LOCUS       NM_011923               3444 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus angiopoietin-like 2 (Angptl2), mRNA.
ACCESSION   NM_011923
VERSION     NM_011923.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3444)
  AUTHORS   Yang,F., Chen,M., Liu,Y., Hu,Y., Chen,Y., Yu,Y. and Deng,L.
  TITLE     ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage
            pyroptosis by reducing LILRB2-mediated inhibition of TREM2
  JOURNAL   J Cell Mol Med 28 (10), e18280 (2024)
   PUBMED   38758159
  REMARK    GeneRIF: ANGPTL2 knockdown induces autophagy to relieve alveolar
            macrophage pyroptosis by reducing LILRB2-mediated inhibition of
            TREM2.
REFERENCE   2  (bases 1 to 3444)
  AUTHORS   Kadomatsu,T., Hara,C., Kurahashi,R., Horiguchi,H., Morinaga,J.,
            Miyata,K., Kurano,S., Kanemaru,H., Fukushima,S., Araki,K., Baba,M.,
            Linehan,W.M., Kamba,T. and Oike,Y.
  TITLE     ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells
            accelerates tumor immune evasion
  JOURNAL   Mol Oncol 17 (12), 2637-2658 (2023)
   PUBMED   37452654
  REMARK    GeneRIF: ANGPTL2-mediated epigenetic repression of MHC-I in tumor
            cells accelerates tumor immune evasion.
REFERENCE   3  (bases 1 to 3444)
  AUTHORS   Li,J., Wan,T., Liu,C., Liu,H., Ke,D. and Li,L.
  TITLE     ANGPTL2 aggravates LPS-induced septic cardiomyopathy via
            NLRP3-mediated inflammasome in a DUSP1-dependent pathway
  JOURNAL   Int Immunopharmacol 123, 110701 (2023)
   PUBMED   37531825
  REMARK    GeneRIF: ANGPTL2 aggravates LPS-induced septic cardiomyopathy via
            NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
REFERENCE   4  (bases 1 to 3444)
  AUTHORS   Horiguchi,H., Kadomatsu,T., Yamashita,T., Yumoto,S., Terada,K.,
            Sato,M., Morinaga,J., Miyata,K. and Oike,Y.
  TITLE     ANGPTL2 promotes immune checkpoint inhibitor-related murine
            autoimmune myocarditis
  JOURNAL   Commun Biol 6 (1), 965 (2023)
   PUBMED   37736764
  REMARK    GeneRIF: ANGPTL2 promotes immune checkpoint inhibitor-related
            murine autoimmune myocarditis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3444)
  AUTHORS   Huang,X., Su,Z., Zhang,S., Xu,X., Yang,B. and Xu,X.
  TITLE     ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive
            Dysfunction Induced by Isoflurane in Aged Mice through Modulating
            MAPK Pathway
  JOURNAL   Mediators Inflamm 2023, 2453402 (2023)
   PUBMED   36865085
  REMARK    GeneRIF: ANGPTL2 Deletion Attenuates Neuroinflammation and
            Cognitive Dysfunction Induced by Isoflurane in Aged Mice through
            Modulating MAPK Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3444)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 3444)
  AUTHORS   Tabata,M., Kadomatsu,T., Fukuhara,S., Miyata,K., Ito,Y., Endo,M.,
            Urano,T., Zhu,H.J., Tsukano,H., Tazume,H., Kaikita,K.,
            Miyashita,K., Iwawaki,T., Shimabukuro,M., Sakaguchi,K., Ito,T.,
            Nakagata,N., Yamada,T., Katagiri,H., Kasuga,M., Ando,Y., Ogawa,H.,
            Mochizuki,N., Itoh,H., Suda,T. and Oike,Y.
  TITLE     Angiopoietin-like protein 2 promotes chronic adipose tissue
            inflammation and obesity-related systemic insulin resistance
  JOURNAL   Cell Metab 10 (3), 178-188 (2009)
   PUBMED   19723494
  REMARK    GeneRIF: Angiopoietin-like protein 2 (Angptl2) was secreted by
            adipose tissue and that its circulating level was closely related
            to adiposity, systemic insulin resistance, and inflammation in
            mice.
REFERENCE   8  (bases 1 to 3444)
  AUTHORS   Liu,X.S., Chopp,M., Zhang,R.L., Hozeska-Solgot,A., Gregg,S.C.,
            Buller,B., Lu,M. and Zhang,Z.G.
  TITLE     Angiopoietin 2 mediates the differentiation and migration of neural
            progenitor cells in the subventricular zone after stroke
  JOURNAL   J Biol Chem 284 (34), 22680-22689 (2009)
   PUBMED   19553662
  REMARK    GeneRIF: Data suggest that interaction of ANG2, a proangiogenic
            factor, with its receptor Tie2 promotes neural progenitor cell
            differentiation into neuronal lineage cells.
REFERENCE   9  (bases 1 to 3444)
  AUTHORS   Dellinger,M., Hunter,R., Bernas,M., Gale,N., Yancopoulos,G.,
            Erickson,R. and Witte,M.
  TITLE     Defective remodeling and maturation of the lymphatic vasculature in
            Angiopoietin-2 deficient mice
  JOURNAL   Dev Biol 319 (2), 309-320 (2008)
   PUBMED   18514180
  REMARK    GeneRIF: This work pinpoints a specific lymphatic defect of
            Ang2(-/-) mice and further defines the sequential steps in
            lymphatic vessel remodeling.
REFERENCE   10 (bases 1 to 3444)
  AUTHORS   Kim,I., Moon,S.O., Koh,K.N., Kim,H., Uhm,C.S., Kwak,H.J., Kim,N.G.
            and Koh,G.Y.
  TITLE     Molecular cloning, expression, and characterization of
            angiopoietin-related protein. angiopoietin-related protein induces
            endothelial cell sprouting
  JOURNAL   J Biol Chem 274 (37), 26523-26528 (1999)
   PUBMED   10473614
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK155464.1.
            
            On Apr 5, 2007 this sequence version replaced NM_011923.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155464.1, AK037265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3444              AK155464.1         2-3445
FEATURES             Location/Qualifiers
     source          1..3444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.36 cM"
     gene            1..3444
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /note="angiopoietin-like 2"
                     /db_xref="GeneID:26360"
                     /db_xref="MGI:MGI:1347002"
     exon            1..493
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..1351
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             535..2016
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /note="angiopoietin-related protein 2; angiopoietin-like
                     protein 2"
                     /codon_start=1
                     /product="angiopoietin-related protein 2 precursor"
                     /protein_id="NP_036053.2"
                     /db_xref="CCDS:CCDS15940.1"
                     /db_xref="GeneID:26360"
                     /db_xref="MGI:MGI:1347002"
                     /translation="MRPLCMTYWWLGLLATVGAATGPEADVEGTEDGSQREYIYLNRY
                     KRAGESPDKCTYTFIVPQQRVTGAICVNSKEPEVHLENRVHKQELELLNNELLKQKRQ
                     IETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLEN
                     RILNQTADMLQLASKYKDLEHKFQHLAMLAHNQSEVIAQLEEHCQRVPAARPMPQPPP
                     AAPPRVYQPPTYNRIINQISTNEIQSDQNLKVLPPSLPTMPALTSLPSSTDKPSGPWR
                     DCLQALEDGHSTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWE
                     TYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEY
                     YKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNG
                     VWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH"
     exon            1352..1545
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1816
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..3444
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2253..2258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /note="hexamer: AATAAA"
     polyA_site      2274
                     /gene="Angptl2"
                     /gene_synonym="Arp2"
                     /note="major polyA site"
ORIGIN      
        1 gtctggagct gaggggaggc ccagagcttt tctggggcct gggggatcct cttgcactgg
       61 tgggcggaga gaagtgcctg cagccaacca gggtcaggct gtgctcacag tttcctctgg
      121 cggcacgtaa aggctccaca aaggacctgg gagttcaact gaggctgctg ctgtcggcct
      181 ggggatggac cccaagccct gagtggtgtt gttggaccca ggacctgcaa gaagcatgca
      241 ctaaggcagc tgcggaccac actgtgaggg agagcaggtt gggagcagcc ccggtgacac
      301 cagagccagc ctcatcccta ggagcttcag agagcataga ctgctgccag ctgaggccag
      361 tgaggcaggg ctgctcggcg gccagtccag cctgagactc gggacctctc ctggaggcca
      421 cggccaggct gtgctgctga tggcaccgtg aggcatgtga agcgctgctc cagggccaag
      481 caggagagaa gaggctttca gttcataaag accaaccagc acactgcaag gaccatgagg
      541 ccactgtgta tgacctactg gtggcttgga ctgctggcca cggtcggagc tgctacaggc
      601 ccagaggctg acgttgaggg cacagaggat ggttcacaga gagagtacat ttacctcaac
      661 aggtacaagc gggcaggtga gtcccccgac aagtgcacct acactttcat tgtgccccag
      721 cagcgggtca caggtgccat ttgtgtcaac tccaaggagc ctgaggtgca cctggagaac
      781 cgtgtgcaca agcaggagct ggagctgctc aacaatgagc tgcttaagca gaagcggcag
      841 atcgagacgc tgcagcagct ggtagaggta gacggaggca tcgtgagcga ggtgaagctg
      901 ctgcgcaagg agagccgcaa catgaactcg agagtcacgc agctgtacat gcaacttcta
      961 catgagatca ttcgaaagcg agacaatgcg ctggagctct cccagctgga gaacaggatc
     1021 ctgaaccaga cagctgacat gctgcagctg gctagcaagt acaaggacct ggagcacaag
     1081 ttccagcacc tggctatgct ggcacacaac caatcagagg tcattgctca gctcgaagag
     1141 cactgccaac gcgtacctgc agccaggcct atgccccagc cacccccagc agctccacct
     1201 cgggtctacc aaccacccac ctacaaccgc atcatcaacc agatttccac caatgagatc
     1261 cagagtgacc agaatctgaa ggtgctgccg ccctccttgc ccaccatgcc tgcccttacc
     1321 agtctcccat cttccactga taagccatca ggtccatgga gagactgcct gcaagccctg
     1381 gaagatggtc acagcaccag ctccatctac ctggtgaagc ctgagaatac caaccgcctg
     1441 atgcaggtgt ggtgtgacca gagacatgac cctggaggtt ggactgtcat ccagagacgc
     1501 ctggatggct ctgtcaactt cttcaggaac tgggagacct ataagcaagg gtttgggaac
     1561 atcgatggtg agtactggct gggcctggag aacatctact ggctgacgaa ccaaggcaac
     1621 tacaaactgc tggtaaccat ggaggactgg tctggccgta aagtctttgc tgagtatgcc
     1681 agtttccgac tggagccaga aagcgagtac tataagctgc ggctggggcg ttatcatggc
     1741 aatgcaggcg actcctttac ctggcacaac ggcaaacagt ttaccaccct ggacagggac
     1801 catgatgtct acacaggaaa ctgtgcccac tatcagaagg gaggatggtg gtataacgcc
     1861 tgtgctcact ccaacctcaa tggggtctgg taccgtgggg gccattaccg gagcagatac
     1921 caggacgggg tctactgggc tgagttccga ggaggctctt actcactcaa gaaggtggtg
     1981 atgatgattc ggcccaaccc caacaccttc cactaagctc tccctgcctg gccactaaca
     2041 ccatggccag aagccatccc agccgtgtga cctcagcaca gctcttcgct ggcccacctc
     2101 aggctggagg actgtgcttt ccaatgtggc tctgtcagac gatggaaatg aacagtgttc
     2161 tctgtcccta ctgcgttctt ttacacctaa cagctccttg tattccagga taggatagaa
     2221 ctgcagagtc ttccaatcag ttaagtccct ttaataaaga cacaactgcc aatatcgcca
     2281 gatctgacag acatgcacac gagccaccag gtgtatgctc ttagacacac atcacacgtg
     2341 ggatgtcgag atacacatat gggtttccac atatacttac cttttcctgc tcagttctca
     2401 ggtgctgact ccagcaccat agctttgcgc ttaagacaat gtatgtctca ttgtctaagg
     2461 acagaacagg cattgtagcc ctgatttcaa aaacagtcct tggcactgcc tggattttcc
     2521 cagaatgtcc tcaagctcat ctctcacata ggggctcctg gccttctctc cttgagcccc
     2581 acctcccctc agactgttgc acttcccctc tcaggacggc tcagcatccc tccgtacagt
     2641 tacccctcag cctgcacctc ctgtgcctta gtctctggct gctcactgga agtcaagtcc
     2701 tcttctccct gctcccctgg cctctccttt tctgccacac agagctttat ttctggcaca
     2761 attcgttggc ctctgggcag gaaacagtct gggctcaggt cctggctgag aagggaaggc
     2821 caggccagaa gccacagagg cagcggcata gacctgtatt cagttctgca ccttccattc
     2881 atactttagc ctccacagaa ttttaacctc tacacaaaca gtaccctgct ttgccagaga
     2941 caccccactg gagagaagtc gctgccaata ggttggggtc cccagacagc tgcagatttg
     3001 aggtcctgtg ctcatgggga acaatcttca ccctgtcacc aagctacatc tcctcagaag
     3061 atgaggccac agaaagaaaa actgactttc catgagttgc catgccatca ggggctcctg
     3121 acacactgca gcagggtggc ttcctgagtc ttgtttagag ttaccagatg actgcaatgc
     3181 caggggcaac atataagtca agaagttgag accctcccag tgggtgtgtg tgccaggtgt
     3241 gtgaggtgtg gggcatttgg tactgtccac atctgggtgc actgccctgt tacctcagca
     3301 tttctcccag tgtaccatgt agcatgttct gtgtatatat aaaagggagg ttttgttcgt
     3361 ttatgttttt aaaaatatat tgccagacac aaatctgtgt attgtaatga cacaaatctg
     3421 caataaaagc catcagtgtt acgt
//
