 gtggcccagt tgctcctcaa caggggagcc agcgtcaact tcacacctca gaatggcatc
      841 accccactac acatcgcctc ccgcaggggg aacgtgatca tggtgagact cctgctggac
      901 cgaggggctc agatagaaac gaggaccaag gatgaattga caccgctcca ctgtgcagct
      961 cggaatggac acgtgagaat ctcagagatc ctgctggacc acggggcacc catccaagcc
     1021 aaaaccaaga atggcttgtc cccaatccac atggccgctc agggagacca cctcgactgt
     1081 gtccgacttc tattgcaata caatgcagag atagacgaca tcaccttgga tcacctgact
     1141 cctctccatg tggcagccca ctgtggccac caccgggtgg ctaaggttct tttggataaa
     1201 ggggccaagc ccaactccag agccctgaat ggttttaccc cgttacacat cgcctgcaag
     1261 aagaaccaca tccgtgtaat ggagttgctg ctgaagacag gagcctccat cgacgcggtc
     1321 actgagtctg gcctgacacc tctccacgta gcctccttca tgggacacct tcctattgtg
     1381 aagaacttac tgcagcgggg agcgtcaccc aatgtctcca atgtgaaagt agaaaccccc
     1441 ttgcacatgg cagcccgagc agggcataca gaagtggcca aatatttgct ccagaacaaa
     1501 gccaaagcca acgccaaggc caaggatgac cagacaccgc ttcactgtgc tgctcgaatc
     1561 ggccacacag gcatggtgaa gctcctgctg gagaatggtg ccagccccaa tctggctacc
     1621 actgctggcc acacacccct acacaccgca gcccgtgagg gacacgtgga cacagccctg
     1681 gccctgctgg agaaggaggc atcccaagcc tgcatgacca agaaaggatt tacccctctg
     1741 cacgtggctg ctaagtacgg gaaggtacgg ttggcggagc tgctgctgga acacgatgca
     1801 caccccaatg cagctgggaa gaacggcttg actcctctgc atgtggccgt ccatcacaac
     1861 aacctggaca ttgtcaaact tcttcttccc cgaggtggct ccccccacag ccctgcctgg
     1921 aatggctaca ctcctttgca catcgctgcc aagcagaacc agatagaggt ggcccgcagt
     1981 ctactgcagt acggagggtc agcgaatgca gagtcggtac aaggcgtgac cccacttcac
     2041 ctggctgccc aagagggcca cacagaaatg gttgctcttc tcctgtccaa gcaagccaac
     2101 ggcaacctgg ggaacaagag tggactcact cccctccacc tggtgtcaca agaaggccat
     2161 gttccagtgg cagacgtgct gatcaaacat ggcgtcaccg tggatgctac cacccggatg
     2221 ggttacaccc cgctccatgt ggccagtcat tatggaaaca tcaagctggt gaagttcttg
     2281 ctacagcacc aggcagatgt caatgccaag accaagctag gatacagccc cttgcaccag
     2341 gcagctcaac aaggacacac agacattgtg acattgctcc tgaagaatgg tgcttctcca
     2401 aatgaggtca gctcgaacgg aaccacacct ctggcaatag ccaaacgttt gggctacatc
     2461 tctgtaacag acgtgctcaa ggtggtcaca gatgaaacca gtgtggtgtt agtcagtgac
     2521 aaacaccgga tgagctaccc tgagacggtg gacgagatcc tggacgtgtc tgaagatgaa
     2581 ggtgacgaac ttgtcggctc gaaggctgaa aggcgggact cccgggatgt gggtgaggag
     2641 aaagagctgt tggattttgt gccgaagcta gaccaagtgg tggagtctcc agccatccca
     2701 aggatccctt gtgtcacacc tgagaccgtt gtgatccgat ctgaagatca ggaacaagca
     2761 tctaaagaat atgatgagga ttccctcatt cccagcagcc cggccacaga gacctcagac
     2821 aacattagcc ctgtggctag cccggtccac acagggttcc tggtgagctt catggtggat
     2881 gcccgagggg gatccatgag aggaagccgt cataatggcc tcagggtggt gatccctccc
     2941 cggacatgcg cagcacccac tcgcatcacc tgccgcctcg ttaagccgca gaagctgaac
     3001 acgccacccc cactggctga ggaagagggc ctagccagca ggatcattgc cctgggaccc
     3061 acgggggccc agttccttag ccctgtgatc gtggaaatcc cccattttgc ctcccatggc
     3121 cgtggggacc gtgagctggt ggttctgagg agtgaaaacg gctctgtgtg gaaggagcac
     3181 aagagtcgtt atggggaaag ctacctggac cagatcctta atggcatgga tgaagagctg
     3241 gggagcctgg aggagctgga gaagaaacgt gtgtgccgca tcatcaccac cgacttccct
     3301 ctgtactttg tcatcatgtc ccggctctgc caggactacg acaccatcgg tcctgaaggg
     3361 ggttccctga gaagcaagct ggtaccgctg gtacaggcaa cgttccctga aaacgctgtg
     3421 accaagaaag tgaagctggc tctgcaggcc cagcctgtcc cggatgagct ggtgaccaag
     3481 ctcctgggta accaggccac attcagcccc attgtgaccg tggagccgag gcgtcggaag
     3541 ttccaccgtc ccatcgggct gcgaatcccg ctccctccct catggacgga caaccccagg
     3601 gacagtgggg agggagacac caccagcctg cgcctactgt gtagcgtcat cggtggaact
     3661 gaccaagccc agtgggaaga tataacggga acaaccaaac ttatatacgc caatgagtgt
     3721 gccaacttta ccaccaatgt ctcagccagg ttctggctgt cagactgtcc ccggactgcg
     3781 gaggctgtgc actttgccac tctcctgtac aaagagctca cagcagtccc ctacatggct
     3841 aagtttgtca tttttgccaa gatgaacgac gctcgggaag gacggctccg ttgctactgc
     3901 atgacggatg acaaagtgga caagaccctg gagcagcatg aaaacttcgt ggaggtggcc
     3961 cggagcaggg acatagaggt tctggaaggg atgcctctgt ttgcagaact ctctgggaac
     4021 ttggttcctg tcaagaaagc ggcccaacag cggagcttcc atttccagtc gtttcgagag
     4081 aatcgtctgg ccatccccgt gaaggtgagg gacagcagcc gcgagccagg agggttcttg
     4141 tcgttcctac gaaagacaat gaagtacgag gacacacagc acatcctctg tcacctgaat
     4201 atcaccatgc ccccctgcac caagggcagt ggagcagaag acaggagaag gaccctgaca
     4261 cccctgaccc ttcgatacag cattctcagc gagtcgcggc tgggttttac cagtgacaca
     4321 gaccgtgtcg aaatgaggat ggctgtcatc agagaacacc tcggcctaag ctgggcagag
     4381 ctggcccggg agctgcagtt cagcgtggaa gacatcaacc ggatccgtgt agaaaaccct
     4441 aactccttgt tggaccagag tacagccttg ctgaccctct gggtggaccg tgaaggcgaa
     4501 aatgcaaaga tggagaattt gtacacagcc ctgcggaaca tcgacaggag tgagattgtt
     4561 aacatgttgg agggctccgg caggcagagc agaaacctca aaccagagcg gagacatggg
     4621 gaccgggagt actcattgtc accctcccag gtgaatggtt actcctcgct gcaggacgag
     4681 ctgctgtccc ccgcctccct gcagtacgct ctcccctctc cactgtgtgc agaccagtac
     4741 tggaacgaag tggccgtcat agacgccatc cccctggcgg ctacagagca tgacaccatg
     4801 ctggagatgt ctgacatgca ggtgtggtct gcgggcctca caccctccct ggtcactgct
     4861 gaggactcct ctctggagtg cagcaaggct gaggactctg acgccatacc agagtggaag
     4921 ttggaagggg cacactcaga ggacacgcag ggcccggagc tgggctctca ggacctggtg
     4981 gaggacgaca cagtggattc agatgccaca aatggcctgg cagatttgct aggtcaggag
     5041 gaaggtcaga ggtcagaaaa gaagaggcag gaagtctcag gcacagagca ggacacggag
     5101 actgaagtgt ctcttgtttc aggccagcag cgagttcacg cccgaatcac agactcaccc
     5161 tcagtgaggc aggtgctgga cagaagccag gccagaacac tggactggga taaacagggt
     5221 tccacagcgg tacacccgca agaagccaca cagagctcct ggcaagagga ggtcacgcag
     5281 ggcccacact cattccagag aaggatcacc accatccaag ggccggagcc tggtgcgctt
     5341 caggaatacg agcaggtgct ggtgtctacc agggagcatg tgcagagggg gccacctgag
     5401 accggcagcc ccaaagctgg caaggaacct agcctgtggg cacctgagag cgccttctct
     5461 caagaggtgc agggggatga gcttcagaat attccaggag agcaggtgac ggaggaacaa
     5521 ttcacagatg aacagggcaa cattgttacc aagaagatca ttcgcaaagt cgtccggcag
     5581 gtagactcgt ctggtgccat cgacacccag cagcacgagg aggtggagct aagagggagt
     5641 ggactccagc cggacctgat agagggcagg aagggggctc agatagtgaa gcgggccagc
     5701 ctgaaaaggg gcaagcagtg acctctcctc aagtagcccc ttgggaggat cacacctcaa
     5761 cacccaaacc ctgaactcca cacactctgt catgcacacg ggaagagacc tggaccagag
     5821 ggctactgaa gggtcgcacg tgttctgagc tccccggcat gacctctgta aggagtttcc
     5881 tttagtctcc tattcgcatg aatgactggc tgtagacgca tgacctacag tcttcagtcc
     5941 tgcctctagc gactatggat ctctgtggga atcaggacaa aggcctcgag agaagggaga
     6001 gaagaaggga gaggatagca agccccaaag agcacacggg tgcagacacg aataataagg
     6061 gctttactgt ggccgggatg gttgatctgt ttgtttgctt tttgttttga ttttttgact
     6121 tcaacctcat ttgtaagaaa tacacataat ctttctggac cgaggaaacc gggaacggcg
     6181 tgaaatcagt ttagcccatt gtcctacatc ctcgttgtac ctgcacacgc cacatgccac
     6241 ttgtaacacc ccaccccacc ccaccccacc ctacccccca gcccccatga agggactgct
     6301 cttctcagaa tgacatgaca caggtgcaca tgcgcaggcc tccccttcac tcagtctaca
     6361 ctggttttac tgtgaccttt gacgacgctg tatggataaa ctggatttat tatttttttt
     6421 atgttgtctc tcagtttcag tattactcat cttccagtgg gaaatcatca ccttgagagt
     6481 gcattcgggg ttccttgtgt tagaaattta agatctgagg caaggacccc ctaggctttg
     6541 ctgtagggct cagagggagc cagggtccca tctcaaagtt ctcggctggg gaagggcctg
     6601 tggctgtccg aggattgcac cagcatgttc aatagaggaa gaggttttct aaatcgtcac
     6661 gtacttctat aatagtctgt gttcaaagtg taaactgtac agtaatcagc cttgtgtata
     6721 tgaaaacaat aaatactatg caaaccaata gaaacacgtt agcagtatgt acaaagccct
     6781 aaagagctca gctcctgagg acttctccag gctgtgggag gagctaaagg ctgtctttca
     6841 ccgaaagagg aagggagtag ggctgtgaat gtacctgcca gttcctaggt cagaccatcc
     6901 tgaggtcttc cagagccaac ttggtgcttg aagtgcaggt ggccgcaggc tggaggtcct
     6961 ggcacagaca actgggctcg ggctggtcgg ccaagtgcct ggctctgacc acgggcccag
     7021 cgcaaggaga gccggagcag gatggagctg ctgaccagga ggctgaggag agaccctctt
     7081 ctatctagac tcagggccag gccaggaagg ggaccctcaa ctggctggtc ttgccttgga
     7141 gccctcaggg aagagcctta acgtcacact agagtctcct gcagagggag gcccgaatca
     7201 gcacaatccg gctccgccat gcccgggcgg cgccccctag ggccaggaga gagactggca
     7261 ggctcttctc gctctcccag agccactggt ggacggcggt caccttcctc gcctgccgct
     7321 cctcggggtg tcgtcgggac acaataaaaa ccttccaagt agcacagacg ccccttcatg
     7381 cccgtacccc cacgccctgg aggccctccc ggggactcca gcccgcgcgc gctctagccc
     7441 cgggccagtg cgcgggttgg gggatgctgt ggtccacggg cgcggctagc tttcctgggg
     7501 gtagggagga ggggcggcgg ccccgggagg gcgggcgagc acgggcgcgg ggtcgccccg
     7561 cctcgccccg caccctccgc ccagtagcgg ctcttagcgc cctgcgcggc ccgactccgc
     7621 tttggcaccc tccgctcggt ctggcttggc tgcttggcac gccgcccccc cgccctcggc
     7681 ggcatggctg cgcgctcccg ttgctagtag gagctgtttt aggaggagtt tggggtctcc
     7741 acttgatgcc tagagaatgc tgcagtctgc accttagacg ctttttagaa gttttgaaat
     7801 gaccttgatt tttttaattg ttatgaaaaa aaatgaacta tgtcttggct ctctcacatg
     7861 ctctgttact gagagagacc agcccaccct actctgatgt atagaccatt ctccctacac
     7921 cagctaaaca aatgtcaaat taataaagaa acggactcat ggcaaaaaaa aaaaaaaaaa
//
