LOCUS       NM_009640               4316 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus angiopoietin 1 (Angpt1), transcript variant 1, mRNA.
ACCESSION   NM_009640
VERSION     NM_009640.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4316)
  AUTHORS   Sekimoto,A., Takaso,Y., Saruyama,H., Ookawa,M., Yamamoto,M.,
            Toyohara,T., Saigusa,D., Fukuuchi,T., Otsuka,M., Fushiki,Y.,
            Yamakoshi,S., Tanaka,K., Ikeda,T., Tanaka,T., Takahashi,N.,
            Mishima,E. and Sato,E.
  TITLE     Impacts of low birthweight on kidney development and
            intergenerational growth of the offspring
  JOURNAL   iScience 27 (11), 111159 (2024)
   PUBMED   39524353
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4316)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   3  (bases 1 to 4316)
  AUTHORS   Zhao,H., Wong,R.J. and Stevenson,D.K.
  TITLE     The placental vasculature is affected by changes in gene expression
            and glycogen-rich cells in a diet-induced obesity mouse model
  JOURNAL   PLoS One 18 (11), e0294185 (2023)
   PUBMED   37948457
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4316)
  AUTHORS   Kapiainen,E., Elamaa,H., Miinalainen,I., Izzi,V. and Eklund,L.
  TITLE     Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal
            Maintenance
  JOURNAL   Invest Ophthalmol Vis Sci 63 (11), 1 (2022)
   PUBMED   36190459
REFERENCE   5  (bases 1 to 4316)
  AUTHORS   Lee,E.H., Woo,J.S., Hwang,J.H., Park,J.H. and Cho,C.H.
  TITLE     Angiopoietin 1 enhances the proliferation and differentiation of
            skeletal myoblasts
  JOURNAL   J Cell Physiol 228 (5), 1038-1044 (2013)
   PUBMED   23041942
  REMARK    GeneRIF: These results provide an insight into the molecular
            mechanisms by which Ang1 directly affects the myogenesis of
            striated muscle.
REFERENCE   6  (bases 1 to 4316)
  AUTHORS   Jeansson,M., Gawlik,A., Anderson,G., Li,C., Kerjaschki,D.,
            Henkelman,M. and Quaggin,S.E.
  TITLE     Angiopoietin-1 is essential in mouse vasculature during development
            and in response to injury
  JOURNAL   J Clin Invest 121 (6), 2278-2289 (2011)
   PUBMED   21606590
  REMARK    GeneRIF: ANG-1 is critical for regulating the number &diameter of
            developing vessels. It is not required for pericyte recruitment. It
            is dispensable in quiescent vessels but powerfully modulates the
            vascular response after injury.
REFERENCE   7  (bases 1 to 4316)
  AUTHORS   Kuo,C.T., Veselits,M.L., Barton,K.P., Lu,M.M., Clendenin,C. and
            Leiden,J.M.
  TITLE     The LKLF transcription factor is required for normal tunica media
            formation and blood vessel stabilization during murine
            embryogenesis
  JOURNAL   Genes Dev 11 (22), 2996-3006 (1997)
   PUBMED   9367982
REFERENCE   8  (bases 1 to 4316)
  AUTHORS   Maisonpierre,P.C., Suri,C., Jones,P.F., Bartunkova,S.,
            Wiegand,S.J., Radziejewski,C., Compton,D., McClain,J.,
            Aldrich,T.H., Papadopoulos,N., Daly,T.J., Davis,S., Sato,T.N. and
            Yancopoulos,G.D.
  TITLE     Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo
            angiogenesis
  JOURNAL   Science 277 (5322), 55-60 (1997)
   PUBMED   9204896
REFERENCE   9  (bases 1 to 4316)
  AUTHORS   Suri,C., Jones,P.F., Patan,S., Bartunkova,S., Maisonpierre,P.C.,
            Davis,S., Sato,T.N. and Yancopoulos,G.D.
  TITLE     Requisite role of angiopoietin-1, a ligand for the TIE2 receptor,
            during embryonic angiogenesis
  JOURNAL   Cell 87 (7), 1171-1180 (1996)
   PUBMED   8980224
REFERENCE   10 (bases 1 to 4316)
  AUTHORS   Davis,S., Aldrich,T.H., Jones,P.F., Acheson,A., Compton,D.L.,
            Jain,V., Ryan,T.E., Bruno,J., Radziejewski,C., Maisonpierre,P.C.
            and Yancopoulos,G.D.
  TITLE     Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by
            secretion-trap expression cloning
  JOURNAL   Cell 87 (7), 1161-1169 (1996)
   PUBMED   8980223
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100734.4, BC067410.1 and
            AC101713.7.
            
            On Oct 31, 2013 this sequence version replaced NM_009640.3.
            
            Summary: This gene encodes a secreted glycoprotein that belongs to
            the angiopoietin family of vascular growth factors. The encoded
            protein is a ligand in the vascular tyrosine kinase signaling
            pathway and regulates the formation and stabilization of blood
            vessels. This protein also functions in striated muscles by
            promoting proliferation, migration and differentiation of skeletal
            myoblasts and plays an essential role in the vascular response to
            tissue injury. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088439.1, BC067410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02146468 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC100734.4         19509-19690
            183-1376            BC067410.1         1-1194
            1377-1377           AC101713.7         156927-156927       c
            1378-3350           BC067410.1         1196-3168
            3351-3351           AC101713.7         106106-106106       c
            3352-4260           BC067410.1         3170-4078
            4261-4316           AC101713.7         105141-105196       c
FEATURES             Location/Qualifiers
     source          1..4316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.69 cM"
     gene            1..4316
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /note="angiopoietin 1"
                     /db_xref="GeneID:11600"
                     /db_xref="MGI:MGI:108448"
     exon            1..813
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..2013
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Angiopoietin-1"
                     /codon_start=1
                     /product="angiopoietin-1 isoform 1 precursor"
                     /protein_id="NP_033770.2"
                     /db_xref="CCDS:CCDS27450.1"
                     /db_xref="GeneID:11600"
                     /db_xref="MGI:MGI:108448"
                     /translation="MTVFLSFAFFAAILTHIGCSNQRRNPENGGRRYNRIQHGQCAYT
                     FILPEHDGNCRESATEQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLEN
                     YIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLE
                     IQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKEN
                     LQGLVSRQTFIIQELEKQLSRATNNNSILQKQQLELMDTVHNLISLCTKEGVLLKGGK
                     REEEKPFRDCADVYQAGFNKSGIYTIYFNNMPEPKKVFCNMDVNGGGWTVIQHREDGS
                     LDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRF
                     HIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFD
                     ACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF"
     exon            814..969
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1091
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1324
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1452
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1554
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1721
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1852
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..4316
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4233..4238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /note="hexamer: AATAAA"
     polyA_site      4260
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /note="major polyA site"
     regulatory      4291..4296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
                     /note="hexamer: AATAAA"
     polyA_site      4316
                     /gene="Angpt1"
                     /gene_synonym="1110046O21Rik; Ang-1; Ang1"
ORIGIN      
        1 aatttgtaag ccgatccgcc gcccaaagcc atcagcaatc cttagcatag gggcacactc
       61 atgcattcct gtcaagtcat cttgtgaagg ctgcctgctt ccagcttggc ttggatgtgc
      121 aaccttaata aaactcactg aggtctggga gaaaatagca gatctgctgc agatagggta
      181 gaggaaaggg gctagaatat gtactcgcag ctgacgcggg caggctccac gctgaacggt
      241 tacacagaga ggaaacaata aatctaagct actattgcaa taaatatctc aagttttaac
      301 gaaggaaact atcattacag ttaaaatttt ttaaagtaac gcttttttag aacaaagcta
      361 acaaatggct agttttctgt ggatcttctt caaacgcttt ctttaacggg gaaagagtca
      421 aacaagcagt tttacctgaa ataaagaact agtttaaagg tcagaagaga agagcaagct
      481 ttgcaggagg cacggaaggc aagcgctggc agtacaatga cagttttcct ttcctttgca
      541 ttcttcgctg ccattctgac tcacataggg tgcagcaacc agcgccgaaa tccagaaaac
      601 ggagggagaa gatataaccg gattcaacat gggcaatgtg cctacacttt cattcttcca
      661 gaacacgacg ggaactgccg tgagagtgcg acagagcagt acaacaccaa cgctctgcaa
      721 agggatgctc cacacgtgga gccggatttc tcttcccaga aacttcagca tctggagcat
      781 gtgatggaaa attatactca gtggctgcaa aaacttgaga attacattgt ggaaaatatg
      841 aagtcggaga tggcccagat acaacagaat gctgttcaaa accacacggc caccatgctt
      901 gagataggaa ccagtctctt atctcagact gcagagcaga cccgaaagct gacagatgtt
      961 gagacccagg tactaaatca aacatcccga cttgaaatac aactgctaga gaattcatta
     1021 tcaacataca agctagagaa gcaacttctc caacagacaa atgaaattct gaagattcac
     1081 gaaaaaaaca gtttactaga gcacaaaatc ttagaaatgg agggaaaaca caaagaagaa
     1141 ttggacacct tgaaggagga gaaagaaaac cttcaaggct tggtttctcg tcagacattc
     1201 atcatccagg agttggagaa gcaacttagt agagctacca acaacaacag catcctgcag
     1261 aagcaacaac tggagctcat ggacacagtt cataacctta tcagcctttg cactaaagaa
     1321 ggtgttttgc taaagggagg aaaaagagaa gaagagaaac catttcgaga ctgtgcagat
     1381 gtatatcaag ctggttttaa taaaagtgga atctacacta tttattttaa taatatgcca
     1441 gaacccaaaa aggtattttg caatatggat gtgaatgggg gaggttggac agtaatacaa
     1501 caccgggaag atggaagcct ggatttccag aggggctgga aggagtataa aatgggtttt
     1561 gggaatccct ctggtgaata ttggcttggg aacgagttca tttttgcaat aaccagtcag
     1621 aggcagtaca tgctgaggat tgagctgatg gactgggaag ggaaccgagc ctactcacag
     1681 tacgacagat tccacatagg aaatgaaaag cagaactata ggttatattt aaaaggtcac
     1741 acagggacag caggcaaaca gagcagcttg atcttacacg gtgccgattt cagcacgaag
     1801 gatgctgata acgacaactg tatgtgcaaa tgcgctctca tgctaacagg aggttggtgg
     1861 ttcgatgcct gtggcccttc caatctaaat ggaatgttct acactgcggg acaaaatcat
     1921 ggaaaactga atgggataaa gtggcactac ttcaaagggc ccagttactc cttacgttcc
     1981 accaccatga tgatccggcc cttggacttt tgaaggtgct ctgccagtat tagaaagctg
     2041 caaagaaagc tgggcatgtt cccagatgag aagctagtca gaggcttcag aaacaaccaa
     2101 cattgtctcc attccagcag caagtggtta tgtcatgtca cctgggtttg gagccttctg
     2161 aggtcaacag aatcgccact tgggtccaga gaatgccact cacaatcatg tttaaaaggg
     2221 aagaaacttc tcagcttgct gcacttcaaa gtgctactgg atcacattct gaacttataa
     2281 catcctgatg ctgaatgcaa cttgtttcat gtaaaagcaa aagaagaaga aacagcaaat
     2341 gggaacaggc tttccagaat ctgttgaaga tggattgtgg aggtgacctg gtatcactgt
     2401 aggaaatcct gctaacaata catcactgcc caaaagagac ataaagaaaa gttttgtcta
     2461 ctgagttggc taaaagttag tggagttcac ctgcccattt ccagtatcat atttactagc
     2521 tgatttcagg tttcctgtgt tcaaatgtaa actctgttct tgtaagccat gatacaatat
     2581 agtacatgga ggataagagt tgggggtaga aggtgcctaa agactcttga gtttctgggg
     2641 attcagtttt caaaagatat aaaatataat caagaatgga taaaacaggt gaaaatcaca
     2701 ctcatgctac agtgttcctt tacatgaaat ttgattaact gatccacaag aatgtttaga
     2761 gcctgagtat atataaagac tggaagtgtt atcacccagt tctcaaaaca ataagcaggc
     2821 agttaacatt ctcattgaca gtatgtagga gagcaatatg tggagtactt gagttggaac
     2881 agcccattgt acagatcttg catgtatttg catatgtatg gcattattat ttttaaagtg
     2941 ttcgtaggcc ttcaattctt catacagatt tttcatgcta atttaatttt tgttaattaa
     3001 ctgcaatgta cttactaaat atatcctact ccagtttttt atgagttata ctttaaagtc
     3061 tacaaataat agaagaattt taaatatcat tgtacataat atcttatacc tgtccatgct
     3121 aaactcaata attgtttagt ctggaatata tgatgctgtc cacaactgat gactataaat
     3181 atgattgttt aaagacagtt accatactat tgattaaata tattactctg catagttttt
     3241 ctcctccagg atctgtttct tcaagcaatt tctaccttgt aaaataatgg tagtagagaa
     3301 aattgacata actccttgta caaaagaatt atagaaaaaa ttacagtcat ttgactagga
     3361 agtttctgat tgttagctgc tataagtgcc ttagttaaga tgcccctgtg ttataatatg
     3421 tagtaaatga agttttggac acaggattct gtgataacct gatgtgactg cagtattcta
     3481 tcaagttctc tttgttgtta aatgttcaag gttatagtag aaaaaaaaca ttcaatcaaa
     3541 cacaatttgc catgaaagga gagaactaaa tgtaggcacc agttctgttt tctcagagaa
     3601 ggagaagact ttctgggacg tacatgtacc aaaatataaa tcttgataac cgcagccaca
     3661 aagccttagt gactttcctc tacctggtaa gacagagctc ttcatgcttt taagaaaaga
     3721 ttctgaatgc ttcccaccac atctttctta tatttatatg tgttcataaa gtactatttt
     3781 gccttacaag aggtatgtgc cgacattaca ggatttttct actatagtga ctccttcaca
     3841 gctttcttaa gcctagccct ctaaaagctt ccttctcatt tagatgaaag aaaatgagta
     3901 tttttgtgat tctggtgatt gtggtggttg ttgttgttgt tgttgttgtt cccacagatg
     3961 ttcgaaaact catcttgggt aaattgtttt tcaatccaca ttacaaaaat aaagcgaaac
     4021 aaggagaaaa aaaagcatgg aatttactga tttgttatgt gggtttgaaa aataagatat
     4081 tgttttcagt tatttataat aaagcagtat aatgtgtaca ttgtataatg ccaacatgtg
     4141 tgtagcaatt tgatacgcat agctttttgc atttaattaa tgcagggcag aaaaattaga
     4201 taactcgaac tttgtcttga agtttctatt tcaataaaag ctgtgtcatt tctatgaaaa
     4261 tgtcttcata agattacatt atttcattta aataaaattg aaaataatgt gggcaa
//
