LOCUS       NM_001357134            3350 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus angel homolog 2 (Angel2), transcript variant 6, mRNA.
ACCESSION   NM_001357134
VERSION     NM_001357134.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3350)
  AUTHORS   Clemente,P., Calvo-Garrido,J., Pearce,S.F., Schober,F.A.,
            Shigematsu,M., Siira,S.J., Laine,I., Spahr,H., Steinmetzger,C.,
            Petzold,K., Kirino,Y., Wibom,R., Rackham,O., Filipovska,A.,
            Rorbach,J., Freyer,C. and Wredenberg,A.
  TITLE     ANGEL2 phosphatase activity is required for non-canonical
            mitochondrial RNA processing
  JOURNAL   Nat Commun 13 (1), 5750 (2022)
   PUBMED   36180430
  REMARK    GeneRIF: ANGEL2 phosphatase activity is required for non-canonical
            mitochondrial RNA processing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3350)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   3  (bases 1 to 3350)
  AUTHORS   Fowler,K.J., Saffery,R., Irvine,D.V., Trowell,H.E. and Choo,K.H.
  TITLE     Mouse centromere protein F (Cenpf) gene maps to the distal region
            of chromosome 1 by interspecific backcross analysis
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 180-181 (1998)
   PUBMED   9858811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112675.12.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.10673.1,
                                           SRR7345562.4855966.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               AC112675.12        222685-222912
            229-485             AC112675.12        231639-231895
            486-555             AC112675.12        233282-233351
            556-977             AC112675.12        235069-235490
            978-1104            AC112675.12        236316-236442
            1105-1162           AC112675.12        237025-237082
            1163-1326           AC112675.12        237972-238135
            1327-3350           AC112675.12        239135-241158
FEATURES             Location/Qualifiers
     source          1..3350
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 96.28 cM"
     gene            1..3350
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /note="angel homolog 2"
                     /db_xref="GeneID:52477"
                     /db_xref="MGI:MGI:1196310"
     exon            1..228
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            229..485
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1478
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /note="isoform 3 is encoded by transcript variant 6;
                     protein angel homolog 2"
                     /codon_start=1
                     /product="protein angel homolog 2 isoform 3"
                     /protein_id="NP_001344063.1"
                     /db_xref="GeneID:52477"
                     /db_xref="MGI:MGI:1196310"
                     /translation="MSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDA
                     DVLCLQEVQEDHYGTEIRPSLESLGYHCEYKMKTGRKPDGCAICFKHSRFSLLSVNPV
                     EFCRRDIPLLDRDNIGLVLLLQPKIPRAASPSICIANTHLLYNPRRGDIKLTQLAMLL
                     AEIANVTHRKDGSSCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLAIGKVSGQEQSSR
                     GQRILSIPIWPPNLGISQNCVYEAQQVPKVEKTDSDVTQAQQEKAEVPVSADKVSSHL
                     QHGFSLSSVYSHYVPDTGVPEVTTCHSRSAITVDYIFYTAKKENTAQGPGAEVALVGG
                     LKLLARLSLLTEQDLWTVNGLPNEHNSSDHLPLLAKFRLEL"
     exon            486..555
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            556..977
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1104
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1162
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1326
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..3350
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2863..2868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /note="hexamer: AATAAA"
     polyA_site      2883
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /note="major polyA site"
     regulatory      3327..3332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /note="hexamer: AATAAA"
     polyA_site      3349
                     /gene="Angel2"
                     /gene_synonym="2610307I21Rik; 5730410O10Rik; D1Ertd396e;
                     D1Ertd654e"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacgctc tgcgcatgcc cggagtcgca ctgcttaaag gaactgcccc agaaggcaag
       61 atggtgaccg ggcctgcggc gagacgctcc tcccagcatg cctagcggcc ggccgggagc
      121 cgagtgatgg ggatccggta ggacccggcg agcggccgaa gctgaggtgc agccgcgggc
      181 ccgggcgttg ggcgctcaca gagagccaag atggagacgt ggcgctgtga acaataaaaa
      241 ggaactggga gtatttatgt agccataata aagaaaatac gaaggaccta gaagacagaa
      301 atgttgactc cacgtgtgag gaccgtgaag ataagtttga cttctcagtg atgtcttata
      361 acatcctctc gcaggattta ctggaggata actctcacct ctacagacat tgccgacgtc
      421 cagtgttaca ctggagtttt cggttcccca atatcttgaa agaaatcaaa cattttgatg
      481 cagatgtgct ttgtctacag gaagttcaag aagatcatta tgggacagaa atcaggccaa
      541 gtctggaatc actgggttat cattgtgaat ataaaatgaa aacaggaagg aagcccgacg
      601 gctgtgccat ctgcttcaaa cattccaggt tctcgctctt atctgtgaac ccagtggagt
      661 tctgccgccg cgacattcct ctgctggaca gggacaacat tggattggtt ttactcctgc
      721 agcccaagat cccacgcgct gcctctccat ccatctgcat agctaacaca catctgctct
      781 ataatccacg gcgcggtgac attaagctga cccagctggc aatgctgcta gctgagattg
      841 ccaatgtgac ccatcgcaaa gatggcagct cctgtcctat tgtcatgtgt ggtgacttta
      901 attctgttcc tggttctcca ctctatagtt tcataaagga aggaaaatta aattatgaag
      961 gtcttgcaat tggaaaggta tctggccagg aacagtcttc acggggacaa agaattttat
     1021 ctattccaat ttggccccca aacctaggca tctctcagaa ctgtgtttat gaggcacagc
     1081 aggttcccaa agtagaaaaa acagacagtg atgtgactca agcacagcag gagaaagcgg
     1141 aggtcccagt gtcagctgac aaagtgtcct cgcatctaca gcacggtttc agcttgtcat
     1201 ctgtctattc ccattatgtt cctgacactg gagttccaga ggtgaccacc tgccattccc
     1261 gaagtgccat aactgttgat tatattttct acactgcaaa gaaggagaac actgctcagg
     1321 ggccaggagc tgaagttgct ttggttggtg gcttgaaact tctagctaga ctgtcacttc
     1381 taacagagca agacttgtgg actgtgaacg gccttcccaa tgagcacaac tcctcagatc
     1441 acctgccttt gctggccaag ttcaggcttg agctctgact gctgctcatt cacgggactt
     1501 cctgtctgta ttcttttcga aggatgtaaa aattttaagt atttgtatgc tgttcacttt
     1561 ttgtgatgtg gggttctgaa tttctgttat atgcttgaaa cagattggaa gaaacaaatt
     1621 tacaactttt ttttaaatga aatattttcc tgacaactga tgtttaaaga actttatggt
     1681 aaatgacttc taagtcctgt taaagttgac agcattttta aaatgtagtt catcttggcc
     1741 ctgaagatag gaagtcagtg ctttttagtt catccggtgg tcctgcccgg acctgcaaag
     1801 ctcagcatgc tgccttttct ggagacccag tttcattggg agaagcctgt gcgtgttctt
     1861 agaaatcact gggtcactca ctcctccaca gggtccaagc ttctgaagag gcttgacaat
     1921 gtgtatgctg tagagaacat tggcccatgt cactgctgcc ctgagctgtg ggatgtgcct
     1981 acattttgta gtggaaatag ttgagaagta tagatcactc tcatacgata cggtggtgca
     2041 cacctttaat cttattagca tttggctgat ggcagcaggt agctgtgtaa agccagcttt
     2101 agcaacacaa caagtgtgag ggcagcctgg gctacatgaa accctatctt aagacaaaaa
     2161 aaaaaaaaaa aaaaaaaaaa aaaggtcaag tcctttatat atgtccactc ctgcctggaa
     2221 aaggttgcca taaggaaagt agatgagcca ggtgcatcca caaacaccct taatcccagc
     2281 atctgggaga cagaggcagg aggatcactg tgtcccaggc tgactagaac tacacacaag
     2341 gccctgtgtc tcaaagacca gcaaaaggtg gcagactcca ggttgtccct ctgtctcctg
     2401 tacttgtctt tctgtttaac gatggtgaaa ggcccttggg tcaggagtga catttcgttg
     2461 agccggtttt gtataaatgt attagagaag tggtctttgg aaggaagcga gagctccgca
     2521 gctgtttatc atttgcctct aacatgcagg agtcatcatg ggagctgtca cttagacccg
     2581 gtagggagcc tcgctgactg ttgactgtac agttgagttt ggtaccgtgg tacagcaggg
     2641 tgccatggcg cttgcactgt tctctgcagc ctcacagcag cctgaccagc cagtagcttg
     2701 ccctgtacaa gtgtccagta gtaaaattct aaatgtaagt agaaatttct ctgcttttta
     2761 aaatagtaga ctcagattac aggcattttt actaagtcat tactgtgcag taataaatgt
     2821 tctctacagt gagttttatt aatagaatgt tttatattag acaataaatc tttgcaattt
     2881 aaatttttac tcatttattc cagttgtttt atgtgtagta gactactgcc tcagaggtgt
     2941 gcaggctaag aagtgcccag tgagcaccaa gcaagccgac cctgctttcc atgtagagta
     3001 tgaatccaat gctgagatgg cccatagttt gcagtaagcc tctctgggtg ctaaggtcct
     3061 ggttggagac ataatcaatc attatcgaat tacagtggtg attgtcttct taatatggag
     3121 gatggcttga ggggatttgt acagacatca ttgtaggcaa actaacattc ataaaaacct
     3181 ttgtaaagtt tttatatcct gatgaagata atgtgaaatt aggcctattt catgtatagc
     3241 acttggatac agttaactta taaattgctg atagcttatt gttaatctat ggccacacaa
     3301 gacttctcac aagcttttaa agctccaata aaaataccta ttttctctac
//
