LOCUS       NM_024213               2668 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus anaphase promoting complex subunit 4 (Anapc4), mRNA.
ACCESSION   NM_024213
VERSION     NM_024213.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Day,J.L., Tirard,M. and Brose,N.
  TITLE     Deletion of a core APC/C component reveals APC/C function in
            regulating neuronal USP1 levels and morphology
  JOURNAL   Front Mol Neurosci 17, 1352782 (2024)
   PUBMED   38932933
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Liu,W., Xie,H., Liu,X., Xu,S., Cheng,S., Wang,Z., Xie,T.,
            Zhang,Z.C. and Han,J.
  TITLE     PQBP1 regulates striatum development through balancing striatal
            progenitor proliferation and differentiation
  JOURNAL   Cell Rep 42 (3), 112277 (2023)
   PUBMED   36943865
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
REFERENCE   5  (bases 1 to 2668)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2668)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2668)
  AUTHORS   Hughes,D.S., Keynes,R.J. and Tannahill,D.
  TITLE     Extensive molecular differences between anterior- and
            posterior-half-sclerotomes underlie somite polarity and spinal
            nerve segmentation
  JOURNAL   BMC Dev Biol 9, 30 (2009)
   PUBMED   19463158
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC102766.5.
            
            On Mar 21, 2007 this sequence version replaced NM_024213.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024870.1, AK146000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC102766.5         79629-79886         c
            259-364             AC102766.5         78238-78343         c
            365-497             AC102766.5         74267-74399         c
            498-572             AC102766.5         72231-72305         c
            573-599             AC102766.5         72090-72116         c
            600-644             AC102766.5         71953-71997         c
            645-729             AC102766.5         71116-71200         c
            730-834             AC102766.5         70430-70534         c
            835-918             AC102766.5         68614-68697         c
            919-1005            AC102766.5         67303-67389         c
            1006-1070           AC102766.5         65966-66030         c
            1071-1113           AC102766.5         65385-65427         c
            1114-1190           AC102766.5         65190-65266         c
            1191-1291           AC102766.5         63463-63563         c
            1292-1343           AC102766.5         63327-63378         c
            1344-1399           AC102766.5         58382-58437         c
            1400-1446           AC102766.5         58131-58177         c
            1447-1503           AC102766.5         57157-57213         c
            1504-1560           AC102766.5         56794-56850         c
            1561-1654           AC102766.5         54815-54908         c
            1655-1752           AC102766.5         52681-52778         c
            1753-1814           AC102766.5         52011-52072         c
            1815-1853           AC102766.5         51892-51930         c
            1854-1955           AC102766.5         51698-51799         c
            1956-2030           AC102766.5         50360-50434         c
            2031-2204           AC102766.5         49369-49542         c
            2205-2328           AC102766.5         48004-48127         c
            2329-2668           AC102766.5         47287-47626         c
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 28.81 cM"
     gene            1..2668
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /note="anaphase promoting complex subunit 4"
                     /db_xref="GeneID:52206"
                     /db_xref="MGI:MGI:1098673"
     exon            1..258
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2553
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /note="cyclosome subunit 4"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 4"
                     /protein_id="NP_077175.1"
                     /db_xref="CCDS:CCDS19290.1"
                     /db_xref="GeneID:52206"
                     /db_xref="MGI:MGI:1098673"
                     /translation="MLRFPTCFPSFRVVGEKQLPQEIIFLAWSPKRDLIALANTTGEV
                     LLHRLASFHRVWSFPPNESTGKEVTCLAWRPDGKLLAFALADTKKIILCDVEKPESLH
                     SFSVEAPVSCMHWTEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYNSTSKIFSEEN
                     SDEIIKLLGDVRLNILVLGGSSGFIELYAYGMFKIARVTGIAGTCIALCLSSDLKSLS
                     VVTEVSSGGESEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAW
                     EEILMQMDSRLTKFVQEKPTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLG
                     QSIESSYSSIQKLVISHLQSGSESLLYHLSELKGMASWKQKYEPLGLDAAGIEDAITA
                     VGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
                     FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSTHLK
                     ESPLLFPYYPRKSLHFVKRRMENVIDQCLQKPADVIGRSMNQAICIPLYKDARSMDCA
                     RRLLKFPFLWNNKTSNLHYLLFTILEDSVYKMCILRRHTDISQSVSNGLIGIKFGSFT
                     SASADKVRRSSYSCLDAQFYDDETVTVILKDSMGREGRDRILVQLSLSLVYNSEDSDE
                     YEFTGSYSTRLDEQGSIIPTRTMHFEKHWRLLESMRAQYVAGNGLRKVSCVLSSNLRH
                     VRVFEMDIDDEWEIDESSDDEEEAGGKPVKIKEEVLSESETEAHQDAAALDPDVVIKV
                     EKLDPELDS"
     exon            259..364
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            365..497
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            498..572
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            573..599
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            600..644
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            645..729
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            730..834
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            835..918
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1005
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1070
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1113
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1190
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1291
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1343
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1399
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1446
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1503
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1560
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1654
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1752
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1814
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1853
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1955
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2030
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2204
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2328
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2668
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2651..2656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /note="hexamer: AATAAA"
     polyA_site      2668
                     /gene="Anapc4"
                     /gene_synonym="2610306D21Rik; APC4; D5Ertd249e"
                     /note="major polyA site"
ORIGIN      
        1 ggccgctggc taggagtagg ccgagtctgc gactctggca ggtaccgctg ctggcagggc
       61 tttgtgccag agctttgtgg ccgggtgctc cggcggcctt ctcgcgcacg tcgttgcagg
      121 gccgcaccca tgctgcgctt tccgacctgt ttcccatcct ttcgggtggt gggagagaag
      181 cagctgccac aggagattat tttcttggcc tggtccccca agcgagacct cattgctttg
      241 gccaacacta caggcgaggt tttgctgcat cgccttgcaa gttttcatcg agtttggagt
      301 ttcccaccaa atgaaagtac aggaaaagaa gtgacctgct tggcctggag accagacggc
      361 aaacttttgg cctttgctct tgcggatacc aagaaaatta ttttgtgtga tgtagaaaag
      421 cctgaaagct tacactcctt ctctgtggag gctccggtct cttgtatgca ttggacagaa
      481 gtgactgtgg aaagcagtgt tttaacatcg ttttataatg ctgaggatga gtccaatctt
      541 ctcttgccta agctgcccac attgccaaaa aattacaaca gcacctcaaa aatatttagt
      601 gaagaaaatt ctgatgaaat tatcaagctc ttgggagatg tcaggctgaa catccttgtc
      661 cttggaggaa gctctggatt tattgagctt tatgcttatg ggatgttcaa aattgcccga
      721 gtaacaggga ttgccggaac ttgtattgct ctgtgtttat caagtgattt gaagtcatta
      781 tcagtggtca cagaggtttc cagcggtggc gaatcagaag tttcatattt tcagcttgaa
      841 accaatctgc tgtattcctt cttacctgaa gtaactcgta tggccaggaa gtttactcac
      901 atttcagctc tcttacagta tataaatttg tcactgacat gtatgtgtga agcatgggaa
      961 gaaattctga tgcagatgga ctcccgtctt accaagtttg tacaggaaaa acctacaacc
     1021 acgtcagtgc aggatgagtt catgcacttg ctgctgtggg ggaaagccag tgctgaactt
     1081 cagactctcc tgatgaacca gttaacagtg aagggcttaa aaaagcttgg ccagtctata
     1141 gagtcatcat attccagtat acaaaaactg gttataagtc acttacagag tggctctgag
     1201 tctttactgt atcatttgag tgaacttaaa ggaatggctt catggaaaca aaaatacgaa
     1261 cctctaggac tggatgctgc aggcattgaa gatgctatta ctgctgtggg ttctttcatc
     1321 ctcaaagcaa acgaacttct ccaagttata gacagtagta tgaaaaactt caaggcattt
     1381 tttcggtggc tgtatgtagc aatgctgaga atgacagagg accatgtgct tcctgagctg
     1441 aacaagatga ctcagaagga tatcacattt gttgctgaat tcctcactga acatttcaat
     1501 gaggctccag acctttataa taggaaagga aaatacttca atgttgaaag agttggtcag
     1561 tatttgaaag atgaagacga cgaccttgtg tcacccccta acacagaagg aaaccagtgg
     1621 tatgacttcc tccaaaacag cacccacctg aaagaaagtc ctttgctgtt tccttattac
     1681 cctcgaaaat cattgcattt tgtgaaaagg cggatggaga acgttattga tcagtgtttg
     1741 caaaagccag cagatgtaat tggaagatcg atgaatcaag caatttgcat tccattatat
     1801 aaagatgcta ggagtatgga ctgtgcacga agattgttaa aattcccatt tctgtggaat
     1861 aataaaactt cgaatcttca ttatcttctt tttactattt tagaagattc ggtttataaa
     1921 atgtgcatct taaggagaca tactgatatt tcccaatctg taagtaatgg actaattggt
     1981 attaaatttg ggagcttcac atctgcctca gctgacaagg tcagaagaag ctcttacagt
     2041 tgtctagacg cccagttcta tgatgatgag actgtcacgg tcatcctgaa ggactccatg
     2101 ggacgtgaag ggagagacag gattttggtt cagttgtcac tgtccttggt gtataacagt
     2161 gaagattctg acgaatatga gttcactggg agttactcga caaggcttga cgagcagggc
     2221 agcattatcc ccacacgcac catgcacttt gagaaacact ggaggctgct agaaagcatg
     2281 agagcgcagt atgttgctgg gaacggcctt cgaaaagtgt cctgtgtgtt aagttcaaac
     2341 ctccggcatg tgagggtgtt tgaaatggac atcgatgatg agtgggagat tgacgagtct
     2401 tcagacgatg aggaggaggc tggcgggaag cctgtgaaga tcaaggagga agtgttgtca
     2461 gagtcagaga cagaggctca ccaagacgct gctgccctag acccggacgt agtcatcaaa
     2521 gtggagaaac ttgaccctga gttggactcg tgacccagct tgacagcatt gtgttagtta
     2581 atgtggcaaa aagacgtagt ggatggacta agaatgtatc ggtcacactg agttgtctgt
     2641 gtatcaaaga aataaatggt aaatttta
//
