LOCUS       NM_001039554            2062 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus angiopoietin-like 7 (Angptl7), mRNA.
ACCESSION   NM_001039554
VERSION     NM_001039554.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2062)
  AUTHORS   Brown,S.F., Nguyen,H., Mzyk,P., De Ieso,M.L., Unser,A.M., Brown,I.,
            Ramesh,P., Afzaal,H., Ahmed,F., Torrejon,K.Y., Nhan,A.,
            Markrush,D., Daly,T., Knecht,E., McConaughy,W., Halmos,S.,
            Liu,Z.L., Rennard,R., Peterson,A. and Stamer,W.D.
  TITLE     ANGPTL7 and Its Role in IOP and Glaucoma
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 22 (2024)
   PUBMED   38497513
  REMARK    GeneRIF: ANGPTL7 and Its Role in IOP and Glaucoma.
REFERENCE   2  (bases 1 to 2062)
  AUTHORS   Fei,M.Y., Wang,Y., Chang,B.H., Xue,K., Dong,F., Huang,D., Li,X.Y.,
            Li,Z.J., Hu,C.L., Liu,P., Wu,J.C., Yu,P.C., Hong,M.H., Chen,S.B.,
            Xu,C.H., Chen,B.Y., Jiang,Y.L., Liu,N., Zhao,C., Jin,J.C., Hou,D.,
            Chen,X.C., Ren,Y.Y., Deng,C.H., Zhang,J.Y., Zong,L.J., Wang,R.J.,
            Gao,F.F., Liu,H., Zhang,Q.L., Wu,L.Y., Yan,J., Shen,S., Chang,C.K.,
            Sun,X.J. and Wang,L.
  TITLE     The non-cell-autonomous function of ID1 promotes AML progression
            via ANGPTL7 from the microenvironment
  JOURNAL   Blood 142 (10), 903-917 (2023)
   PUBMED   37319434
  REMARK    GeneRIF: The non-cell-autonomous function of ID1 promotes AML
            progression via ANGPTL7 from the microenvironment.
REFERENCE   3  (bases 1 to 2062)
  AUTHORS   Praveen,K., Patel,G.C., Gurski,L., Ayer,A.H., Persaud,T.,
            Still,M.D., Miloscio,L., Van Zyl,T., Di Gioia,S.A., Brumpton,B.,
            Krebs,K., Asvold,B.O., Chen,E., Chavali,V.R.M., Fury,W.,
            Gudiseva,H.V., Hyde,S., Jorgenson,E., Lefebvre,S., Li,D., Li,A.,
            Mclninch,J., Patel,B., Rabinowitz,J.S., Salowe,R., Schurmann,C.,
            Seidelin,A.S., Stahl,E., Sun,D., Teslovich,T.M.,
            Tybjaerg-Hansen,A., Willer,C., Waldron,S., Walley,S., Yang,H.,
            Zaveri,S., Hu,Y., Hveem,K., Melander,O., Milani,L., Stender,S.,
            O'Brien,J.M., Jones,M.B., Abecasis,G.R., Cantor,M.N., Weyne,J.,
            Karalis,K., Economides,A., Della Gatta,G., Ferreira,M.A.,
            Yancopoulos,G.D., Baras,A., Romano,C. and Coppola,G.
  CONSRTM   Regeneron Genetics Center; GHS-RGC DiscovEHR Collaboration;
            Estonian Biobank Research Team
  TITLE     ANGPTL7, a therapeutic target for increased intraocular pressure
            and glaucoma
  JOURNAL   Commun Biol 5 (1), 1051 (2022)
   PUBMED   36192519
  REMARK    GeneRIF: ANGPTL7, a therapeutic target for increased intraocular
            pressure and glaucoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2062)
  AUTHORS   Xu,T., Xu,L., Meng,P., Ma,X., Yang,X., Zhou,Y. and Feng,M.
  TITLE     Angptl7 promotes insulin resistance and type 2 diabetes mellitus by
            multiple mechanisms including SOCS3-mediated IRS1 degradation
  JOURNAL   FASEB J 34 (10), 13548-13560 (2020)
   PUBMED   32786125
  REMARK    GeneRIF: Angptl7 promotes insulin resistance and type 2 diabetes
            mellitus by multiple mechanisms including SOCS3-mediated IRS1
            degradation.
REFERENCE   5  (bases 1 to 2062)
  AUTHORS   Lu,X., Lu,J., Zhang,L. and Xu,Y.
  TITLE     Effect of ANGPTL7 on Proliferation and Differentiation of MC3T3-E1
            Cells
  JOURNAL   Med Sci Monit 25, 9524-9530 (2019)
   PUBMED   31835268
  REMARK    GeneRIF: When MC3T3-E1 cells were exposed to osteogenic medium,
            there was a significant increase in ANGPTL7, and overexpression of
            ANGPTL7 markedly promoted cell proliferation, ALP activity, and
            mineralization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2062)
  AUTHORS   Qian,T., Wang,K., Cui,J., He,Y. and Yang,Z.
  TITLE     Angiopoietin-Like Protein 7 Promotes an Inflammatory Phenotype in
            RAW264.7 Macrophages Through the P38 MAPK Signaling Pathway
  JOURNAL   Inflammation 39 (3), 974-985 (2016)
   PUBMED   26973239
  REMARK    GeneRIF: Angptl7 is a factor that promotes pro-inflammatory
            responses in macrophages through the P38 MAPK signaling pathway
REFERENCE   7  (bases 1 to 2062)
  AUTHORS   Xiao,Y., Wei,X., Jiang,Z., Wang,X., Ye,W., Liu,X., Zhang,M., Xu,Y.,
            Wu,D., Lai,L., Yao,H., Liu,Z., Cao,S., Liu,P., Xu,B., Li,Y.,
            Yao,Y., Pei,D. and Li,P.
  TITLE     Loss of Angiopoietin-like 7 diminishes the regeneration capacity of
            hematopoietic stem and progenitor cells
  JOURNAL   J Hematol Oncol 8, 7 (2015)
   PUBMED   25652910
  REMARK    GeneRIF: Angptl7 was indispensable for bone marrow microenvironment
            to support hematopoietic stem cells repopulation
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2062)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   9  (bases 1 to 2062)
  AUTHORS   Scott,C.A., van Huyen,D. and Bany,B.M.
  TITLE     Angiopoietin-like gene expression in the mouse uterus during
            implantation and in response to steroids
  JOURNAL   Cell Tissue Res 348 (1), 199-211 (2012)
   PUBMED   22350948
REFERENCE   10 (bases 1 to 2062)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL713995.11.
            
            On May 2, 2007 this sequence version replaced NM_001039554.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031675.1, BC023373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               AL713995.11        21183-21704         c
            523-623             AL713995.11        19230-19330         c
            624-818             AL713995.11        18525-18719         c
            819-1017            AL713995.11        17735-17933         c
            1018-2062           AL713995.11        16522-17566         c
FEATURES             Location/Qualifiers
     source          1..2062
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.76 cM"
     gene            1..2062
                     /gene="Angptl7"
                     /note="angiopoietin-like 7"
                     /db_xref="GeneID:654812"
                     /db_xref="MGI:MGI:3605801"
     exon            1..522
                     /gene="Angptl7"
                     /inference="alignment:Splign:2.1.0"
     exon            523..623
                     /gene="Angptl7"
                     /inference="alignment:Splign:2.1.0"
     exon            624..818
                     /gene="Angptl7"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1017
                     /gene="Angptl7"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..2062
                     /gene="Angptl7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagactaag gaaggaaaga gttccatttc agaatctcta gctttaagaa aggctaagca
       61 agcacacaga ggaaggagat cacggggaag gaagaaaact gccagtgtgg gtcagagaaa
      121 gaagcttcct acttctccag ggacagactc taaggggaac aggcctgcac accatgctga
      181 gggagacctg gctatgtgtt atccttgtag cctttgtcag ccacccagtg tggctgcaga
      241 agcctcataa acgcaagaca cagctcaaag cagcgggctg ctgtgaggag atgagggagc
      301 tcaaagccca ggtggccaac ctcagcagtc tgctgggaga gctgagcagg aagcaggaga
      361 gcgactgggt cagtgtggtc atgcaggtga tggagctgga gagcagcagc aagcacatgg
      421 agtctcggct cagcactgcc gagagcaagt actctgagat gaacaaccag attgacatca
      481 tgcagctgca ggctgcgcag accgtcacgc agacctcggc agatgccatc tatgactgtt
      541 cttccctgta ccagaagaac taccgaatct ctggagtgta caagcttcct cctgacgagt
      601 tcctggggag ccctgagcta gaggtgttct gtgacatgga aacttcagga ggaggctgga
      661 ccatcatcca gagacgtaag agtggccttg tctccttcta ccaagactgg agacagtata
      721 agcaagggtt tggcagcatc cgaggtgact tctggctggg gaatgaacat atccaccggc
      781 tcaccaggca gccaagccgg cttcgtgtgg agctggagga ctgggagggc aatgcacgct
      841 acgcagagta tagctacttt gcgttgggca atgaactgaa cagctaccgc ctcttcctgg
      901 ggaactacag tggcaacgtg gggaaggacg ccctcctcta ccataacaac accgtcttca
      961 gcaccaagga caaggacaac gacaactgct tggacaagtg cgcacagctc cgaaaaggtg
     1021 gctactggta caactgctgc acagactcca acctcaatgg ggtgtactac cgccttggcg
     1081 agcaccgaaa gcacatggat ggcatcagct ggtatggctg gcatggagcc aactattccc
     1141 tcaaacgtgt ggaaatgaag atccgcccag aagccttcaa gccctgagag aaggcagaca
     1201 ctgaggaggg agaacagcat gggaggagga ggtggacaca gggtaggagg gaacagttta
     1261 tcatccagga gcacaatata actttacctg tgtgagcaca cacacacaat agaaccacac
     1321 gtgccaacag tgcacactag cagatggagc caggcggacc cagtggggcc tgccacggtg
     1381 cctcacggga gaactcatgg acaacggtaa ccctgaggtc acttaaccca ttttccctaa
     1441 ctgaggctta gatgacacga gggaaaagaa caaataaaaa cctggtgtga ttctcagcgg
     1501 agaggctgtg agaaatgaaa gaaagcaggt ggtggagaag gggcttccaa gtcttacccc
     1561 gcgacacttc cttgtgtcta tagtatttgt tttgtttttc tttttgagac agggtctctc
     1621 tacacagctc tttctgtcct ggaactcact atgtagacca ggctgacctt gaactcacag
     1681 agatctacct gcttctgcct cccaagtaca gggattaaag gcatgtacca ccatacccag
     1741 tatatataat ttttaagaca caaaaaacat ggagatagag agcagctgcc caggtgtctc
     1801 cgggggggcc ttgttgtcag agtcctgggg gagagaggag cactggacaa catgctgcgg
     1861 gtctgacgtg gcgagaacac cagccggagg tgagcacaga ctctgggtga tcacaatact
     1921 gccttcaaac atcctcagtc aaaaaccaaa agatcccctt taataaaaat gcttggaaaa
     1981 tgaaggtaga tggcgctgtg gtttaaaact tgtgatgtat atagaagcat cttccttgta
     2041 aaaataaaat attgtaattc ct
//
