LOCUS       NM_009641               2355 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus angiopoietin 4 (Angpt4), mRNA.
ACCESSION   NM_009641
VERSION     NM_009641.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Wu,Z., Shi,Y., Cui,Y., Xing,X., Zhang,L., Liu,D., Zhang,Y.,
            Dong,J., Jin,L., Pang,M., Xiao,R.P., Zhu,Z., Xiong,J.W., Tong,X.,
            Zhang,Y., Wang,S., Tang,F. and Zhang,B.
  TITLE     Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM
            cellular coordination cascade during heart regeneration
  JOURNAL   Protein Cell 14 (5), 350-368 (2023)
   PUBMED   37155312
  REMARK    GeneRIF: Single-cell analysis reveals an Angpt4-initiated
            EPDC-EC-CM cellular coordination cascade during heart regeneration.
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Kapiainen,E., Elamaa,H., Miinalainen,I., Izzi,V. and Eklund,L.
  TITLE     Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal
            Maintenance
  JOURNAL   Invest Ophthalmol Vis Sci 63 (11), 1 (2022)
   PUBMED   36190459
  REMARK    GeneRIF: Cooperation of Angiopoietin-2 and Angiopoietin-4 in
            Schlemm's Canal Maintenance.
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Zhang,X., Yuan,S., Zhang,X., Zhang,T., Meng,C., Zhuang,K. and
            Dang,S.
  TITLE     ANGPTL4 regulates CD163 expression and Kuppfer cell polarization
            induced cirrhosis via TLR4/NF-kappaB pathway
  JOURNAL   Exp Cell Res 405 (2), 112706 (2021)
   PUBMED   34146541
  REMARK    GeneRIF: ANGPTL4 regulates CD163 expression and Kuppfer cell
            polarization induced cirrhosis via TLR4/NF-kappaB pathway.
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Chatterjee,S., Nandakumar,P., Auer,D.R., Gabriel,S.B. and
            Chakravarti,A.
  TITLE     Gene- and tissue-level interactions in normal gastrointestinal
            development and Hirschsprung disease
  JOURNAL   Proc Natl Acad Sci U S A 116 (52), 26697-26708 (2019)
   PUBMED   31818953
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Elamaa,H., Kihlstrom,M., Kapiainen,E., Kaakinen,M., Miinalainen,I.,
            Ragauskas,S., Cerrada-Gimenez,M., Mering,S., Natynki,M. and
            Eklund,L.
  TITLE     Angiopoietin-4-dependent venous maturation and fluid drainage in
            the peripheral retina
  JOURNAL   Elife 7, e37776 (2018)
   PUBMED   30444491
  REMARK    GeneRIF: This study identifies Angpt4 as the first growth factor
            for venous-specific development and its importance in venous
            remodeling, retinal fluid clearance and neuronal function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Shike,T., Gohda,T., Tanimoto,M., Kobayashi,M., Makita,Y.,
            Funabiki,K., Horikoshi,S., Hirose,S., Shirai,T. and Tomino,Y.
  TITLE     Chromosomal mapping of a quantitative trait locus for the
            development of albuminuria in diabetic KK/Ta mice
  JOURNAL   Nephrol Dial Transplant 20 (5), 879-885 (2005)
   PUBMED   15769825
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Xu,Y., Liu,Y.J. and Yu,Q.
  TITLE     Angiopoietin-3 is tethered on the cell surface via heparan sulfate
            proteoglycans
  JOURNAL   J Biol Chem 279 (39), 41179-41188 (2004)
   PUBMED   15280392
  REMARK    GeneRIF: Angiopoietin-3 binds to the cell membrane via heparan
            sulfate proteoglycans
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Lee,H.J., Cho,C.H., Hwang,S.J., Choi,H.H., Kim,K.T., Ahn,S.Y.,
            Kim,J.H., Oh,J.L., Lee,G.M. and Koh,G.Y.
  TITLE     Biological characterization of angiopoietin-3 and angiopoietin-4
  JOURNAL   FASEB J 18 (11), 1200-1208 (2004)
   PUBMED   15284220
  REMARK    GeneRIF: Recombinant Ang3 formed disulfide-linked dimers. Ang3 was
            more potent than Ang4 in phosphorylating Akt in primary cultured
            mouse lung microvascular endothelial cells. It is a Tie2 agonist &
            causes corneal angiogenesis.
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Davis,S., Papadopoulos,N., Aldrich,T.H., Maisonpierre,P.C.,
            Huang,T., Kovac,L., Xu,A., Leidich,R., Radziejewska,E., Rafique,A.,
            Goldberg,J., Jain,V., Bailey,K., Karow,M., Fandl,J.,
            Samuelsson,S.J., Ioffe,E., Rudge,J.S., Daly,T.J., Radziejewski,C.
            and Yancopoulos,G.D.
  TITLE     Angiopoietins have distinct modular domains essential for receptor
            binding, dimerization and superclustering
  JOURNAL   Nat Struct Biol 10 (1), 38-44 (2003)
   PUBMED   12469114
  REMARK    Erratum:[Nat Struct Biol. 2003 Feb;10(2):146]
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Valenzuela,D.M., Griffiths,J.A., Rojas,J., Aldrich,T.H.,
            Jones,P.F., Zhou,H., McClain,J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Huang,T., Papadopoulos,N., Maisonpierre,P.C.,
            Davis,S. and Yancopoulos,G.D.
  TITLE     Angiopoietins 3 and 4: diverging gene counterparts in mice and
            humans
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 1904-1909 (1999)
   PUBMED   10051567
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK132988.1, AF113707.1 and
            BQ032449.1.
            
            On Jul 20, 2016 this sequence version replaced NM_009641.1.
            
            Summary: This gene is a member of the angiopoietin family of
            secreted growth factors comprising Angiopoietins-1, -2, and -3, all
            of which bind the TEK Receptor Tyrosine Kinase. Angiopoietin/TEK
            Receptor Tyrosine Kinase signaling is involved in survival and
            migration of endothelial cells and regulates vascular remodeling
            and maintenance of vascular integrity. Angiopoietin/TEK Receptor
            Tyrosine Kinase signaling is also required for lymphangiogenesis.
            Family members bind TEK Receptor Tyrosine Kinase as multimeric
            clusters but their oligomerization properties differ from one
            another and this is thought to provide a mechanistic basis for
            their distinct physiologic roles. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132988.1, BC129965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AK132988.1         1-125
            126-1655            AF113707.1         1-1530
            1656-2337           AK132988.1         1656-2337
            2338-2355           BQ032449.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..2355
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /note="angiopoietin 4"
                     /db_xref="GeneID:11602"
                     /db_xref="MGI:MGI:1336887"
     exon            1..461
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1655
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /note="angiopoietin-3"
                     /codon_start=1
                     /product="angiopoietin-4 precursor"
                     /protein_id="NP_033771.1"
                     /db_xref="CCDS:CCDS16874.1"
                     /db_xref="GeneID:11602"
                     /db_xref="MGI:MGI:1336887"
                     /translation="MLCQPAMLLDGLLLLATMAAAQHRGPEAGGHRQIHQVRRGQCSY
                     TFVVPEPDICQLAPTAAPEALGGSNSLQRDLPASRLHLTDWRAQRAQRAQRVSQLEKI
                     LENNTQWLLKLEQSIKVNLRSHLVQAQQDTIQNQTTTMLALGANLMNQTKAQTHKLTA
                     VEAQVLNQTLHMKTQMLENSLSTNKLERQMLMQSRELQRLQGRNRALETRLQALEAQH
                     QAQLNSLQEKREQLHSLLGHQTGTLANLKHNLHALSSNSSSLQQQQQQLTEFVQRLVR
                     IVAQDQHPVSLKTPKPVFQDCAEIKRSGVNTSGVYTIYETNMTKPLKVFCDMETDGGG
                     WTLIQHREDGSVNFQRTWEEYKEGFGNVAREHWLGNEAVHRLTSRTAYLLRVELHDWE
                     GRQTSIQYENFQLGSERQRYSLSVNDSSSSAGRKNSLAPQGTKFSTKDMDNDNCMCKC
                     AQMLSGGWWFDACGLSNLNGIYYSVHQHLHKINGIRWHYFRGPSYSLHGTRMMLRPMG
                     A"
     exon            462..617
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     exon            618..739
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..978
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1094
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1196
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1363
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1494
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..2338
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /note="hexamer: AATAAA"
     polyA_site      2338
                     /gene="Angpt4"
                     /gene_synonym="Agpt4; ANG-3; ANG-4; Ang3"
                     /note="major polyA site"
ORIGIN      
        1 gacttacagc agttggactc tgcatcacag gccccagctg cacagcacat ctgggcgagg
       61 gctggctgtg aggagttacc tgtcctggta cctgacaaga ccacctcacc accacttggt
      121 ctcagatgct ctgccagcca gctatgctac tagatggcct cctcctgctg gccaccatgg
      181 ctgcagccca gcacagaggg ccagaagccg gtgggcaccg ccagattcac caggtccggc
      241 gtggccagtg cagctacacc tttgtggtgc cggagcctga tatctgccag ctggcgccga
      301 cagcggcgcc tgaggctttg gggggctcca atagcctcca gagggacttg cctgcctcga
      361 ggctgcacct aacagactgg cgagcccaga gggcccagcg ggcccagcgt gtgagccagc
      421 tggagaagat actagagaat aacactcagt ggctgctgaa gctggagcag tccatcaagg
      481 tgaacttgag gtcacacctg gtgcaggccc agcaggacac aatccagaac cagacaacta
      541 ccatgctggc actgggtgcc aacctcatga accagaccaa agctcagacc cacaagctga
      601 ctgctgtgga ggcacaggtc ctaaaccaga cattgcacat gaagacccaa atgctggaga
      661 actcactgtc caccaacaag ctggagcggc agatgctgat gcagagccga gagctgcagc
      721 ggctgcaggg tcgcaacagg gccctggaga ccaggctgca ggcactggaa gcacaacatc
      781 aggcccagct taacagcctc caagagaaga gggaacaact gcacagtctc ctgggccatc
      841 agaccgggac cctggctaac ctgaagcaca atctgcacgc tctcagcagc aattccagct
      901 ccctgcagca gcagcagcag caactgacgg agtttgtaca gcgcctggta cggattgtag
      961 cccaggacca gcatccggtt tccttaaaga cacctaagcc agtgttccag gactgtgcag
     1021 agatcaagcg ctccggggtt aataccagcg gtgtctatac catctatgag accaacatga
     1081 caaagcctct caaggtgttc tgtgacatgg agactgatgg aggtggctgg accctcatcc
     1141 agcaccggga ggatggaagc gtaaatttcc agaggacctg ggaagaatac aaagagggtt
     1201 ttggtaatgt ggccagagag cactggctgg gcaatgaggc tgtgcaccgc ctcaccagca
     1261 gaacggccta cttgctacgc gtggaactgc atgactggga aggccgccag acctccatcc
     1321 agtatgagaa cttccagctg ggcagcgaga ggcagcggta cagcctctct gtgaatgaca
     1381 gcagcagttc agcagggcgc aagaacagcc tggctcctca gggcaccaag ttcagcacca
     1441 aagacatgga caatgataac tgcatgtgta aatgtgctca gatgctgtct ggagggtggt
     1501 ggtttgatgc ctgtggcctc tccaacctca atggcatcta ctattcagtt catcagcact
     1561 tgcacaagat caatggcatc cgctggcact acttccgagg ccccagctac tcactgcacg
     1621 gcacacgcat gatgctgagg ccaatgggtg cctgacacac agccctgcag agactgatgc
     1681 cgtaggagga ttctcaaccc aggtgactct gtgcacgctg ggccctgccc agaaatcagt
     1741 gcccagggct catcttgaca ttctggaaca tcggagccag cttaccttgc ccctgaatta
     1801 caagagtcac ctgcctccct gtgcccctct agtgtgaaat gctgggtgct tgaggcacct
     1861 gcctctgtgg aacccatact ctttcccctc ctgctgcatg ccgggactcc ctgccatgac
     1921 ctgaggcaga ctgaacttga ccccctcaga gggtggggtt gcagcaggtg gggaaatctt
     1981 gcagcctggg gtgccctcct ccaggtgaga acgagagtct ctcactcttc tctaattcca
     2041 agtttctctc ggcttgagat gtccgcagac tttctttcca aggctggtga acactgttcc
     2101 cactcccagt ccccagtgct agccaccatt ccccgagccc cgtggctctt ggacttcaat
     2161 gactgagtca gacctgatct ctcagaggct tctagaaata ggagaaggga tctttttacg
     2221 ccagtgtgcc ctagagtgtt ttccataggt aataactaag gctcctctct aaagtacttt
     2281 ggataaagtg agagagaaac agcaggttaa ataaagagaa tagactttcc taactgcaaa
     2341 aaaaaaaaaa aaaaa
//
