LOCUS       NM_027532                885 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus anaphase promoting complex C subunit 15 (Anapc15),
            transcript variant 3, mRNA.
ACCESSION   NM_027532
VERSION     NM_027532.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 885)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 885)
  AUTHORS   Chee,J.M., Lanoue,L., Clary,D., Higgins,K., Bower,L., Flenniken,A.,
            Guo,R., Adams,D.J., Bosch,F., Braun,R.E., Brown,S.D.M., Chin,H.G.,
            Dickinson,M.E., Hsu,C.W., Dobbie,M., Gao,X., Galande,S.,
            Grobler,A., Heaney,J.D., Herault,Y., de Angelis,M.H., Mammano,F.,
            Nutter,L.M.J., Parkinson,H., Qin,C., Shiroishi,T., Sedlacek,R.,
            Seong,J.K., Xu,Y., Brooks,B., McKerlie,C., Lloyd,K.C.K.,
            Westerberg,H. and Moshiri,A.
  CONSRTM   International Mouse Phenotyping Consortium
  TITLE     Genome-wide screening reveals the genetic basis of mammalian
            embryonic eye development
  JOURNAL   BMC Biol 21 (1), 22 (2023)
   PUBMED   36737727
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 885)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 885)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 885)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 885)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 885)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF166358.1 and AK135201.1.
            
            On Apr 5, 2014 this sequence version replaced NM_027532.3.
            
            Transcript Variant: This variant (3) uses an alternate splice
            junction at the 3' end of one exon and at the 5' end of the next
            exon compared to variant 1. The resulting isoform (c) has a shorter
            and distinct N-terminus compared to isoform a. Variants 3, 4, and 5
            all encode the same isoform (c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135201.1, AK014309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                CF166358.1         1-85
            86-885              AK135201.1         2-801
FEATURES             Location/Qualifiers
     source          1..885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.68 cM"
     gene            1..885
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /note="anaphase promoting complex C subunit 15"
                     /db_xref="GeneID:75430"
                     /db_xref="MGI:MGI:1922680"
     exon            1..120
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /inference="alignment:Splign:2.1.0"
     exon            121..205
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..581
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /note="isoform c is encoded by transcript variant 3;
                     anaphase-promoting complex subunit 15; anaphase prompoting
                     complex C subunit 15"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 15 isoform c"
                     /protein_id="NP_081808.2"
                     /db_xref="CCDS:CCDS21518.1"
                     /db_xref="GeneID:75430"
                     /db_xref="MGI:MGI:1922680"
                     /translation="MEPGLKLSLGAMSTLFPSLFPRVTETLWFNLDRPCVEETELQQQ
                     EQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMDE
                     MNDYNESPDDGEVNEVDMEGNEQDQDQWMI"
     exon            206..335
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /inference="alignment:Splign:2.1.0"
     exon            336..395
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /inference="alignment:Splign:2.1.0"
     exon            396..533
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /inference="alignment:Splign:2.1.0"
     exon            534..885
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      855..860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /note="hexamer: AATAAA"
     polyA_site      885
                     /gene="Anapc15"
                     /gene_synonym="3200002M19Rik; 6330414C15Rik; APC15"
                     /note="major polyA site"
ORIGIN      
        1 gcgggaaaca aaaggagacg caagacgcat gcgttagtga gtcccggatt ctggtgggtt
       61 cttccgctca gacctgggga aacgcttccg ggtcgccgcc ggctgccggc tcttggcgcg
      121 atgaggaaac tgaggcccag agaggttaag tgtattggcc aaaatcaaag agctagtaag
      181 tgatggagcc aggactcaaa ctcagcttag gagccatgtc caccttgttc ccgtcactct
      241 tccctcgtgt gactgagaca ctgtggttta atctggaccg accctgtgtg gaggagacag
      301 agctgcagca gcaggagcag cagcatcagg cctggctcca aagcatcgca gagaaagaca
      361 acaacctggt accaattggc aagccggcct cagagcacta cgatgatgag gaagaagagg
      421 atgatgaaga tgatgaggac agtgaagagg attccgaaga tgatgaggac atgcaagaca
      481 tggatgagat gaatgactat aatgagtcac ctgatgatgg agaggtcaat gaggtggaca
      541 tggaaggcaa cgaacaggat caggaccagt ggatgatcta ggtagacaag ccaaggtggc
      601 ctcagtgatt ccagaccacc ccaacctatt ttgaatctac agcctcagcc cctcagcctg
      661 cagaaccagc ttgtggctgt agtgcctaaa gctttccctt aggcactttc tcagctactg
      721 ccaggacaag gtctccttgg gcccttccag gccatgagtc ttcccttgaa tcccaagagc
      781 ctgagcccat cccaccttcc tggctggtac ctcactcctt ggttgccagg tgtggtccct
      841 ttctagccct ctttaataaa gacacaggac tgattgtttc cccaa
//
