LOCUS       NM_001110783            8283 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ankyrin 1, erythroid (Ank1), transcript variant 1,
            mRNA.
ACCESSION   NM_001110783
VERSION     NM_001110783.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8283)
  AUTHORS   Argall,A.D., Sucharski-Argall,H.C., Comisford,L.G., Jurs,S.J.,
            Seminetta,J.T., Wallace,M.J., Crawford,C.A., Takenaka,S.S., Han,M.,
            El Refaey,M., Hund,T.J., Mohler,P.J. and Koenig,S.N.
  TITLE     Novel Identification of Ankyrin-R in Cardiac Fibroblasts and a
            Potential Role in Heart Failure
  JOURNAL   Int J Mol Sci 25 (15), 8403 (2024)
   PUBMED   39125973
  REMARK    GeneRIF: Novel Identification of Ankyrin-R in Cardiac Fibroblasts
            and a Potential Role in Heart Failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8283)
  AUTHORS   Stevens,S.R., van der Heijden,M.E., Ogawa,Y., Lin,T., Sillitoe,R.V.
            and Rasband,M.N.
  TITLE     Ankyrin-R Links Kv3.3 to the Spectrin Cytoskeleton and Is Required
            for Purkinje Neuron Survival
  JOURNAL   J Neurosci 42 (1), 2-15 (2022)
   PUBMED   34785580
REFERENCE   3  (bases 1 to 8283)
  AUTHORS   Zhang,C., Joshi,A., Liu,Y., Sert,O., Haddix,S.G., Teliska,L.H.,
            Rasband,A., Rodney,G.G. and Rasband,M.N.
  TITLE     Ankyrin-dependent Na+ channel clustering prevents neuromuscular
            synapse fatigue
  JOURNAL   Curr Biol 31 (17), 3810-3819 (2021)
   PUBMED   34289389
REFERENCE   4  (bases 1 to 8283)
  AUTHORS   Stevens,S.R., Longley,C.M., Ogawa,Y., Teliska,L.H.,
            Arumanayagam,A.S., Nair,S., Oses-Prieto,J.A., Burlingame,A.L.,
            Cykowski,M.D., Xue,M. and Rasband,M.N.
  TITLE     Ankyrin-R regulates fast-spiking interneuron excitability through
            perineuronal nets and Kv3.1b K+ channels
  JOURNAL   Elife 10, e66491 (2021)
   PUBMED   34180393
  REMARK    GeneRIF: Ankyrin-R regulates fast-spiking interneuron excitability
            through perineuronal nets and Kv3.1b K(+) channels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8283)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8283)
  AUTHORS   Peters,L.L., Birkenmeier,C.S. and Barker,J.E.
  TITLE     Fetal compensation of the hemolytic anemia in mice homozygous for
            the normoblastosis (nb) mutation
  JOURNAL   Blood 80 (8), 2122-2127 (1992)
   PUBMED   1391963
REFERENCE   7  (bases 1 to 8283)
  AUTHORS   Peters,L.L., White,R.A., Birkenmeier,C.S., Bloom,M.L., Lux,S.E. and
            Barker,J.E.
  TITLE     Changing patterns in cytoskeletal mRNA expression and protein
            synthesis during murine erythropoiesis in vivo
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5749-5753 (1992)
   PUBMED   1385865
REFERENCE   8  (bases 1 to 8283)
  AUTHORS   Iolascon,A., Miraglia del Giudice,E. and Camaschella,C.
  TITLE     Molecular pathology of inherited erythrocyte membrane disorders:
            hereditary spherocytosis and elliptocytosis
  JOURNAL   Haematologica 77 (1), 60-72 (1992)
   PUBMED   1356891
  REMARK    Review article
REFERENCE   9  (bases 1 to 8283)
  AUTHORS   White,R.A., Birkenmeier,C.S., Peters,L.L., Barker,J.E. and Lux,S.E.
  TITLE     Murine erythrocyte ankyrin cDNA: highly conserved regions of the
            regulatory domain
  JOURNAL   Mamm Genome 3 (5), 281-285 (1992)
   PUBMED   1386265
REFERENCE   10 (bases 1 to 8283)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ105945.1, AK158131.1, AK147278.1, AK147483.1 and AI846810.1.
            
            On Aug 10, 2013 this sequence version replaced NM_001110783.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CJ105945.1         1-8
            9-46                AK158131.1         2-39
            47-6657             AK147278.1         2-6612
            6658-8266           AK147483.1         6757-8365
            8267-8283           AI846810.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..8283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..8283
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="ankyrin 1, erythroid"
                     /db_xref="GeneID:11733"
                     /db_xref="MGI:MGI:88024"
     exon            1..426
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..6024
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin-1; erythrocyte ankyrin; normoblastic anemia"
                     /codon_start=1
                     /product="ankyrin-1 isoform 1"
                     /protein_id="NP_001104253.1"
                     /db_xref="CCDS:CCDS52523.1"
                     /db_xref="GeneID:11733"
                     /db_xref="MGI:MGI:88024"
                     /translation="MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKAD
                     AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI
                     ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV
                     KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD
                     TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL
                     HIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAK
                     TKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD
                     KGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHL
                     PIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLH
                     CAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACMT
                     KKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR
                     GGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTE
                     MVALLLSKQANGNLGNKSGLTPLHLVSQEGHVPVADVLIKHGVTVDATTRMGYTPLHV
                     ASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSS
                     NGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKHRMSYPETVDEILDVSEDEGTA
                     HISIMGDELVGSKAERRDSRDVGEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIR
                     SEDQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRH
                     NGLRVVIPPRTCAAPTRITCRLVKPQKLNTPPPLAEEEGLASRIIALGPTGAQFLSPV
                     IVEIPHFASHGRGDRELVVLRSENGSVWKEHKSRYGESYLDQILNGMDEELGSLEELE
                     KKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLRSKLVPLVQATFPENAVTKKVK
                     LALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSG
                     EGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYANECANFTTNVSARFWLSDCPRTAE
                     AVHFATLLYKELTAVPYMAKFVIFAKMNDAREGRLRCYCMTDDKVDKTLEQHENFVEV
                     ARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAIPVKVRDSSREPG
                     GFLSFLRKTMKYEDTQHILCHLNITMPPCTKGSGAEDRRRTLTPLTLRYSILSESRLG
                     FTSDTDRVEMRMAVIREHLGLSWAELARELQFSVEDINRIRVENPNSLLDQSTALLTL
                     WVDREGENAKMENLYTALRNIDRSEIVNMLEGSGRQSRNLKPERRHGDREYSLSPSQV
                     NGYSSLQDELLSPASLQYALPSPLCADQYWNEVAVIDAIPLAATEHDTMLEMSDMQVW
                     SAGLTPSLVTAEDSSLECSKAEDSDAIPEWKLEGAHSEDTQGPELGSQDLVEDDTVDS
                     DATNGLADLLGQEEGQRSEKKRQEVSGTEQDTETEVSLVSGQQRVHARITDSPSVRQV
                     LDRSQARTLDWDKQGSTAVHPQEATQSSWQEEVTQGPHSFQRRITTIQGPEPGALQEY
                     EQVLVSTREHVQRGPPETGSPKAGKEPSLWAPESAFSQEVQGDELQNIPGEQVTEEQF
                     TDEQGNIVTKKIIRKVVRQVDSSGAIDTQQHEEVELRGSGLQPDLIEGRKGAQIVKRA
                     SLKRGKQ"
     exon            427..528
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            529..627
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            628..726
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            727..825
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1011
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1110
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1209
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1308
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1506
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1605
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1704
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1803
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2001
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2100
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2199
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2397
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2496
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2595
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2694
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2787
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2860
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2884
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..2981
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3060
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3158
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3383
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3538
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3750
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3955
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4052
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4281
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4407
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..4527
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4606
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4607..4681
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4682..4813
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..4960
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            4961..5498
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5499..5775
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5776..5859
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5860..5925
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            5926..6050
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     exon            6051..8267
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6698..6703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="hexamer: GATAAA"
     polyA_site      6724
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
     regulatory      7031..7036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="hexamer: AATAAA"
     polyA_site      7051
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="major polyA site"
     regulatory      8245..8250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
                     /note="hexamer: AATAAA"
     polyA_site      8267
                     /gene="Ank1"
                     /gene_synonym="Ank-1; nb; pale"
ORIGIN      
        1 gggcgggcgg gcgggcgcgg cgagggcgcg cggcgagccc agagccggtg cggggcgcgg
       61 gcgagcgagc tccggccgcg gcgggaggcg ccaccccggg gctcggctag ccgcgcgccg
      121 gcctctcctc gccctccgcc ccgcgccccg gcccccgggc gccgcagcct tcgcctccgc
      181 cggggagaag ctcgcgccct gcgcagctga aggagccggc tctccccggg agggtgtcgt
      241 cgccgccggc tcgcagaggg cgcgggcccg ggaggcgggg accgagcgcc gcgacccgcc
      301 atggctcagg cggccaaaca gctgaagaaa atcaaagaca tcgaggcgca ggccctccag
      361 gagcagaagg agaaggagga atccaacagg aagcggcgga accgctcccg tgaccgcaag
      421 aagaaggccg atgctgctac cagctttctg cgggcggcac gctcggggaa cctggacaag
      481 gctctggatc acctgcgcaa tggagtggac attaacacct gtaaccagaa cgggttgaac
      541 ggcctgcatc tggcctccaa agaaggccat gtgaagatgg tggttgaact tctgcacaaa
      601 gagatcattc tagaaacgac aaccaagaag gggaacactg ctctgcacat cgctgccctt
      661 gctggtcagg atgaggtggt ccgggagctg gtcaactatg gagccaatgt caatgcccag
      721 tctcagaaag gctttactcc cctgtacatg gctgctcagg agaaccactt ggaagtggtg
      781 aaatttctac tggagaatgg agccaatcag aatgtagcca cagaagatgg cttcacccca
      841 ctggccgtgg ctctacagca gggtcacgag aatgtggtgg ctcacctcat caactatggg
      901 acgaaaggga aagtgcgcct ccctgccctg cacatcgcgg cccgcaacga tgacacacgg
      961 acagccgcag tccttctgca gaatgacccc aacccagatg tgctttccaa gacgggattc
     1021 acacccctcc acatcgcagc tcactatgag aacctcaacg tggcccagtt gctcctcaac
     1081 aggggagcca gcgtcaactt cacacctcag aatggcatca ccccactaca catcgcctcc
     1141 cgcaggggga acgtgatcat ggtgagactc ctgctggacc gaggggctca gatagaaacg
     1201 aggaccaagg atgaattgac accgctccac tgtgcagctc ggaatggaca cgtgagaatc
     1261 tcagagatcc tgctggacca cggggcaccc atccaagcca aaaccaagaa tggcttgtcc
     1321 ccaatccaca tggccgctca gggagaccac ctcgactgtg tccgacttct attgcaatac
     1381 aatgcagaga tagacgacat caccttggat cacctgactc ctctccatgt ggcagcccac
     1441 tgtggccacc accgggtggc taaggttctt ttggataaag gggccaagcc caactccaga
     1501 gccctgaatg gttttacccc gttacacatc gcctgcaaga agaaccacat ccgtgtaatg
     1561 gagttgctgc tgaagacagg agcctccatc gacgcggtca ctgagtctgg cctgacacct
     1621 ctccacgtag cctccttcat gggacacctt cctattgtga agaacttact gcagcgggga
     1681 gcgtcaccca atgtctccaa tgtgaaagta gaaaccccct tgcacatggc agcccgagca
     1741 gggcatacag aagtggccaa atatttgctc cagaacaaag ccaaagccaa cgccaaggcc
     1801 aaggatgacc agacaccgct tcactgtgct gctcgaatcg gccacacagg catggtgaag
     1861 ctcctgctgg agaatggtgc cagccccaat ctggctacca ctgctggcca cacaccccta
     1921 cacaccgcag cccgtgaggg acacgtggac acagccctgg ccctgctgga gaaggaggca
     1981 tcccaagcct gcatgaccaa gaaaggattt acccctctgc acgtggctgc taagtacggg
     2041 aaggtacggt tggcggagct gctgctggaa cacgatgcac accccaatgc agctgggaag
     2101 aacggcttga ctcctctgca tgtggccgtc catcacaaca acctggacat tgtcaaactt
     2161 cttcttcccc gaggtggctc cccccacagc cctgcctgga atggctacac tcctttgcac
     2221 atcgctgcca agcagaacca gatagaggtg gcccgcagtc tactgcagta cggagggtca
     2281 gcgaatgcag agtcggtaca aggcgtgacc ccacttcacc tggctgccca agagggccac
     2341 acagaaatgg ttgctcttct cctgtccaag caagccaacg gcaacctggg gaacaagagt
     2401 ggactcactc ccctccacct ggtgtcacaa gaaggccatg ttccagtggc agacgtgctg
     2461 atcaaacatg gcgtcaccgt ggatgctacc acccggatgg gttacacccc gctccatgtg
     2521 gccagtcatt atggaaacat caagctggtg aagttcttgc tacagcacca ggcagatgtc
     2581 aatgccaaga ccaagctagg atacagcccc ttgcaccagg cagctcaaca aggacacaca
     2641 gacattgtga cattgctcct gaagaatggt gcttctccaa atgaggtcag ctcgaacgga
     2701 accacacctc tggcaatagc caaacgtttg ggctacatct ctgtaacaga cgtgctcaag
     2761 gtggtcacag atgaaaccag tgtggtgtta gtcagtgaca aacaccggat gagctaccct
     2821 gagacggtgg acgagatcct ggacgtgtct gaagatgaag gaactgctca catatctata
     2881 atgggtgacg aacttgtcgg ctcgaaggct gaaaggcggg actcccggga tgtgggtgag
     2941 gagaaagagc tgttggattt tgtgccgaag ctagaccaag tggtggagtc tccagccatc
     3001 ccaaggatcc cttgtgtcac acctgagacc gttgtgatcc gatctgaaga tcaggaacaa
     3061 gcatctaaag aatatgatga ggattccctc attcccagca gcccggccac agagacctca
     3121 gacaacatta gccctgtggc tagcccggtc cacacagggt tcctggtgag cttcatggtg
     3181 gatgcccgag ggggatccat gagaggaagc cgtcataatg gcctcagggt ggtgatccct
     3241 ccccggacat gcgcagcacc cactcgcatc acctgccgcc tcgttaagcc gcagaagctg
     3301 aacacgccac ccccactggc tgaggaagag ggcctagcca gcaggatcat tgccctggga
     3361 cccacggggg cccagttcct tagccctgtg atcgtggaaa tcccccattt tgcctcccat
     3421 ggccgtgggg accgtgagct ggtggttctg aggagtgaaa acggctctgt gtggaaggag
     3481 cacaagagtc gttatgggga aagctacctg gaccagatcc ttaatggcat ggatgaagag
     3541 ctggggagcc tggaggagct ggagaagaaa cgtgtgtgcc gcatcatcac caccgacttc
     3601 cctctgtact ttgtcatcat gtcccggctc tgccaggact acgacaccat cggtcctgaa
     3661 gggggttccc tgagaagcaa gctggtaccg ctggtacagg caacgttccc tgaaaacgct
     3721 gtgaccaaga aagtgaagct ggctctgcag gcccagcctg tcccggatga gctggtgacc
     3781 aagctcctgg gtaaccaggc cacattcagc cccattgtga ccgtggagcc gaggcgtcgg
     3841 aagttccacc gtcccatcgg gctgcgaatc ccgctccctc cctcatggac ggacaacccc
     3901 agggacagtg gggagggaga caccaccagc ctgcgcctac tgtgtagcgt catcggtgga
     3961 actgaccaag cccagtggga agatataacg ggaacaacca aacttatata cgccaatgag
     4021 tgtgccaact ttaccaccaa tgtctcagcc aggttctggc tgtcagactg tccccggact
     4081 gcggaggctg tgcactttgc cactctcctg tacaaagagc tcacagcagt cccctacatg
     4141 gctaagtttg tcatttttgc caagatgaac gacgctcggg aaggacggct ccgttgctac
     4201 tgcatgacgg atgacaaagt ggacaagacc ctggagcagc atgaaaactt cgtggaggtg
     4261 gcccggagca gggacataga ggttctggaa gggatgcctc tgtttgcaga actctctggg
     4321 aacttggttc ctgtcaagaa agcggcccaa cagcggagct tccatttcca gtcgtttcga
     4381 gagaatcgtc tggccatccc cgtgaaggtg agggacagca gccgcgagcc aggagggttc
     4441 ttgtcgttcc tacgaaagac aatgaagtac gaggacacac agcacatcct ctgtcacctg
     4501 aatatcacca tgcccccctg caccaagggc agtggagcag aagacaggag aaggaccctg
     4561 acacccctga cccttcgata cagcattctc agcgagtcgc ggctgggttt taccagtgac
     4621 acagaccgtg tcgaaatgag gatggctgtc atcagagaac acctcggcct aagctgggca
     4681 gagctggccc gggagctgca gttcagcgtg gaagacatca accggatccg tgtagaaaac
     4741 cctaactcct tgttggacca gagtacagcc ttgctgaccc tctgggtgga ccgtgaaggc
     4801 gaaaatgcaa agatggagaa tttgtacaca gccctgcgga acatcgacag gagtgagatt
     4861 gttaacatgt tggagggctc cggcaggcag agcagaaacc tcaaaccaga gcggagacat
     4921 ggggaccggg agtactcatt gtcaccctcc caggtgaatg gttactcctc gctgcaggac
     4981 gagctgctgt cccccgcctc cctgcagtac gctctcccct ctccactgtg tgcagaccag
     5041 tactggaacg aagtggccgt catagacgcc atccccctgg cggctacaga gcatgacacc
     5101 atgctggaga tgtctgacat gcaggtgtgg tctgcgggcc tcacaccctc cctggtcact
     5161 gctgaggact cctctctgga gtgcagcaag gctgaggact ctgacgccat accagagtgg
     5221 aagttggaag gggcacactc agaggacacg cagggcccgg agctgggctc tcaggacctg
     5281 gtggaggacg acacagtgga ttcagatgcc acaaatggcc tggcagattt gctaggtcag
     5341 gaggaaggtc agaggtcaga aaagaagagg caggaagtct caggcacaga gcaggacacg
     5401 gagactgaag tgtctcttgt ttcaggccag cagcgagttc acgcccgaat cacagactca
     5461 ccctcagtga ggcaggtgct ggacagaagc caggccagaa cactggactg ggataaacag
     5521 ggttccacag cggtacaccc gcaagaagcc acacagagct cctggcaaga ggaggtcacg
     5581 cagggcccac actcattcca gagaaggatc accaccatcc aagggccgga gcctggtgcg
     5641 cttcaggaat acgagcaggt gctggtgtct accagggagc atgtgcagag ggggccacct
     5701 gagaccggca gccccaaagc tggcaaggaa cctagcctgt gggcacctga gagcgccttc
     5761 tctcaagagg tgcaggggga tgagcttcag aatattccag gagagcaggt gacggaggaa
     5821 caattcacag atgaacaggg caacattgtt accaagaaga tcattcgcaa agtcgtccgg
     5881 caggtagact cgtctggtgc catcgacacc cagcagcacg aggaggtgga gctaagaggg
     5941 agtggactcc agccggacct gatagagggc aggaaggggg ctcagatagt gaagcgggcc
     6001 agcctgaaaa ggggcaagca gtgacctctc ctcaagtagc cccttgggag gatcacacct
     6061 caacacccaa accctgaact ccacacactc tgtcatgcac acgggaagag acctggacca
     6121 gagggctact gaagggtcgc acgtgttctg agctccccgg catgacctct gtaaggagtt
     6181 tcctttagtc tcctattcgc atgaatgact ggctgtagac gcatgaccta cagtcttcag
     6241 tcctgcctct agcgactatg gatctctgtg ggaatcagga caaaggcctc gagagaaggg
     6301 agagaagaag ggagaggata gcaagcccca aagagcacac gggtgcagac acgaataata
     6361 agggctttac tgtggccggg atggttgatc tgtttgtttg ctttttgttt tgattttttg
     6421 acttcaacct catttgtaag aaatacacat aatctttctg gaccgaggaa accgggaacg
     6481 gcgtgaaatc agtttagccc attgtcctac atcctcgttg tacctgcaca cgccacatgc
     6541 cacttgtaac accccacccc accccacccc accctacccc ccagccccca tgaagggact
     6601 gctcttctca gaatgacatg acacaggtgc acatgcgcag gcctcccctt cactcagtct
     6661 acactggttt tactgtgacc tttgacgacg ctgtatggat aaactggatt tattattttt
     6721 tttatgttgt ctctcagttt cagtattact catcttccag tgggaaatca tcaccttgag
     6781 agtgcattcg gggttccttg tgttagaaat ttaagatctg aggcaaggac cccctaggct
     6841 ttgctgtagg gctcagaggg agccagggtc ccatctcaaa gttctcggct ggggaagggc
     6901 ctgtggctgt ccgaggattg caccagcatg ttcaatagag gaagaggttt tctaaatcgt
     6961 cacgtacttc tataatagtc tgtgttcaaa gtgtaaactg tacagtaatc agccttgtgt
     7021 atatgaaaac aataaatact atgcaaacca atagaaacac gttagcagta tgtacaaagc
     7081 cctaaagagc tcagctcctg aggacttctc caggctgtgg gaggagctaa aggctgtctt
     7141 tcaccgaaag aggaagggag tagggctgtg aatgtacctg ccagttccta ggtcagacca
     7201 tcctgaggtc ttccagagcc aacttggtgc ttgaagtgca ggtggccgca ggctggaggt
     7261 cctggcacag acaactgggc tcgggctggt cggccaagtg cctggctctg accacgggcc
     7321 cagcgcaagg agagccggag caggatggag ctgctgacca ggaggctgag gagagaccct
     7381 cttctatcta gactcagggc caggccagga aggggaccct caactggctg gtcttgcctt
     7441 ggagccctca gggaagagcc ttaacgtcac actagagtct cctgcagagg gaggcccgaa
     7501 tcagcacaat ccggctccgc catgcccggg cggcgccccc tagggccagg agagagactg
     7561 gcaggctctt ctcgctctcc cagagccact ggtggacggc ggtcaccttc ctcgcctgcc
     7621 gctcctcggg gtgtcgtcgg gacacaataa aaaccttcca agtagcacag acgccccttc
     7681 atgcccgtac ccccacgccc tggaggccct cccggggact ccagcccgcg cgcgctctag
     7741 ccccgggcca gtgcgcgggt tgggggatgc tgtggtccac gggcgcggct agctttcctg
     7801 ggggtaggga ggaggggcgg cggccccggg agggcgggcg agcacgggcg cggggtcgcc
     7861 ccgcctcgcc ccgcaccctc cgcccagtag cggctcttag cgccctgcgc ggcccgactc
     7921 cgctttggca ccctccgctc ggtctggctt ggctgcttgg cacgccgccc ccccgccctc
     7981 ggcggcatgg ctgcgcgctc ccgttgctag taggagctgt tttaggagga gtttggggtc
     8041 tccacttgat gcctagagaa tgctgcagtc tgcaccttag acgcttttta gaagttttga
     8101 aatgaccttg atttttttaa ttgttatgaa aaaaaatgaa ctatgtcttg gctctctcac
     8161 atgctctgtt actgagagag accagcccac cctactctga tgtatagacc attctcccta
     8221 caccagctaa acaaatgtca aattaataaa gaaacggact catggcaaaa aaaaaaaaaa
     8281 aaa
//
