LOCUS       NM_020581               1916 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus angiopoietin-like 4 (Angptl4), mRNA.
ACCESSION   NM_020581
VERSION     NM_020581.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1916)
  AUTHORS   Min,E.K., Kim,S.R., Lee,C.M., Na,K.H., Park,C.H., Oh,B.C., Jung,Y.
            and Hong,I.S.
  TITLE     Identification of memory mechanism in tissue-resident stem cells
            via ANGPTL4 beyond immune cells upon viral antigen exposure
  JOURNAL   Mol Ther 32 (9), 3042-3058 (2024)
   PUBMED   38582960
  REMARK    GeneRIF: Identification of memory mechanism in tissue-resident stem
            cells via ANGPTL4 beyond immune cells upon viral antigen exposure.
REFERENCE   2  (bases 1 to 1916)
  AUTHORS   Deng,W., Zhong,L., Ye,S., Luo,J., Ren,G., Huang,J. and Zhuang,X.
  TITLE     Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis
            by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA
            stability
  JOURNAL   J Bioenerg Biomembr 56 (4), 405-418 (2024)
   PUBMED   38842666
  REMARK    GeneRIF: Mir22hg facilitates ferritinophagy-mediated ferroptosis in
            sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4
            mRNA stability.
REFERENCE   3  (bases 1 to 1916)
  AUTHORS   Wang,X., Chang,H.C., Gu,X., Han,W., Mao,S., Lu,L., Jiang,S.,
            Ding,H., Han,S., Qu,X. and Bao,Z.
  TITLE     Renal lipid accumulation and aging linked to tubular cells injury
            via ANGPTL4
  JOURNAL   Mech Ageing Dev 219, 111932 (2024)
   PUBMED   38580082
  REMARK    GeneRIF: Renal lipid accumulation and aging linked to tubular cells
            injury via ANGPTL4.
REFERENCE   4  (bases 1 to 1916)
  AUTHORS   Deng,M. and Kersten,S.
  TITLE     Characterization of sexual dimorphism in ANGPTL4 levels and
            function
  JOURNAL   J Lipid Res 65 (4), 100526 (2024)
   PUBMED   38431115
  REMARK    GeneRIF: Characterization of sexual dimorphism in ANGPTL4 levels
            and function.
REFERENCE   5  (bases 1 to 1916)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1916)
  AUTHORS   Yoshida,K., Shimizugawa,T., Ono,M. and Furukawa,H.
  TITLE     Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing
            factor in mice and inhibitor of lipoprotein lipase
  JOURNAL   J Lipid Res 43 (11), 1770-1772 (2002)
   PUBMED   12401877
  REMARK    GeneRIF: potent hyperlipidemia-inducing factor in mice and
            inhibitor of lipoprotein lipase
REFERENCE   7  (bases 1 to 1916)
  AUTHORS   Zhu,H., Li,J., Qin,W., Yang,Y., He,X., Wan,D. and Gu,J.
  TITLE     [Cloning of a novel gene, ANGPTL4 and the functional study in
            angiogenesis]
  JOURNAL   Zhonghua Yi Xue Za Zhi 82 (2), 94-99 (2002)
   PUBMED   11953136
REFERENCE   8  (bases 1 to 1916)
  AUTHORS   Kersten,S., Mandard,S., Tan,N.S., Escher,P., Metzger,D.,
            Chambon,P., Gonzalez,F.J., Desvergne,B. and Wahli,W.
  TITLE     Characterization of the fasting-induced adipose factor FIAF, a
            novel peroxisome proliferator-activated receptor target gene
  JOURNAL   J Biol Chem 275 (37), 28488-28493 (2000)
   PUBMED   10862772
REFERENCE   9  (bases 1 to 1916)
  AUTHORS   Yoon,J.C., Chickering,T.W., Rosen,E.D., Dussault,B., Qin,Y.,
            Soukas,A., Friedman,J.M., Holmes,W.E. and Spiegelman,B.M.
  TITLE     Peroxisome proliferator-activated receptor gamma target gene
            encoding a novel angiopoietin-related protein associated with
            adipose differentiation
  JOURNAL   Mol Cell Biol 20 (14), 5343-5349 (2000)
   PUBMED   10866690
REFERENCE   10 (bases 1 to 1916)
  AUTHORS   Kim,I., Kim,H.G., Kim,H., Kim,H.H., Park,S.K., Uhm,C.S., Lee,Z.H.
            and Koh,G.Y.
  TITLE     Hepatic expression, synthesis and secretion of a novel
            fibrinogen/angiopoietin-related protein that prevents
            endothelial-cell apoptosis
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 603-610 (2000)
   PUBMED   10698685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY783212.1, AK014564.1 and AW495750.1.
            
            On Aug 5, 2009 this sequence version replaced NM_020581.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021343.1, AK014564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY783212.1         1-25
            26-1822             AK014564.1         27-1823
            1823-1916           AW495750.1         1-94                c
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1916
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /note="angiopoietin-like 4"
                     /db_xref="GeneID:57875"
                     /db_xref="MGI:MGI:1888999"
     exon            1..513
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1416
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /note="fibrinogen/angiopoietin-related protein; major
                     histocompatibility complex region NG27;
                     angiopoietin-related protein 4; 425O18-1; secreted protein
                     Bk89; angiopoietin-like protein 4; fasting-induced adipose
                     factor; hepatic fibrinogen/angiopoietin-related protein"
                     /codon_start=1
                     /product="angiopoietin-related protein 4 precursor"
                     /protein_id="NP_065606.2"
                     /db_xref="CCDS:CCDS28629.1"
                     /db_xref="GeneID:57875"
                     /db_xref="MGI:MGI:1888999"
                     /translation="MRCAPTAGAALVLCAATAGLLSAQGRPAQPEPPRFASWDEMNLL
                     AHGLLQLGHGLREHVERTRGQLGALERRMAACGNACQGPKGKDAPFKDSEDRVPEGQT
                     PETLQSLQTQLKAQNSKIQQLFQKVAQQQRYLSKQNLRIQNLQSQIDLLAPTHLDNGV
                     DKTSRGKRLPKMTQLIGLTPNATHLHRPPRDCQELFQEGERHSGLFQIQPLGSPPFLV
                     NCEMTSDGGWTVIQRRLNGSVDFNQSWEAYKDGFGDPQGEFWLGLEKMHSITGNRGSQ
                     LAVQLQDWDGNAKLLQFPIHLGGEDTAYSLQLTEPTANELGATNVSPNGLSLPFSTWD
                     QDHDLRGDLNCAKSLSGGWWFGTCSHSNLNGQYFHSIPRQRQERKKGIFWKTWKGRYY
                     PLQATTLLIQPMEATAAS"
     exon            514..624
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /inference="alignment:Splign:2.1.0"
     exon            625..742
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /inference="alignment:Splign:2.1.0"
     exon            743..856
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /inference="alignment:Splign:2.1.0"
     exon            857..952
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1234
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1903
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /note="hexamer: AATAAA"
     polyA_site      1903
                     /gene="Angptl4"
                     /gene_synonym="Arp4; Bk89; Fiaf; Hfarp; Ng27; Pgar; Pgarg;
                     Pp1158"
                     /note="major polyA site"
ORIGIN      
        1 gctttataaa gtggggcttt aggtgcaacc gtgaaacgct tatgagctac gggctccaga
       61 tcttcttctg caccagagca agtctaagtc tgagccggct cccccagaac tccagctgct
      121 gggtcttgaa ctcctgcgtt ccggagtcct agcgttgctg cacccaaggc cacccccaga
      181 atcatgcgct gcgctccgac agcaggcgct gccctggtgc tatgcgcggc tactgcgggg
      241 cttttgagcg cgcaagggcg ccctgcacag ccagagccac cgcgctttgc atcctgggac
      301 gagatgaact tgctggctca cgggctgcta cagctcggcc atgggctgcg cgaacacgtg
      361 gagcgcaccc gtgggcagct gggcgcgctg gagcgccgca tggctgcctg tggtaacgct
      421 tgtcaggggc ccaagggaaa agatgcaccc ttcaaagact ccgaggatag agtccctgaa
      481 ggccagactc ctgagactct gcagagtttg cagactcagc tcaaggctca aaacagcaag
      541 atccagcaat tgttccagaa ggtggcccag cagcagagat acctatcaaa gcagaatctg
      601 agaatacaga atcttcagag ccagatagac ctcttggccc ccacgcacct agacaatgga
      661 gtagacaaga cttcgagggg aaagaggctt cccaagatga cccagctcat tggcttgact
      721 cccaacgcca cccacttaca caggccgccc cgggactgcc aggaactctt ccaagaaggg
      781 gagcggcaca gtggactttt ccagatccag cctctggggt ctccaccatt tttggtcaac
      841 tgtgagatga cttcagatgg aggctggaca gtgattcaga gacgcctgaa cggctctgtg
      901 gacttcaacc agtcctggga agcctacaag gatggcttcg gagatcccca aggcgagttc
      961 tggctgggcc tggaaaagat gcacagcatc acagggaacc gaggaagcca attggctgtg
     1021 cagctccagg actgggatgg caatgccaaa ttgctccaat ttcccatcca tttggggggt
     1081 gaggacacag cctacagcct gcagctcact gagcccacgg ccaatgagct gggtgccacc
     1141 aatgtttccc ccaatggcct ttccctgccc ttctctactt gggaccaaga ccatgacctc
     1201 cgtggggacc ttaactgtgc caagagcctc tctggtggct ggtggtttgg tacctgtagc
     1261 cattccaatc tcaatggaca atacttccac tctatcccac ggcaacggca ggagcgtaaa
     1321 aagggtatct tctggaaaac atggaagggc cgctactatc ctctgcaggc taccaccctg
     1381 ctgatccagc ccatggaggc tacagcagcc tcttagcctc ctcactggag cctggttcca
     1441 ggcctaagaa gacagtgact ttggttgtgg ccctgagatt tggccattct ctgctggggg
     1501 caggagctct aagtagggct atctgcgtct tgtggacaaa gaagaagccc gtaactggag
     1561 agactggagg accccttttc cgtgttgggg tctgcaagca ttgttgtctg aaacagtcag
     1621 agcaacagga aacaaatggc ccagatccag aaaacatggg ctcgaggggc actgaatatc
     1681 acttctcgcc taccagagaa gttggggatg cagagggacc actacagtcc aactagctgg
     1741 gcccttaatg gcggactcag tcatattgac tgactggaga cagggtgcca ggagccctgg
     1801 atacactcat ggtgctgttg taggtgctgt ggatgcacag gtgctaactg tggttcccag
     1861 gcacagctca cagcattctt acaataaaaa caacctcaga acaaaaaaaa aaaaaa
//
