LOCUS       NM_021421               3230 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus angel homolog 2 (Angel2), transcript variant 1, mRNA.
ACCESSION   NM_021421
VERSION     NM_021421.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Clemente,P., Calvo-Garrido,J., Pearce,S.F., Schober,F.A.,
            Shigematsu,M., Siira,S.J., Laine,I., Spahr,H., Steinmetzger,C.,
            Petzold,K., Kirino,Y., Wibom,R., Rackham,O., Filipovska,A.,
            Rorbach,J., Freyer,C. and Wredenberg,A.
  TITLE     ANGEL2 phosphatase activity is required for non-canonical
            mitochondrial RNA processing
  JOURNAL   Nat Commun 13 (1), 5750 (2022)
   PUBMED   36180430
  REMARK    GeneRIF: ANGEL2 phosphatase activity is required for non-canonical
            mitochondrial RNA processing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Fowler,K.J., Saffery,R., Irvine,D.V., Trowell,H.E. and Choo,K.H.
  TITLE     Mouse centromere protein F (Cenpf) gene maps to the distal region
            of chromosome 1 by interspecific backcross analysis
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 180-181 (1998)
   PUBMED   9858811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158731.1 and AC112675.12.
            
            On Nov 18, 2010 this sequence version replaced NM_021421.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158731.1, BC024907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1958              AK158731.1         17-1974
            1959-3230           AC112675.12        239415-240686
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..3230
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /note="angel homolog 2"
                     /db_xref="GeneID:52477"
                     /db_xref="MGI:MGI:1196310"
     exon            1..254
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1830
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein angel homolog 2"
                     /codon_start=1
                     /product="protein angel homolog 2 isoform 1"
                     /protein_id="NP_067396.3"
                     /db_xref="CCDS:CCDS15612.1"
                     /db_xref="GeneID:52477"
                     /db_xref="MGI:MGI:1196310"
                     /translation="METWRCVRRGYGRCVAGRGRYSMFPYPLKSLGRDWTTPWEDLQK
                     YCWRRHISSCLRWPGHYSRAPYPYFSSRHFSLNCRPPFLFESGTQFQYYNWRSDHLSN
                     ASLIHLSRHVMTSDRDEPLSKRRKHQGTIKRNWEYLCSHNKENTKDLEDRNVDSTCED
                     REDKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCL
                     QEVQEDHYGTEIRPSLESLGYHCEYKMKTGRKPDGCAICFKHSRFSLLSVNPVEFCRR
                     DIPLLDRDNIGLVLLLQPKIPRAASPSICIANTHLLYNPRRGDIKLTQLAMLLAEIAN
                     VTHRKDGSSCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSRGQRIL
                     SIPIWPPNLGISQNCVYEAQQVPKVEKTDSDVTQAQQEKAEVPVSADKVSSHLQHGFS
                     LSSVYSHYVPDTGVPEVTTCHSRSAITVDYIFYTAKKENTAQGPGAEVALVGGLKLLA
                     RLSLLTEQDLWTVNGLPNEHNSSDHLPLLAKFRLEL"
     exon            255..580
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            581..837
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            838..907
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1329
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1456
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1514
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1678
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..3230
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcccggag tcgcactgct taaaggaact gccccagaag gcaagatggt gaccgggcct
       61 gcggcgagac gctcctccca gcatgcctag cggccggccg ggagccgagt gatggggatc
      121 cggtaggacc cggcgagcgg ccgaagctga ggtgcagccg cgggcccggg cgttgggcgc
      181 tcacagagag ccaagatgga gacgtggcgc tgtgtgagga ggggctacgg ccgctgtgtg
      241 gcggggcgag gccgatactc catgtttccc tatcctctaa agagtttggg tcgagactgg
      301 accacgccgt gggaggatct acagaaatat tgctggcgca gacacatttc cagttgtctg
      361 aggtggccag gacattactc ccgtgcgcct tacccatact tcagtagcag gcatttctca
      421 ttgaactgta gaccaccttt tctgtttgag tctggaacgc agtttcagta ctataattgg
      481 agatctgacc accttagcaa cgcatccttg atccatctct ctcgtcacgt catgacctct
      541 gacagagatg agcccttatc taaacgaaga aaacatcaag gaacaataaa aaggaactgg
      601 gagtatttat gtagccataa taaagaaaat acgaaggacc tagaagacag aaatgttgac
      661 tccacgtgtg aggaccgtga agataagttt gacttctcag tgatgtctta taacatcctc
      721 tcgcaggatt tactggagga taactctcac ctctacagac attgccgacg tccagtgtta
      781 cactggagtt ttcggttccc caatatcttg aaagaaatca aacattttga tgcagatgtg
      841 ctttgtctac aggaagttca agaagatcat tatgggacag aaatcaggcc aagtctggaa
      901 tcactgggtt atcattgtga atataaaatg aaaacaggaa ggaagcccga cggctgtgcc
      961 atctgcttca aacattccag gttctcgctc ttatctgtga acccagtgga gttctgccgc
     1021 cgcgacattc ctctgctgga cagggacaac attggattgg ttttactcct gcagcccaag
     1081 atcccacgcg ctgcctctcc atccatctgc atagctaaca cacatctgct ctataatcca
     1141 cggcgcggtg acattaagct gacccagctg gcaatgctgc tagctgagat tgccaatgtg
     1201 acccatcgca aagatggcag ctcctgtcct attgtcatgt gtggtgactt taattctgtt
     1261 cctggttctc cactctatag tttcataaag gaaggaaaat taaattatga aggtcttgca
     1321 attggaaagg tatctggcca ggaacagtct tcacggggac aaagaatttt atctattcca
     1381 atttggcccc caaacctagg catctctcag aactgtgttt atgaggcaca gcaggttccc
     1441 aaagtagaaa aaacagacag tgatgtgact caagcacagc aggagaaagc ggaggtccca
     1501 gtgtcagctg acaaagtgtc ctcgcatcta cagcacggtt tcagcttgtc atctgtctat
     1561 tcccattatg ttcctgacac tggagttcca gaggtgacca cctgccattc ccgaagtgcc
     1621 ataactgttg attatatttt ctacactgca aagaaggaga acactgctca ggggccagga
     1681 gctgaagttg ctttggttgg tggcttgaaa cttctagcta gactgtcact tctaacagag
     1741 caagacttgt ggactgtgaa cggccttccc aatgagcaca actcctcaga tcacctgcct
     1801 ttgctggcca agttcaggct tgagctctga ctgctgctca ttcacgggac ttcctgtctg
     1861 tattcttttc gaaggatgta aaaattttaa gtatttgtat gctgttcact ttttgtgatg
     1921 tggggttctg aatttctgtt atatgcttga aacagattgg aagaaacaaa tttacaactt
     1981 ttttttaaat gaaatatttt cctgacaact gatgtttaaa gaactttatg gtaaatgact
     2041 tctaagtcct gttaaagttg acagcatttt taaaatgtag ttcatcttgg ccctgaagat
     2101 aggaagtcag tgctttttag ttcatccggt ggtcctgccc ggacctgcaa agctcagcat
     2161 gctgcctttt ctggagaccc agtttcattg ggagaagcct gtgcgtgttc ttagaaatca
     2221 ctgggtcact cactcctcca cagggtccaa gcttctgaag aggcttgaca atgtgtatgc
     2281 tgtagagaac attggcccat gtcactgctg ccctgagctg tgggatgtgc ctacattttg
     2341 tagtggaaat agttgagaag tatagatcac tctcatacga tacggtggtg cacaccttta
     2401 atcttattag catttggctg atggcagcag gtagctgtgt aaagccagct ttagcaacac
     2461 aacaagtgtg agggcagcct gggctacatg aaaccctatc ttaagacaaa aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaggtca agtcctttat atatgtccac tcctgcctgg aaaaggttgc
     2581 cataaggaaa gtagatgagc caggtgcatc cacaaacacc cttaatccca gcatctggga
     2641 gacagaggca ggaggatcac tgtgtcccag gctgactaga actacacaca aggccctgtg
     2701 tctcaaagac cagcaaaagg tggcagactc caggttgtcc ctctgtctcc tgtacttgtc
     2761 tttctgttta acgatggtga aaggcccttg ggtcaggagt gacatttcgt tgagccggtt
     2821 ttgtataaat gtattagaga agtggtcttt ggaaggaagc gagagctccg cagctgttta
     2881 tcatttgcct ctaacatgca ggagtcatca tgggagctgt cacttagacc cggtagggag
     2941 cctcgctgac tgttgactgt acagttgagt ttggtaccgt ggtacagcag ggtgccatgg
     3001 cgcttgcact gttctctgca gcctcacagc agcctgacca gccagtagct tgccctgtac
     3061 aagtgtccag tagtaaaatt ctaaatgtaa gtagaaattt ctctgctttt taaaatagta
     3121 gactcagatt acaggcattt ttactaagtc attactgtgc agtaataaat gttctctaca
     3181 gtgagtttta ttaatagaat gttttatatt agacaataaa tctttgcaat
//
