LOCUS       NM_013913               1609 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus angiopoietin-like 3 (Angptl3), mRNA.
ACCESSION   NM_013913
VERSION     NM_013913.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1609)
  AUTHORS   Yang,L., Wang,Y., Xu,Y., Li,K., Yin,R., Zhang,L., Wang,D., Wei,L.,
            Lang,J., Cheng,Y., Wang,L., Ke,J. and Zhao,D.
  TITLE     ANGPTL3 is a novel HDL component that regulates HDL function
  JOURNAL   J Transl Med 22 (1), 263 (2024)
   PUBMED   38462608
  REMARK    GeneRIF: ANGPTL3 is a novel HDL component that regulates HDL
            function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1609)
  AUTHORS   Ma,Y., Chen,Y., Xu,H. and Du,N.
  TITLE     The influence of angiopoietin-like protein 3 on macrophages
            polarization and its effect on the podocyte EMT in diabetic
            nephropathy
  JOURNAL   Front Immunol 14, 1228399 (2023)
   PUBMED   37638046
  REMARK    GeneRIF: The influence of angiopoietin-like protein 3 on
            macrophages polarization and its effect on the podocyte EMT in
            diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1609)
  AUTHORS   Zhang,Z., Fu,J., Zhang,Y., Qin,X., Wang,Y. and Xing,C.
  TITLE     METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA
            and potentiates malignant progression of stomach adenocarcinoma
  JOURNAL   BMC Gastroenterol 23 (1), 217 (2023)
   PUBMED   37344779
  REMARK    GeneRIF: METTL3 regulates N6-methyladenosine modification of
            ANGPTL3 mRNA and potentiates malignant progression of stomach
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1609)
  AUTHORS   Bini,S., Pecce,V., Di Costanzo,A., Polito,L., Ghadiri,A.,
            Minicocci,I., Tambaro,F., Covino,S., Arca,M. and D'Erasmo,L.
  TITLE     The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in
            3T3-L1 Cells by Activating the Intracellular Erk Pathway
  JOURNAL   Biomolecules 12 (4), 585 (2022)
   PUBMED   35454174
  REMARK    GeneRIF: The Fibrinogen-like Domain of ANGPTL3 Facilitates
            Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk
            Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1609)
  AUTHORS   Li,Y. and Teng,C.
  TITLE     Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism
            and providing new hope for metabolic syndrome
  JOURNAL   J Drug Target 22 (8), 679-687 (2014)
   PUBMED   24960069
  REMARK    Review article
REFERENCE   7  (bases 1 to 1609)
  AUTHORS   Camenisch,G., Pisabarro,M.T., Sherman,D., Kowalski,J., Nagel,M.,
            Hass,P., Xie,M.H., Gurney,A., Bodary,S., Liang,X.H., Clark,K.,
            Beresini,M., Ferrara,N. and Gerber,H.P.
  TITLE     ANGPTL3 stimulates endothelial cell adhesion and migration via
            integrin alpha vbeta 3 and induces blood vessel formation in vivo
  JOURNAL   J Biol Chem 277 (19), 17281-17290 (2002)
   PUBMED   11877390
  REMARK    GeneRIF: ANGPTL3 stimulates endothelial cell adhesion and migration
            via integrin alpha vbeta 3 and induces blood vessel formation in
            vivo
REFERENCE   8  (bases 1 to 1609)
  AUTHORS   Koishi,R., Ando,Y., Ono,M., Shimamura,M., Yasumo,H., Fujiwara,T.,
            Horikoshi,H. and Furukawa,H.
  TITLE     Angptl3 regulates lipid metabolism in mice
  JOURNAL   Nat Genet 30 (2), 151-157 (2002)
   PUBMED   11788823
REFERENCE   9  (bases 1 to 1609)
  AUTHORS   Pham,V.N., Roman,B.L. and Weinstein,B.M.
  TITLE     Isolation and expression analysis of three zebrafish angiopoietin
            genes
  JOURNAL   Dev Dyn 221 (4), 470-474 (2001)
   PUBMED   11500985
REFERENCE   10 (bases 1 to 1609)
  AUTHORS   Conklin,D., Gilbertson,D., Taft,D.W., Maurer,M.F., Whitmore,T.E.,
            Smith,D.L., Walker,K.M., Chen,L.H., Wattler,S., Nehls,M. and
            Lewis,K.B.
  TITLE     Identification of a mammalian angiopoietin-related protein
            expressed specifically in liver
  JOURNAL   Genomics 62 (3), 477-482 (1999)
   PUBMED   10644446
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY137245.1, AK149450.1 and
            AL935325.14.
            
            On Aug 20, 2015 this sequence version replaced NM_013913.3.
            
            Summary: This gene encodes a member of the angiopoietin-like family
            of proteins. The encoded preproprotein is proteolytically processed
            to generate multiple protein products, which may inhibit
            triglyceride metabolism. Homozygous knockout mice for this gene
            exhibit reduced plasma lipid concentrations, including reduced
            plasma triglyceride concentrations, and enhanced activity of
            enzymes involved in triglyceride metabolism. [provided by RefSeq,
            Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149450.1, BC019491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BY137245.1         33-33
            2-1605              AK149450.1         2-1605
            1606-1609           AL935325.14        68444-68447
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.6 cM"
     gene            1..1609
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /note="angiopoietin-like 3"
                     /db_xref="GeneID:30924"
                     /db_xref="MGI:MGI:1353627"
     exon            1..546
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /inference="alignment:Splign:2.1.0"
     exon            547..657
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /inference="alignment:Splign:2.1.0"
     exon            658..772
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /inference="alignment:Splign:2.1.0"
     exon            773..886
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /inference="alignment:Splign:2.1.0"
     exon            887..982
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1249
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1609
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /note="hexamer: AATAAA"
     polyA_site      1482
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /note="major polyA site"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angptl3"
                     /gene_synonym="hypl"
                     /note="hexamer: ATTAAA"
     polyA_site      1525
                     /gene="Angptl3"
                     /gene_synonym="hypl"
ORIGIN      
        1 acaggaggga gaagttccaa attgcttaaa attgaataat tgagacaaaa aatgcacaca
       61 attaaattat tcctttttgt tgttccttta gtaattgcat ccagagtgga tccagacctt
      121 tcatcatttg attctgcacc ttcagagcca aaatcaagat ttgctatgtt ggatgatgtc
      181 aaaattttag cgaatggcct cctgcagctg ggtcatggac ttaaagattt tgtccataag
      241 actaagggac aaattaacga catatttcag aagctcaaca tatttgatca gtctttttat
      301 gacctatcac ttcgaaccaa tgaaatcaaa gaagaggaaa aggagctaag aagaactaca
      361 tctacactac aagttaaaaa cgaggaggtg aagaacatgt cagtagaact gaactcaaag
      421 cttgagagtc tgctggaaga gaagacagcc cttcaacaca aggtcagggc tttggaggag
      481 cagctaacca acttaattct aagcccagct ggggctcagg agcacccaga agtaacatca
      541 ctcaaaagtt ttgtagaaca gcaagacaac agcataagag aactcctcca gagtgtggaa
      601 gaacagtata aacaattaag tcaacagcac atgcagataa aagaaataga aaagcagctc
      661 agaaagactg gtattcaaga accctcagaa aattctcttt cttctaaatc aagagcacca
      721 agaactactc cccctcttca actgaacgaa acagaaaata cagaacaaga tgaccttcct
      781 gccgactgct ctgccgttta taacagaggc gaacatacaa gtggcgtgta cactattaaa
      841 ccaagaaact cccaagggtt taatgtctac tgtgataccc aatcaggcag tccatggaca
      901 ttaattcaac accggaaaga tggctcacag gacttcaacg aaacatggga aaactacgaa
      961 aagggctttg ggaggctcga tggagaattt tggttgggcc tagagaagat ctatgctata
     1021 gtccaacagt ctaactacat tttacgactc gagctacaag actggaaaga cagcaagcac
     1081 tacgttgaat actcctttca cctgggcagt cacgaaacca actacacgct acatgtggct
     1141 gagattgctg gcaatatccc tggggccctc ccagagcaca cagacctgat gttttctaca
     1201 tggaatcaca gagcaaaggg acagctctac tgtccagaaa gttactcagg tggctggtgg
     1261 tggaatgaca tatgtggaga aaacaaccta aatggaaaat acaacaaacc cagaaccaaa
     1321 tccagaccag agagaagaag agggatctac tggagacctc agagcagaaa gctctatgct
     1381 atcaaatcat ccaaaatgat gctccagccc accacctaag aagcttcaac tgaactgaga
     1441 caaaataaaa gatcaataaa ttaaatatta aagtcctccc gatcactgta gtaatctggt
     1501 attaaaattt taatggaaag cttgagaatt gaatttcaat taggtttaaa ctcattgtta
     1561 agatcagata tcaccgaatc aacgtaaaca aaatttatct ttttcaatc
//
