LOCUS       NP_780509                837 aa            linear   ROD 03-JUN-2024
DEFINITION  anaphase-promoting complex subunit 2 [Mus musculus].
ACCESSION   NP_780509
VERSION     NP_780509.2
DBSOURCE    REFSEQ: accession NM_175300.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 837)
  AUTHORS   Chen,A., Bai,L., Zhong,K., Shu,X., Wang,A., Xiao,Y., Zhang,K. and
            Shen,C.
  TITLE     APC2CDH1 negatively regulates agrin signaling by promoting the
            ubiquitination and proteolytic degradation of DOK7
  JOURNAL   FASEB J 34 (9), 12009-12023 (2020)
   PUBMED   32687671
  REMARK    GeneRIF: APC2(CDH1) negatively regulates agrin signaling by
            promoting the ubiquitination and proteolytic degradation of DOK7.
REFERENCE   2  (residues 1 to 837)
  AUTHORS   Rattani,A., Ballesteros Mejia,R., Roberts,K., Roig,M.B., Godwin,J.,
            Hopkins,M., Eguren,M., Sanchez-Pulido,L., Okaz,E., Ogushi,S.,
            Wolna,M., Metson,J., Pendas,A.M., Malumbres,M., Novak,B.,
            Herbert,M. and Nasmyth,K.
  TITLE     APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent
            Chromosomes by Moderating Cyclin-Dependent Kinase Activity
  JOURNAL   Curr Biol 27 (10), 1462-1476 (2017)
   PUBMED   28502659
REFERENCE   3  (residues 1 to 837)
  AUTHORS   He,Y., Tollini,L., Kim,T.H., Itahana,Y. and Zhang,Y.
  TITLE     The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase
            for Mdm2
  JOURNAL   Cell Cycle 13 (13), 2101-2109 (2014)
   PUBMED   24804778
  REMARK    GeneRIF: The regulation of Mdm2 by the E3 ubiquitin ligase APC/C is
            shown. It has important therapeutic implications for tumors with
            Mdm2 overexpression.
REFERENCE   4  (residues 1 to 837)
  AUTHORS   Kuczera,T., Stilling,R.M., Hsia,H.E., Bahari-Javan,S., Irniger,S.,
            Nasmyth,K., Sananbenesi,F. and Fischer,A.
  TITLE     The anaphase promoting complex is required for memory function in
            mice
  JOURNAL   Learn Mem 18 (1), 49-57 (2010)
   PUBMED   21191042
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 837)
  AUTHORS   Yang,Y., Kim,A.H., Yamada,T., Wu,B., Bilimoria,P.M., Ikeuchi,Y., de
            la Iglesia,N., Shen,J. and Bonni,A.
  TITLE     A Cdc20-APC ubiquitin signaling pathway regulates presynaptic
            differentiation
  JOURNAL   Science 326 (5952), 575-578 (2009)
   PUBMED   19900895
REFERENCE   6  (residues 1 to 837)
  AUTHORS   McGuinness,B.E., Anger,M., Kouznetsova,A., Gil-Bernabe,A.M.,
            Helmhart,W., Kudo,N.R., Wuensche,A., Taylor,S., Hoog,C., Novak,B.
            and Nasmyth,K.
  TITLE     Regulation of APC/C activity in oocytes by a Bub1-dependent spindle
            assembly checkpoint
  JOURNAL   Curr Biol 19 (5), 369-380 (2009)
   PUBMED   19249208
REFERENCE   7  (residues 1 to 837)
  AUTHORS   Artus,J., Babinet,C. and Cohen-Tannoudji,M.
  TITLE     The cell cycle of early mammalian embryos: lessons from genetic
            mouse models
  JOURNAL   Cell Cycle 5 (5), 499-502 (2006)
   PUBMED   16481745
  REMARK    Review article
REFERENCE   8  (residues 1 to 837)
  AUTHORS   Wirth,K.G., Ricci,R., Gimenez-Abian,J.F., Taghybeeglu,S.,
            Kudo,N.R., Jochum,W., Vasseur-Cognet,M. and Nasmyth,K.
  TITLE     Loss of the anaphase-promoting complex in quiescent cells causes
            unscheduled hepatocyte proliferation
  JOURNAL   Genes Dev 18 (1), 88-98 (2004)
   PUBMED   14724179
REFERENCE   9  (residues 1 to 837)
  AUTHORS   Morgan,D., Eley,L., Sayer,J., Strachan,T., Yates,L.M.,
            Craighead,A.S. and Goodship,J.A.
  TITLE     Expression analyses and interaction with the anaphase promoting
            complex protein Apc2 suggest a role for inversin in primary cilia
            and involvement in the cell cycle
  JOURNAL   Hum Mol Genet 11 (26), 3345-3350 (2002)
   PUBMED   12471060
REFERENCE   10 (residues 1 to 837)
  AUTHORS   Abidari,J.M., Gonzales,E.T., Inoue,K., Lupski,J.R., Karsenty,G. and
            Katsanis,N.
  TITLE     Identification of novel genes expressed during metanephric
            induction through single-cell library screening
  JOURNAL   Kidney Int 57 (6), 2221-2228 (2000)
   PUBMED   10844592
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ164053.1, CJ072758.1,
            AK033784.1, AA727217.1 and CR520037.1.
            
            On Oct 8, 2009 this sequence version replaced NP_780509.1.
            
            Summary: This gene encodes a component of the anaphase promoting
            complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase
            that controls progression through mitosis and the G1 phase of the
            cell cycle by ubiquitinating its specific substrates, such as
            mitotic cyclins and anaphase inhibitor, for subsequent degradation
            by the proteasome. [provided by RefSeq, Oct 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033784.1, SRR1660811.201899.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.12 cM"
     Protein         1..837
                     /product="anaphase-promoting complex subunit 2"
                     /note="cyclosome subunit 2; expressed during mesenchymal
                     induction 4; induced during mesenchymal induction 4"
                     /calculated_mol_wt=95176
     Site            233
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX6; propagated from
                     UniProtKB/Swiss-Prot (Q8BZQ7.2)"
     Site            329
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX6; propagated from
                     UniProtKB/Swiss-Prot (Q8BZQ7.2)"
     Region          478..508
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZQ7.2)"
     Site            485
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX6; propagated from
                     UniProtKB/Swiss-Prot (Q8BZQ7.2)"
     Region          <527..709
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Site            549
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BZQ7.2)"
     Site            712
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BZQ7.2)"
     Region          772..832
                     /region_name="APC2"
                     /note="Anaphase promoting complex (APC) subunit 2;
                     smart01013"
                     /db_xref="CDD:198081"
     Site            825
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660; propagated from
                     UniProtKB/Swiss-Prot (Q8BZQ7.2)"
     CDS             1..837
                     /gene="Anapc2"
                     /gene_synonym="9230107K09Rik; Apc2; Emi4; Imi4; mKIAA1406"
                     /coded_by="NM_175300.4:51..2564"
                     /db_xref="CCDS:CCDS15761.1"
                     /db_xref="GeneID:99152"
                     /db_xref="MGI:MGI:2139135"
ORIGIN      
        1 meaegvavaa aaaaaaaaat iiasddcdsr pgqellvawn tvstglvppa alglassrts
       61 gavppkeeel raavevlrgh glhsvleewf vevlqndlqg niatefwnai alrensvdep
      121 qclgllldaf gllesrldpy lhslellekw trlgllmgag aqglrekvht mlrgvlffst
      181 prtfqemvqr lygrflrvym qskrkgeggt dpelegelds ryarrryyrl lqsplcagcg
      241 sdkqqcwcrq aleqfnqlsq vlhrlsller vcaeavtttl hqvtrermed rcrgeyersf
      301 lrefhkwier vvgwlgkvfl qdnptrptsp eagntlrrwr chvqrffyri yatlrieelf
      361 siirdfpdsr paiedlkycl ertdqrqqll vslkvaletr llhpgvntcd iitlyisaik
      421 alrvldpsmv ilevacepir rylrtredtv rqivagltgd sdgtgdlave lsktdpacle
      481 tgqdseddsg epedwvpdpv dadpvksssk rrssdiisll vsiygskdlf ineyrsllad
      541 rllhqfsfsp ereirnvell klrfgeapmh fcevmlkdma dsrrinanir eedekrpvee
      601 qppfgvyavi lssefwppfk deklevpedi raaldvyckk yeklkamrtl swkhtlglvt
      661 mdveladrtl svavtpvqav vllyfqnqas wtleelskvv kmpvallrrr msvwlqqgvl
      721 reeppgtfsv ieeerpqdrd nmvlidsdde sdsgmasqad qkeeelllfw ayiqamltnl
      781 eslsleriys mlrmfvmtgp alaeidlqel qgylqkkvrd qqliysagvy rlpknsn
//
