LOCUS       NM_007449                691 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus angiogenin, ribonuclease A family, member 2 (Ang2),
            mRNA.
ACCESSION   NM_007449
VERSION     NM_007449.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 691)
  AUTHORS   Suzuki,K., Iwata,D., Namba,K., Hase,K., Hiraoka,M., Murata,M.,
            Kitaichi,N., Foxton,R. and Ishida,S.
  TITLE     Involvement of Angiopoietin 2 and vascular endothelial growth
            factor in uveitis
  JOURNAL   PLoS One 18 (11), e0294745 (2023)
   PUBMED   38015876
  REMARK    GeneRIF: Involvement of Angiopoietin 2 and vascular endothelial
            growth factor in uveitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 691)
  AUTHORS   Lee,E., O'Keefe,S., Leong,A., Park,H.R., Varadarajan,J.,
            Chowdhury,S., Hiner,S., Kim,S., Shiva,A., Friedman,R.A.,
            Remotti,H., Fojo,T., Yang,H.W., Thurston,G. and Kim,M.
  TITLE     Angiopoietin-2 blockade suppresses growth of liver metastases from
            pancreatic neuroendocrine tumors by promoting T cell recruitment
  JOURNAL   J Clin Invest 133 (20), e167994 (2023)
   PUBMED   37843277
  REMARK    GeneRIF: Angiopoietin-2 blockade suppresses growth of liver
            metastases from pancreatic neuroendocrine tumors by promoting T
            cell recruitment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 691)
  AUTHORS   Wilson,R.L., Troja,W., Courtney,J., Williams,A. and Jones,H.N.
  TITLE     Placental and fetal characteristics of the Ohia mouse line
            recapitulate outcomes in human hypoplastic left heart syndrome
  JOURNAL   Placenta 117, 131-138 (2022)
   PUBMED   34890862
REFERENCE   4  (bases 1 to 691)
  AUTHORS   Chatterjee,A., Eshwaran,R., Huang,H., Zhao,D., Schmidt,M.,
            Wieland,T. and Feng,Y.
  TITLE     Role of the Ang2-Tie2 Axis in Vascular Damage Driven by High
            Glucose or Nucleoside Diphosphate Kinase B Deficiency
  JOURNAL   Int J Mol Sci 21 (10), 3713 (2020)
   PUBMED   32466219
  REMARK    GeneRIF: Role of the Ang2-Tie2 Axis in Vascular Damage Driven by
            High Glucose or Nucleoside Diphosphate Kinase B Deficiency.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 691)
  AUTHORS   Li,Z., Korhonen,E.A., Merlini,A., Strauss,J., Wihuri,E., Nurmi,H.,
            Antila,S., Paech,J., Deutsch,U., Engelhardt,B., Chintharlapalli,S.,
            Koh,G.Y., Flugel,A. and Alitalo,K.
  TITLE     Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by
            inhibiting leukocyte recruitment into the CNS
  JOURNAL   J Clin Invest 130 (4), 1977-1990 (2020)
   PUBMED   32149735
REFERENCE   6  (bases 1 to 691)
  AUTHORS   Furuyama,T., Kitayama,K., Shimoda,Y., Ogawa,M., Sone,K.,
            Yoshida-Araki,K., Hisatsune,H., Nishikawa,S., Nakayama,K.,
            Nakayama,K., Ikeda,K., Motoyama,N. and Mori,N.
  TITLE     Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice
  JOURNAL   J Biol Chem 279 (33), 34741-34749 (2004)
   PUBMED   15184386
REFERENCE   7  (bases 1 to 691)
  AUTHORS   Heber-Katz,E., Chen,P., Clark,L., Zhang,X.M., Troutman,S. and
            Blankenhorn,E.P.
  TITLE     Regeneration in MRL mice: further genetic loci controlling the ear
            hole closure trait using MRL and M.m. Castaneus mice
  JOURNAL   Wound Repair Regen 12 (3), 384-392 (2004)
   PUBMED   15225218
REFERENCE   8  (bases 1 to 691)
  AUTHORS   Holloway,D.E., Hares,M.C., Shapiro,R., Subramanian,V. and
            Acharya,K.R.
  TITLE     High-level expression of three members of the murine angiogenin
            family in Escherichia coli and purification of the recombinant
            proteins
  JOURNAL   Protein Expr Purif 22 (2), 307-317 (2001)
   PUBMED   11437607
  REMARK    GeneRIF: Improved methods are presented for substantially increased
            production of mAngrp in a bacterial expression system and for
            refolding and purification of the protein from inclusion bodies.
REFERENCE   9  (bases 1 to 691)
  AUTHORS   Nobile,V., Vallee,B.L. and Shapiro,R.
  TITLE     Characterization of mouse angiogenin-related protein: implications
            for functional studies on angiogenin
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4331-4335 (1996)
   PUBMED   8633065
REFERENCE   10 (bases 1 to 691)
  AUTHORS   Brown,W.E., Nobile,V., Subramanian,V. and Shapiro,R.
  TITLE     The mouse angiogenin gene family: structures of an
            angiogenin-related protein gene and two pseudogenes
  JOURNAL   Genomics 29 (1), 200-206 (1995)
   PUBMED   8530072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163664.3.
            
            On Sep 14, 2022 this sequence version replaced NM_007449.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.169306.1,
                                           SRR17253011.4747612.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC163664.3         32155-32227
            74-691              AC163664.3         35157-35774
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.42 cM"
     gene            1..691
                     /gene="Ang2"
                     /gene_synonym="Angrp; Raa3; Rnase5b"
                     /note="angiogenin, ribonuclease A family, member 2"
                     /db_xref="GeneID:11731"
                     /db_xref="MGI:MGI:104984"
     exon            1..73
                     /gene="Ang2"
                     /gene_synonym="Angrp; Raa3; Rnase5b"
                     /inference="alignment:Splign:2.1.0"
     exon            74..691
                     /gene="Ang2"
                     /gene_synonym="Angrp; Raa3; Rnase5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..529
                     /gene="Ang2"
                     /gene_synonym="Angrp; Raa3; Rnase5b"
                     /note="angiogenin related protein; angiogenin-2;
                     ribonuclease A a3"
                     /codon_start=1
                     /product="angiogenin-2 precursor"
                     /protein_id="NP_031475.2"
                     /db_xref="CCDS:CCDS27040.1"
                     /db_xref="GeneID:11731"
                     /db_xref="MGI:MGI:104984"
                     /translation="MAMSPGPLFLVFLLGLVVIPPTLSQDDSRYTKFLTQHYDAKPKG
                     RDDRYCESMMVKRKLTSFCKDVNTFIHDTKNNIKAICGKKGSPYGRNLRISKSHFQVT
                     TCTHKGRSPRPPCRYRASKGFRYIIIGCENGWPVHFDESFISP"
     regulatory      670..675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ang2"
                     /gene_synonym="Angrp; Raa3; Rnase5b"
                     /note="hexamer: AATAAA"
     polyA_site      691
                     /gene="Ang2"
                     /gene_synonym="Angrp; Raa3; Rnase5b"
                     /note="major polyA site"
ORIGIN      
        1 acaccccagg accctgtttc caggagcacg aagctagaca catcccccgt tggaggaaag
       61 ctggccagct ttggaatctc tgttggaaga gatggcgatg agcccaggtc ctttgttctt
      121 ggtcttcctg ttgggtctgg ttgtgatccc tcccactctg tctcaggatg actccaggta
      181 cacaaaattc ctgactcagc actatgatgc caagccaaaa ggccgggacg acagatactg
      241 cgaaagtatg atggtgaaaa gaaagctaac ctctttctgc aaagatgtca acacctttat
      301 ccatgacacc aagaacaaca tcaaggccat ctgtggaaag aaaggaagcc cttatggacg
      361 aaatttaaga ataagcaagt ctcacttcca ggtcaccact tgcacacaca aaggaaggtc
      421 tccccggcct ccatgcaggt accgagcctc taaagggttc agatatatta ttattggctg
      481 tgagaatggc tggcctgtcc actttgatga gtcttttatc agtccataga cagcagaccc
      541 ctggcacagg cctagctctc ttttcttttt atctcccctc acagccaaaa tcactgtttt
      601 aacgttcact gtcacgagcc agaaaatgaa ttatctgaaa tatacttctc ctgatttata
      661 atgcacaaaa ataaagatat ctcaaaaacc a
//
