LOCUS       NM_001161731             724 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus angiogenin, ribonuclease, RNase A family, 5 (Ang),
            transcript variant 2, mRNA.
ACCESSION   NM_001161731
VERSION     NM_001161731.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   Li,D., Gao,X., Ma,X., Wang,M., Cheng,C., Xue,T., Gao,F., Shen,Y.,
            Zhang,J. and Liu,Q.
  TITLE     Aging-induced tRNAGlu-derived fragment impairs glutamate
            biosynthesis by targeting mitochondrial translation-dependent
            cristae organization
  JOURNAL   Cell Metab 36 (5), 1059-1075 (2024)
   PUBMED   38458203
REFERENCE   2  (bases 1 to 724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 724)
  AUTHORS   Wu,Z., Xiang,Q., Feng,L., Wu,D., Huang,S., Zhang,L., Rao,S.,
            Luo,J., Xiong,W., Deng,J., Zhou,K., Yin,Y., Shi,W. and Tan,C.
  TITLE     Adenosine-ADORA2A Promotes Ang-Induced Angiogenesis in Intrauterine
            Growth Restriction Placenta via the Stat3/Akt Pathway
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (6), e190-e209 (2023)
   PUBMED   37051927
  REMARK    GeneRIF: Adenosine-ADORA2A Promotes Ang-Induced Angiogenesis in
            Intrauterine Growth Restriction Placenta via the Stat3/Akt Pathway.
REFERENCE   4  (bases 1 to 724)
  AUTHORS   Hu,A., Roberts,C., Moscalu,A., Redston,M. and Yoo,J.
  TITLE     Ang1 and Ang4 differentially affect colitis and carcinogenesis in
            an AOM-DSS mouse model
  JOURNAL   PLoS One 18 (3), e0281529 (2023)
   PUBMED   36881568
  REMARK    GeneRIF: Ang1 and Ang4 differentially affect colitis and
            carcinogenesis in an AOM-DSS mouse model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 724)
  AUTHORS   Dyer,K.D. and Rosenberg,H.F.
  TITLE     The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters
            for tissue-specific expression
  JOURNAL   Nucleic Acids Res 33 (3), 1077-1086 (2005)
   PUBMED   15722482
  REMARK    GeneRIF: RNase 4 and RNase 5/ang 1 are unique among the RNase A
            ribonuclease genes in that they maintain a complex gene locus that
            is conserved across species with transcription initiated from
            tissue-specific dual promoters followed by differential exon
            splicing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 724)
  AUTHORS   Brown,W.E., Nobile,V., Subramanian,V. and Shapiro,R.
  TITLE     The mouse angiogenin gene family: structures of an
            angiogenin-related protein gene and two pseudogenes
  JOURNAL   Genomics 29 (1), 200-206 (1995)
   PUBMED   8530072
REFERENCE   7  (bases 1 to 724)
  AUTHORS   Billingsley,G.D., Cox,D.W., Duncan,A.M., Goodfellow,P.J. and
            Grzeschik,K.H.
  TITLE     Regional localization of loci on chromosome 14 using somatic cell
            hybrids
  JOURNAL   Cytogenet Cell Genet 66 (1), 33-38 (1994)
   PUBMED   8275705
REFERENCE   8  (bases 1 to 724)
  AUTHORS   Bond,M.D., Strydom,D.J. and Vallee,B.L.
  TITLE     Characterization and sequencing of rabbit, pig and mouse
            angiogenins: discernment of functionally important residues and
            regions
  JOURNAL   Biochim Biophys Acta 1162 (1-2), 177-186 (1993)
   PUBMED   8448182
REFERENCE   9  (bases 1 to 724)
  AUTHORS   Steinhelper,M.E. and Field,L.J.
  TITLE     Assignment of the angiogenin gene to mouse chromosome 14 using a
            rapid PCR-RFLP mapping technique
  JOURNAL   Genomics 12 (1), 177-179 (1992)
   PUBMED   1346389
REFERENCE   10 (bases 1 to 724)
  AUTHORS   Bond,M.D. and Vallee,B.L.
  TITLE     Isolation and sequencing of mouse angiogenin DNA
  JOURNAL   Biochem Biophys Res Commun 171 (3), 988-995 (1990)
   PUBMED   2222458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163664.3.
            
            On Sep 14, 2022 this sequence version replaced NM_001161731.2.
            
            Summary: This gene encodes a member of the pancreatic ribonuclease
            A superfamily and is a potent inducer of neovascularization. The
            encoded protein is a secreted multifunctional tRNA-specific
            ribonuclease that promotes angiogenesis in response to angiogenetic
            stimuli such as hypoxia, mediates stress-induced translational
            repression by cleaving cellular tRNAs, stimulates cell
            proliferation by mediating rRNA transcription in prostate cancer
            cells, and is involved in neurite pathfinding. This gene resides in
            a cluster of highly related genes. It shares dual promoters and 5'
            exons with the ribonuclease, RNase A family 4 gene. Two
            alternatively spliced variants, with different 5' exons but the
            same coding exon, have been identified. Multiple pseudogenes have
            been found for this gene. [provided by RefSeq, Jun 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171251.1, AI121741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC163664.3         139845-139948       c
            105-724             AC163664.3         129093-129712       c
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.37 cM"
     gene            1..724
                     /gene="Ang"
                     /gene_synonym="Ang1; Rnase5; Rnase5a"
                     /note="angiogenin, ribonuclease, RNase A family, 5"
                     /db_xref="GeneID:11727"
                     /db_xref="MGI:MGI:88022"
     exon            1..104
                     /gene="Ang"
                     /gene_synonym="Ang1; Rnase5; Rnase5a"
                     /inference="alignment:Splign:2.1.0"
     exon            105..724
                     /gene="Ang"
                     /gene_synonym="Ang1; Rnase5; Rnase5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..560
                     /gene="Ang"
                     /gene_synonym="Ang1; Rnase5; Rnase5a"
                     /EC_number="3.1.27.-"
                     /note="angiogenin, ribonuclease A family, member 1;
                     ribonuclease 5; angiogenin-1"
                     /codon_start=1
                     /product="angiogenin precursor"
                     /protein_id="NP_001155203.1"
                     /db_xref="CCDS:CCDS27034.1"
                     /db_xref="GeneID:11727"
                     /db_xref="MGI:MGI:88022"
                     /translation="MAISPGPLFLIFVLGLVVIPPTLAQDDSRYTKFLTQHHDAKPKG
                     RDDRYCERMMKRRSLTSPCKDVNTFIHGNKSNIKAICGANGSPYRENLRMSKSPFQVT
                     TCKHTGGSPRPPCQYRASAGFRHVVIACENGLPVHFDESFFSL"
     regulatory      703..708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ang"
                     /gene_synonym="Ang1; Rnase5; Rnase5a"
                     /note="hexamer: AATAAA"
     polyA_site      724
                     /gene="Ang"
                     /gene_synonym="Ang1; Rnase5; Rnase5a"
                     /note="major polyA site"
ORIGIN      
        1 atatcgggga cgagattcca aaggaaattt cattcttcta ttcgccatcc caacaggaag
       61 gaaggagtga gaaacaaagc tgccgcctcc agttccgggt ccaggaatct ctgttggaag
      121 agatggcgat aagcccaggc ccgttgttct tgatcttcgt gctgggtctg gttgtgatcc
      181 ctcccactct ggctcaggat gactccaggt acacaaaatt cctgactcag caccatgacg
      241 ccaagccaaa gggccgggac gacagatact gtgaacgtat gatgaagaga agaagcctaa
      301 cctcaccctg caaagatgtc aacaccttta tccatggcaa caagagcaac atcaaggcca
      361 tctgtggagc gaatggaagc ccttacagag aaaacttaag aatgagcaag tctcccttcc
      421 aggtcaccac ttgcaagcac acaggagggt ctccccgacc tccatgccag taccgagcct
      481 ctgcagggtt cagacatgtt gttattgcct gtgagaatgg tttgcctgtc cacttcgatg
      541 agtcgttttt cagtctatag tcagcaggcc cctggcacag acctagctat gttttctttt
      601 tatctcccct catagcccag aacactggtt ccatcgttca ttgtcagggg ccagaaaaac
      661 gaactatcta aaacatatgt ctcctgattt gcaatgcaca gaaataaaga tgtctcaaaa
      721 gcca
//
