LOCUS       NM_175300               3021 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus anaphase promoting complex subunit 2 (Anapc2), mRNA.
ACCESSION   NM_175300
VERSION     NM_175300.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3021)
  AUTHORS   Chen,A., Bai,L., Zhong,K., Shu,X., Wang,A., Xiao,Y., Zhang,K. and
            Shen,C.
  TITLE     APC2CDH1 negatively regulates agrin signaling by promoting the
            ubiquitination and proteolytic degradation of DOK7
  JOURNAL   FASEB J 34 (9), 12009-12023 (2020)
   PUBMED   32687671
  REMARK    GeneRIF: APC2(CDH1) negatively regulates agrin signaling by
            promoting the ubiquitination and proteolytic degradation of DOK7.
REFERENCE   2  (bases 1 to 3021)
  AUTHORS   Rattani,A., Ballesteros Mejia,R., Roberts,K., Roig,M.B., Godwin,J.,
            Hopkins,M., Eguren,M., Sanchez-Pulido,L., Okaz,E., Ogushi,S.,
            Wolna,M., Metson,J., Pendas,A.M., Malumbres,M., Novak,B.,
            Herbert,M. and Nasmyth,K.
  TITLE     APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent
            Chromosomes by Moderating Cyclin-Dependent Kinase Activity
  JOURNAL   Curr Biol 27 (10), 1462-1476 (2017)
   PUBMED   28502659
REFERENCE   3  (bases 1 to 3021)
  AUTHORS   He,Y., Tollini,L., Kim,T.H., Itahana,Y. and Zhang,Y.
  TITLE     The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase
            for Mdm2
  JOURNAL   Cell Cycle 13 (13), 2101-2109 (2014)
   PUBMED   24804778
  REMARK    GeneRIF: The regulation of Mdm2 by the E3 ubiquitin ligase APC/C is
            shown. It has important therapeutic implications for tumors with
            Mdm2 overexpression.
REFERENCE   4  (bases 1 to 3021)
  AUTHORS   Kuczera,T., Stilling,R.M., Hsia,H.E., Bahari-Javan,S., Irniger,S.,
            Nasmyth,K., Sananbenesi,F. and Fischer,A.
  TITLE     The anaphase promoting complex is required for memory function in
            mice
  JOURNAL   Learn Mem 18 (1), 49-57 (2010)
   PUBMED   21191042
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3021)
  AUTHORS   Yang,Y., Kim,A.H., Yamada,T., Wu,B., Bilimoria,P.M., Ikeuchi,Y., de
            la Iglesia,N., Shen,J. and Bonni,A.
  TITLE     A Cdc20-APC ubiquitin signaling pathway regulates presynaptic
            differentiation
  JOURNAL   Science 326 (5952), 575-578 (2009)
   PUBMED   19900895
REFERENCE   6  (bases 1 to 3021)
  AUTHORS   McGuinness,B.E., Anger,M., Kouznetsova,A., Gil-Bernabe,A.M.,
            Helmhart,W., Kudo,N.R., Wuensche,A., Taylor,S., Hoog,C., Novak,B.
            and Nasmyth,K.
  TITLE     Regulation of APC/C activity in oocytes by a Bub1-dependent spindle
            assembly checkpoint
  JOURNAL   Curr Biol 19 (5), 369-380 (2009)
   PUBMED   19249208
REFERENCE   7  (bases 1 to 3021)
  AUTHORS   Artus,J., Babinet,C. and Cohen-Tannoudji,M.
  TITLE     The cell cycle of early mammalian embryos: lessons from genetic
            mouse models
  JOURNAL   Cell Cycle 5 (5), 499-502 (2006)
   PUBMED   16481745
  REMARK    Review article
REFERENCE   8  (bases 1 to 3021)
  AUTHORS   Wirth,K.G., Ricci,R., Gimenez-Abian,J.F., Taghybeeglu,S.,
            Kudo,N.R., Jochum,W., Vasseur-Cognet,M. and Nasmyth,K.
  TITLE     Loss of the anaphase-promoting complex in quiescent cells causes
            unscheduled hepatocyte proliferation
  JOURNAL   Genes Dev 18 (1), 88-98 (2004)
   PUBMED   14724179
REFERENCE   9  (bases 1 to 3021)
  AUTHORS   Morgan,D., Eley,L., Sayer,J., Strachan,T., Yates,L.M.,
            Craighead,A.S. and Goodship,J.A.
  TITLE     Expression analyses and interaction with the anaphase promoting
            complex protein Apc2 suggest a role for inversin in primary cilia
            and involvement in the cell cycle
  JOURNAL   Hum Mol Genet 11 (26), 3345-3350 (2002)
   PUBMED   12471060
REFERENCE   10 (bases 1 to 3021)
  AUTHORS   Abidari,J.M., Gonzales,E.T., Inoue,K., Lupski,J.R., Karsenty,G. and
            Katsanis,N.
  TITLE     Identification of novel genes expressed during metanephric
            induction through single-cell library screening
  JOURNAL   Kidney Int 57 (6), 2221-2228 (2000)
   PUBMED   10844592
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ164053.1, CJ072758.1,
            AK033784.1, AA727217.1 and CR520037.1.
            
            On Oct 8, 2009 this sequence version replaced NM_175300.3.
            
            Summary: This gene encodes a component of the anaphase promoting
            complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase
            that controls progression through mitosis and the G1 phase of the
            cell cycle by ubiquitinating its specific substrates, such as
            mitotic cyclins and anaphase inhibitor, for subsequent degradation
            by the proteasome. [provided by RefSeq, Oct 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033784.1, SRR1660811.201899.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CJ164053.1         1-1
            2-33                CJ072758.1         3-34
            34-2087             AK033784.1         2-2055
            2088-2088           AA727217.1         416-416
            2089-3016           AK033784.1         2057-2984
            3017-3021           CR520037.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..3021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.12 cM"
     gene            1..3021
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /note="anaphase promoting complex subunit 2"
                     /db_xref="GeneID:99152"
                     /db_xref="MGI:MGI:2139135"
     exon            1..212
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2564
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /note="cyclosome subunit 2; expressed during mesenchymal
                     induction 4; induced during mesenchymal induction 4"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 2"
                     /protein_id="NP_780509.2"
                     /db_xref="CCDS:CCDS15761.1"
                     /db_xref="GeneID:99152"
                     /db_xref="MGI:MGI:2139135"
                     /translation="MEAEGVAVAAAAAAAAAAATIIASDDCDSRPGQELLVAWNTVST
                     GLVPPAALGLASSRTSGAVPPKEEELRAAVEVLRGHGLHSVLEEWFVEVLQNDLQGNI
                     ATEFWNAIALRENSVDEPQCLGLLLDAFGLLESRLDPYLHSLELLEKWTRLGLLMGAG
                     AQGLREKVHTMLRGVLFFSTPRTFQEMVQRLYGRFLRVYMQSKRKGEGGTDPELEGEL
                     DSRYARRRYYRLLQSPLCAGCGSDKQQCWCRQALEQFNQLSQVLHRLSLLERVCAEAV
                     TTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFLQDNPTRPTSPEAGN
                     TLRRWRCHVQRFFYRIYATLRIEELFSIIRDFPDSRPAIEDLKYCLERTDQRQQLLVS
                     LKVALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDTV
                     RQIVAGLTGDSDGTGDLAVELSKTDPACLETGQDSEDDSGEPEDWVPDPVDADPVKSS
                     SKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGE
                     APMHFCEVMLKDMADSRRINANIREEDEKRPVEEQPPFGVYAVILSSEFWPPFKDEKL
                     EVPEDIRAALDVYCKKYEKLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVVL
                     LYFQNQASWTLEELSKVVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRD
                     NMVLIDSDDESDSGMASQADQKEEELLLFWAYIQAMLTNLESLSLERIYSMLRMFVMT
                     GPALAEIDLQELQGYLQKKVRDQQLIYSAGVYRLPKNSN"
     exon            213..835
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            836..968
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1143
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1263
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1381
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1563
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1705
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1781
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1985
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2115
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2351
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..3017
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2687..2692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /note="hexamer: ATTAAA"
     polyA_site      2713
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /note="major polyA site"
     regulatory      2993..2998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /note="hexamer: ATTAAA"
     polyA_site      3017
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /note="major polyA site"
ORIGIN      
        1 ttgcgtcatc accgtgcgct ctactgggcg ggtctgtttt gtggacagtg atggaggccg
       61 agggtgtggc ggtggcggcg gcggcggcgg cggcggcggc ggcggcgaca attattgcct
      121 ccgatgactg cgactctagg cctggacagg agctcttggt tgcctggaat actgtgagca
      181 ccggtctggt gccgccggcc gcgctggggc tggcgtcttc ccggaccagc ggtgcagtcc
      241 caccaaagga ggaagagctt cgtgcagcgg tggaggttct gaggggacac ggtctgcact
      301 ctgtcctgga ggagtggttc gtggaagtgc tgcagaacga ccttcaaggc aatattgcca
      361 cggagttctg gaatgccatc gctctgcgag aaaactctgt cgatgagccc cagtgccttg
      421 ggctgctcct ggatgcgttc ggtctgctgg aaagccgctt ggatccctat ctgcatagcc
      481 tagaactcct agagaaatgg actcgtctgg gcttgctgat gggcgctgga gctcaggggc
      541 ttcgggagaa agttcacact atgttgcggg gagtcctgtt tttttccacc cctaggacat
      601 tccaggagat ggtccagcgc ctctatggtc gtttcttgag agtctatatg cagagcaaga
      661 gaaaaggaga agggggcaca gacccggaac tagagggtga gctagatagc cggtatgccc
      721 gccgcaggta ctaccgactt ttgcagagtc ctctgtgcgc aggatgtggc agtgacaagc
      781 agcagtgctg gtgccggcag gcactggagc agttcaacca gctgagccag gtcctgcata
      841 ggctcagtct gctggagcgg gtttgtgctg aggccgtgac aaccaccctg catcaggtga
      901 cccgggaaag gatggaagac cgctgccgag gagagtatga gcgctctttt ttgcgtgagt
      961 ttcacaagtg gatagagaga gtggttggtt ggcttggcaa agtgttcctt caggacaacc
     1021 ccaccagacc aacttctcca gaagctggga acacactgcg tcgttggcgc tgccacgtac
     1081 agagattctt ctaccgtatc tatgccaccc tacgcatcga ggagcttttc agcatcatcc
     1141 gagactttcc agactcccgg ccagccattg aagaccttaa gtactgcttg gagaggacag
     1201 atcagaggca gcaacttctt gtgtccctca aggtggccct agagactcga ctcctccacc
     1261 caggtgtcaa cacatgtgac atcatcactc tctacatttc tgccatcaag gcattacgtg
     1321 tgctagatcc ctctatggtc atcctggaag tggcttgtga gcccatccgt cgatacctga
     1381 ggacacgaga ggacaccgta cggcagattg tggctgggct aaccggggac tcagatggga
     1441 ctggggactt ggctgttgag ctgtctaaga ctgaccctgc ctgcctggag accggtcagg
     1501 acagtgagga tgattctgga gagcccgagg actgggtccc tgaccctgtg gatgctgatc
     1561 cagtgaagtc gagttccaag cgacgttctt cagacatcat cagcctgctg gtcagcatct
     1621 atggcagcaa agacctcttt atcaatgagt accgctcgct acttgcagat cgccttctcc
     1681 accaattcag cttcagccct gagagggaga ttcgtaatgt ggagctgttg aagctgcgct
     1741 ttggtgaagc ccccatgcac ttctgtgagg tcatgctcaa ggacatggca gactcccgcc
     1801 gcatcaatgc caatatccga gaggaggatg agaagcggcc tgtggaagaa cagccaccat
     1861 ttggggtcta tgctgtcata ttgtccagtg aattttggcc tcccttcaaa gatgagaagc
     1921 tggaggtccc tgaggacatc agggcagccc tagacgttta ctgcaagaag tatgagaaac
     1981 tgaaggctat gcggacactt agttggaagc acaccctggg cctggtgaca atggatgtgg
     2041 agcttgctga ccgcaccctg tctgttgcgg tgaccccagt acaggcagtg gtcttgctgt
     2101 atttccagaa ccaagccagc tggaccctgg aggaactgag caaggtggtg aagatgcctg
     2161 tggcactgct tcgaagacgc atgtcagtgt ggctgcaaca gggtgtgctg cgggaggaac
     2221 ctccaggcac tttctctgtc attgaggaag agcggcctca ggatagggac aacatggtgc
     2281 tgattgacag tgatgatgag agtgactcag gcatggcctc ccaggctgac cagaaggaag
     2341 aggagctact gctcttctgg gcatacatcc aggccatgtt aaccaaccta gagagcctct
     2401 ctctggagcg tatctacagc atgctccgga tgtttgtaat gactggccct gcgctggctg
     2461 agattgacct gcaggagctg cagggctact tgcagaagaa ggtccgagac cagcagctca
     2521 tctattctgc aggtgtctac cgcctgccta agaattccaa ctgatgttcc ctttccaggc
     2581 tctgactaca gcattcatgc ctgtgcaacc cctagatgga cagcttctat ttccatgttc
     2641 ctgtgcccag tccctgcccg ttccctgcct aacacccaca gaacaaatta aagcatattg
     2701 gctcatcctt tcatgtattt tgttggatcc catgaataca aacaggtttg ccctctatag
     2761 ccacccaacc ataaccctac agggcctgga ttcccagcag caggtaactg agccacccaa
     2821 gaagccaggc ttaccccagc ctaagcttgt atgtttgggc aatagattac cctaaagcta
     2881 tctcctgtag cctgtcttag aatatgctgg gacctgtttc agcaagagtg aatagggttg
     2941 gcagctcaga gtctcccgag ttagactttg gccccatcct gcttttgtgg ccattaaaag
     3001 gaactcttgg tccttcaaaa a
//
