LOCUS       NM_177544                695 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus angiogenin, ribonuclease A family, member 4 (Ang4),
            mRNA.
ACCESSION   NM_177544
VERSION     NM_177544.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 695)
  AUTHORS   Hu,A., Roberts,C., Moscalu,A., Redston,M. and Yoo,J.
  TITLE     Ang1 and Ang4 differentially affect colitis and carcinogenesis in
            an AOM-DSS mouse model
  JOURNAL   PLoS One 18 (3), e0281529 (2023)
   PUBMED   36881568
  REMARK    GeneRIF: Ang1 and Ang4 differentially affect colitis and
            carcinogenesis in an AOM-DSS mouse model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 695)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian ribonuclease A genes
  JOURNAL   Mol Genet Genomics 289 (2), 161-167 (2014)
   PUBMED   24337645
REFERENCE   3  (bases 1 to 695)
  AUTHORS   Walker,C.R., Hautefort,I., Dalton,J.E., Overweg,K., Egan,C.E.,
            Bongaerts,R.J., Newton,D.J., Cruickshank,S.M., Andrew,E.M. and
            Carding,S.R.
  TITLE     Intestinal intraepithelial lymphocyte-enterocyte crosstalk
            regulates production of bactericidal angiogenin 4 by Paneth cells
            upon microbial challenge
  JOURNAL   PLoS One 8 (12), e84553 (2013)
   PUBMED   24358364
  REMARK    GeneRIF: Intestinal intraepithelial lymphocyte-enterocyte crosstalk
            regulates production of bactericidal angiogenin 4 by Paneth cells
            upon microbial challenge.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 695)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 695)
  AUTHORS   Forman,R.A., deSchoolmeester,M.L., Hurst,R.J., Wright,S.H.,
            Pemberton,A.D. and Else,K.J.
  TITLE     The goblet cell is the cellular source of the anti-microbial
            angiogenin 4 in the large intestine post Trichuris muris infection
  JOURNAL   PLoS One 7 (9), e42248 (2012)
   PUBMED   22970115
  REMARK    GeneRIF: The cellular source of mouse Ang4 in the colon following
            T. muris infection is the goblet cell and expression is under the
            control of IL-13.
REFERENCE   6  (bases 1 to 695)
  AUTHORS   Gregorieff,A., Stange,D.E., Kujala,P., Begthel,H., van den Born,M.,
            Korving,J., Peters,P.J. and Clevers,H.
  TITLE     The ets-domain transcription factor Spdef promotes maturation of
            goblet and paneth cells in the intestinal epithelium
  JOURNAL   Gastroenterology 137 (4), 1333-45 (2009)
   PUBMED   19549527
REFERENCE   7  (bases 1 to 695)
  AUTHORS   Crabtree,B., Holloway,D.E., Baker,M.D., Acharya,K.R. and
            Subramanian,V.
  TITLE     Biological and structural features of murine angiogenin-4, an
            angiogenic protein
  JOURNAL   Biochemistry 46 (9), 2431-2443 (2007)
   PUBMED   17279775
REFERENCE   8  (bases 1 to 695)
  AUTHORS   Pan,Y.R., Wu,K.P., Lou,Y.C., Liao,Y.D. and Chen,C.
  TITLE     1H, 13C and 15N resonance assignments and secondary structure of
            murine angiogenin 4
  JOURNAL   J Biomol NMR 31 (2), 175-176 (2005)
   PUBMED   15772759
  REMARK    GeneRIF: protein structure of angiogenin 4
REFERENCE   9  (bases 1 to 695)
  AUTHORS   Cho,S., Beintema,J.J. and Zhang,J.
  TITLE     The ribonuclease A superfamily of mammals and birds: identifying
            new members and tracing evolutionary histories
  JOURNAL   Genomics 85 (2), 208-220 (2005)
   PUBMED   15676279
REFERENCE   10 (bases 1 to 695)
  AUTHORS   Hooper,L.V., Stappenbeck,T.S., Hong,C.V. and Gordon,J.I.
  TITLE     Angiogenins: a new class of microbicidal proteins involved in
            innate immunity
  JOURNAL   Nat Immunol 4 (3), 269-273 (2003)
   PUBMED   12548285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136415.1 and AK165799.1.
            
            On Sep 20, 2007 this sequence version replaced NM_177544.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY219870.1, AK136415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AK136415.1         2-299
            299-691             AK165799.1         300-692
            692-695             AK136415.1         693-696
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.66 cM"
     gene            1..695
                     /gene="Ang4"
                     /gene_synonym="Raa4; Rnase5d"
                     /note="angiogenin, ribonuclease A family, member 4"
                     /db_xref="GeneID:219033"
                     /db_xref="MGI:MGI:2656551"
     exon            1..79
                     /gene="Ang4"
                     /gene_synonym="Raa4; Rnase5d"
                     /inference="alignment:Splign:2.1.0"
     exon            80..695
                     /gene="Ang4"
                     /gene_synonym="Raa4; Rnase5d"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..532
                     /gene="Ang4"
                     /gene_synonym="Raa4; Rnase5d"
                     /note="angiogenin-4; ribonuclease A a4"
                     /codon_start=1
                     /product="angiogenin-4 precursor"
                     /protein_id="NP_808212.2"
                     /db_xref="CCDS:CCDS36911.1"
                     /db_xref="GeneID:219033"
                     /db_xref="MGI:MGI:2656551"
                     /translation="MTMSPCPLLLVFVLGLVVIPPTLAQNERYEKFLRQHYDAKPNGR
                     DDRYCESMMKERKLTSPCKDVNTFIHGTKKNIRAICGKKGSPYGENFRISNSPFQITT
                     CTHSGASPRPPCGYRAFKDFRYIVIACEDGWPVHFDESFISP"
     regulatory      673..678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ang4"
                     /gene_synonym="Raa4; Rnase5d"
                     /note="hexamer: AATAAA"
     polyA_site      694
                     /gene="Ang4"
                     /gene_synonym="Raa4; Rnase5d"
                     /note="major polyA site"
ORIGIN      
        1 agcttgacac cgaaggaccc tgtctccagg agcacacagc tagactcgtc cccagttgga
       61 ggaaagctgg ccagctttgg aatcactgtt ggaagagatg acaatgagcc catgtccttt
      121 gttgttggtc ttcgtgctgg gtctggttgt gattcctcca actctggctc agaatgaaag
      181 gtacgaaaaa ttcctacgtc agcactatga tgccaagcca aatggccggg acgacagata
      241 ctgtgaaagt atgatgaagg aaagaaagct aacctcgcct tgcaaagatg tcaacacctt
      301 tatccatggc accaagaaaa acatcagggc catctgtgga aagaaaggaa gcccttatgg
      361 agaaaacttc agaataagca attctccctt ccagatcacc acttgtacgc actcaggagc
      421 gtctcccagg cctccatgcg ggtaccgagc ctttaaagat ttcagatata ttgttattgc
      481 ctgtgaagat ggctggcctg tccacttcga tgagtctttt atcagtccgt agacagcagg
      541 cccctggcac aaacctaggt ctgttttctt tttatctccc ctcacagcca tgatcactgg
      601 ttcagcgttc actgtcatgg gccagaaaat gaattatctg aaatatactt ctcctgattt
      661 ataatgcaca gaaataaaga tatctcaaaa accat
//
