LOCUS       NM_145154               1564 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus angiopoietin-like 6 (Angptl6), mRNA.
ACCESSION   NM_145154 XM_975796 XM_975829
VERSION     NM_145154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Morita,T. and Hayashi,K.
  TITLE     Regulation of Arp5 expression by alternative splicing coupled to
            nonsense-mediated RNA decay
  JOURNAL   Biochem Biophys Res Commun 657, 50-58 (2023)
   PUBMED   36977368
  REMARK    GeneRIF: Regulation of Arp5 expression by alternative splicing
            coupled to nonsense-mediated RNA decay.
REFERENCE   2  (bases 1 to 1564)
  AUTHORS   Jang,Y., Heo,J.Y., Lee,M.J., Zhu,J., Seo,C., Go,D.H., Yoon,S.K.,
            Yukari,D., Oike,Y., Sohn,J.W., Shong,M. and Kweon,G.R.
  TITLE     Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the
            Hypothalamus
  JOURNAL   Int J Mol Sci 22 (7), 3443 (2021)
   PUBMED   33810547
  REMARK    GeneRIF: Angiopoietin-Like Growth Factor Involved in Leptin
            Signaling in the Hypothalamus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Kim,M.J., Namkung,J., Chang,J.S., Kim,S.J., Park,K.S. and Kong,I.D.
  TITLE     Leptin regulates the expression of angiopoietin-like 6
  JOURNAL   Biochem Biophys Res Commun 502 (3), 397-402 (2018)
   PUBMED   29852166
  REMARK    GeneRIF: Since upregulation of ANGPTL6 is induced on metabolic
            stress, we investigated the hepatic expression of ANGPTL6 by
            leptin, a representative adipokine of obesity. Mice on a high-fat
            diet showed increased serum leptin levels and hepatic Angptl6
            expression.
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   Kang,S.G., Yi,H.S., Choi,M.J., Ryu,M.J., Jung,S., Chung,H.K.,
            Chang,J.Y., Kim,Y.K., Lee,S.E., Kim,H.W., Choi,H., Kim,D.S.,
            Lee,J.H., Kim,K.S., Kim,H.J., Lee,C.H., Oike,Y. and Shong,M.
  TITLE     ANGPTL6 expression is coupled with mitochondrial OXPHOS function to
            regulate adipose FGF21
  JOURNAL   J Endocrinol 233 (1), 105-118 (2017)
   PUBMED   28184000
  REMARK    GeneRIF: mitochondrial OXPHOS function governs the expression of
            ANGPTL6, which is an essential factor for FGF21 production in
            adipose tissue and cultured adipocytes.
REFERENCE   5  (bases 1 to 1564)
  AUTHORS   Tanigawa,H., Miyata,K., Tian,Z., Aoi,J., Kadomatsu,T.,
            Fukushima,S., Ogata,A., Takeda,N., Zhao,J., Zhu,S., Terada,K.,
            Endo,M., Morinaga,J., Sugizaki,T., Sato,M., Morioka,M.S.,
            Manabe,I., Mashimo,Y., Hata,A., Taketomi,Y., Yamamoto,K.,
            Murakami,M., Araki,K., Jinnin,M., Ihn,H. and Oike,Y.
  TITLE     Upregulation of ANGPTL6 in mouse keratinocytes enhances
            susceptibility to psoriasis
  JOURNAL   Sci Rep 6, 34690 (2016)
   PUBMED   27698489
  REMARK    GeneRIF: Upregulation of ANGPTL6 in mouse keratinocytes enhances
            susceptibility to psoriasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1564)
  AUTHORS   Urano,T., Ito,Y., Akao,M., Sawa,T., Miyata,K., Tabata,M.,
            Morisada,T., Hato,T., Yano,M., Kadomatsu,T., Yasunaga,K.,
            Shibata,R., Murohara,T., Akaike,T., Tanihara,H., Suda,T. and
            Oike,Y.
  TITLE     Angiopoietin-related growth factor enhances blood flow via
            activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb
            ischemia model
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (5), 827-834 (2008)
   PUBMED   18258819
  REMARK    GeneRIF: Activation of an ERK1/2-eNOS-NO pathway is a crucial
            signaling mechanism by which angiopoietin-related growth factor
            increases blood flow through induction of angiogenesis and
            arteriogenesis.
REFERENCE   7  (bases 1 to 1564)
  AUTHORS   Zhang,Y., Hu,X., Tian,R., Wei,W., Hu,W., Chen,X., Han,W., Chen,H.
            and Gong,Y.
  TITLE     Angiopoietin-related growth factor (AGF) supports adhesion,
            spreading, and migration of keratinocytes, fibroblasts, and
            endothelial cells through interaction with RGD-binding integrins
  JOURNAL   Biochem Biophys Res Commun 347 (1), 100-108 (2006)
   PUBMED   16806062
  REMARK    GeneRIF: Our results strongly suggest that AGF is an integrin
            ligand as well as a mitogenic growth factor and theoretically
            participates in cutaneous wound healing in a more complex
            mechanism.
REFERENCE   8  (bases 1 to 1564)
  AUTHORS   Oike,Y., Akao,M., Yasunaga,K., Yamauchi,T., Morisada,T., Ito,Y.,
            Urano,T., Kimura,Y., Kubota,Y., Maekawa,H., Miyamoto,T., Miyata,K.,
            Matsumoto,S., Sakai,J., Nakagata,N., Takeya,M., Koseki,H.,
            Ogawa,Y., Kadowaki,T. and Suda,T.
  TITLE     Angiopoietin-related growth factor antagonizes obesity and insulin
            resistance
  JOURNAL   Nat Med 11 (4), 400-408 (2005)
   PUBMED   15778720
  REMARK    GeneRIF: we show that (>80%) of the AGF-deficient mice die at about
            embryonic day 13, while the surviving AGF-deficient mice develop
            marked obesity, lipid accumulation in skeletal muscle and liver,
            and insulin resistance accompanied by reduced energy expenditure
REFERENCE   9  (bases 1 to 1564)
  AUTHORS   Oike,Y., Ito,Y., Maekawa,H., Morisada,T., Kubota,Y., Akao,M.,
            Urano,T., Yasunaga,K. and Suda,T.
  TITLE     Angiopoietin-related growth factor (AGF) promotes angiogenesis
  JOURNAL   Blood 103 (10), 3760-3765 (2004)
   PUBMED   14764539
REFERENCE   10 (bases 1 to 1564)
  AUTHORS   Oike,Y., Yasunaga,K., Ito,Y., Matsumoto,S., Maekawa,H.,
            Morisada,T., Arai,F., Nakagata,N., Takeya,M., Masuho,Y. and Suda,T.
  TITLE     Angiopoietin-related growth factor (AGF) promotes epidermal
            proliferation, remodeling, and regeneration
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9494-9499 (2003)
   PUBMED   12871997
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC170598.2.
            
            On Nov 17, 2006 this sequence version replaced NM_145154.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB054065.1, BC025904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC170598.2         107186-107293       c
            109-663             AC170598.2         105632-106186       c
            664-841             AC170598.2         103975-104152       c
            842-1029            AC170598.2         103097-103284       c
            1030-1300           AC170598.2         102749-103019       c
            1301-1564           AC170598.2         101392-101655       c
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.66 cM"
     gene            1..1564
                     /gene="Angptl6"
                     /gene_synonym="6330404E11Rik; AGF; ARP3; Arp5"
                     /note="angiopoietin-like 6"
                     /db_xref="GeneID:70726"
                     /db_xref="MGI:MGI:1917976"
     exon            1..108
                     /gene="Angptl6"
                     /gene_synonym="6330404E11Rik; AGF; ARP3; Arp5"
                     /inference="alignment:Splign:2.1.0"
     exon            109..663
                     /gene="Angptl6"
                     /gene_synonym="6330404E11Rik; AGF; ARP3; Arp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1491
                     /gene="Angptl6"
                     /gene_synonym="6330404E11Rik; AGF; ARP3; Arp5"
                     /note="angiopoietin-related protein 6; angiopoietin-like
                     protein 6; Angiopoietin-related growth factor;
                     angiopoietin-related protein 5"
                     /codon_start=1
                     /product="angiopoietin-related protein 6 precursor"
                     /protein_id="NP_660136.1"
                     /db_xref="CCDS:CCDS22886.1"
                     /db_xref="GeneID:70726"
                     /db_xref="MGI:MGI:1917976"
                     /translation="MGTARLRKLQLLLLLGAWRALGGAARCRVTLVLSPQKATSAVCR
                     SSEATQDSELATLRMRLGRHEELLRALQRRAAEGGALADEVRALREHSLTLNTRLGQL
                     RAQLQQEARAEPDLGAEPAAALGLLAERALDAEAEARRTTARLQQLDAQLREHAQLMS
                     QHSSLLGRLQRACAGPERGQQQVLPLPLAPLVPLSLVGSASNTSRRLDQTPEHQREQS
                     LRQQGPPSSLLPTGHLAVPTRPVGPWRDCAEAHGAGHWQSGVYDLRLGRRVVAVWCEQ
                     QQEGGGWTVIQRRQDGSVNFFTNWQHYKAGFGRPEGEYWLGLEPVHQVTSRGDHELLI
                     LLEDWGGRAARAHYDSFSLEPESDHYRLRLGQYHGDAGDSLSWHNDKPFSTVDRDRDS
                     YSGNCALYHRGGWWYHACAHSNLNGVWYHGGHYRSRYQDGVYWAEFRGGAYSLKKAVM
                     LTRLVRL"
     exon            664..841
                     /gene="Angptl6"
                     /gene_synonym="6330404E11Rik; AGF; ARP3; Arp5"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1029
                     /gene="Angptl6"
                     /gene_synonym="6330404E11Rik; AGF; ARP3; Arp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1300
                     /gene="Angptl6"
                     /gene_synonym="6330404E11Rik; AGF; ARP3; Arp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1564
                     /gene="Angptl6"
                     /gene_synonym="6330404E11Rik; AGF; ARP3; Arp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tactcaccca gaaggactcc cggtccttcg tcctggtcct tcaggccttc ctcagatttt
       61 gtggaattgc cgcaaacctc actggagcca gcgtctgggc tgtgagaggt gacggccatg
      121 gggaccgcca ggctacgcaa gctgcaactg ctgcttctgc tgggcgcttg gagggcgctc
      181 ggaggtgccg cgcgttgccg cgtcacccta gttttgtccc cgcagaaggc aactagcgcc
      241 gtctgcagga gctcagaagc cacccaagac agcgaactgg ccacgctgcg catgcgcctg
      301 ggtcgccacg aggagctgct gcgcgcgctg caaaggcgtg cggcggaggg tggtgcgctc
      361 gcggacgagg tgcgcgcact gcgcgagcac agtctcaccc tgaacacgcg cctgggccag
      421 ctgcgcgcgc aattgcagca ggaggcgagg gcggagcctg acctgggggc ggagcctgct
      481 gctgcacttg gtttgctagc cgagcgcgcg ctggacgctg aggccgaagc gcgccggacg
      541 acggcacgcc tgcagcagct ggacgcacag ctccgtgagc atgcgcagct catgagccag
      601 catagcagcc tcctcggccg cctgcaacgc gcgtgcgcgg gcccggaacg gggacagcag
      661 caggtcctgc cactgcccct ggcgcctctg gtgcctctga gcctcgtggg cagtgccagc
      721 aacaccagca ggaggctgga ccaaactcca gagcaccaga gagagcagag cttgagacag
      781 caggggcctc catcttctct gctgcccaca gggcaccttg ctgtccccac aaggccagtg
      841 ggcccatgga gggattgtgc agaggctcac ggggcaggtc actggcagag tggagtgtat
      901 gacctgcggc tgggccgtcg tgtagtagcc gtgtggtgtg aacagcagca ggaaggtgga
      961 ggctggactg tcatccagag acggcaggac ggctctgtca acttcttcac caactggcag
     1021 cactacaagg cgggctttgg gcgtccagaa ggagaatact ggctgggcct ggaacctgtg
     1081 catcaggtga caagccgtgg ggaccacgag ctgctgatac tcctagagga ctgggggggc
     1141 cgtgcagcac gcgcccacta cgacagcttc tccttggagc ctgagagtga ccactaccgt
     1201 ctgcggcttg gccagtacca cggcgatgcc ggagactccc tctcttggca caatgacaaa
     1261 cctttcagca ctgtggatag ggacagagac tcatattctg gtaactgtgc cctgtaccat
     1321 cgtgggggct ggtggtacca tgcctgtgcc cactctaacc tcaatggagt atggtatcat
     1381 ggaggtcatt accggagccg ataccaggac ggggtctact gggccgagtt ccgtggtggg
     1441 gcgtactctc tgaagaaagc tgttatgttg acccggcttg tgcgcttgtg actgtcccat
     1501 cagtaccccc aagggtgttc ctatctcctt cagctggtat cttatagcaa cacgaggtgg
     1561 ccac
//
