LOCUS       NP_032595               1944 aa            linear   ROD 02-MAY-2024
DEFINITION  anaphase-promoting complex subunit 1 [Mus musculus].
ACCESSION   NP_032595
VERSION     NP_032595.2
DBSOURCE    REFSEQ: accession NM_008569.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1944)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1944)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
REFERENCE   3  (residues 1 to 1944)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   4  (residues 1 to 1944)
  AUTHORS   Cao,J., Dai,X., Wan,L., Wang,H., Zhang,J., Goff,P.S.,
            Sviderskaya,E.V., Xuan,Z., Xu,Z., Xu,X., Hinds,P., Flaherty,K.T.,
            Faller,D.V., Goding,C.R., Wang,Y., Wei,W. and Cui,R.
  TITLE     The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated
            proteolysis of PAX3 to suppress melanocyte proliferation and
            melanoma growth
  JOURNAL   Sci Signal 8 (392), ra87 (2015)
   PUBMED   26329581
  REMARK    GeneRIF: findings suggest a tumor suppressor role for APC/C(Cdh1)
            in melanocytes and that targeting PAX3 may be a strategy for
            treating melanoma.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1944)
  AUTHORS   Sun,J., Karoulia,Z., Wong,E.Y., Ahmed,M., Itoh,K. and Xu,P.X.
  TITLE     The phosphatase-transcription activator EYA1 is targeted by
            anaphase-promoting complex/Cdh1 for degradation at M-to-G1
            transition
  JOURNAL   Mol Cell Biol 33 (5), 927-936 (2013)
   PUBMED   23263983
  REMARK    GeneRIF: EYA1 is efficiently degraded during mitotic exit in a
            ANAPC1-dependent manner and these two proteins physically interact.
REFERENCE   6  (residues 1 to 1944)
  AUTHORS   Fan,M., Rhee,J., St-Pierre,J., Handschin,C., Puigserver,P., Lin,J.,
            Jaeger,S., Erdjument-Bromage,H., Tempst,P. and Spiegelman,B.M.
  TITLE     Suppression of mitochondrial respiration through recruitment of
            p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
  JOURNAL   Genes Dev 18 (3), 278-289 (2004)
   PUBMED   14744933
REFERENCE   7  (residues 1 to 1944)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 1944)
  AUTHORS   Davis,E.S., Wille,L., Chestnut,B.A., Sadler,P.L., Shakes,D.C. and
            Golden,A.
  TITLE     Multiple subunits of the Caenorhabditis elegans anaphase-promoting
            complex are required for chromosome segregation during meiosis I
  JOURNAL   Genetics 160 (2), 805-813 (2002)
   PUBMED   11861581
REFERENCE   9  (residues 1 to 1944)
  AUTHORS   Jorgensen,P.M., Graslund,S., Betz,R., Stahl,S., Larsson,C. and
            Hoog,C.
  TITLE     Characterisation of the human APC1, the largest subunit of the
            anaphase-promoting complex
  JOURNAL   Gene 262 (1-2), 51-59 (2001)
   PUBMED   11179667
REFERENCE   10 (residues 1 to 1944)
  AUTHORS   Starborg,M., Brundell,E., Gell,K. and Hoog,C.
  TITLE     A novel murine gene encoding a 216-kDa protein is related to a
            mitotic checkpoint regulator previously identified in Aspergillus
            nidulans
  JOURNAL   J Biol Chem 269 (39), 24133-24137 (1994)
   PUBMED   7929068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077847.1, BC139002.1, AK034858.1, BE987509.1 and BB676785.1.
            
            On Apr 29, 2009 this sequence version replaced NP_032595.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090134.1, X80169.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.63 cM"
     Protein         1..1944
                     /product="anaphase-promoting complex subunit 1"
                     /note="cyclosome subunit 1; mitotic checkpoint regulator;
                     testis-specific gene 24 protein; meiotic check point
                     regulator"
                     /calculated_mol_wt=215864
     Region          1..136
                     /region_name="Apc1_N"
                     /note="Anaphase-promoting complex subunit 1 N-terminal;
                     pfam19521"
                     /db_xref="CDD:437353"
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            60
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Region          151..359
                     /region_name="ANAPC1"
                     /note="Anaphase-promoting complex subunit 1 WD40
                     beta-propeller domain; pfam12859"
                     /db_xref="CDD:463732"
     Site            291
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Region          312..343
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53995.2)"
     Site            313
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            341
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            343
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            355
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            362
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Region          370..395
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53995.2)"
     Site            373
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            377
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            537
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            547
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            555
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            571
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Region          615..985
                     /region_name="Apc1_MidN"
                     /note="Anaphase-promoting complex subunit 1 middle domain;
                     pfam20518"
                     /db_xref="CDD:466667"
     Site            680
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            686
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H1A4; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Site            688
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P53995.2)"
     Region          991..1014
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53995.2)"
     Region          1297..1325
                     /region_name="PC 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P53995.2)"
     Region          1366..1404
                     /region_name="PC 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P53995.2)"
     Region          1467..1501
                     /region_name="PC 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P53995.2)"
     Region          1467..1501
                     /region_name="PC_rep"
                     /note="Proteasome/cyclosome repeat; pfam01851"
                     /db_xref="CDD:460361"
     Region          1520..1552
                     /region_name="PC 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P53995.2)"
     Region          1739..1895
                     /region_name="APC1_C"
                     /note="Anaphase-promoting complex sub unit 1 C-terminal
                     domain; pfam18122"
                     /db_xref="CDD:465659"
     CDS             1..1944
                     /gene="Anapc1"
                     /gene_synonym="2610021O03Rik; Apc1; Mcpr; tsg24"
                     /coded_by="NM_008569.2:268..6102"
                     /db_xref="CCDS:CCDS16715.1"
                     /db_xref="GeneID:17222"
                     /db_xref="MGI:MGI:103097"
ORIGIN      
        1 msnfseerat miaagdlqef vpfgrdhckh hpnalnlqlr qlqpaselws sdgaaglvgs
       61 lqevtihekq keswqlrkgv seigdaadyd eelyvagnmv iwskgsksqa lavykaftvd
      121 stvqqalwcd fiisqdksek iykshelekc icilqsscmn mhsidgkdyi aslpfqvanv
      181 watkygllfe rcssshevpp slpreplptm fsmlhpldei tplvcksgsl fgssrvqyvv
      241 dpavkivfln idpsivmtyd avqnvhsvwt lrrvkpeeen avlkfpeqag tlqnattsss
      301 ltahlrslsk gespvaspfq nyssihsqsr stsspslhsr spsisnmaal srahspalgv
      361 hsfsgaqrfn lsshsqspkr hsishspsgs fndsflapet epivpelcid hlwtetlpni
      421 reknsqaskv fittdlcgqk flcflveaql qlrcvkfqes ndktqlifgs vtnihakdaa
      481 pvekihtmlv legngnlvly tgvvrvgkvf ipglpapslt msnmmprpst pldgvgtpkp
      541 lskllgsmde vvllspvpel rdssklndsl ynedctfqql gtyihsvrdp vhnrvtlels
      601 ngsmvritip evatselvqt clqaikfilp kevaiqvlvk wynvhsapgg pschsewslf
      661 vicllnmmgy ntdrlawtrs fdfegslspv iapkkarpsd tgsdedweyl lnseyhrnve
      721 shllnkslcl talevsnakd edfsqnlsld sstllfahip aiffvlhlvy eelklntlmg
      781 egicslidll vqlardlkld syldhyyrds ptlvkttgqv ctidqgqmgf mhhppfftse
      841 ppsiyqwvss clkgegmppy pylpgicers rlvvlsialy tlgdescvsd etcqylskvt
      901 stpqkpqaeq eenrftfrhs asvsvlaerl vvwmasvgft lrdletlpfg ialpirdaiy
      961 hcreqpdsdw seavclligr qdlskqaceg nlprgksvls sevssgteae eeddgmndln
     1021 hevmsliwse dlrvqdvrrl lqsaqpvrvn vvqypelsdh efieekenrl lqlcqrtmal
     1081 pvgrgmftlf syhpvptepl pvpklnltgr apprnttvdl nsgnidvppn maswasfhng
     1141 vaaglkiapa sqidsawivy nkpkhaelan eyagflmalg lnghltklat lnihdyltkg
     1201 hemtsiglll gvsaaklgtm dmsitrllsi hvpallppts teldvphnvq vaavvgiglv
     1261 yqgtahrhta evllaeigrp pgpemeyctd resyslaagl algmvclghg snligmsdln
     1321 vpeqlyqymv gghrrfqtgm hrekhkspsy qikegdtinv dvtcpgatla lamiylktnn
     1381 rsiadwlrap dtmylldfvk peflllrtla rclilwddil pnskwvdsnv pqiirensis
     1441 lseielpcse dlnletlsqa hvyiiagacl slgfrfagse nlsafsclhk fakdfmnyls
     1501 apnasvtgpy nletclsvvl lslamvmags gnlkvlqlcr flhmktggem nygfhlahhm
     1561 algllflggg ryslstsnss iaallcalyp hfpahstdnr yhlqalrhly vlaaeprllv
     1621 pvdvdtntpc yalievtykg tqwyeqtkee lmaptllpel hllkqmkvkg prywellidl
     1681 skgeqhlrsi lskdgvlyvk lragqlsyke dpmgwqslla qtvanrnsea rafkpetiss
     1741 ftsdpallsf aeyfckptvs mgpkqeildl fssilyecva qetpemlpay iamdqalrsl
     1801 kkrdmsdtsd lwqiklilef fssrshqdrq htypkrglfi nseflpvvkc tvdatldqwl
     1861 qaggdvcvha ylsgqpveks qlnmlacflv yhsvpaprhl ppmglegsts faellyrfrh
     1921 lkmpvrallr lapvllgnpq pmvm
//
