LOCUS       NM_021505               2790 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus anaphase-promoting complex subunit 5 (Anapc5),
            transcript variant 1, mRNA.
ACCESSION   NM_021505 XM_001001407 XM_001001415
VERSION     NM_021505.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Ho,A.W., Garg,A.V., Monin,L., Simpson-Abelson,M.R., Kinner,L. and
            Gaffen,S.L.
  TITLE     The anaphase-promoting complex protein 5 (AnapC5) associates with
            A20 and inhibits IL-17-mediated signal transduction
  JOURNAL   PLoS One 8 (7), e70168 (2013)
   PUBMED   23922952
  REMARK    GeneRIF: The anaphase-promoting complex protein 5 (AnapC5)
            associates with A20 and inhibits IL-17-mediated signal
            transduction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Sone,M., Hayashi,T., Tarui,H., Agata,K., Takeichi,M. and
            Nakagawa,S.
  TITLE     The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear
            domain in a subset of neurons
  JOURNAL   J Cell Sci 120 (Pt 15), 2498-2506 (2007)
   PUBMED   17623775
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115728.11, AK159916.1 and BP766822.1.
            
            On Jan 23, 2014 this sequence version replaced NM_021505.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031432.1, BC010339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC115728.11        42917-42978
            63-2489             AK159916.1         2-2428
            2490-2790           BP766822.1         28-328              c
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.58 cM"
     gene            1..2790
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /note="anaphase-promoting complex subunit 5"
                     /db_xref="GeneID:59008"
                     /db_xref="MGI:MGI:1929722"
     exon            1..363
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2415
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /note="isoform a is encoded by transcript variant 1;
                     cyclosome subunit 5"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 5 isoform a"
                     /protein_id="NP_067480.2"
                     /db_xref="CCDS:CCDS39258.1"
                     /db_xref="GeneID:59008"
                     /db_xref="MGI:MGI:1929722"
                     /translation="MMTNGVVHANLFGIKDWVTPYKIAVLVLLNEMGRTGEGAVSLVE
                     RRKLNQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDD
                     LSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVED
                     ADMDREDGEKQMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQAALLKNDETKALTP
                     ASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAEGKSN
                     GEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYV
                     LGQKRADSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDL
                     LHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLESLNAGVQQNNTES
                     FAVALCHLAELHAEQGCFAAAGEVLKHLKDRFPPNSQHAQLWMLCDQKIQFDRAMNDG
                     KFHLADSLVTGITALNGIEGVYRKAVVLQAQNQMTEAHKLLQKLLTYCQKLKNTEMVI
                     SVLLSVAELYWRSSSPTIAMPVLLEALALSKEYRLQYLASETVLNLAYAQLILGIPEQ
                     ALTLLHMAIEPILADGAVLDKGRAMFLVSKCQVASAASYDPVKKAEALEAAIQNLSEA
                     KNYFAQVDCRERIRDVAYFQARLYHALGKTQERNHCAMIFRQLHQELPAHGVPLINHL
                     "
     exon            364..443
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            444..553
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            554..737
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            738..804
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            805..906
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1097
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1179
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1269
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1451
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1587
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1662
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1784
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1892
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2040
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2203
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2763
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2475..2480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /note="hexamer: AATAAA"
     polyA_site      2503
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /note="major polyA site"
     regulatory      2742..2747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
                     /note="hexamer: AATAAA"
     polyA_site      2763
                     /gene="Anapc5"
                     /gene_synonym="2510006G12Rik; Anpc5; APC5"
ORIGIN      
        1 attggtcgaa ggcaccgccg gggtgggaga gggacactga ggcccccgct actgtgggaa
       61 acagtcttgg gcgggttaag gtgccgggcg gctgcagcca tggcgtaaag gcggctcgtg
      121 ggcgcggcgc gtggcaggcc tggagagggc ctgtccttgc cggcgtccac gaagagccag
      181 gacttcagcc cgatgatgac caacggggta gtgcacgcca acttgtttgg catcaaggac
      241 tgggtgacgc cctataagat cgccgtcctg gtgctgctca acgagatggg ccgcacgggc
      301 gagggcgccg tcagcctcgt ggagcggcgg aagctcaacc agctgctcct gcccctgctg
      361 cagggcccag atattacact gtcaaagctg tacaagctaa ttgaagaatc gtgtcctcag
      421 ctggcaaatt cagtgcagat cagaatcaag ctcatggctg aaggcgaact gaaggatatg
      481 gaacaatttt ttgatgacct ttcagattct ttttctggaa ctgaaccaga ggttcacaaa
      541 acgagtgtag taggtctgtt cctgcgccac atgatcttgg cctacagtaa gctttctttc
      601 agtcaagtgt ttaagctgta cactgccctc cagcagtact tccagaacgg ggagaaaaag
      661 acggtggaag atgctgatat ggaccgagag gatggagaga aacagatgga gaaggaagag
      721 ctcgacgtgt ccgtgagaga agaggaagta tcttgcagtg gtcctctgtc ccaaaaacaa
      781 gcggaatttt ttctctctca gcaggccgct ttgttgaaga atgatgagac taaagccctc
      841 accccagctt ccttgcagaa ggaattgaac aacctgttga aatttaatcc tgattttgct
      901 gaagctcatt acctcagcta cttaaacaac ctccgtgttc aagatgtttt cagctcaaca
      961 cacagcctcc tgcattattt tgaccgcctg attctcactg gagcggaggg caaaagtaat
     1021 ggggaagagg gttatggccg gagcctgaga tacgctgctc tcaacctggc tgccctgcac
     1081 tgccgcttcg gtcactatca acaggcagag ctcgccctgc aggaggcaat taggattgcc
     1141 caggagtcca acgatcacgt gtgtctgcag cactgtttga gctggcttta tgtgctgggg
     1201 cagaagagag ccgatagcta tgttctgctg gagcactctg tgaagaaagc agtacatttt
     1261 gggttaccgt acctcgcctc cctgggaata cagtcccttg ttcaacagag agcttttgct
     1321 gggaagacgg ccaacaaact gatggatgcc ctaaaggact ctgacctcct gcactggaaa
     1381 cacagcctgt cagaacttat cgatatcagc attgcacaga aaacggccat ctggaggctg
     1441 tacggccgca gcaccatggc actgcaacaa gcccagatgt tgctgagcat gaacagcctg
     1501 gagtcgctga atgcgggtgt gcagcagaac aatactgagt cctttgccgt cgctctctgc
     1561 catcttgcag agctccatgc agaacagggc tgttttgcgg ctgctggtga agtattaaag
     1621 cacttgaagg accgatttcc acccaacagt cagcacgccc agttatggat gctgtgtgat
     1681 caaaaaatac agtttgacag agcaatgaat gatggcaaat tccatttggc tgattcactt
     1741 gttacaggaa tcacagcgct taatggcata gaaggtgtat acaggaaagc agtcgtactg
     1801 caggctcaga accaaatgac agaggcacac aagctactac agaagttgct gacgtactgt
     1861 cagaagctaa agaacacaga aatggtcatc agtgtcctcc tatcggtggc agagctgtac
     1921 tggcgatctt cgtccccgac catcgccatg cctgtgctcc tggaagctct ggccctctcc
     1981 aaagaatacc gattgcagta cttggcctcc gaaactgtgc tcaacttggc ttatgcccag
     2041 ctcatccttg gaatcccgga acaggcctta acccttctcc acatggctat cgagcccatc
     2101 ctagccgacg gggctgtcct ggacaaaggt cgtgccatgt tcttagtgtc caagtgccaa
     2161 gtggcttcgg cagcgtccta tgacccagtg aagaaagcgg aagctctgga agctgccatt
     2221 cagaacctca gtgaagccaa gaactacttt gcacaagtcg actgcagaga gcgcatcagg
     2281 gatgttgctt acttccaggc caggctgtac cacgctcttg gcaagaccca ggagaggaac
     2341 cattgtgcca tgatcttccg gcagctgcac caggagttgc ccgcccatgg ggtgcccttg
     2401 attaaccacc tctagccagg actccctgct tgatggtgtg catttagggg tgggtcatta
     2461 catgctatct tgtcaataaa ctgttctgat cagtttgtct gaagtgggtt tttttttatt
     2521 tttctgggtt gaattgtcag tatctttgtt aagaactgtg tatctagggg ctggagagat
     2581 ggcttagcag ttaagagcac taactgttct tctaaaggac ctgggttcaa ttcctagcac
     2641 cctcatgaca gctcacagct gtctgtaact cctgttccag ggactctgac accctcaggc
     2701 agacataaaa gcagtcaaaa caccgatgta cataaaatta aaataaatta tttaaaaata
     2761 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
