LOCUS       NM_025275               2816 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus archaelysin family metallopeptidase 2 (Amz2),
            transcript variant 1, mRNA.
ACCESSION   NM_025275
VERSION     NM_025275.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Ingham,N.J., Rook,V., Di Domenico,F., James,E., Lewis,M.A.,
            Girotto,G., Buniello,A. and Steel,K.P.
  TITLE     Functional analysis of candidate genes from genome-wide association
            studies of hearing
  JOURNAL   Hear Res 387, 107879 (2020)
   PUBMED   31927188
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Tchernev,V.T., Barbosa,M.D., Detter,J.C., Patel,T.D., Achey,K.,
            Wakeland,E.K., Gueorguieva,R.V., Yang,M.C., Gossler,A. and
            Kingsmore,S.F.
  TITLE     Genetic mapping of 20 novel expressed sequence tags from
            midgestation mouse embryos suggests chromosomal clustering
  JOURNAL   Genomics 40 (1), 170-174 (1997)
   PUBMED   9070936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645791.14.
            
            On Oct 3, 2006 this sequence version replaced NM_025275.3.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075748.1, SRR1660813.398140.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL645791.14        33040-33124
            86-175              AL645791.14        33580-33669
            176-303             AL645791.14        34064-34191
            304-586             AL645791.14        35896-36178
            587-760             AL645791.14        36758-36931
            761-889             AL645791.14        37018-37146
            890-1053            AL645791.14        40984-41147
            1054-1230           AL645791.14        41674-41850
            1231-2816           AL645791.14        43657-45242
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 71.89 cM"
     gene            1..2816
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /note="archaelysin family metallopeptidase 2"
                     /db_xref="GeneID:13929"
                     /db_xref="MGI:MGI:104837"
     exon            1..85
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     exon            86..175
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     exon            176..303
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1383
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /note="archeobacterial metalloproteinase-like protein 2"
                     /codon_start=1
                     /product="archaemetzincin-2"
                     /protein_id="NP_079551.3"
                     /db_xref="CCDS:CCDS25579.1"
                     /db_xref="GeneID:13929"
                     /db_xref="MGI:MGI:104837"
                     /translation="MADKMQVLRHSEHTLKTALLSKNPVLVSQYEKLDAGEQRLMNEA
                     FQPRSNLFEPITVHSQSDWISSHPEAPQDFEQFFSDRYRKAPCPKKHIIYIQSIGSLG
                     NTRVISEEYIKWLKGYCEAFFYGLKVKFLEPVSVSETKCSFRVNEHTQNLQIHTGHIL
                     AFLKKNKPEDAFCIVGITMIDLYPRDSWNFVFGQASLSSGVGIFSFARYGKDFYTSKY
                     EGNVTSLQLTSPTDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHILGLRHCQWLACLM
                     QGSNHLEESDRRPLNVCPICLRKLQSAIGFNIVERYRALVKWIDDESCNESGATPKSS
                     SEHAHLPKPVEAFKDWREWLMRCIALLEK"
     exon            304..586
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     exon            587..760
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     exon            761..889
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1053
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1230
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..2816
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1408..1413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /note="hexamer: AATAAA"
     polyA_site      1426
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /note="major polyA site"
     regulatory      1638..1643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /note="hexamer: AATAAA"
     polyA_site      1657
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
     regulatory      2793..2798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
                     /note="hexamer: ATTAAA"
     polyA_site      2816
                     /gene="Amz2"
                     /gene_synonym="ESTM12"
ORIGIN      
        1 gtgaaagggt gaggtgcgtc cgcgcgaggc gcatgcgtgc taggaccacc gtggcagctt
       61 gagggcggcc tagaggcctg tccggggtga aggccacacc cctttgccag acatgcattg
      121 tccttagaaa aacataaatg gaaaaacagc agctggagat ttctccttta taaagcgtct
      181 gcttggtatg aaggatgaac gtgccacgta gggacttgat aggaatgggg aaagtcctgt
      241 caccatgagt atggcgtctc attggtcatc ttagatctac ccccgtgtct tatggctgac
      301 aagatgcagg tactacggca ctccgagcac acactgaaaa cagctctcct ctcaaagaac
      361 ccagtgcttg tgtcacagta tgagaagtta gatgctgggg agcaacggtt aatgaatgaa
      421 gccttccagc cacgcagtaa cctgtttgag cccattactg tgcactccca gtcagactgg
      481 atctcctccc accccgaggc tccccaagac tttgagcagt ttttctctga ccgctacaga
      541 aaggcaccct gtccaaagaa acatataatc tacattcagt ccattggctc tctaggcaac
      601 accagagtca tcagtgaaga gtatattaaa tggctcaagg gctactgtga agcatttttc
      661 tacggtttga aggtgaagtt cttagaacct gtttcggtct ctgaaaccaa gtgttccttt
      721 agagtgaatg agcacacaca aaacctgcaa atccacacag gacatatcct ggcattcttg
      781 aagaagaata aaccggaaga tgccttctgc atcgtgggga tcacaatgat cgatctctac
      841 cctcgggact cgtggaactt cgtctttgga caggcctcct tgtcaagtgg tgtgggcata
      901 ttcagctttg ccaggtatgg caaggacttc tacacctcga aatacgaagg caatgtgacg
      961 tctctgcagc taacgtctcc cactgactac tccatttttg ataactatta catccctgaa
     1021 atcactagtg ttttgctgtt gcgatcctgt aagactttaa cccatgagat cggacacata
     1081 cttggactgc gacactgcca gtggcttgcg tgtttaatgc aaggctccaa tcacttggag
     1141 gaatctgacc ggcgtcctct gaatgtttgc cctatctgct tacgaaagct gcagagtgcc
     1201 attggcttca atattgtgga gagatacaga gcactggtga agtggattga cgacgaatct
     1261 tgcaacgaat caggagcaac tccgaaaagt agttctgagc atgcgcattt gccgaaacct
     1321 gtggaagcct ttaaggattg gagagagtgg ctaatgagat gcattgctct ccttgagaaa
     1381 taaggacttt gagacaggag taactgaaat aaatactggc acactaggtg ttcgtgggta
     1441 gagttcttca ttgggataca ctgtctgcgg aggccaggtg acagactaga gcttgtctga
     1501 gccctggggc aggaacaagg ttcactaaga acaacaaaac cctctctgcc ttccttcccg
     1561 tatcacagct ggtctgtggc agtaactcca tcacctctgc ccttcagata ggattaggtg
     1621 aagctagacg gcaaacaaat aaatactttg aaaatcattc tgtgtggccc taggaatgaa
     1681 tcagcacttt tccaggttgc agaagagatg ctgccccttg tgaggcccag ccgagtcacc
     1741 agggctttgg ccttgcacag gctgccatcc ttctgacccg tgggtgccct gcactctttc
     1801 ctggccattt ctgagcctgt ccctgcagga agcgatggct tctatcagtt ctcagcagtg
     1861 agaacagcag tggtcctttc ccacagcagc tggggcgggg gggggggggg gggggggtta
     1921 gagcgccttt ctcagctgta actgatggct gcgtctgaag cctttactct aatggtgctt
     1981 atgtctgtgt gggttgcacc cattctatag ggctaggtgg aattgacgtt tgttcttacg
     2041 gtgttttgtc tacttcattg tactgtgaca tgcttgaata agggagggag ggaatggatt
     2101 acttacctgt caggatgcca agagcacctg tgtggtctgt cagcctggat ctcagtgagc
     2161 tgcggtaagc aggttggcaa cctcaggctc aacccatctg tgaggtcaat gcatcttgga
     2221 aaacagaaag tgacctggca gcatattcct tatttgtagt actgttttgt gtttagtttg
     2281 ttgttgtcct ttgagacagg gtctctttaa gtagccctgg ctggccgtga atgcacagag
     2341 aaccccttcc tctgcctctc aagagctggg actgaaggtg tttgctacca cacctggtgg
     2401 tactggactc tgactcaggg ccttgtgcaa gcttagcact ctacagttga gcaacaactc
     2461 tggcccccag ctccccactt tcctatttta tccttaaggt aagacttcct ctctctttca
     2521 tttttttatt tcagtgctgg ggcagggtga ggagatgggg gcgaggctga agggcaacct
     2581 caggtatcac tcctcagcaa ttaggtcagg ctggctgtcc agtgagcctc agggatccac
     2641 ctgcctgctt ccctcacccc caccccgtgg gtactgggta tcccacgggg gcctgtgctt
     2701 acatgacaag ccccttacag gctgagctat ttccagctct ctttttccat ttgaaatcta
     2761 aatgaagtca ttgttgtgat tcacatggtg taattaaaag catggtgaca actgaa
//
