LOCUS       NM_028333               2288 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus angiopoietin-like 1 (Angptl1), mRNA.
ACCESSION   NM_028333
VERSION     NM_028333.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2288)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2288)
  AUTHORS   Chang,T.Y., Lan,K.C., Chiu,C.Y., Sheu,M.L. and Liu,S.H.
  TITLE     ANGPTL1 attenuates cancer migration, invasion, and stemness through
            regulating FOXO3a-mediated SOX2 expression in colorectal cancer
  JOURNAL   Clin Sci (Lond) 136 (9), 657-673 (2022)
   PUBMED   35475476
  REMARK    GeneRIF: ANGPTL1 attenuates cancer migration, invasion, and
            stemness through regulating FOXO3a-mediated SOX2 expression in
            colorectal cancer.
REFERENCE   3  (bases 1 to 2288)
  AUTHORS   Ishida,M., Kawao,N., Mizukami,Y., Takafuji,Y. and Kaji,H.
  TITLE     Influence of Angptl1 on osteoclast formation and osteoblastic
            phenotype in mouse cells
  JOURNAL   BMC Musculoskelet Disord 22 (1), 398 (2021)
   PUBMED   33910546
  REMARK    GeneRIF: Influence of Angptl1 on osteoclast formation and
            osteoblastic phenotype in mouse cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2288)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2288)
  AUTHORS   Scott,C.A., van Huyen,D. and Bany,B.M.
  TITLE     Angiopoietin-like gene expression in the mouse uterus during
            implantation and in response to steroids
  JOURNAL   Cell Tissue Res 348 (1), 199-211 (2012)
   PUBMED   22350948
REFERENCE   6  (bases 1 to 2288)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 2288)
  AUTHORS   Lai,D.M., Li,H., Lee,C.C., Tzeng,Y.S., Hsieh,Y.H., Hsu,W.M.,
            Hsieh,F.J., Cheng,J.T. and Tu,Y.K.
  TITLE     Angiopoietin-like protein 1 decreases blood brain barrier damage
            and edema following focal cerebral ischemia in mice
  JOURNAL   Neurochem Int 52 (3), 470-477 (2008)
   PUBMED   17919782
  REMARK    GeneRIF: We conclude that angptl1 may have a beneficial role in the
            preservation of vascular integrity following focal cerebral
            ischemia.
REFERENCE   8  (bases 1 to 2288)
  AUTHORS   Lai,D.M., Tu,Y.K., Hsieh,Y.H., Hsu,W.M., Lee,C.C., Cheng,W.C.,
            Hsieh,F.J. and Li,H.
  TITLE     Angiopoietin-like protein 1 expression is related to intermuscular
            connective tissue and cartilage development
  JOURNAL   Dev Dyn 236 (9), 2643-2652 (2007)
   PUBMED   17676644
  REMARK    GeneRIF: Angiopoietin-like protein 1 expression is related to
            intermuscular connective tissue and cartilage development
REFERENCE   9  (bases 1 to 2288)
  AUTHORS   Xu,Y., Liu,Y.J. and Yu,Q.
  TITLE     Angiopoietin-3 is tethered on the cell surface via heparan sulfate
            proteoglycans
  JOURNAL   J Biol Chem 279 (39), 41179-41188 (2004)
   PUBMED   15280392
REFERENCE   10 (bases 1 to 2288)
  AUTHORS   Valenzuela,D.M., Griffiths,J.A., Rojas,J., Aldrich,T.H.,
            Jones,P.F., Zhou,H., McClain,J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Huang,T., Papadopoulos,N., Maisonpierre,P.C.,
            Davis,S. and Yancopoulos,G.D.
  TITLE     Angiopoietins 3 and 4: diverging gene counterparts in mice and
            humans
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 1904-1909 (1999)
   PUBMED   10051567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138109.3.
            
            On Mar 11, 2022 this sequence version replaced NM_028333.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082563.1, AK142319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC138109.3         103524-103836
            314-1159            AC138109.3         109179-110024
            1160-1353           AC138109.3         121682-121875
            1354-1624           AC138109.3         122959-123229
            1625-2288           AC138109.3         125014-125677
FEATURES             Location/Qualifiers
     source          1..2288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.75 cM"
     gene            1..2288
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /note="angiopoietin-like 1"
                     /db_xref="GeneID:72713"
                     /db_xref="MGI:MGI:1919963"
     exon            1..313
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1159
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1812
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /note="angiopoietin-related protein 1; angiopoietin-like
                     protein 1"
                     /codon_start=1
                     /product="angiopoietin-related protein 1 precursor"
                     /protein_id="NP_082609.2"
                     /db_xref="CCDS:CCDS15397.1"
                     /db_xref="GeneID:72713"
                     /db_xref="MGI:MGI:1919963"
                     /translation="MKAFVWTLSVLLFLLGSGHCKGGQLKIKKITQRRYPRATDGKEE
                     AKKCSYTFLVPEQKITGPICVNTKGQDAGTIKDMITRMDLENLKDVLSRQKREIDVLQ
                     LVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILNV
                     TTEMLKMATRYRELEVKYASLTDLVNNQSVTITVLEEQCLRMFSRQDPHASPPLVQVV
                     PRHSPNSHQYTPGLLGGNEIQRDPGYPRDVMPPPDLPTAPTKSPFKIPAVTFINEGPF
                     KDCQQAKEAGHSASGIYMIKPENSNGLMQLWCENSLDPGGWTVIQKRTDGSVNFFRNW
                     ENYKKGFGNIDGEYWLGLDNIYKLSNQDNYKLMIELEDWSEKKVYAEYSSFRLEPESD
                     YYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDTYTGNCAHFHKGGWWYNACAHSNLN
                     GVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMIKPID"
     exon            1160..1353
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1624
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..2288
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /note="hexamer: AATAAA"
     polyA_site      2288
                     /gene="Angptl1"
                     /gene_synonym="2810039D03Rik; ANG3; ANGPT3; ANGY; ARP1"
                     /note="major polyA site"
ORIGIN      
        1 actcttcgga ctgtgtggac agtctgtcag ctgcggctgg tttctgcaca tttccatgca
       61 gcagacagca caggcacaga accttctctg ctgcattaga gaagtccaca gatagcccca
      121 agttacatag gtggcccagc aaactcagtc cattagtgct gtgaaaagaa gttccttact
      181 ccttggattc accggtcaga gcaaaaaacg cagttacctc tgaagtaaag ccgaacaaac
      241 ttctacactg atctcagaga gcaagggcaa ggacgcacgt tcacggactc gcttttttca
      301 acagacaaca aagacgctgt ggtagaattt catttcaaaa tgaaggcttt tgtttggacc
      361 ctaagtgtac tactcttcct actgggcagt ggtcattgca aaggaggaca actcaaaata
      421 aaaaaaataa cccaaaggag atatccccgt gctactgatg ggaaagagga agcaaagaaa
      481 tgttcatata cattcttggt acctgaacaa aaaataacag ggccaatctg tgtcaacacc
      541 aaaggtcagg atgcaggcac tattaaggac atgatcacca ggatggacct ggagaacctc
      601 aaggatgtgc tgtctaggca gaagcgggag atagatgtcc tgcagctggt ggtagatgtg
      661 gacgggaaca ttgtaaacga ggtgaagctg ctgagaaagg aaagccggaa catgaactcc
      721 agagtcacgc agctctacat gcagctacta catgagatca tccgtaaaag agacaattca
      781 ctcgaacttt cccagctgga aaacaaaatc ctcaatgtca ccacagaaat gctgaagatg
      841 gcaacaaggt acagggagct agaggtgaag tatgcgtcct tgacggatct tgtcaataac
      901 cagtctgtga cgatcactgt attggaagag cagtgcctga ggatgttttc ccgacaagac
      961 ccccacgcgt ctccccctct tgtccaggtg gtaccgcgac acagtcctaa cagccaccag
     1021 tacacccctg gtctgctggg aggcaatgag atacagaggg acccaggtta ccccagagac
     1081 gtaatgccac cacctgatct gccaacagct cccacgaaaa gccctttcaa gattccagca
     1141 gtgactttca tcaatgaagg accattcaaa gactgtcagc aagcaaagga agctggacac
     1201 tcagccagtg gaatttacat gattaaacct gaaaacagca acggtctgat gcagttatgg
     1261 tgtgagaaca gtttggatcc tgggggttgg actgttattc agaaaagaac agatggctct
     1321 gtcaatttct tcagaaactg ggaaaattat aagaaagggt ttggaaacat tgatggagag
     1381 tactggcttg gactggacaa tatctacaag cttagtaatc aagacaatta taagctgatg
     1441 attgaactag aagactggag cgagaagaag gtctatgcag aatacagcag ctttcgtctg
     1501 gagcccgaaa gtgactacta cagactgcgc ctggggacgt accaggggaa tgctggggac
     1561 tctatgatgt ggcataatgg taaacagttc accacgctgg acagagataa agatacgtac
     1621 acaggaaact gcgcccactt ccataaagga ggctggtggt acaacgcctg tgcacactct
     1681 aacctcaacg gagtatggta cagaggtggt cattacagaa gcaagcacca agatggcatt
     1741 ttctgggctg aatacagagg cgggtcctac tccttgaggg cagtacagat gatgatcaag
     1801 cctattgact gacacctcca agtaaatgac acagaacttc acttccagtt ccccaaatct
     1861 aaacattaca cgttactctg cacaacttat ttttacaggt acagttttta aaatacattt
     1921 tactactata aaaatgtatc tgtgaaaaca gttccattct ccttcaagga agattatgca
     1981 aatccttgtt attttaaaaa ttatattgac tgaatattgg taaatgtaaa tattggccac
     2041 aatgtaaaac aaatcttagc tttattttga atcaaatcca aatacatgtt caagatactt
     2101 catgatttat ttaaaaaata taagtctgct ctaactttca ctgaaaaaaa ttatttcaag
     2161 agttcagcca attagtgcat tttatttatg aaaatacaga caggaaacta gaggaaaaaa
     2221 actctagttt tgccactagg aaatgttttt ccagtaagta caactttaaa ataaaatttt
     2281 aaattgaa
//
