LOCUS       NM_001080940             887 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus angiopoietin-like 8 (Angptl8), mRNA.
ACCESSION   NM_001080940 XM_890672 XM_911098 XM_979460
VERSION     NM_001080940.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Meng,X., Li,D., Kan,R., Xiang,Y., Pan,L., Guo,Y., Yu,P., Luo,P.,
            Zou,H., Huang,L., Zhu,Y., Mao,B., He,Y., Xie,L., Xu,J., Liu,X.,
            Li,W., Chen,Y., Zhu,S., Yang,Y. and Yu,X.
  TITLE     Inhibition of ANGPTL8 protects against diabetes-associated
            cognitive dysfunction by reducing synaptic loss via the PirB
            signaling pathway
  JOURNAL   J Neuroinflammation 21 (1), 192 (2024)
   PUBMED   39095838
  REMARK    GeneRIF: Inhibition of ANGPTL8 protects against diabetes-associated
            cognitive dysfunction by reducing synaptic loss via the PirB
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 887)
  AUTHORS   Feng,Y., Luo,S., Fang,C., Ma,S., Fan,D., Chen,Y., Chen,Z.,
            Zheng,X., Tang,Y., Duan,X., Liu,X., Ruan,X. and Guo,X.
  TITLE     ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver
            injury by improving lipid metabolic dysregulation
  JOURNAL   J Lipid Res 65 (8), 100595 (2024)
   PUBMED   39019343
  REMARK    GeneRIF: ANGPTL8 deficiency attenuates lipopolysaccharide-induced
            liver injury by improving lipid metabolic dysregulation.
REFERENCE   3  (bases 1 to 887)
  AUTHORS   Ghosh,A., Leung,Y.H., Yu,J., Sladek,R., Chenier,I., Oppong,A.K.,
            Peyot,M.L., Madiraju,S.R.M., Al-Khairi,I., Thanaraj,T.A.,
            Abubaker,J., Al-Mulla,F., Prentki,M. and Abu-Farha,M.
  TITLE     Silencing ANGPTL8 reduces mouse preadipocyte differentiation and
            insulin signaling
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (3), 159461 (2024)
   PUBMED   38272177
  REMARK    GeneRIF: Silencing ANGPTL8 reduces mouse preadipocyte
            differentiation and insulin signaling.
REFERENCE   4  (bases 1 to 887)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 887)
  AUTHORS   Meng,M., Cao,Y., Qiu,J., Shan,G., Wang,Y., Zheng,Y., Guo,M., Yu,J.,
            Ma,Y., Xie,C., Hu,C., Xu,L., Mueller,E. and Ma,X.
  TITLE     Zinc finger protein ZNF638 regulates triglyceride metabolism via
            ANGPTL8 in an estrogen dependent manner
  JOURNAL   Metabolism 152, 155784 (2024)
   PUBMED   38211696
  REMARK    GeneRIF: Zinc finger protein ZNF638 regulates triglyceride
            metabolism via ANGPTL8 in an estrogen dependent manner.
REFERENCE   6  (bases 1 to 887)
  AUTHORS   Wang,Y., Quagliarini,F., Gusarova,V., Gromada,J., Valenzuela,D.M.,
            Cohen,J.C. and Hobbs,H.H.
  TITLE     Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride
            metabolism without impaired glucose homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 110 (40), 16109-16114 (2013)
   PUBMED   24043787
  REMARK    GeneRIF: Mice lacking ANGPTL8 (Betatrophin) manifest disrupted
            triglyceride metabolism without impaired glucose homeostasis.
REFERENCE   7  (bases 1 to 887)
  AUTHORS   Fu,Z., Yao,F., Abou-Samra,A.B. and Zhang,R.
  TITLE     Lipasin, thermoregulated in brown fat, is a novel but atypical
            member of the angiopoietin-like protein family
  JOURNAL   Biochem Biophys Res Commun 430 (3), 1126-1131 (2013)
   PUBMED   23261442
  REMARK    GeneRIF: These results suggest Lipasin and some ANGPTLs play
            distinct physiological roles in mediating thermogenesis and energy
            homeostasis.
            GeneRIF: Lipasin is a novel but atypical member of the
            angiopoietin-like protein family.
REFERENCE   8  (bases 1 to 887)
  AUTHORS   Quagliarini,F., Wang,Y., Kozlitina,J., Grishin,N.V., Hyde,R.,
            Boerwinkle,E., Valenzuela,D.M., Murphy,A.J., Cohen,J.C. and
            Hobbs,H.H.
  TITLE     Atypical angiopoietin-like protein that regulates ANGPTL3
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19751-19756 (2012)
   PUBMED   23150577
REFERENCE   9  (bases 1 to 887)
  AUTHORS   Zhang,R.
  TITLE     Lipasin, a novel nutritionally-regulated liver-enriched factor that
            regulates serum triglyceride levels
  JOURNAL   Biochem Biophys Res Commun 424 (4), 786-792 (2012)
   PUBMED   22809513
  REMARK    GeneRIF: Lipasin is thus a novel nutritionally-regulated
            liver-enriched factor that plays a role in lipid metabolism.
REFERENCE   10 (bases 1 to 887)
  AUTHORS   Ren,G., Kim,J.Y. and Smas,C.M.
  TITLE     Identification of RIFL, a novel adipocyte-enriched insulin target
            gene with a role in lipid metabolism
  JOURNAL   Am J Physiol Endocrinol Metab 303 (3), E334-E351 (2012)
   PUBMED   22569073
  REMARK    GeneRIF: RIFL is an important new regulator of lipid metabolism.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK791522.1, BC051501.1 and BC038127.1.
            
            On or before Feb 1, 2007 this sequence version replaced
            XM_911098.2, XM_890672.2, XM_979460.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KM253766.1, BC024408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CK791522.1         1-51
            52-861              BC051501.1         11-820
            862-887             BC038127.1         776-801
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.9 cM"
     gene            1..887
                     /gene="Angptl8"
                     /gene_synonym="EG624219; Gm6484; Rifl"
                     /note="angiopoietin-like 8"
                     /db_xref="GeneID:624219"
                     /db_xref="MGI:MGI:3643534"
     exon            1..305
                     /gene="Angptl8"
                     /gene_synonym="EG624219; Gm6484; Rifl"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..605
                     /gene="Angptl8"
                     /gene_synonym="EG624219; Gm6484; Rifl"
                     /note="hepatocellular carcinoma-associated protein TD26
                     homolog; lipasin; angiopoietin-like protein 8;
                     refeeding-induced fat and liver protein; betatrophin"
                     /codon_start=1
                     /product="angiopoietin-like protein 8 precursor"
                     /protein_id="NP_001074409.1"
                     /db_xref="CCDS:CCDS40556.1"
                     /db_xref="GeneID:624219"
                     /db_xref="MGI:MGI:3643534"
                     /translation="MAVLALCLLWTLASAVRPAPVAPLGGPEPAQYEELTLLFHGALQ
                     LGQALNGVYRATEARLTEAGHSLGLYDRALEFLGTEVRQGQDATQELRTSLSEIQVEE
                     DALHLRAEATARSLGEVARAQQALRDTVRRLQVQLRGAWLGQAHQEFETLKARADKQS
                     HLLWALTGHVQRQQREMAEQQQWLRQIQQRLHTAALPA"
     exon            306..467
                     /gene="Angptl8"
                     /gene_synonym="EG624219; Gm6484; Rifl"
                     /inference="alignment:Splign:2.1.0"
     exon            468..577
                     /gene="Angptl8"
                     /gene_synonym="EG624219; Gm6484; Rifl"
                     /inference="alignment:Splign:2.1.0"
     exon            578..865
                     /gene="Angptl8"
                     /gene_synonym="EG624219; Gm6484; Rifl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      841..846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angptl8"
                     /gene_synonym="EG624219; Gm6484; Rifl"
                     /note="hexamer: AATAAA"
     polyA_site      865
                     /gene="Angptl8"
                     /gene_synonym="EG624219; Gm6484; Rifl"
                     /note="major polyA site"
ORIGIN      
        1 tgtcagccat ggctgtgctt gctctctgcc tcctgtggac cttagcatca gcagtgcgac
       61 ccgctccagt ggcccctctg ggtggtccag agccagctca atatgaagag ctgaccctgc
      121 tctttcacgg ggccctgcag ctaggccagg ccctcaatgg cgtgtacaga gccacagagg
      181 ctcgcctgac agaagctggg cacagcctgg gcctctatga cagagcactg gaattcctgg
      241 ggacagaagt caggcagggc caggatgcca cacaggagct tcgcaccagc ctgtcggaga
      301 ttcaggtgga agaggacgct ttacaccttc gagctgaagc cacagcccga tcactggggg
      361 aagtggcccg ggcccagcag gctctgcggg acactgtacg gagactacaa gtgcagctga
      421 gaggcgcctg gctcggtcaa gcccaccaag aatttgagac cttaaaggct cgagctgata
      481 agcagagcca cctcttatgg gctctcactg gccacgtgca gcgacagcag cgggagatgg
      541 cagagcagca acagtggctg cgacagatcc agcagagact ccacacagca gccctcccag
      601 cctgagacta cctggatgcc accgaggacc agttgtgctg caaggaacac tgaagcgctc
      661 caccaggccc atgaacaggg ctgacagagc cggctgccca tcagctggac ctggccagtg
      721 caccccgctt cctggcagag cggagacaga agcaagcagg cgggatggaa ggcagaagac
      781 agagccctgt ggaggagggc tggaaaaaga cacgagcccc cttatgccca cacaccccac
      841 aataaaagag aacagaggca atctaaaaaa aaaaaaaaaa aaaaaaa
//
